Tag: M.W=100-150

Nitrile is any organic compound with a −C≡N functional group. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. Recommanded Product: 4-Ethynylbenzonitrile.

Qin, Yinhui;Sun, Min;Zhang, Na;Yang, Yan;Ma, Peizhi research published 《 Synthesis and biological evaluation of antibacterial activity of novel clarithromycin derivatives incorporating 1,2,3-triazole moieties at the 4′′- and 11-OH positions》, the research content is summarized as follows. Bacterial infection is still one of the diseases that threaten human health, and bacterial drug resistance is widespread worldwide. As a result, their eradication now largely relies on antibacterial drug discovery. Here, we reveal a novel approach to the development of 14-membered macrolide antibiotics by describing the design, synthesis, and evaluation of novel clarithromycin derivatives incorporating 1,2,3-triazole moieties at the 4′′- and 11-OH positions. Using chem. synthesis, I [R¹ = H, 4-Me, 4-Et, etc.,], II [R² = 4-Et, 4-Pr, 4-tert-Bu, etc.,] were prepared, and their antibacterial properties were profiled. We found that compounds I = [R¹ = 4-Bu, 4-n-pentyl, 4-n-hexyl and 4-Ph, 4-n-pentoxy, 4-F, 4-Cl, 4-Br, 3,5-bis(trifluoromethyl)] and II = [R² = 4-n-pentyl] were as potent as azithromycin against Enterococcus faecalis ATCC29212. Furthermore, compounds I = [R¹ = 4-Et, 4-Pr, 4-Cl and 4-Br] showed slightly improved antibacterial activity (2-fold) against Acinetobacter baumannii ATCC19606 when compared with azithromycin and clarithromycin. In addition, compounds I = [R¹ = 4-Bu, 4-n-pentyl, 4-Ph, 4-n-pentoxy and 3,5-bis(trifluoromethyl)] exhibited excellent antibacterial activity against Staphylococcus aureus ATCC43300, Staphylococcus aureus PR, and Streptococcus pneumoniae ER-2. These compounds were generally 64- to 128-fold more active than azithromycin, and 32- to 128-fold more active than clarithromycin. The results of mol. docking indicated that compound 8f may bind to the nucleotide residue A752 through hydrogen-bonding, hydrophobic, electrostatic, or π-π stacking interactions. The predicted ClogP data suggested that higher values of ClogP (>6.65) enhanced the antibacterial activity of compounds such as I = [R¹ = 4-Bu, 4-n-pentyl, 4-Ph, 4-n-pentoxy and 3,5-bis(trifluoromethyl)]. The determination of the min. bactericidal concentration showed that most of the tested compounds were bacteriostatic agents. From this study of bactericidal kinetics, we can conclude that compound 8f had a concentration- and time-dependent effect on the proliferation of Staphylococcus aureus ATCC43300. Finally, the results of the cytotoxicity assay showed that compound I = [R¹ = 4-n-pentyl] exhibited no toxicity at the effective antibacterial concentration

Recommanded Product: 4-Ethynylbenzonitrile, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Recommanded Product: 4-Ethynylbenzonitrile.

Qing, Bin;Bai, Xueying;Huang, Liliang;Zhao, Jiahui;Zhou, Pengyu;Feng, Huangdi research published 《 Vinyl fluorosulfonamide: a practical vinyl electrophilic reagent for mild and efficient synthesis of ketones under catalyst- and additive-free conditions》, the research content is summarized as follows. A catalyst- and additive-free hydrolysis of alkenyl fluorosulfonamides is achieved, providing an efficient approach for the synthesis of various aryl ketones in moderate to excellent yields. This reaction exhibits broad functional group compatibility without the formation of undesired desulfonation compounds Moreover, the procedure operates under the mild conditions avoiding the use of addnl. metal catalysts or potential security risk substrate (vinyl azide), and the reaction finishes in short reaction time (30 min) at room temperate.

Recommanded Product: 4-Ethynylbenzonitrile, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Recommanded Product: 4-Ethynylbenzonitrile.

Qu, Hongmin;Chen, Yu;Ceng, Xiangling;Tang, Pei;Wang, Huijing;Chen, Fener research published 《 Enantioselective synthesis of chiral 3-alkynyl-3-hydroxyindolin-2-ones by Zn/bis(sulfonamide)-diamine catalyzed asymmetric addition of alkynes to isatins》, the research content is summarized as follows. The catalytic enantioselective alkynylation of isatins, catalyzed by a Zn(OCOCF₃)₂/chiral bis(sulfonamide)-diamine (BSDA) catalyst under mild condition, had been developed. The desired chiral 3-alkynyl-3-hydroxy-2-oxindoles I [R = H, 5-F, 7-Me, etc.; R¹ = Et, Bn, MOM, PMB; R² = cyclopropyl, Ph, 2-thienyl, etc.] were obtained in moderate to excellent yields (up to 96%) and good to excellent enantioselectivities (up to 97% ee). The reaction was broad in scope with respect to aryl-substituted terminal alkynes and substituted isatins.

3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., Recommanded Product: 4-Ethynylbenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Quality Control of 3032-92-6.

Nguyen, Yennie H.;Soares, Joao Vitor;Nguyen, Sami H.;Wu, Yanyu;Wu, Judy I.;Teets, Thomas S. research published 《 Platinum(II)-Substituted Phenylacetylide Complexes Supported by Acyclic Diaminocarbene Ligands》, the research content is summarized as follows. The authors introduce phosphorescent Pt aryl acetylide complexes supported by tert-butyl-isocyanide and strongly σ-donating acyclic diaminocarbene (ADC) ligands. The precursor complexes cis-[Pt(CNtBu)₂(CCAr)₂] (4a–4f) are treated with diethylamine, which undergoes nucleophilic addition with one of the isocyanides to form the cis-[Pt(CNtBu)(ADC)(CCAr)₂] complexes (5a–5f). The new compounds incorporate either electron-donating groups (4-OMe and 4-NMe₂) or electron-withdrawing groups [3,5-(OMe)₂, 3,5-(CF₃)₂, 4-CN, and 4-NO₂] on the aryl acetylide. Exptl. HOMO-LUMO gaps, estimated from cyclic voltammetry, span the range of 2.68-3.61 eV and are in most cases smaller than the unsubstituted parent complex, as corroborated by DFT. In the ADC complexes, peak photoluminescence wavelengths span the range of 428 nm (2a, unsubstituted phenylacetylide) to 525 nm (5f, 4-NO₂-substituted), with the substituents inducing a red shift in all cases. The phosphorescence E_0,0 values and electrochem. HOMO-LUMO gaps are loosely correlated, showing that both can be reduced by either electron-donating or electron-withdrawing substituents on the aryl acetylides. The photoluminescence quantum yields in the ADC complexes are 0.044-0.31 and the lifetimes are 4.8-14μs, a factor of 1.8-10x higher (for Φ_PL) and 1.2-3.6x longer (for τ) than the resp. isocyanide precursor (Φ_PL = 0.014-0.12, τ = 2.8-8.2μs).

Quality Control of 3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Electric Literature of 3032-92-6.

Pan, Shitao;Xie, Qiqiang;Wang, Xiu;Wang, Qian;Ni, Chuanfa;Hu, Jinbo research published 《 Copper-mediated pentafluoroethylation of organoboronates and terminal alkynes with TMSCF₃》, the research content is summarized as follows. The TMSCF₃-derived CuCF₂CF₃ species has been successfully applied in pentafluoroethylation of organoboronates and terminal alkynes. By using 1,10-phenanthroline as a ligand, a broad range of (hetero)arylboronates and alkenylboronates were smoothly pentafluoroethylated under aerobic conditions. Furthermore, terminal alkynes can undergo aerobic cross-coupling with the TMSCF₃-derived CuCF₂CF₃ species in the absence of addnl. ligands.

3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., Electric Literature of 3032-92-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Synthetic Route of 3032-92-6.

Pan, Xuemei;Yu, Limei;Wang, Simin;Wu, Rui;Ou, Chunyan;Xu, Minghui;Chen, Bin;Gao, Yuanji;Ni, Hai-Liang;Hu, Ping;Wang, Bi-Qin;Cao, Peng research published 《 Pd-Catalyzed Enantioselective (3+2)-Cycloaddition of Vinyl-Substituted Oxyallyl Carbonates with Isocyanates and Ketones》, the research content is summarized as follows. The vinyl-substituted oxyallyl carbonates were exploited as a new C,O-dipole for enantioselective Pd-catalyzed (3+2) cycloaddition The corresponding oxyallyl-Pd species was weakly nucleophilic to react with activated carbonyl compounds, affording multisubstituted and enantioenriched oxazolidinones and 1,3-dioxolanes with a high degree of chemo- and stereoselectivity. The synthetic transformations of oxazolidinone product were carried out to build enantioenriched α-chiral aminoketone and epoxy derivatives

Synthetic Route of 3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. Related Products of 3032-92-6.

Mo, Xueling;Huang, Han;Zhang, Guozhu research published 《 Tetrasubstituted Carbon Stereocenters via Copper-Catalyzed Asymmetric Sonogashira Coupling Reactions with gem-Dihaloketones and α-Bromo-γ-lactams》, the research content is summarized as follows. The construction of chiral tetrasubstituted carbon stereocenters is an ongoing challenge in synthetic organic chem. due to its prevalence in multiple disciplines. One efficient approach is the catalytic asym. C-C coupling reactions of a readily available racemic tertiary alkyl electrophile by simple organic nucleophiles. While a variety of secondary alkyl halides succeeded in asym. Cu-catalyzed Sonogashira-type cross-coupling reactions with diverse alkynes, tertiary alkyl halides have rarely been used in this kind of coupling reaction. Herein, tertiary bromides can serve as efficient coupling partners in copper/bisoxazoline Ph amine (BOPA)-catalyzed asym. alkynylation is demonstrated, leading to synthetically and medicinally valuable tertiary C-F stereocenters and all-carbon quaternary stereocenters.

3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., Related Products of 3032-92-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Application In Synthesis of 3032-92-6.

Mudshinge, Sagar R.;Yang, Yuhao;Xu, Bo;Hammond, Gerald B.;Lu, Zhichao research published 《 Gold (I/III)-Catalyzed Trifluoromethylthiolation and Trifluoromethylselenolation of Organohalides》, the research content is summarized as follows. The first C-SCF₃/SeCF₃ cross-coupling reactions using gold redox catalysis [(MeDalphos)AuCl], AgSCF₃ or Me₄NSeCF₃, and organohalides ArI (Ar = Ph, 4-bromophenyl, 2,6-dimethoxypyridin-3-yl, ec.), (E/Z)-RCH=CHI (R = C(O)OMe, Ph, naphthalen-1-yl, etc.) and R¹CCBr (R¹ = Ph, 4-fluorophenyl, 4-nitrophenyl, etc.) as substrates are reported. The new methodol. enables a one-stop shop synthesis of aryl/alkenyl/alkynyl trifluoromethylthio- and selenoethers ArSCF₃, (E/Z)-RCH=CHSCF₃, R¹CCSCF₃, and RSeCF₃ with a broad substrate scope (>60 examples with up to 97% isolated yield). The method is scalable, and its robustness is evidenced by the late-stage functionalization of various bioactive mols., which makes this reaction an attractive alternative in the synthesis of trifluoromethylthio- and selenoethers for pharmaceutical and agrochem. research and development.

Application In Synthesis of 3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Recommanded Product: 4-Ethynylbenzonitrile.

Murayama, Nina;Hao Jorolan, Joel;Minoura, Mao;Nakano, Haruyuki;Ikoma, Tadaaki;Matano, Yoshihiro research published 《 9-(Diphenylphosphoryl)-10-(phenylethynyl)anthracene Derivatives: Synthesis and Implications for the Substituent and Solvent Effects on the Light-Emitting Properties》, the research content is summarized as follows. Herein, we report a series of 9-(diphenylphosphoryl)-10-(phenylethynyl)anthracenes (DPPPEAs) as novel fluorescent 9,10-disubstituted anthracene derivatives The DPPPEAs were prepared by Sonogashira coupling of (10-bromoanthracen-9-yl)diphenylphosphine oxide with terminal arylacetylenes, and their structures were fully characterized. UV/Vis fluorescence spectroscopy and theor. calculations were used to evaluate substituent effects on fluorescence properties of DPPPEAs. The nature of emissive excited state of DPPPEAs was found to vary greatly depending on the substituent, solvent, and temperature Unsubstituted DPPPEA emitted intense fluorescence from locally excited (LE) state, whereas donor-acceptor (D-A) type DPPPEAs substituted with diphenylamino groups showed strong solvatofluorochromism derived from the charge-transfer (CT) state. Notably, carbazolyl derivatives exhibited fluorescence from LE hybridized with CT state. The disappearance of CT emission in rigid media suggests that solvent reorganization plays a crucial role in producing large Stokes shifts of D-A type derivatives The DPPPEAs have also been found to function as annihilators in porphyrin-sensitized triplet-triplet annihilation processes.

3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., Recommanded Product: 4-Ethynylbenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. Related Products of 3032-92-6.

Ma, Peng;Wang, Yuhang;Wang, Jianhui research published 《 Copper-Catalyzed Domino Three-Component Benzannulation: Access to Isoquinolines》, the research content is summarized as follows. The authors report herein the synthesis of isoquinolines through a Cu(I)-catalyzed domino reaction. During this transformation, three mols. of terminal alkynes, 2-bromoaryl aldehydes (ketones), and acetamide react together, in a sequence including Sonogashira coupling, condensation, 6-endo-dig cyclization, elimination of HOAc ,and hydrolysis. In this reaction, isoquinolines with broad functional group tolerance were successfully obtained by using acetamide as N source, which provides an alternative to odorous and toxic amines.

Related Products of 3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts