Tag: M.W=100-150

Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. Recommanded Product: 4-Ethynylbenzonitrile.

Ji, Xiaoliang;Nie, Jinli;Peng, Xin;Hu, Jinhui;Xu, Xuetao;Huang, Yubing;Li, Yibiao;Jiang, Huanfeng research published ã€?Palladium-Catalyzed Cross Haloalkynylation of Haloalkynesã€? the research content is summarized as follows. A robust Pd-catalyzed haloalkynylation of haloalkynes for the synthesis of dihaloalkenyne derivatives R¹R²C(OH)C≡CC(R³)=C(R⁴)R⁵ [R¹ = Me, Et, n-Bu, i-Bu, 3-ClC₆H₄CH₂; R² = Me, Et, n-Bu, i-Bu; R³ = Br, Cl; R⁴ = Br, Cl; R⁵ = hexyl, Ph, 4-MeC₆H₄, etc.; R¹R² = (CH₂)₄, (CH₂)₅, (CH₂)₇, etc.] was developed. This cross-haloalkynylation reaction proceeded in a highly chemo- and regioselective manner under mild conditions in the presence of two slightly structurally different haloalkynes and showed strong functional group tolerance under ligand- and base-free conditions.

3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., Recommanded Product: 4-Ethynylbenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Recommanded Product: 4-Ethynylbenzonitrile.

Jia, Jun-Song;Wu, Tai-Xue;Fu, Yi-Jia;Hu, Zhi-Rong;Tang, Hai-Tao;Pan, Ying-Ming;Huang, Fu-Ping research published ã€?Integrating Terminal CoBr_n Salts into a 2D Cobalt(II) Coordination Polymer to Promote the β-(E)-Selective Hydroboration of Alkynesã€? the research content is summarized as follows. In the present study, 2D Co(II) coordination polymer [[Co₅(4,4′-H₂dbpt)₂Br₁₀]·8(MeCOEt)]_n (CP-1, 4,4′-H₂dbpt = ), which integrate terminal CoBr_n (CoBr₂ and CoBr₃) sites immobilized on the framework, are synthesized at the gram level. As a special heterogeneous catalyst, CP-1 shows regioselectivity (β:α>99:1) and stereoselectivity (only E configuration) in the hydroboration of alkynes. The hydroboration reaction conditions are mild and cover a broad substrate range (31 examples). In addition, the heterogeneous catalyst can be recycled for at least five times.

Recommanded Product: 4-Ethynylbenzonitrile, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Tian, Shi-Kai; Hong, Ran; Deng, Li published the artcile< Catalytic Asymmetric Cyanosilylation of Ketones with Chiral Lewis Base>, SDS of cas: 6136-93-2, the main research area is ketone dialkoxy catalytic asym cyanosilylation chiral Lewis base; cyanohydrin silylated asym synthesis; cinchona alkaloid chiral catalyst enantioselective cyanosilylation dialkoxy ketone.

A highly enantioselective cyanosilylation of α,α-dialkoxy ketones R1COCH(OR2) (R1 = Me, Me2CH, n-Bu, Ph, 4-MeOC6H4, PhCH2, PhCH:CH, PhCC, etc.; R2 = Et, n-Pr) with trimethylsilyl cyanide catalyzed by modified cinchona alkaloids was developed. This reaction is the first highly enantioselective cyanosilylation of ketones catalyzed by an organic chiral Lewis base and, combined with the versatility of the acetal functionality, provides a broadly useful synthetic method for chiral building blocks bearing quaternary stereocenters. Acetal ketones, readily accessible but previously unexplored in asym. synthesis, demonstrate unusual reactivity and selectivity toward the nucleophilic cyanosilylation, thereby suggesting that they may be interesting substrates for other catalytic enantioselective reactions.

Journal of the American Chemical Society published new progress about Addition reaction, stereoselective (cyanosilylation). 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, SDS of cas: 6136-93-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Glover, Christian; Merritt, Eleanor A.; Bagley, Mark C. published the artcile< Synthesis of saramycetic acid>, Electric Literature of 6136-93-2, the main research area is saramycetic acid preparation degradation product thiopeptide antibiotic cyclothiazomycin.

The first reported synthesis of saramycetic acid [2′-acetyl-[2,4′-bithiazole]-4-carboxylic acid], a degradation product of the complex thiopeptide antibiotic cyclothiazomycin, is achieved in nine steps and 11% overall yield from diethoxyacetonitrile by a strategy which incorporates two Hantzsch thiazole syntheses using thioamides prepared from the corresponding nitriles without the use of gaseous H2S. The synthetic material was transformed to Me saramycetate, which had spectroscopic properties in excellent agreement with the literature data.

Tetrahedron Letters published new progress about 6136-93-2. 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, Electric Literature of 6136-93-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mai, Duy N.; Wolfe, John P. published the artcile< Asymmetric Palladium-Catalyzed Carboamination Reactions for the Synthesis of Enantiomerically Enriched 2-(Arylmethyl)- and 2-(Alkenylmethyl)pyrrolidines>, Electric Literature of 6136-93-2, the main research area is pentenylamine asym carboamination bromide aryl alkenyl palladium catalyst; pyrrolidine arylmethyl asym preparation; alkenylmethyl pyrrolidine asym preparation; tylophorine asym preparation.

The enantioselective synthesis of 2-(arylmethyl)- and 2-(alkenylmethyl)pyrrolidine derivatives, e.g., I, via Pd-catalyzed alkene carboamination reactions was described. These transformations generated enantiomerically enriched products with up to 94% ee from readily available alkenyl or aryl bromides and N-Boc-pent-4-enylamines. The application of this method to a concise asym. synthesis of (-)-tylophorine was also discussed.

Journal of the American Chemical Society published new progress about Amination catalysts (stereoselective, intramol., carbo-). 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, Electric Literature of 6136-93-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Patalag, Lukas J.; Jones, Peter G.; Werz, Daniel B. published the artcile< Aza-BOIMPYs: a tetrazole auxochrome for highly red-emissive dipyrromethene-based fluorophores>, Quality Control of 6136-93-2, the main research area is boron complex iminopyrrolide ligand fluorophore tetrazole auxochrome; BODIPY; BOIMPY; dyes; fluorophores; tetrazole.

A structural derivative of the recently designed BOIMPY motif is introduced; this derivative engages a meso tetrazole moiety and a dipyrromethene scaffold in a twofold BF2-coordination scheme. A one-pot synthesis allows the isolation of unusual dipyrro-perazafulvene precursors and subsequent access to nonfluorescent mono-BF2 and fluorescent bis-BF2 species. The novel fluorophore, denoted Aza-BOIMPY, is highly emissive (ΦF up to 0.82), structurally compact, and provides useful inherent polarity. Absorption and emission events focus at roughly 600 nm with exceptionally small Stokes shifts (209 cm-1) and high attenuation coefficients (up to 120 000 M-1 cm-1). X-ray crystallog. and computational investigations provide insights into geometrical and electronic properties of the novel dye type.

Chemistry – A European Journal published new progress about Chromophores, auxochromes. 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, Quality Control of 6136-93-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Murakami, Teiichi; Otsuka, Masami; Kobayashi, Susumu; Ohno, Masaji published the artcile< Efficient synthesis of 3-formyl-1,2,4-triazole nucleoside using diethoxyacetonitrile as a synthon>, Safety of 2,2-Diethoxyacetonitrile, the main research area is triazolecarboxaldehyde; nucleoside triazolecarboxaldehyde; diethoxyacetonitrile synthon triazolecarboxaldehyde; cyclization diethoxyiminoethylhydrazinoribofuranose.

(EtO)2CHCN (I) was used as a synthon for the synthesis of 1,2,4-triazole-3-carboxaldehyde and nucleoside II. I was treated with MeOH in the presence of MeONa and the resultant (EtO)2CHC(:NH)OMe was treated with ribofuranose III (R = H) to give III [R = C(:NH)CH(OEt)2] (IV). IV was cyclized with HC(OEt)3 and the resultant nucleoside was deblocked to give II.

Heterocycles published new progress about Cyclization. 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, Safety of 2,2-Diethoxyacetonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Si, Chong; Myers, Andrew G. published the artcile< A Versatile Synthesis of Substituted Isoquinolines>, SDS of cas: 6136-93-2, the main research area is isoquinoline preparation cyclization imine nitrile.

This communication present the direct assembly of substituted isoquinolines and biisoquinolines for use in versatile and unique methodologies for the construction of heterocyclic compounds

Angewandte Chemie, International Edition published new progress about Condensation reaction. 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, SDS of cas: 6136-93-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Bagley, Mark C.; Chapaneri, Krishna; Glover, Christian; Merritt, Eleanor A. published the artcile< Simple microwave-assisted method for the synthesis of primary thioamides from nitriles>, Application of C6H11NO2, the main research area is nitrile reaction ammonium sulfide microwave irradiation; thioamide primary preparation.

Primary thioamides are prepared in excellent yield from the corresponding nitrile by treatment with ammonium sulfide in methanol, at room temperature for electron-deficient aromatic nitriles or under microwave irradiation at 80 °C or 130 °C in 15-30 min for other aromatic and aliphatic nitriles. This procedure avoids the use of gaseous H2S under high pressure, proceeds in the absence of base and provides thioamides usually without the need for chromatog. purification

Synlett published new progress about Microwave irradiation. 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, Application of C6H11NO2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ressmann, Anna K.; Schwendenwein, Daniel; Leonhartsberger, Simon; Mihovilovic, Marko D.; Bornscheuer, Uwe T.; Winkler, Margit; Rudroff, Florian published the artcile< Substrate-Independent High-Throughput Assay for the Quantification of Aldehydes>, Computed Properties of 38487-85-3, the main research area is aldehyde quantification high throughput assay aminobenzamidoxime derivative.

The selective and direct reduction of carboxylic acids into the corresponding aldehydes by chem. methods is still a challenging task in synthesis. Several reductive and oxidative chem. methods are known to produce aldehydes, but most of them require expensive reagents, special reaction conditions, are 2-step procedures and often lack chemoselectivity. Nature provides an elegant tool, so called carboxylic acid reductases (CARs) for the direct reduction of carboxylic acids to aldehydes. Discovery as well as engineering of novel CAR enzymes necessitates a robust, product selective high-throughput assay (HTA). The authors report a simple and fast HTA that allows the substrate-independent and chemoselective quantification of aldehydes (irresp. of their chem. structure) and is sensitive to the nM range. The HTA was validated by NMR and GC analyses and in microbial cells by reexamination of the substrate scope of CAR from Nocardia iowensis (CARNi). The results were fully consistent with reported data.

Advanced Synthesis & Catalysis published new progress about Aldehydes Role: ANT (Analyte), RCT (Reactant), SPN (Synthetic Preparation), ANST (Analytical Study), RACT (Reactant or Reagent), PREP (Preparation). 38487-85-3 belongs to class nitriles-buliding-blocks, and the molecular formula is C8H8N2O, Computed Properties of 38487-85-3.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts