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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 4556-23-4, is researched, SMILESS is SC1=CC=NC=C1, Molecular C5H5NSJournal, Article, Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy called Effect of the functionalization agent on the surface-enhanced Raman scattering (SERS) spectrum: Case study of pyridine derivatives, Author is Dumont, Elodie; De Bleye, Charlotte; Haouchine, Merzouk; Coic, Laureen; Sacre, Pierre-Yves; Hubert, Philippe; Ziemons, Eric, the main research direction is functionalization agent surface enhanced raman scattering pyridine derivative; Aggregation; Functionalization agents; Pyridine derivatives; Stability; Surface-enhanced Raman scattering (SERS).HPLC of Formula: 4556-23-4.

Nowadays, the use of functionalized surface-enhanced Raman scattering (SERS) substrates has become common. These surface modifying agents notably act as Raman reporters, as sensors of biol. processes (pH, redox probes) or to increase the sensitivity and/or the specificity of SERS detections. However, the effects of the functionalization agents are deeply examined in very few studies, even though they can affect the aggregation behavior of the SERS substrate. Moreover, depending on their concentration and on the pH, their spectral signature can be modified and they can even degrade if stored inappropriately. In this context, this paper aims at emphasizing the importance of the different aspects previously listed in the selection of a functionalization agent. Pyridine derivatives were picked out to highlight these parameters, as some of these compounds are commonly used to be grafted onto SERS substrates. Two widespread syntheses of nanoparticles were selected as SERS substrates: citrate-reduced gold and silver nanoparticles. The surface of the nanoparticles was functionalized with several pyridine derivatives at different concentrations and in several solvents. It was observed that the mols. under study had a concentration-dependent effect on nanoparticle aggregation. A stability study was furthermore conducted in order to determine the best preservation conditions of the grafting solutions In conclusion, this paper shines a light on the relevance of the investigation of the too-often neglected behavior of the surface modifying agents. Before their application in SERS analyses, parameters such as the label concentration should therefore be included in an exptl. design to optimize the sample preparation

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Pyridine-4-thiol( cas:4556-23-4 ) is researched.Quality Control of Pyridine-4-thiol.Li, Kan; Li, Jing-jing; Zhao, Ni; Ma, Ying; Di, Bin published the article 《Removal of tetracycline in sewage and dairy products with high-stable MOF》 about this compound( cas:4556-23-4 ) in Molecules. Keywords: metal organic framework tetracycline adsorption milk yogurt sewage; MOF; adsorption and removal; tetracycline. Let’s learn more about this compound (cas:4556-23-4).

Serious environmental and human health problems caused by the abuse of antibiotics have attracted worldwide concern. Recently, metal-organic frameworks (MOFs) with high porosity have drawn wide attention for their effects in the adsorption and removal of pollutants from complex matrixes. Herein, a high-stable metal organic framework (MOF), i.e., ((ZnCl2)3(L)2·DMF)n, where L=1,3,5-tris((pyridin-4-ylthio)methyl)benzene), MOF 1, was applied to adsorb and remove tetracycline from sewage and dairy products. The results showed that MOF 1 exhibited a strong performance in the adsorption of tetracycline. The effects of initial pH values, adsorbent dose, contact time and ionic strength of the adsorption performance of MOF 1 were investigated. The adsorption kinetics best fit the pseudo-second order model, and the adsorption isotherms matched the Langmuir adsorption model well. It was indicated that both chem. adsorption and phys. adsorption play an important role in the adsorption process, and the adsorption of tetracycline was homogeneous and occurred on a monolayer on the surface of MOF 1. Addnl., the stability of MOF 1 and the details of the adsorption mechanism were also investigated. Thus, this study provides a new candidate for the application of MOFs-based adsorbents in the removal of antibiotics from sewage and dairy products.

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Recommanded Product: 5-Chloro-1-methyl-4-nitroimidazole. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about A controlled-oxidation synthesis of substituted aryl 1-methyl-4-nitro-5-imidazolyl sulfones. Author is Heindel, Ned D.; Lacey, C. Jeffrey; Egolf, Roger; Mease, Belle N.; Schray, Keith J..

Aryl imidazolyl sulfones I (R = 2-, 3-, 4-NHCOCH2CH2CO2H) bearing pendant hemisuccinamido groups for conjugation to biopolymer transport systems were synthesized from sulfide precursors. The peroxide-effected oxidation at sulfur was invariably accompanied by some cleavage-oxidation of the carboxamido groups to nitro functionalities, a process which could be minimized by careful control of the reaction conditions.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Chloro-1-methyl-4-nitroimidazole( cas:4897-25-0 ) is researched.Reference of 5-Chloro-1-methyl-4-nitroimidazole.Yan, Qiu-mei; He, Bin; Pan, Fu-you published the article 《Process improvement on the synthesis of 5-chloro-1-methyl-4-nitroimidazole》 about this compound( cas:4897-25-0 ) in Hecheng Huaxue. Keywords: nitroimidazole preparation. Let’s learn more about this compound (cas:4897-25-0).

5-Chloro-1-methyl-4-nitroimidazole in overall yield of 61.3% was synthesized from di-Et oxalate by a four-step reaction of amination, cyclization, salt formation, and nitration. The structure was characterized by NMR, IR and MS. Two improvements were that 30%∼40% methylamine aqueous solution was substituted for methylamine gas in amination, and crystal of 5-chloro-1-methylimidazole nitrate was separated out by adding nitric acid into acetone solution of cyclization product in salt formation.

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Application of 4897-25-0. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about 4-Cyclopropyl-1-(1-methyl-4-nitro-1H-imidazol-5-yl)-1H-1,2,3-triazole and Ethyl 1-(1-methyl-4-nitro-1H-imidazol-5-yl)-1H-1,2,3-triazole-4-carboxylate. Author is Boechat, Nubia; Carvalho, Alcione S.; Quaresma, Bruna M. C. S.; Wardell, James L.; Wardell, Solange M. S. V..

The crystal structures of 4-cyclopropyl-1-(1-methyl-4-nitro-1H-imidazol-5-yl)-1H-1,2,3-triazole (I) and Et 1-(1-methyl-4-nitro-1H-imidazol-5-yl)-1H-1,2,3-triazole-4-carboxylate (II) were reported. The two mols. were non-planar as indicated by the dihedral angles between the heteroaryl rings of 53.94 (7)° in I (R = cyclopropyl) and 70.68 (12)° in I (R = EtOCO). Considerable delocalization of π-electron d. within the triazole ring was indicated by the pattern of bond distances in I. By contrast to I, localization of π-electron d. within the triazole ring in II was apparent. In both mols., the nitro group took part in N-O···π(imidazole) interactions. Compound I crystallized in the orthorhombic space group P212121 with a = 7.8053(3) Å, b = 8.5264(3) Å, c = 15.7343(11) Å and Z = 4. Compound II crystallized in the monoclinic space group, P21/c with a = 5.2740(4) Å, b = 8.9695(5) Å, c = 26.0080(18) Å, β = 92.622(2)° and Z = 4.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called SERS active substrates of gold nanoparticles embedded in the pool of 5-CB liquid crystal molecules organized in Langmuir-Reverse Schaefer films: A facile fabrication route to make the topological defects useful, published in 2019-08-01, which mentions a compound: 4556-23-4, mainly applied to gold cyano pentylbiphenyl Langmuir Reverse Schaefer film topol defect, HPLC of Formula: 4556-23-4.

This paper reports for the first time, fabrications of SERS active substrates I and II from Langmuir Reverse Schaefer (L-R Sh) films of 5-CB nematic liquid crystal mols. immersed in gold nanocolloids for 36 and 48 h resp. Under parallel or slightly crossed polarizations, the POM images of these two substrates exhibit micro aggregated textures embedded in the pool of 5-CB mols. Under crossed polarizations, the aggregated textures disappear with the appearance of bright birefringent defects of various sizes and shapes. The rationale behind the evolution of such micro aggregated textures and spatial locations of birefringent defects in these substrates are suggested. The FESEM images of the substrates exhibit distinctive patterns driven by the birefringent defects and confirm trapping of gold nanoparticles within the defect sites. The instabilities appeared in the patterns are estimated from statistical considerations in terms of Hurst exponent and phase space trajectories. The chaotic domains prevailing in these substrates are confirmed from the Lyapunov exponents. The efficacies of both the substrates as efficient SERS sensing platform have been tested to detect 4-MPy mols. at trace concentration The as prepared substrates can be used as “”lab on a chip”” for chem. and biochem. sensing at ultralow concentrations

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Pyridine-4-thiol, is researched, Molecular C5H5NS, CAS is 4556-23-4, about Eliminating irreproducibility in SERS substrates.Formula: C5H5NS.

Irreproducibility in surface-enhanced Raman spectroscopy (SERS) due to variability among substrates is a source of recurrent debate within the field. It is regarded as a major hurdle towards the widespread adoption of SERS as a sensing platform. Most of the literature focused on developing substrates for various applications considers reproducibility of lower importance. Here, we address and analyze the sources of this irreproducibility in order to show how these can be minimised. We apply our findings to a simple substrate demonstrating reproducible SERS measurements with relative standard deviations well below 1% between different batches and days. Identifying the sources of irreproducibility and understanding how to reduce these can aid in the transition of SERS from the lab to real-world applications.

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Synthetic Route of C4H4ClN3O2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about The synthesis of aryl 4-nitro-5-imidazolyl sulfone radiation sensitizers sterically protected against glutathione reaction. Author is Egolf, Roger A.; Heindel, Ned D..

Title sulfones I (R1 = R2 = Me, R3 = OCH2CO2H; R1 = Cl, R2 = Me, Cl, R3 = H; R1 = R3 = Cl, R2 = CO2H) were prepared by treating chloroimidazole II with thiophenols III in the presence of NH3 in EtOH and oxidizing the resulting sulfides with H2O2 in HOAc. Title neopentyl derivatives IV (R1 = R2 = Me, R3 = OCH2CO2H; R1 = Cl, R2 = Me, Cl, R3 = H; R1 = CO2Me, R2 = R3 = H) were prepared similarly. I and V were tested as radiation sensitizers of hypoxic carcinoma cells. These sterically crowded imidazoles show decreased displacement reactivity with glutathione at C-5, a major metabolic reaction known to deplete effective plasma drug levels in traditional aryl imidazolyl sulfone radiation sensitizers.

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Zhang, Meng; Wang, Yanan; Wang, Xu; Zhao, Bing; Ruan, Weidong published the article 《Surface-enhanced Raman scattering (SERS) on indium-doped CdO (ICO) substrates: New charge-transfer enhancement contribution from electrons in conduction bands》. Keywords: surface enhanced Raman scattering indium doped cadmium oxide; charge transfer enhancement contribution electron conduction band.They researched the compound: Pyridine-4-thiol( cas:4556-23-4 ).Name: Pyridine-4-thiol. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:4556-23-4) here.

Surface-enhanced Raman scattering (SERS) substrates have shown rapid development in recent years, but the use of transparent conductive oxides (TCOs) in SERS is still limited. Here, a series of In-doped CdO (ICO) NPs with different In3+ doping contents x (x = 0, 0.025, 0.050, 0.075, 0.100, 0.125, 0.150, and 0.200) were synthesized by a hydrothermal method and first employed as a SERS platform. The structures and properties of the ICO NPs influenced by dopant concentration of In3+ ions were characterized by powder X-ray diffraction (XRD), inductively coupled plasma (ICP) anal., SEM (SEM), XPS, and Fourier transform IR (FTIR) spectroscopy. Furthermore, the SERS spectra of ICO-MPY were investigated. Interestingly, the enhancement was dominated by the charge-transfer (CT) contribution through the free electrons in conduction bands (CBs). The changes in electronic distributions in energy levels of ICO NPs at different doping contents were explored, and the corresponding effect on SERS was discussed by employing 633 and 785 nm excitation lines, resp. The CT route was found to be the excitation of electrons from CBs of semiconductor to the LUMO of mol., which provides a new perspective in understanding SERS mechanisms. The present work provides a new approach to develop potential semiconductive SERS substrates.

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Li, Kan; Li, Jing-jing; Zhao, Ni; Xie, Ting-ting; Di, Bin; Xu, Li-li published the article 《Thioether-based recyclable metal-organic frameworks for selective and efficient removal of Hg2+ from water》. Keywords: thioether metal organic framework removal mercury.They researched the compound: Pyridine-4-thiol( cas:4556-23-4 ).Safety of Pyridine-4-thiol. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:4556-23-4) here.

Hg2+ is highly toxic and hazardous and widely found in polluted water. To remove mercury ions from wastewater, there is an urgent need to investigate and develop new adsorbents. Herein, we synthesized three novel thioether-based metal-organic frameworks (MOFs) through a facile diffusion method or a solvothermal strategy, i.e. [(ZnCl2)3(L1)2·χ(solvent)]n (1), [(Cu2I3O2)4(CH4N0.5)4(L1)4(DMA)4·3(H2O)·χ(solvent)]n (2) and [(CuBr2)2(L2)2 CH3CN·χ(solvent)]n (3), where L1 = 1,3,5-tris((pyridin-4-ylthio)methyl)benzene and L2 = 2,4,6-trimethoxy-1,3,5-tris((pyridin-4-ylthio)methyl)benzene. The obtained thioether-based MOFs were characterized by single-crystal X-ray diffraction, Fourier transform IR spectroscopy, elemental anal. and thermogravimetric anal. Further studies revealed that they could remove Hg2+ from water. They have high adsorptivity (up to 362 mg g-1) and are highly efficient in removing Hg2+ (up to 95%). Besides, these MOFs can be recycled and can selectively remove Hg2+ from water in the presence of other metal ions. Consequently, these MOFs are highly promising candidates for the selective absorption and removal of mercury ions from water.

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