Tag: M.W=100-200

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Analytical and synthetic studies on the photodecomposition of nitroimidazole compounds, published in 1987-06-30, which mentions a compound: 4897-25-0, mainly applied to azathioprine photodegradation product identification, Product Details of 4897-25-0.

The photodegradation products and synthetic byproducts of azathioprine (I) were isolated and identified to study their potential role in the photosensitization process. Synthetic byproducts observed in the preparation of I included 1-methyl-5-chloroimidazole, 1-methyl-4-chloroimidazole, and 1-methyl-2,4,5-trichloroimidazole. Photolysis at wavelengths >300 nm for 1 h caused a marked change in the UV spectrum of I, giving increased absorption at longer wavelengths. This may be associated with its reported activity as a photosensitizer.

Compound(4897-25-0)Product Details of 4897-25-0 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(5-Chloro-1-methyl-4-nitroimidazole), if you are interested, you can check out my other related articles.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

de Gombert, Antoine; McKay, Alasdair I.; Davis, Christopher J.; Wheelhouse, Katherine M.; Willis, Michael C. published an article about the compound: Pyridine-4-thiol( cas:4556-23-4,SMILESS:SC1=CC=NC=C1 ).HPLC of Formula: 4556-23-4. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:4556-23-4) through the article.

Pyridine and related heterocyclic sulfinates have recently emerged as effective nucleophilic coupling partners in palladium-catalyzed cross-coupling reactions with (hetero)aryl halides. These sulfinate reagents are straightforward to prepare, stable to storage and coupling reaction conditions, and deliver efficient reactions, thus offering many advantages, compared to the corresponding boron-derived reagents. Despite the success of these reactions, there are only scant details of the reaction mechanism. In this study, we use structural and kinetic anal. to investigate the mechanism of these important coupling reactions in detail. We compare a pyridine-2-sulfinate with a carbocyclic sulfinate and establish different catalyst resting states, and turnover limiting steps, for the two classes of reagent. For the carbocyclic sulfinate, the aryl bromide oxidative addition complex is the resting state intermediate, and transmetalation is turnover-limiting. In contrast, for the pyridine sulfinate, a chelated Pd(II) sulfinate complex formed post-transmetalation is the resting-state intermediate, and loss of SO2 from this complex is turnover-limiting. We also investigated the role of the basic additive potassium carbonate, the use of which is crucial for efficient reactions, and deduced a dual function in which carbonate is responsible for the removal of free sulfur dioxide from the reaction medium, and the potassium cation plays a role in accelerating transmetalation. In addition, we show that sulfinate homocoupling is responsible for converting Pd(OAc)2 to a catalytically active Pd(0) complex. Together, these studies shed light on the challenges that must be overcome to deliver improved, lower temperature versions of these synthetically important processes.

Here is just a brief introduction to this compound(4556-23-4)HPLC of Formula: 4556-23-4, more information about the compound(Pyridine-4-thiol) is in the article, you can click the link below.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

SDS of cas: 4556-23-4. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Pyridine-4-thiol, is researched, Molecular C5H5NS, CAS is 4556-23-4, about Tuning the electrochemical behavior of organodisulfides in rechargeable lithium batteries using N-containing heterocycles. Author is Wang, Dan-Yang; Si, Yubing; Li, Junjie; Fu, Yongzhu.

S-S bonds in organodisulfides can break and obtain Li+ and e- in the discharge of lithium batteries. Organodisulfides provide precise lithiation sites, and therefore are valuable models for the study of redox reactions in lithium batteries. To understand their electrochem. behavior, we investigate three disulfides with different N-containing heterocycles including 2,2′-dipyridyl disulfide (2,2′-DpyDS), 4,4′-dipyridyl disulfide (4,4′-DpyDS), and 2,2′-dipyridyl disulfide-N,N’-dioxide (DpyDSDO). The three disulfides all show higher discharge voltage plateaus due to the electron-withdrawing groups: DPDS (2.20 V) < 2,2'-DpyDS (2.45 V) = 4,4'-DpyDS (2.45 V) < DpyDSDO (2.80 V). In particular, 2,2'-DpyDS exhibits an outstanding 69% capacity retention over 500 cycles. Our theor. simulations show that lithium pyridine-2-thiolate, the discharge product of 2,2'-DpyDS, forms compact clusters via N···Li···S bridges coordinated by lithium ions, which can help reduce its dissolution in liquid electrolyte, and therefore increase the cycle life. Liquid chromatog.-mass spectrometry is demonstrated to be a powerful tool for the investigation of discharge/recharge products of soluble organodisulfides in rechargeable lithium batteries. In some applications, this compound(4556-23-4)SDS of cas: 4556-23-4 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Chemical Science called Effect of nanostructuration on the spin crossover transition in crystalline ultrathin films, Author is Rubio-Gimenez, Victor; Bartual-Murgui, Carlos; Galbiati, Marta; Nunez-Lopez, Alejandro; Castells-Gil, Javier; Quinard, Benoit; Seneor, Pierre; Otero, Edwige; Ohresser, Philippe; Cantarero, Andres; Coronado, Eugenio; Real, Jose Antonio; Mattana, Richard; Tatay, Sergio; Marti-Gastaldo, Carlos, which mentions a compound: 4556-23-4, SMILESS is SC1=CC=NC=C1, Molecular C5H5NS, Computed Properties of C5H5NS.

Mastering the nanostructuration of mol. materials onto solid surfaces and understanding how this process affects their properties are of utmost importance for their integration into solid-state electronic devices. This is even more important for spin crossover (SCO) systems, in which the spin transition is extremely sensitive to size reduction effects. These bi-stable materials have great potential for the development of nanotechnol. applications provided their intrinsic properties can be successfully implemented in nanometric films, amenable to the fabrication of functional nanodevices. Here we report the fabrication of crystalline ultrathin films (<1-43 nm) of two-dimensional Hofmann-type coordination polymers by using an improved layer-by-layer strategy and a close examination of their SCO properties at the nanoscale. X-ray absorption spectroscopy data in combination with extensive at. force microscopy anal. reveal critical dependence of the SCO transition on the number of layers and the microstructure of the films. This originates from the formation of segregated nanocrystals in early stages of the growth process that coalesce into a continuous film with an increasing number of growth cycles for an overall behavior reminiscent of the bulk. As a result, the completeness of the high spin/low spin transition is dramatically hindered for films of less than 15 layers revealing serious limitations to the ultimate thickness that might be representative of the performance of the bulk when processing SCO materials as ultrathin films. This unprecedented exploration of the particularities of the growth of SCO thin films at the nanoscale should encourage researchers to put a spotlight on these issues when contemplating their integration into devices. In some applications, this compound(4556-23-4)Computed Properties of C5H5NS is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ding, Xin; Tuikka, Matti; Haukka, Matti published an article about the compound: Pyridine-4-thiol( cas:4556-23-4,SMILESS:SC1=CC=NC=C1 ).SDS of cas: 4556-23-4. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:4556-23-4) through the article.

Sulfur is a widely used halogen bond (XB) acceptor, but only a limited number of neutral XB acceptors with bifurcated sp3-S sites have been reported. In this work, a new bidentate XB acceptor, 1-(4-pyridyl)-4-thiopyridine (PTP), which combines sp3-S and sp2-N acceptor sites, is introduced. Three halogen bonded cocrystals were obtained by using 1,4-diiodobenzene (DIB), 1,4-diiodotetrafluorobenzene (DIFB), and iodopentafluorobenzene (IPFB) as XB donors and PTP as acceptor. The structures of the cocrystals showed some XB selectivity between the S and N donors in PTP. However, the limited contribution of XB to the overall mol. packing in these three cocrystals and the results from DSC measurements clearly point out the synergetic influence and interplay of all noncovalent interactions in crystal packing of these compounds

Compounds in my other articles are similar to this one(Pyridine-4-thiol)SDS of cas: 4556-23-4, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 4897-25-0. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Fluoride relay: a new concept for the rapid preparation of anhydrous nucleophilic fluoride salts from KF. Author is Sun, Haoran; DiMagno, Stephen G..

Fluoride relay is used to generate exceptionally nucleophilic fluoride reagents from KF on a time scale commensurate with radiotracer synthesis. Anhydrous TBAF was prepared and used in the fluorination reaction of heterocyclic aromatic substrates.

Compounds in my other articles are similar to this one(5-Chloro-1-methyl-4-nitroimidazole)Related Products of 4897-25-0, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 4897-25-0, is researched, Molecular C4H4ClN3O2, about Tyrosine kinase 4 is involved in the reproduction of the platyhelminth parasite Schistosoma japonicum, the main research direction is sequence Schistosoma schistosomiasis reproduction gametogenesis tyrosine kinase 4; Piceatannol; Reproduction; Schistosoma japonicum; SjTK4.Product Details of 4897-25-0.

Background: Schistosomiasis is one of the most common parasitic diseases affecting millions of humans and animals worldwide. Understanding the signal transduction pathways and the mol. basis of reproductive regulation in schistosomes is critically important for developing new strategies for preventing and treating these infections. Syk kinases regulate the proliferation, differentiation, morphogenesis, and survival of various types of cells and have been identified in invertebrates. Tyrosine kinase 4 (TK4), a member of the Syk kinase family, plays a pivotal role in gametogenesis in S. mansoni, affecting the development of the testis and ovaries in this parasite. The role of TK4, however, in the reproduction of S. japonicum is poorly understood. Methods: Here, the complete coding sequence of TK4 gene in S. japonicum (SjTK4) was cloned and characterized. The expression of SjTK4 was analyzed at different life-cycle stages and in various tissues of S. japonicum by qPCR. Piceatannol, a Syk kinase inhibitor, was applied to S. japonicum in vitro. The piceatannol-induced morphol. changes of the parasites were observed using confocal laser scanning microscopy and the alterations in important egg-shell synthesis-related genes were examined using qPCR analyses. Results: SjTK4 mRNA was differentially expressed throughout the life-cycle of S. japonicum. SjTK4 mRNA was highly expressed in the ovary and testis of S. japonicum, with the level of gene expression significantly higher in males than in females. The expression levels of some important egg-shell synthesis related genes were higher in the piceatannol-treated groups than in the vehicle-treated control group and the number of eggs and germ cells also decreased in a concentration-dependent manner. Importantly, large pore-like structures can be found in the testis and ovaries of males and females after treating with piceatannol. Conclusion: The results suggest that SjTK4 may play an important role in regulating gametogenesis of S.japonicum. The findings may help better understand the fundamental biol. of S. japonicum. Moreover, the effect of S. japonicum treatment by piceatannol provides us with a new idea that inhibition of SjTK4 signaling pathway can effectively retard the development of the testis and ovaries.

When you point to this article, it is believed that you are also very interested in this compound(4897-25-0)Product Details of 4897-25-0 and due to space limitations, I can only present the most important information.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Pyridine-4-thiol(SMILESS: SC1=CC=NC=C1,cas:4556-23-4) is researched.Category: catalysis-chemistry. The article 《Reliable Quantification of pH Variation in Live Cells Using Prussian Blue-Caged Surface-Enhanced Raman Scattering Probes》 in relation to this compound, is published in Analytical Chemistry (Washington, DC, United States). Let’s take a look at the latest research on this compound (cas:4556-23-4).

Intracellular pH is an important parameter that is highly associated with diverse physiol. processes. The reliable measurement of pH values inside cells remains a formidable challenge because of the complexity of cytoplasm. Herein, we report a robust Prussian blue (PB)-caged pH-responsive surface-enhanced Raman scattering (SERS) probe for precisely mapping the dynamic pH values in live cells. The PB shell has a subnanoscale porous structure that allows only very small biospecies such as H+ or OH- to pass freely through the shell and react with the encased pH-responsive SERS probe, while phys. resisting the entry of large biomols. This probe achieved unmatched detection linearity (R2 > 0.999) for pH measurements in diverse complex biol. samples. Moreover, the nitrile (CN) in PB shows a sharp band in the cellular Raman-silent region, which serves as a background-free internal standard for accurate profiling of the probe distribution inside the cells. We applied the proposed probe to monitor the dynamic pH changes during cellular autophagy induced by different stimuli and thereby demonstrated that the PB-caged probe can reliably quantify subtle intracellular pH variations, providing an effective tool for revealing the relationship between abnormal intracellular pH and cellular functions.

When you point to this article, it is believed that you are also very interested in this compound(4556-23-4)Electric Literature of C5H5NS and due to space limitations, I can only present the most important information.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Pyridine-4-thiol, is researched, Molecular C5H5NS, CAS is 4556-23-4, about Revealing Mitochondrial Microenvironmental Evolution Triggered by Photodynamic Therapy, the main research direction is mitochondrial microenvironment cancer photodynamic therapy nanosensor sequence.Formula: C5H5NS.

Mitochondrion is one of the most important organelles and becomes a target in many cancer therapeutic strategies. Mitochondrial microenvironments in response to therapeutic methods are the key to understand therapeutic mechanisms. However, they are almost rarely studied. Herein, the mitochondrial microenvironments, including mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) after different photodynamic therapy (PDT) dosages, were monitored by fluorescent imaging and compared among three cell lines (HepG2, MCF-7, and LO2). Furthermore, the fluctuations of intramitochondrial pHs were revealed via a plasmonic mitochondrion-targeting surface-enhanced Raman scattering (SERS) pH nanosensor. Results indicate that the MMP decreases gradually with the ROS generation and the cancerous cells exhibit less response to excess ROS relative to normal cells. On the other hand, the pH value in the mitochondria decreases initially and then increases when the amount of ROS increases. The LO2 cell is preliminarily evidenced to have a higher self-adjustment ability due to its better tolerance to differential intra/extracellular pHs. This study may provide a basis for an in-depth understanding of the mechanisms of the mitochondrial targeting-based PDT therapeutic processes. It is also helpful for more accurate and useful diagnosis according to intramitochondrial microenvironments and improvement on therapy efficiency of cancers.

When you point to this article, it is believed that you are also very interested in this compound(4556-23-4)Formula: C5H5NS and due to space limitations, I can only present the most important information.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Chemical Modifications of Gold Surfaces with Basic Groups and a Fluorescent Nanoparticle Adhesion Assay To Determine Their Surface pKa, published in 2019-06-04, which mentions a compound: 4556-23-4, Name is Pyridine-4-thiol, Molecular C5H5NS, Category: nitriles-buliding-blocks.

Purpose For pharmaceutical, biol. and biomedical applications the functionalization of gold surfaces with pH-sensitive groups has great potential. The aim of this work was to modify gold surfaces with pH-sensitive groups and to determine the pKa of the modified gold surfaces using a fluorescent nanoparticle adhesion assay. Methods To introduce pH-sensitive groups onto gold surfaces, we modified gold-coated silicon slides with four different bases: 4-mercaptopyridine (4-MP), 4-pyridylethylmercaptan (4-PEM), 4-aminothiophenol (4-ATP), and 2-mercaptoethylamine (2-MEA). To screen whether the modifications were successful, the binding of neg. charged fluorescently-labeled nanoparticles to the pos. charged surfaces was visualized by fluorescence microscopy and at. force microscopy. Next, the pKa of the modified surfaces was determined by quantifying the pH-dependent adhesion of the fluorescently-labeled nanoparticles with fluorescence spectroscopy. Results Fluorescence microscopy showed that the gold surfaces were successfully modified with the four different basic mols. Moreover, fluorescence spectroscopy revealed that fluorescently-labeled neg. charged nanoparticles bound onto gold surfaces that were modified with one of the four bases in a pH-dependent manner. By quantifying the adsorption of neg. charged fluorescently-labeled nanoparticles onto the functionalized gold surfaces and using the Henderson-Hasselbalch equation, the pKa of these surfaces was determined to be 3.7 ± 0.1 (4-MP), 5.0 ± 0.1 (4-PEM), 5.4 ± 0.1 (4-ATP), and 7.4 ± 0.3 (2-MEA). Conclusion We successfully functionalized gold surfaces with four different basic mols., yielding modified surfaces with different pKa values as determined with a fluorescent nanoparticle adhesion assay.

When you point to this article, it is believed that you are also very interested in this compound(4556-23-4)Category: nitriles-buliding-blocks and due to space limitations, I can only present the most important information.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts