Share a compound : 4-Methyl-3-oxopentanenitrile

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Adding a certain compound to certain chemical reactions, such as: 29509-06-6, name is 4-Methyl-3-oxopentanenitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 29509-06-6, Computed Properties of C6H9NO

Sodium hydride (60%, 11.52 g, 287 mmol) in a round bottomflask was cooled using an ice-water bath and kept under nitrogenatmosphere on a Schlenk line. Anhydrous acetonitrile (15.0 mL,287 mmol) and 9.0 mL of anhydrous DMSO were added to the flaskand the mixture was stirred for 30 min. Methyl isobutyrate(33.0 mL, 29.3 g, 287 mmol) was added to the reaction mixture.After stirring for approximately 2 h, the reaction mixture turnedinto a thick white solid. The excess NaH in the reaction mixturewas quenched by slow addition of deionized water. NH4Cl(30.7 g) was added to fully protonate the product, which immediatelygave a milky white suspension. The product was thenextracted three times (150 mL each) with ethyl acetate. All organiclayers were combined and washed with NaCl brine. The organiclayer was dried over anhydrous MgSO4 and filtered. To this solutionwas added 16.0 ml (13.1 g, 110 mmol) of DMF-DMA and thereaction was stirred for 18 h, after which the solvent was removedunder reduced pressure and the product (2-isobutyryl-3-dimethylaminoacrylonitrile) purified by column chromatographyusing CHCl3 as the mobile phase. The solvent was removed andthe product dissolved in 50 mL of methanol. Hydrazine hydrate(8.0 mL, 78 mmol) was added and the reaction stirred overnight.Solvent was removed under reduced pressure and the productpurified by column chromatography using 50:50 ethyl acetate/hexanes to give 2e as a light yellow powder (5.86 g, 43.4 mmol,15% yield based on acetonitrile).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Kadel, Lava R.; Kromer, John R.; Moore, Curtis E.; Eichhorn, David M.; Polyhedron; vol. 125; (2017); p. 206 – 218;,
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New downstream synthetic route of 14447-18-8

The synthetic route of 14447-18-8 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 14447-18-8, name is Benzyl cyanoacetate belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C10H9NO2

General procedure: A 100-mL round-bottom flask equipped with a stir bar is charged with dimethyl malonate (2.0 g, 15.0 mmol), crotonaldehyde (1.3 mL, 15.0 mmol), piperidine (0.2 mL, 3.0 mmol), benzoic acid (0.4 g, 3.0 mmol) and toluene (50 mL). The reaction mixture is heated at reflux using a Dean-Stark apparatus for 2 h. The toluene solution is washed with water, dried over Na2SO4 and concentrated in vacuo. The crude product is purified by silica gel column chromatography eluting with hexanes/ethyl acetate (20/1) to afford 1a (1.7 g, 60% yield) as a red liquid.

The synthetic route of 14447-18-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhang, Wei; Ghiviriga, Ion; Grenning, Alexander J.; Tetrahedron; vol. 73; 29; (2017); p. 4076 – 4083;,
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The important role of 6136-68-1

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Acetylbenzonitrile, its application will become more common.

Application of 6136-68-1,Some common heterocyclic compound, 6136-68-1, name is 3-Acetylbenzonitrile, molecular formula is C9H7NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Br2 (1 mmol) was dropwise added to a solution of 3-acetylbenzonitrile (1 mmol) in Et2O (15 ml) at 0 C., and then the mixture was stirred at r.t. for 4 h. Water was added, and the mixture was extracted with EtOAc. The organic layer was dried over Na2SO4, and was concentrated to give an oil, i.e., 3-(2-bromoacetyl)benzonitrile, which was directly used for the next step without purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Acetylbenzonitrile, its application will become more common.

Reference:
Patent; Hutchison Medipharma Enterprises Limited; US2009/118292; (2009); A1;,
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Introduction of a new synthetic route about C8H5F3N2

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 654-70-6, its application will become more common.

Some common heterocyclic compound, 654-70-6, name is 4-Cyano-3-trifluoromethylaniline, molecular formula is C8H5F3N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 4-Cyano-3-trifluoromethylaniline

At 0 C, liquid bromine (21.68 g, 135.66 mmol) was slowly added dropwise to a solution of Compound 36a (25.00 g, 134.31 mmol) in methanol (200 mL). After the resulting reaction mixture was further stirred for 0.5 hr, a saturated solution of sodium thiosulfate (200 mL) was added to the reaction system at 0 C to quench the reaction. The resulting mixture was diluted with water (1000 mL), and filtered. The filter cake was washed with water (200 mL×3), and dried under reduced pressure to give Compound 36b (34.30 g). 1H NMR (400 MHz, DMSO-d6) delta8.14 (s, 1H), 7.20 (s, 1H), 6.90 (brs, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 654-70-6, its application will become more common.

Reference:
Patent; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; Medshine Discovery Inc.; CHEN, Bin; YAO, Yuanshan; CHEN, Yuan; LI, Ao; XU, Ran; HUANG, Zhensheng; TIAN, Dongdong; LI, Hongwei; YANG, Chengshuai; LI, Jian; CHEN, Shuhui; (69 pag.)EP3489235; (2019); A1;,
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Research on new synthetic routes about 21667-62-9

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 21667-62-9, its application will become more common.

Some common heterocyclic compound, 21667-62-9, name is 3-(3-Chlorophenyl)-3-oxopropanenitrile, molecular formula is C9H6ClNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 3-(3-Chlorophenyl)-3-oxopropanenitrile

EXAMPLE 41 Preparation OF 3- [5-AMINO-4- (3-CHLOROBENZOYL)-PYRAZOL-1-YL]-N-CYCLOPROPYL-4- methyl-benzamide A. 2- (3-Chlorobenzoyl)-3-phenylaminoacrylonitrile A solution of 3-chlorobenzoylacetonitrile (476 mg, 2.66 mmol, 1.0 eq) and diphenylformamidine (522 mg, 2.66 mmol, 1.0 eq) in 25 mL of toluene was stirred at room temperature for 2h then heated to 100 C overnight. The solution was cooled and diluted with hexanes. The resulting solid was filtered and dried to provide the desired product (566 mg, 75%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 21667-62-9, its application will become more common.

Reference:
Patent; TRIAD THERAPEUCTICS, INC.; WO2005/9973; (2005); A1;,
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Continuously updated synthesis method about 71682-97-8

The synthetic route of 71682-97-8 has been constantly updated, and we look forward to future research findings.

Related Products of 71682-97-8, These common heterocyclic compound, 71682-97-8, name is 3-(3,4-Difluorophenyl)-3-oxopropanenitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[0531] A thoroughly mixed mixture of 3-ethyl 4-methyl 2-hydrazinylthiophene-3 ,4- dicarboxylate (0.3 g, 1.228 mmol, 1 eq) and 3-(3,4-difluorophenyl)-3-oxopropanenitrile (0.222 g, 1.228 mmol, 1 eq) in an open vial was stirred neat at 130 °C for 1.5 h. The melted liquid becomes thick solid which is triturated in DCM/MeOH. The crude product was purified on flash system using a 24 g silica column eluting with 1-10 percent methanol in DCM over 12 column volumes. The pure fraction was pooled and concentrated to get 0.49 g (Yield = 84 percent) of white solid.

The synthetic route of 71682-97-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; VANDERBILT UNIVERSITY; MALONEY, David J.; JADHAV, Ajit; BANTUKALLU, Ganesha Rai; BRIMACOMBE, Kyle Ryan; MOTT, Bryan T.; YANG, Shyh Ming; URBAN, Daniel Jason; HU, Xin; SIMEONOV, Anton; KOUZNETSOVA, Jennifer L.; WATERSON, Alex Gregory; SULIKOWSKI, Gary Allen; KIM, Kwangho; CHRISTOV, Plamen; JANA, Somnath; (387 pag.)WO2016/109559; (2016); A2;,
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Simple exploration of 133116-83-3

The chemical industry reduces the impact on the environment during synthesis 2-Fluoro-6-(trifluoromethyl)benzonitrile. I believe this compound will play a more active role in future production and life.

Electric Literature of 133116-83-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 133116-83-3, name is 2-Fluoro-6-(trifluoromethyl)benzonitrile, This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 2-fluoro-6-(trifluoromethyl)benzonitrile (1.0 g, 5.29 mmol) and K2C03 (1.46 g, 10.58 mmol) in DMF (5 mL) was added 2-(trimethylsilyl)ethanethiol (1.01 ml, 6.35 mmol). The mixture was stirred at room temperature for 4 hours. The TLC indicated complete consumption of starting material. The mixture was filtered and evaporated to dryness in vacuo. The crude was adsorbed onto silica gel, and purified by hexane and ethyl acetate to afford the desired compound. LC/MS [M+H]+:304.

The chemical industry reduces the impact on the environment during synthesis 2-Fluoro-6-(trifluoromethyl)benzonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Patent; MERCK SHARP & DOHME CORP.; MANDAL, Mihir; TANG, Haifeng; XIAO, Li; SU, Jing; LI, Guoqing; YANG, Shu-Wei; PAN, Weidong; TANG, Haiqun; DEJESUS, Reynalda; HICKS, Jacqueline; LOMBARDO, Matthew; CHU, Hong; HAGMANN, William; PASTERNAK, Alex; GU, Xin; JIANG, Jinlong; DONG, Shuzhi; DING, Fa-Xiang; LONDON, Clare; BISWAS, Dipshikha; YOUNG, Katherine; HUNTER, David, N.; ZHAO, Zhiqiang; YANG, Dexi; WO2015/112441; (2015); A1;,
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Application of 3,5-Dimethoxybenzonitrile

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,5-Dimethoxybenzonitrile, and friends who are interested can also refer to it.

Electric Literature of 19179-31-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19179-31-8 name is 3,5-Dimethoxybenzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Adding 0.02 equivalents of anhydrous copper sulfate and 4.0 equivalents of potassium t-butoxide to a 25 mL Schlenk reaction tube, drying in vacuum for 15 minutes, and sequentially adding 1,4-dioxane 1.5 mL and t-butanol 1 mL under argon atmosphere, 3,5-dimethoxybenzonitrile 5.0 equivalents,1 mmol of 1-(phenylthio)benzyl-2-iodobenzene was placed in the reaction tube after adding polytetrafluoroethylene stopper was placed into an oil bath of the reaction 100 C for 4 h. After the reaction is completed, the solvent is removed by filtration, and the solvent is separated by column chromatography. The eluent is petroleum ether/dichloromethane/ethyl acetate (v:v:v=20:10:1) to give a yellow liquid as 2-(3,5-dimethoxyphenyl)-3-(phenylthio)-1H-indole. The yield was 98%

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,5-Dimethoxybenzonitrile, and friends who are interested can also refer to it.

Reference:
Patent; University of Science and Technology of China; Kang Yanbiao; Shan Xianghuan; (12 pag.)CN108863894; (2018); A;,
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The origin of a common compound about 51762-67-5

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 51762-67-5, name is 3-Nitrophthalonitrile, A new synthetic method of this compound is introduced below., COA of Formula: C8H3N3O2

The phthalonitrile compund ( 5) was synthesized by the reaction between 5-Methyl-1,3,4-thiadiazole-2-thiol (1) and 3-nitrophthalonitrile (3) in dry DMF in the presence of K2CO3 according to literature [25].

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Demirba?, Uemit; Pi?kin, Mehmet; Bayrak, R?za; Durmu?, Mahmut; Kantekin; Journal of Molecular Structure; vol. 1197; (2019); p. 594 – 602;,
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The important role of 50670-64-9

The synthetic route of 5-Amino-2-methylbenzonitrile has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 50670-64-9, name is 5-Amino-2-methylbenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 5-Amino-2-methylbenzonitrile

Add a solution of sodium nitrile (2.1 g, 31 mmol) in water (15 mL) drop wise at 5 C to a stirred solution of 5-amino-2-methylbenzonitrile (4.0 g, 31 mmol) in 33% sulfuric acid (45 mL) and keep the temperature below 5 C. In a separate flask, add concentrated sulfuric acid (30 mL) cautiously to a stirred solution of sodium sulfate (21.7 g, 153 mmol) in water (15 mL) and heat the mixture to reflux. Add the prepared diazonium solution to the re fluxing mixture in portions and continue refluxing for 2 hours. Cool the mixture slowly to room temperature and stir overnight. Extract the mixture with ethyl acetate (2 x 100 mL) and wash the combined organic extracts with water (2 x 150 mL) and 10% NaOH water solution (3 x 100 mL). Acidify the combined NaOH extracts with concentrated HC1 and then extract with ethyl acetate (2 x 200 mL). Dry the organic extracts over Na2S04 and concentrate under reduced pressure to give the title compound as a yellow solid (2.4 g, 60%): ES/MS (m/z) 134 (M+H), which is used directly without further purification.

The synthetic route of 5-Amino-2-methylbenzonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ELI LILLY AND COMPANY; LILLY CHINA RESEARCH AND DEVELOPMENT CO., LTD.; LIU, Kevin Kun-Chin; XIE, Yinong; WU, Liang; ZHOU, Guoqiang; WO2015/89800; (2015); A1;,
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