Tag: M.W=100-200

Reference of 6283-71-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6283-71-2, name is Dimethyl 2-cyanosuccinate, This compound has unique chemical properties. The synthetic route is as follows.

Cyanodiester 12 (1.16 g; 6.78 mmol) was dissolved in ethanol/water 1:1 (12 mL), cooled to 0-5 C and Et3N (1.2 mL) was added dropwise. After 15 min tert-butyl acrylate (1.05 mL; 0.92 g; 7.14 mmol) was added dropwise. The mixture was stirred at 0-5 C for 1.5 h, allowed to warm to room temperature and stirred for further 2 h. It was then concentrated, diluted with water, acidified with 2 N HCl to pH 4 and extracted 3* with AcOEt. The combined organic extracts were dried with MgSO4, concentrated in vacuo and chromatographed on silica gel in hexane/AcOEt (4:1) to give 20 (0.61 g; 29%; Rf 0.27) and 21 (0.77 g; 38%; Rf 0.23) as colourless oils.

The chemical industry reduces the impact on the environment during synthesis Dimethyl 2-cyanosuccinate. I believe this compound will play a more active role in future production and life.

Reference:
Article; Weinberg, Kamil; Stoit, Axel; Kruse, Chris G.; Haddow, Mairi F.; Gallagher, Timothy; Tetrahedron; vol. 69; 23; (2013); p. 4694 – 4707;,
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Application of 69975-66-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 69975-66-2, name is 3-Oxo-indan-5-carbonitrile, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a series of 1.5 mL glass tubes was added amine 5 or 6 in NMP (0.95 M, 0.095 mmol), followed by solutions of different indanones (0.5 M, 0.1 mmol) in NMP, and these mixtures were subsequently treated with acetic acid (0.1 mmol), followed by 5-ethyl-2-methylpyridineborane (PEMB) (0.2 mmol). The reaction mixture was heated at 65 C on a reaction block for 24 h. The reaction mixtures were purified directly using an automated mass-guided reverse phase HPLC, and product containing fractions were concentrated to give final products of >90% purity as judged by LC-MS (average of 220 and 254 nm traces).

The chemical industry reduces the impact on the environment during synthesis 3-Oxo-indan-5-carbonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Article; Vilums, Maris; Zweemer, Annelien J. M.; Barmare, Farhana; Van Der Gracht, Anouk M. F.; Bleeker, Dave C. T.; Yu, Zhiyi; De Vries, Henk; Gross, Raymond; Clemens, Jeremy; Krenitsky, Paul; Brussee, Johannes; Stamos, Dean; Saunders, John; Heitman, Laura H.; Ijzerman, Adriaan P.; European Journal of Medicinal Chemistry; vol. 93; (2015); p. 121 – 134;,
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Reference of 500912-18-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 500912-18-5 as follows.

A mixture of 6-chloro-4-(ethyl amino) nicotinaldehyde (Scheme 1 compound 6) (1.7 g, 9.32 mmol), Scheme 56 compound 4 (2.0 g, 12.11 mmol) and K2C03 (3.8 g, 27.96 mmol) in dry DMF (10 mL) was heated to 100 C under nitrogen atmosphere for 16 h. After TLC showed the starting material was completely consumed, the reaction mixture was cooled to RT, diluted with EtOAc (2 x 50 mL), washed with water (2 x 20 mL) and brine (10 mL) then dried over Na2S04 and concentrated to give a residue which was purified by flash chromatography on silica gel (eluting with petroleum ether/EtOAc 100/0 gradually increasing to 60/40) to give 7-chloro-l-ethyl-3-(2-fluoro-6-methoxyphenyl)-l,6-naphthyridin-2(lH)- imine (800 mg, 26%) as a yellow solid. 1H NMR (400 MHz, DMSO-d6): delta 8.41 (s, 1H), 7.51 (q, J= 8.0 Hz, 1H), 7.41 (d, J= 10.6 Hz, 2H), 7.07-6.92 (m, 2H), 4.26 (m, 2H), 3.77 (d, J = 2.4 Hz, 3H), 1.22-1.16 (m, 3H). MS [ESI, MH+] = 332.09.

According to the analysis of related databases, 500912-18-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MANNKIND CORPORATION; TOLERO PHARMACEUTICALS, INC.; ZENG, Qingping; FARIS, Mary; MOLLARD, Alexis; WARNER, Steven L.; FLYNN, Gary A.; WO2014/52365; (2014); A1;,
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Application of 143879-78-1, These common heterocyclic compound, 143879-78-1, name is 3-Amino-2,6-difluorobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Methyl (3 S)-3 ,7-dimethyl- 1,1 -dioxo-2,3 ,4,5 -tetrahydropyrrolo [3 ,4-f]thiazepine-6- carboxylate (200 mg, 0.73 mmol) and 3-amino-2,6-difluoro-benzonitrile (0.16 g, 0.88 mmol) in dry THF (5 mL) was treated with lithium bis(trimethylsilyl)amide (2.2 mL, 1 M in THF, 2.2 mmol) and this was stirred overnight at room temperature. Theresulting mixture was quenched with NH4C1 (aq., sat., 5 mL). Then 5 mL of brine wasadded and the layers were separated. The water layer was extracted using EtOAc (2 X30 mL). The combined extracts were concentrated in vacuo and the obtained crude waspurified using silica gel column chromatography (gradient elution: EtOAc:heptane0:100 to 100:0). The desired fractions were concentrated in vacuo and the obtainedresidue was purified via preparative HPLC (Stationary phase: RP XBridge Prep C18 OBD-l0jim, 3OxlSOmm, Mobile phase: 0.25% NH4HCO3 solution in water, ACN). The desired fractions were concentrated under reduced pressure, co-evaporated with methanol (2 X 25 mL) and dried in a vacuum oven at 55C for 18 hours yielding compound 157 (7.6 mg). ?H NMR (400 MHz, DMSO-d6) oe ppm 1.14 (d, J=6.82 Hz,3H)1.31-1.45(m,1H)1.81-1.91(m,1H)2.77-2.89(m,1H)3.07-3.18(m,1H)3.58 – 3.67 (m, 1 H) 3.70 (s, 3 H) 7.03 (d, J=9.68 Hz, 1 H) 7.40 – 7.51 (m, 2 H) 8.06(td,J=8.97, 6.05 Hz, 1 H) 10.31 (s, 1 H); Method B; Rt: 0.85 mi mlz :393 (M-H)Exact mass: 394.1, MP: 247.5 C.

The synthetic route of 143879-78-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JANSSEN SCIENCES IRELAND UC; VENDEVILLE, Sandrine, Marie, Helene; LAST, Stefaan, Julien; DEMIN, Samuel, Dominique; GROSSE, Sandrine, Celine; HACHE, Geerwin, Yvonne, Paul; HU, Lili; PIETERS, Serge, Maria, Aloysius; ROMBOUTS, Geert; VANDYCK, Koen; VERSCHUEREN, Wim, Gaston; RABOISSON, Pierre, Jean-Marie, Bernard; (244 pag.)WO2017/1655; (2017); A1;,
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Electric Literature of 1528-41-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1528-41-2, name is Ethyl 2-(4-cyanophenyl)acetate belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A mixture of 1.0 g of 3,3-dimethylcyclohexanone (S6; 7.9 mmol), hydroxylamine hydrochloride (0.66 g,9.5 mmol), 10 mL of ethanol, and 1.6 g of K2CO3 (12 mmol) was heated to 70 C for 64 hours. Themixture was concentrated suspended in 10 mL of water, the extracted three times each with 30 mL ofEtOAc. The extracts were combined and concentrated to provide 1.2 g of 3,3-dimethylcyclohexanoneoxime (S7) that was used crude. To a 0 C solution of S7 (0.20 g, 1.4 mmol) in 2 mL of THF was added dropwise 1.6 M BuLi in hexanes(1.8 mL, 2.8 mmol). The mixture stirred for 30 minutes at room temperature, then ethyl 2-(4-cyanophenyl)acetate (0.27 g, 1.4 mmol) was added. After stirring for 1 hour, 0.7 mL of concentratedH2SO4 was added. After stirring for 1 hour, 25 mL of water was added and the mixture was extractedthree times each with 15 mL of EtOAc. The extracts were concentrated and the residue was purified firstby silica chromatography (0-50% EtOAc in heptanes), then by preparative HPLC (C18 column 10-90%MeCN in H2O, both 0.1% v/v formic acid) or give 41 mg of 16.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2-(4-cyanophenyl)acetate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Meyers, Kenneth; Cogan, Derek A.; Burke, Jennifer; Arenas, Raquel; Balestra, Michael; Brown, Nicholas F.; Chen, Zhidong; Cerny, Matthew A.; Clifford, Holly E.; Colombo, Federico; Fader, Lee; Frederick, Kosea S.; Guo, Xin; Goldberg, Daniel; Hornberger, Keith R.; Kugler, Stanley; Lord, John; Marshall, Daniel R.; Moss, Neil; Parmentier, Jean-Huges; Richman, Jeremy R.; Schmenk, Jennifer; Weldon, Steven M.; Yu, Maolin; Zhang, Michael; Bioorganic and Medicinal Chemistry Letters; vol. 28; 5; (2018); p. 979 – 984;,
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Related Products of 1123172-88-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1123172-88-2, name is 3,5-Difluoro-4-nitrobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a 250 ml stainless steel autoclave, 120 g of N,N-dimethylformamide and 18.5 g (0.1 mol) of 3,5-difluoro-4-nitrobenzonitrile were added.15.0 g of potassium carbonate, 6.0 g (0.1 mol) of isopropylamine, sealed in an autoclave, stirred at 60 to 65 C for 5 hours, cooled to 20 to 25 C, the material was removed, filtered, and the filtrate was evaporated under reduced pressure to give a solvent. To 25 C,Add 20 g of methyl tert-butyl ether, filter, and dry.20.7 g of 3-fluoro-4-nitro-5-isopropylaminobenzonitrile (II) were obtained.The yield was 92.8%, and the liquid phase purity was 99.5%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Difluoro-4-nitrobenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Xin Fa Pharmaceutical Co., Ltd.; Qi Yuxin; Liu Yuesheng; Zhu Chengchen; Zhang Mingfeng; Wang Tao; (14 pag.)CN110218189; (2019); A;,
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Reference of 3100-67-2, The chemical industry reduces the impact on the environment during synthesis 3100-67-2, name is 1-Amino-2-naphthonitrile, I believe this compound will play a more active role in future production and life.

The mixture was stirred into 200 mL of tetrahydrofuran and <9-a>, obtained from scheme 21, 25.0 g (149 mmol), phenyl magnesium bromide (3.0 M in Et2O) 87.4 mL (297 mmol) was added dropwise at 0 C and refluxed for about one hour. Ethyl chloroformate 19.4 g (179 mmol) was added dropwise and it was refluxed for about 1 hour. Then aqueous solution of ammonium chloride was added and then washed with water and heptane to give <9-b> 32.4 g (80% yield).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Amino-2-naphthonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SFC Co. Ltd.,; Yoo, Se Jin; Lee, Se Jin; (64 pag.)KR101554545; (2015); B1;,
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Related Products of 3100-67-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3100-67-2, name is 1-Amino-2-naphthonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

The [Reaction Scheme 1-1 [Intermediate a-1] 50.0 g (297 mmol), 500 mL of dimethylformamide was stirred obtained from. Then N-bromo-succinimide 55.56 g (312 mmol) was added slowly to the reactor. After raising to room temperature and stirred for 4 hours. When the reaction is completed, distilled water was added dropwise thereto at room temperature saenggimyeon brown crystals Crystals were filtered and separated by column chromatography with [intermediate 1-b] compound 68 g. (Yield: 92.6%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Amino-2-naphthonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SFC CO., LTD.; PARK, PU BAE; PARK, JI HEE; SHIN, PONG KI; YOO, JUNG HO; YANG, BYUNG SOON; LEE, SE JIN; (61 pag.)KR2015/111106; (2015); A;,
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Electric Literature of 6283-71-2, These common heterocyclic compound, 6283-71-2, name is Dimethyl 2-cyanosuccinate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Sodium nitrite (1.32 g, 19.1 mmol) was added carefully to sulphuric acid (concentrated, 6.8 ml), whilst cooling the solution to 0° C. The solution was heated to 60° C. for 30 min, allowed to cool and then diluted with acetic acid (12 ml). To the solution was added Preparation 182 (5.0 mg, 17.4 mmol) in acetic acid (11 ml) and the reaction mixture was heated at 55° C. for 1 h. To a solution of Preparation 248 (3.09 g, 18.1 mmol) in acetic acid (24 ml) and water (36 ml) was added dropwise the solution of the diazonium salt, followed by sodium acetate (24.2 g) in water (42 ml). The reaction mixture was then stirred at room temperature for 30 min. The reaction mixture was poured into ice/water (200 ml) and the mixture was extracted with dichloromethane (4.x.60 ml). The combined extracts were then washed with ammonium hydroxide (48 ml), dried and concentrated in vacuo. To a solution of sodium methoxide (25 wt.percent, 11.5 ml, 50.1 mmol) in methanol (450 ml) was added dropwise a solution of the residue in methanol (100 ml). The reaction mixture was then stirred at room temperature for 2 h. The reaction mixture was concentrated in vacuo and to the residue was added water. This solution was adjusted to pH 1 by addition of hydrochloric acid (4 N) and the mixture was extracted with dichloromethane (3.x.100 ml). The combined extracts were dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography, eluting with hexane/ethyl acetate [3: 1]. The appropriate fractions were combined and concentrated to give the titled compound (4.5 g). Experimental MH+ 379.8; expected 380.0

The synthetic route of 6283-71-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Billen, Denis; Boyle, Jessica; Critcher, Douglas James; Gethin, David Morris; Hall, Kim Thomas; Kyne, Graham Michael; US2006/287365; (2006); A1;,
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These common heterocyclic compound, 64248-63-1, name is 3,5-Difluorobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 64248-63-1

Preparation 33 3-Fluoro-5-methoxybenzonitrile Sodium methoxide (1.50 ml of a 4.5M solution in methanol, 7.10 mmol) was added dropwise to a stirred solution of 3,5-difluorobenzonitrile (1.00 g, 7.10 mmol) in N,N-dimethylformamide (36 ml) at 0 C. under nitrogen. The reaction was allowed to warm to room temperature and stirred for 14 hours. The reaction was diluted with ether (40 ml), washed with water (3*100 ml) and brine (100 ml), dried over magnesium sulphate, filtered and concentrated under reduced pressure. The crude product was purified by flash chromatography on silica gel eluding with cyclohexane:ethyl acetate (95:5, by volume) to provide the title compound (418 mg) as a yellow oil. 1H-NMR (400 MHz, CDCl3): delta=3.84 (s, 3H), 6.82 (dd, 1H), 6.95 (dd, 1H), 6.96 (s, 1H).

The synthetic route of 3,5-Difluorobenzonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Jones, Lyn Howard; Mowbray, Charles Eric; Price, David Anthony; Selby, Matthew Duncan; Stupple, Paul Anthony; US2003/100554; (2003); A1;,
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