Tag: M.W=100-200

Synthetic Route of 3544-25-0, A common heterocyclic compound, 3544-25-0, name is 2-(4-Aminophenyl)acetonitrile, molecular formula is C8H8N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Stage 10.2 2,3-Dichloro-N-(4-cyanomethyl-phenyl)-benzenesulfonamide To the solution of 4-aminobenzylcyanide (12 g, 90.8 mmol) in pyridine (11 mL) at RT, a solution of 2,3-dichlorobenzene-sulphonylchloride (22.29 g, 90.8 mmol) in THF (80 mL) is added within 20 minutes. The reaction is stirred at reflux for 2 hours. After cooling, the solvent is removed under reduced pressure and the remaining solid suspended in 10% HCl (200 mL). The crude crystalline product is filtered-off, washed with H2O and dried at 60 C. Final purification is done by suspending the crude compound in MeOH (250 mL), heating to reflux, filtration and drying. 2,3-Dichloro-N-(4-cyanomethyl-phenyl)-benzenesulfonamide (26.54 g, 86%) is obtained as orange crystals: m.p: 202-206 C.; (CH2Cl2/MeOH 98:2): 0.54; ES-MS [M-1]-=338.8; HPLC BtRet=5.85 minutes.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 57381-51-8, name is 4-Chloro-2-fluorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 57381-51-8

General procedure: Into an oven-dried flask equipped with a magnetic stir bar was added aryl fluoride (1.00 g, 1.0 eq.), Na2S (1.1 eq.) and DMF (5 mL) under argon. The reaction mixture was stirred at room temperature for 1 h. Then 1 M NaOH (50 mL) was added and was washed with CH2Cl2 (2 x 25 mL). The aqueous layer was acidified to pH ~ 1-2 with 6 N HCl and extracted with CH2Cl2 (2 x 50 mL). The combined organic layer was washed with brine (50 mL), dried over MgSO4, filtered and concentrated under reduced pressure to provide a crude residue. To the residue was added 10% HCl (40 mL) and cooled with an ice-water bath. Then zinc dust (4 g) was added and the mixture was stirred for 1 h. Then EtOAc (100 mL) was added and the mixture was stirred for an additional 30 minutes. The organic layer was separated and washed with water (40 mL) and brine (40 mL), dried over MgSO4, filtered and concentrated to provide the desired product with satisfactory purity.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 57381-51-8.

Synthetic Route of 50594-78-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 50594-78-0, name is 5-Fluoro-2-nitrobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.

Step 1 : 6-(N-(3-cyano-4-nitrophenyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N- methylbenzofuran-3-carboxamide A mixture of 5-fluoro-2-nitrobenzonitrile (1 .280 mL, 1 1 .18 mmol), 5-cyclopropyl-2-(4- fluorophenyl)-N-methyl-6-(methylsulfonamido)benzofuran-3-carboxamide (3.0 g, 7.45 mmol) and K2CO3 (3.09 g, 22.36 mmol) in 1 ,2-dimethoxyethane (30 mL) and water (7.5 mL) in a seal tube was heated to 80 0 C overnight. It was cooled down to room temperature, diluted with EtOAc, filtered and the off-white solid was washed with water and then dried in vacuo to give crude desired product as a yellow solid (80 % purity, 3.9 g, 76 %). LCMS {m/z, ES+) = 549 (M+H+)

The chemical industry reduces the impact on the environment during synthesis 5-Fluoro-2-nitrobenzonitrile. I believe this compound will play a more active role in future production and life.

Some common heterocyclic compound, 50397-74-5, name is 4-Amino-3-bromobenzonitrile, molecular formula is C7H5BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C7H5BrN2

General procedure: A mixture of benzyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate (247 mg, 1.0 mmol), 2-bromo-4-methoxyaniline (303 mg, 1.5 mmol) and lithium perchlorate (190 mg, 1.7 mmol) were taken in acetonitrile (3.0 mL). The reaction mixture was heated to 90 C for 18 h. The reaction mixture was diluted with ethyl acetate (20 mL) and washed with water. The organic layer was dried over sodium sulfate and concentrated under reduced pressure, and the product was purified by column chromatography (silica gel, 50% EtOAc/hexanes) to provide benzyl 4-(((2-bromo-4-methoxyphenyl)amino)methyl)-4-hydroxypiperidine-1-carboxylate, 5c (358 mg, 80%) as a colourless syrup.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 50397-74-5, its application will become more common.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3939-09-1 as follows. Formula: C7H3F2N

To a solution of 2,4-difluorobenzonitrile (10 g, 72 mmol) dissolved in tetrahydrofuran (20 mL), and dimethylformamide (40 mL) was added 1,2,4-triazole sodium salt (6.3 g, 70 mmol) and the mixture stirred at 90 0C for 3 h after which the mixture was filtered and the solvent removed. The resulting residue was adsorbed onto silica gel and intermediates 67 and 68 separated by flash chromatography, eluting with 0% to 30% ethyl acetate/hexanes.Intermediate 674-Fluoro-2-(lH-l,2,4-triazol-l-yl)benzonitrile. Colorless needles (2.46 g,18% yield) 1H NMR (500 MHz, CDCl3) delta: 8.89 (IH, s), 8.19 (IH, s), 7.85 (IH, dd, J = 8.7, 5.6 Hz), 7.60 (IH, dd, J= 8.8, 2.4 Hz), 7.28-7.24 (IH, m). LCMS (M+H) calcd for C9H6N4F: 189.05; found: 189.13. Intermediate e 684-(lH-l,2,4-Triazol-l-yl)-2-fluorobenzonitrile. White solid (0.746 g, 6% yield) 1H NMR (500 MHz, CDCl3) delta: 8.66 (IH, s), 8.15 (IH, s), 7.79 (IH, dd, J= 8.5, 6.7 Hz), 7.69 (IH, dd, J= 9.5, 1.8 Hz), 7.65-7.63 (IH, m). LCMS (M+H) calcd for C9H6N4F: 189.05; found: 189.13.

According to the analysis of related databases, 3939-09-1, the application of this compound in the production field has become more and more popular.

Reference of 51762-67-5, The chemical industry reduces the impact on the environment during synthesis 51762-67-5, name is 3-Nitrophthalonitrile, I believe this compound will play a more active role in future production and life.

Using 3-nitrophthalonitrile (20 mmol) and sodium p-hydroxybenzenesulfonate (20-70 mmol, preferably 60 mmol) as reactants and dimethyl sulfoxide (40-200 mL, preferably 140 mL) as solvent in carbonic acid Potassium (30 to 90 mmol, preferably 80 mmol) is present and under nitrogen protection, the reaction is stirred at room temperature to 60C (preferably 60C) for 24 to 72 hours and monitored by thin layer chromatography. After the reaction was completed, the reaction solution was poured into ice chloroform to precipitate a yellow-white precipitate, which was filtered, washed with ethanol and acetone until the filtrate was colorless, and dried in vacuum at 50 C. to obtain a pale yellow product with a yield of 92%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Nitrophthalonitrile, other downstream synthetic routes, hurry up and to see.

Reference of 218632-01-0,Some common heterocyclic compound, 218632-01-0, name is 3-Fluoro-4-nitrobenzonitrile, molecular formula is C7H3FN2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The mixture of 16.7 g (100 mmol) of 3-fluoro-4-nitrobenzonitrile and 100 mL of the solution of dimethylamine in ethanol (5 M) was refluxed overnight. The resulting dark red solution was then poured in to 100 mL of ice-water. The precipitate was collected by filtration and washed by H2O (50 mL*2) and ethanol (50 mL*2) to give 16.9 g of a organe needle crystal as the desired product. MS ESI (m/z) 192 (M+1)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Fluoro-4-nitrobenzonitrile, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 35202-54-1, name is 4,5-Dimethoxy-1-cyanobenzocyclobutane, A new synthetic method of this compound is introduced below., SDS of cas: 35202-54-1

4,5-Dimethoxy-1-cyanobenzocyclobutane (10 g, 52.85 mmol)Soluble in ammonia-methanol solution (2M, 530ml), replacing nitrogen three times,Then add Raney nickel (1.0g)Replace hydrogen (45psi),The reaction was stirred at 20 °C for 12 h. TLC detection is complete, filtered through diatomaceous earth,The solvent was evaporated to give 4,5-dimethoxy-1-methylaminobenzocyclobutane (10.0 g, 98percent) as an oil.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Some common heterocyclic compound, 63069-50-1, name is 4-Amino-3-fluorobenzonitrile, molecular formula is C7H5FN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 63069-50-1

Step 8 30.8 g (0.45 mol) of sodium nitrite was added slowly to 244 cm3 of concentrated sulfuric acid while stirring. After the addition was complete, the solution was heated to a temperature of 50 C. to dissolve the crystals. The solution was added drop-wise to 406 cm3 of acetic acid while cooling on an ice water bath and stirring. 55 g (0.40 mol) of 4-amino-3-fluorobenzonitrile was added slowly to maintain the temperature below 25 C. and the mixture was stirred at 25 C. for one hour to dissolve the crystals and form the corresponding diazonium salt. While cooling with ice water and stirring, the diazonium salt was added drop-wise to a solution of 87.4 g (0.61 mol) of copper (I) bromide and 244 cm3 of hydrobromic acid (47%) and allowed to remain overnight at room temperature. The crystals deposited were filtered out, washed with water and recrystallized from hexane to yield 61.7 g (0.31 mol) of 4-bromo-3-fluorobenzonitrile.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 63069-50-1, its application will become more common.

Related Products of 915394-29-5,Some common heterocyclic compound, 915394-29-5, name is 2-(3-Aminophenyl)-2-methylpropanenitrile, molecular formula is C10H12N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: 4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) benzoic acid (8.95g, 31mmol) was stirred in a solvent of 58 dimethyl formamide (25mL).The reaction solution was added with 59 HATU (12.98g, 34.1mmol), 72 DIPEA (10.26mL, 62.0mmol) and 104 3-(trifluoromethyl)aniline (5g, 31mmol), followed by stirring for about 8h at room temperature. The reaction mixture was diluted with ethyl acetate and washed with a saturated aqueous sodium bicarbonate solution and saline. The organic layer thus obtained was dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The resulting mixture was concentrated to give the crude 132 product, which was purified by silica gel column chromatography.

The synthetic route of 915394-29-5 has been constantly updated, and we look forward to future research findings.