Tag: M.W=100-200

Application of 622-75-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 622-75-3, name is 2,2′-(1,4-Phenylene)diacetonitrile, This compound has unique chemical properties. The synthetic route is as follows.

1,4-Benzene diacetonitrile solid (0.312 g, 2 mmol) and pyridine-4-carbaldehyde liquid (0.45 mL, 4.4 mmol) were added to a round bottom flask containing dichloromethane (40 mL). When the solid is completely dissolved, the solution is brownish yellow. The mixture was heated and stirred at 50 C in a water bath, and 0.45 mL of tetrabutylammonium hydroxide (TBAH, 40% methanol solution) was added by a syringe, and the solution was changed from brownish yellow to dark green. The reaction was stirred with a water bath at 50 C for 2 h, and TLC showed the reaction was completed. The solvent was evaporated to dryness with a rotary evaporator, and the solid was washed with water, filtered, and filtered, and then filtered, and then filtered and washed with EtOAc. The solid was 0.49 g. The yield was 73.5%.

The chemical industry reduces the impact on the environment during synthesis 2,2′-(1,4-Phenylene)diacetonitrile. I believe this compound will play a more active role in future production and life.

Reference of 149793-69-1,Some common heterocyclic compound, 149793-69-1, name is 3-Fluoro-5-(trifluoromethyl)benzonitrile, molecular formula is C8H3F4N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a 500-mL, 3N round-bottomed flask equipped with anlOO-mL pressure- equalizing addition funnel fitted with a nitrogen inlet, and a rubber septum, 3-fluoro-5- (trifluoromethyl)benzonitrile (8.0 g, 1.0 eq.), in acetone (40 mL). Sodium thiomethoxide (3.42 g, 1.15 eq) was dissolved in water to make 21% aqueous solution and was added dropwise in 30 min at 5C temperature. The temperature of the reaction was slowly raised to RT and stirred for 3 h. Then temperature was raised to 50-60C and maintained for further 4-6 h. The progress of the reaction was followed by TLC analysis on silica gel with 10% MeOH – DCM as mobile phase and visualization with UV, SM Rf=0.40 and Product Rf=0.25. Reaction was stirred for 3 hr at 25C and 4-6 Hrs at 50-60C and reaction mixture was transparent. The reaction mass was quench by water and extracted by ethyl acetate (3×100 mL). The combined organic layer was washed with brine 50 mL and dried over sodium sulphate and evaporated on buchi rotaevaporator. The resulting crude compound White (8 g) was subjected to further stage Yield (80.9 %).Mass: (ES+) 235.94 (M+l).

The synthetic route of 149793-69-1 has been constantly updated, and we look forward to future research findings.

Related Products of 63069-50-1, The chemical industry reduces the impact on the environment during synthesis 63069-50-1, name is 4-Amino-3-fluorobenzonitrile, I believe this compound will play a more active role in future production and life.

4-Amino-3-chloro-5-fluorobenzonitrile A mixture of 4-amino-3-fluorobenzonitrile (1 equiv.) and N-chlorosuccinimide (1.5 equiv.) in acetonitrile (0.24 M) was stirred at 85 C. for 5 h. The solvent was removed by concentration and the residue was partitioned between ethyl acetate and 5% NaOH. The organic phase was washed with 5% NaOH and brine. Then the organic phase was dried over MgSO4 and dried in vacuum to afford 4-amino-3-chloro-5-fluorobenzonitrile (88%) as a beige solid. 1H NMR (400 MHz, CDCl3) delta ppm: 7.41 (t, J=6 Hz, 1H), 7.24 (dd, J=1.8, 10.2 Hz, 1H), 4.66 (s, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Amino-3-fluorobenzonitrile, other downstream synthetic routes, hurry up and to see.

Electric Literature of 51762-67-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 51762-67-5 as follows.

3-Nitrophthalonitrile (1.73 g, 0.01 mol) and 4-tert-butylphenol (1.50 g, 0.01 mol) were dissolved in DMSO (30 mL), LiOH (0.42 g,0.01 mol) was then added. The resulted mixture was then stirred at 50 C for 24 h under N2 atmosphere. The product solution was cooled and then poured into NaCl solution (10% aqueous, 100 mL), the precipitated solid was filtered, washed with water and dried under vacuum. White needles were obtained after recrystallization in toluene. Yield: 51%. m.p. 116-118 C. IR (KBr), nu(cm-1): 3083, 3014, 2232 (C?N), 1695, 1632, 1563, 1506, 1485, 1465, 1429, 1386, 1351, 1275 (C-O-C), 1258, 1222, 1165, 1142, 1015, 938, 917. 1H NMR (400 MHZ, CDCl3, ppm): delta 1.353 (s, 9H, t-butyl), 6.992 (d, 2H, J=7 Hz, Ar-H), 7.245 (d, 1H, J=6 Hz, Ar-H), 7.510 (d, 2H, J=7 Hz, Ar-H), 7.799 (m, 2H, Ar-H), 7.835 (m, 1H, Ar-H). MS, m/z: 298.95 [M+Na]+.

According to the analysis of related databases, 51762-67-5, the application of this compound in the production field has become more and more popular.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 72291-30-6, name is Methyl 2-cyano-2-methylpropanoate belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. category: nitriles-buliding-blocks

The experiment examples are carried out in a 1 l reactor (10×2000 mm), equipped with feed pumps for solvent, ammonia and nitrile ester, charged with 250 ml of steel rings in the lower and upper reactor section, and centrally with 500 ml of tablets (5×3 mm) of a hydrogenation catalyst of the following composition: 28% NiO, 28% CoO, 13% CuO and 31% ZrO2, in liquid phase mode. The reduction procedure of the catalyst is as follows: the reactor is heated to 180 C. at a hydrogen feed of 50 l/h within 5 hours, then kept at 180 C. with 50 l/h of hydrogen for 20 hours, cooled under hydrogen and purged with MeOH, before ammonia and reactant and also solvent are fed in. The steel rings in the lower part of the reactor serve as the delay time zone for the amidation. 11 equivalents of hydrogen are fed in per nitrile used. The delay time is thus approx. 10 minutes.Example 9503 g/h of MeOH and, as the nitrile ester, methyl 2-cyano-2,2-dimethylacetate (in a weight ratio of 1:1) and 670 g of ammonia (20 equivalents of ammonia based on nitrile ester) are conducted through the reactor at 200 bar and 100 C. The volume space velocity is 0.5 kg/l*h. The effluent analysis shows (calculated without solvent) 99.89% aminopivalinamide, 0.03% methyl aminopivalate and 0.08% others. The delay time is approx. 9.8 minutes.

The synthetic route of 72291-30-6 has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 64248-62-0, name is 3,4-Difluorobenzonitrile, molecular formula is C7H3F2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 3,4-Difluorobenzonitrile

Pyrrole (2, 6, 6-trimethyltetrahydroindol-4-one) (1.0 g, 5.6 iranol) and 3, 4-difluorobenzonitrile (785 mg, 5.6 mmol) were dissolved in anhydrous DMF (20 mL) . To this NaH (95%, 270 mg, 11.2 mmol) was added and stirred at 50 0C for 30 min. The reaction mixture was cooled to RT and washed with H2O and EtOAc. The organic layer was dried over MgSO4. Column chromatography on silica eluting with EtOAc-hexanes (1:1) gave the product as a yellow solid (100% clean by LCMS, product M+H = 397.1) .

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 64248-62-0, its application will become more common.

Electric Literature of 26391-06-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 26391-06-0 as follows.

To a solution of N, N-diethylcyanoacetamide(14.1 g, 0.1 mol) in toluene was added 0.2 g IRA 96 resin and isonitrovanillin (19.7g, 0.1 mol). The mixture was heated to reflux with azeotropic distillation of water. The reaction was continued until a TLC test showed completion of reaction.The mass was filtered hot. The filtrate was concentrated under vacuum to give the crude product, which wasre crystallized from absolute alcohol to afford 13. 61% isolated yield as light yellow solid. MR: 175-176C;1H-NMR (400 MHz, DMSO): delta 1.13 (br s, 6H), 3.39(br s, 4H), 3.92 (s, 3H), 7.67 (s, 1H), 7.76 (d, J=2.1Hz,Ar-H), 7.78 (d, J=2.1Hz, Ar-H), 10.98 (br s,-OH); ms:m/z 318.1 (negative mode).

According to the analysis of related databases, 26391-06-0, the application of this compound in the production field has become more and more popular.

Synthetic Route of 1897-52-5, The chemical industry reduces the impact on the environment during synthesis 1897-52-5, name is 2,6-Difluorobenzonitrile, I believe this compound will play a more active role in future production and life.

Take 2 L four bottles, add 600 mL of 60% sulfuric acid, electric stirring by adding 2,6_ difluorobenzonitrile 139.0 g (1.0 mol). Under N2 protection, the control reaction temperature was below 35 C, and 250 mum g of KBr03 (1.5 mol) was added to 10 batches. TLC monitoring, reaction 5-6 days, until the raw material point disappears, stop the reaction, the preparation of 800 mL 20% ice salt solution, the reaction solution Into the ice salt. After the product settling, the rapid filtration, the orange crude products, with CC14 dissolved crude products, respectively, with 5% Of NaHS03 solution, saturated Na2C03 solution and water to the solution was neutral, dried over anhydrous sodium sulfate, the solution was filtered, the water bath 60 C steamed to obtain light yellow liquid, rest for some time to cool into a pale yellow solid, vacuum distillation, warm water condensing steam, oil The bath was heated to 90 C and the fraction at a steam temperature of 58-62 C was cooled to give a white solid product in 71% yield

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,6-Difluorobenzonitrile, other downstream synthetic routes, hurry up and to see.

Electric Literature of 50397-74-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 50397-74-5, name is 4-Amino-3-bromobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Step 1 :- Preperation of (E)-methyl 3-(2-amino-5-cyanophenyl)acrylate To a mixture of 4-amino-3-bromobenzonitrile (10.0 g, 0.050 mmol) and methyl acrylate (9.19 mL, 0.101 mmol) in acetonitrile (200 mL) was added palladium acetate (0.568 g, 0.0025 mmol) and tri-o-tolyl phosphine (1.54 g, 0.005 mmol) and Et3N (14.64 mL, 0.105 mmol). The reaction mixture was heated to reflux for 48 h. The reaction mass was filtered through celite and washed the bed with ethyl acetate. The filtrate was concentrated to afford 6.0 g of title product. 1H NMR (300 MHz, DMSO): delta 7.92 (s, 1H), 7.82-7.77 (d, = 15.6 Hz, 1H), 7.41-7.38 (d, = 8.7 Hz, 1H), 6.77- 6.74(d, = 8.7 Hz, 1H), 6.64 (s, 2H), 6.56-6.51 (d, = 15.6 Hz, 1H), 3.70 (s, 3H).

The synthetic route of 4-Amino-3-bromobenzonitrile has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 21524-39-0, name is 2,3-Difluorobenzonitrile, A new synthetic method of this compound is introduced below., Recommanded Product: 2,3-Difluorobenzonitrile

To a solution of 7-hydroxy-2-(4-(1-methyl-1H-pyrazol-9-yl}benzyl)isoindolin-1-one (0.050 g) obtained in Reference Example 6 in DMF (2 mL) was added potassium tert-butoxide (0.018 g), and the mixture was stirred under an argon atmosphere at room temperature for 30 min. To the reaction solution was added 2,3-difluorobenzonitrile (0.024 g), and the mixture was stirred at 50C for 6 hr. The reaction mixture was diluted with ethyl acetate, and washed with saturated brine. The organic layer was separated, dried over anhydrous sodium sulfate, and concentrated. The residue was crudely purified by NH silica gel chromatography (hexane-ethyl acetate), and solidified with hexane-ethyl acetate to give the title compound (0.035 g). MS: [M+H]+ 439.2 1H NMR (400 MHz, DMSO-d6) 5 3.85 (3H, s), 4.41 (2H, s), 4.66 (2H, s), 6.84 (1H, d, J = 8.3 Hz), 7.27 (2H, d, J = 8.1 Hz), 7.33 (1H, d, J = 7.3 Hz), 7.46-7.58 (4H, m), 7.77-7.86 (3H, m), 8.12 (1H, s).

The synthetic route of 21524-39-0 has been constantly updated, and we look forward to future research findings.