Tag: M.W=100-200

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 623-03-0, name is 4-Chlorobenzonitrile, A new synthetic method of this compound is introduced below., name: 4-Chlorobenzonitrile

General procedure: A flask (25 mL) containing ruthenium(II) complex (1 M%) and 2-butanol (5 mL) was stirredfor 5 min under an argon atmosphere at room temperature. Afterwards, KOtBu(0.05 mM) was added and the mixture was stirred for another 5 min. Then, the nitrile(0.5 mM) was added and placed on a hot plate at 120 C for 30 min. After completion ofthe reaction, the catalyst was removed from the reaction mixture by addition of petroleumether followed by filtration and subsequent neutralization with 1 M HCl. The ether layerwas filtered through a short path of silica gel by column chromatography. To the filtrate,hexadecane was added as a standard and the yield was determined by GC.

The synthetic route of 623-03-0 has been constantly updated, and we look forward to future research findings.

Application of 127667-01-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 127667-01-0 as follows.

Preparation 27 5- Meth lox -1 /-/-indazol-3-amine 5-(Methyloxy)-1 H-indazol-3-amine: 2-Fluoro-5-(methyloxy)benzonitrile (5 g, 33.1 mmol) was dissolved in 1 -Butanol (50 mL), and hydrazine hydrate (20.61 mL, 662 mmol) was added. The reaction mixture was heated at 150 C for 48 hours then it was cooled to rt, diluted with water, and extracted with EtOAc (2×100 mL). The organic layer was washed with brine, dried over Na2S04 and concentrated under vacuum to give the title compound (2 g, 37%). 1H NMR (400 MHz, DMSO-cf6) delta ppm 3.75 (s, 3 H) 5.17 (s, 0 H) 6.89 (dd, J=9.03, 2.51 Hz, 0 H) 7.09 – 7.22 (m, 1 H) 1 1.18 (br. s., 7 H); MS (m/z) 164 (M+H+).

According to the analysis of related databases, 127667-01-0, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16532-79-9, name is 4-Bromophenylacetonitrile, A new synthetic method of this compound is introduced below., Application In Synthesis of 4-Bromophenylacetonitrile

To a solution of 2-(4-bromophenyl)acetonitrile (2.00 g, 10.20 mmo) in THF (20 mL) was added NaH (1.22 g, 30.60 mmol, 60% purity) at 0 C. The mixture was stirred at 0 C for 30 mins, then Mel (4.34 g, 30.60 mmol, 1.90 mL, 3.00 eq) was added to the mixture. The mixture was stirred at 15 C for 16 hours. The mixture was quenched with sat.NH4Cl (50 mL) and extracted with EtOAc (50 mL x 2). The combined organic phase was washed with brine (20 mL), dried over Na2S04, filtered and concentrated to give the crude product that was purified by flash chromatography on silica gel (PE: EtOAc = 20:1 to 10:1) to afford A-73 (400.00 mg) as an oil. H NMR (400MHz, CDC13) _ = 7.53 (d, 2H), 7.36 (d, 2H), 1.72 (s, 6H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Electric Literature of 17626-40-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 17626-40-3, name is 3,4-Diaminobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A mixture of commercial o-phenylendiamines 1, 4-12 (1 mmol), 1-(4-formylpheny)-1H-benzimidazole (3) (1 mmol), and Na2S2O5 (1 mmol) in DMF (3 mL) was heated at 110-120C for 3 h.14 The reaction mixture was cooled, poured into H2O, and the solid was filtered. The residue was purified by column chromatography using chloroform/methanol (100:10) as eluant.

The chemical industry reduces the impact on the environment during synthesis 3,4-Diaminobenzonitrile. I believe this compound will play a more active role in future production and life.

Application of 53312-81-5, The chemical industry reduces the impact on the environment during synthesis 53312-81-5, name is 5-Amino-2-fluorobenzonitrile, I believe this compound will play a more active role in future production and life.

AM-1 -1 CN AM-1-1 amine To a solution of AM-1 -1_CN (1.36 g, 10 mmol) in MeOH (50 mL) was added CoCI2.6H20 (4.7 g, 20 mmol). NaBH4 (1.13 g, 30 mmol) was added in portions to the above mixture at 0 C. The reaction mixture was warmed to r.t. and continued stirring for 12 hrs. The reaction mixture was made pH=13 with NH3.H20 and extracted with EA. The combined organic layer was washed with brine, dried over Na2S04 and concentrated. The crude was purified by column chromatography on silica gel (DCM / MeOH, 9:1 ) to give the product (0.6 g, 43%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Amino-2-fluorobenzonitrile, other downstream synthetic routes, hurry up and to see.

Related Products of 40497-11-8,Some common heterocyclic compound, 40497-11-8, name is Ethyl 2,3-dicyanopropanoate, molecular formula is C7H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Preparation 104; 5-amino-1-[2, 6-dichloro-4-(trifluoromethoxy) phenyl]-1 H-pyrazole-3-carbonitrile To sulphuric acid (18M, 54 mi) was added sodium nitrite (13.9 g, 201.2 mmol) and the solution was stirred at 15C for 1 h. To the solution was added acetic acid (200 ml), followed by 2, 6-dichloro-4- (trifluoromethoxy) aniline (45.0 g, 182.9 mmol) in acetic acid (90 ml), ensuring the temperature of the solution did not rise above 20C. After addition was complete, the mixture was heated at 50C for 1 h, cooled to room temperature and added dropwise to a solution of ethyl 2,3-dicyanopropanoate (Hainzl, D.; Cole, L. M. ; Casida, J. E. Chemical Research in Toxicology (1998), 11 (12), 1529-1535,27. 8 g, 182.9 mmol) in acetic acid (115 ml) and ice cold water (145 ml). The reaction mixture was then stirred overnight at room temperature. To the reaction mixture was added dichloromethane (500 mi) and the mixture was stirred for 10 min. The two phases were separated and the organic phase was washed with water (200 mi) and ammonia (0.88, 400 ml) was added dropwise, maintaining the temperature of the mixture below 10C. This mixture was stirred overnight at room temperature and the organic phase was separated and concentrated in vacuo. The residue was re-crystallised from toluene/pentane [2: 1] to give the titled compound (22.4 g). Experimental MH+ 337.0 ; expected 337.0

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 2,3-dicyanopropanoate, its application will become more common.

Related Products of 6621-59-6, A common heterocyclic compound, 6621-59-6, name is 6-Bromohexanenitrile, molecular formula is C6H10BrN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Preparation of 2-(5-Cyanopentyl)malonic Acid Di-tert-butyl Ester (2021050) Potassium tert-butoxide (13.5 g, 0.12 mol) followed by di-tent-butyl malonate (21.6 g, 0.10 mol) was added portionwise to stirred tetrahydrofuran (200 mL) then 6-bromohexanenitrile (18.0 g, 0.10 mol) was added to the resultant yellow slurry. The mixture was subsequently stirred at room temperature for 48 h before being quenched with citric acid (30 g) in water (150 mL) and extracted with dichloromethane (3*200 mL). The combined organic fractions were dried (MgSO4) and the solvent was removed under reduced pressure to afford 2-(5-cyanopentyl)malonic acid di-tert-butyl ester (2021050) (32.3 g, 100%) as a clear oil.

The synthetic route of 6621-59-6 has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 31643-49-9, name is 4-Nitrophthalonitrile, molecular formula is C8H3N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 31643-49-9

A mixture of 4-nitro-phthalonitrile (3.46 g, 20 mmol), pyridin-3-ol (1.90 g, 20 mmol), K2CO3 (8.29 g, 60 mmol), and DMF (50 ml) was stirred at ambient temperature overnight. The reaction mixture was then combined with another batch of the same reaction performed on the same scale. Subsequently, the solid components were removed by filtration and the filtrate was concentrated in vacuo. To the residue was added water and the mixture was extracted with EtOAc. The organic phase was then washed with brine, dried, and evaporated in vacuo. The residue was recrystallized from EtOAc/MeOH to give 8.3 g of the title compound; 1H NMR (CDCl3): delta=8.56 to 8.59 (m, 1 H), 8.45 to 8.47 (m, 1 H), 7.76 (d, 1 H), 7.42 to 7.44 (m, 2 H), 7.22 to 7.32 (m, 2 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 31643-49-9, its application will become more common.

Reference of 194853-86-6,Some common heterocyclic compound, 194853-86-6, name is 4-Fluoro-2-(trifluoromethyl)benzonitrile, molecular formula is C8H3F4N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A.7V-[4-cyano-3-(trifluoromethyl)phenyl]-D-valineA mixture of 4-fluoro-2-(trifluoromethyl)benzonitrile (reagent A) (500 mg, 2.64 mmol, 1 eq), D- valine (reagent B) (341 mg, 2.91 mmol, 1.1 eq), and K2CO3 (547 mg, 3.96 mmol, 1.5 eq) in DMF (6 mL) was sealed in a 10-20 mL microwave process vial and heated in a microwave reactor for 20 min at 100 0C. The reaction mixture was partitioned between ethyl acetate and water and acidified to pH 3 with IN HCl. The layers were separated, and the organic layer was washed with saturated aqueous sodium carbonate (2-50 mL portions) and dried over sodium sulfate. The residue was purified by ISCO silica gel chromatography (1Og silica cartridge, 100% CH2Cl2 grading to 10% CH3OH/CH2C12 over 10 min followed by 10% CH2Cl2 for 10 min) to provide the title compound (320 mg, 42%) as a pale yellow oil. 1H NMR (400 MHz, CD3OD) delta 7.63 (d, IH, J = 8.8 Hz), 7.13 (d, IH, J= 2.0 Hz), 6.88 (dd, IH, J = 8.4, 2.0 Hz), 3.91 (d, IH, 7= 6.4 Hz), 2.24 (m, IH), 1.09 (t, 6H, J = 6.8 Hz); LC/MS 287.2 (MH)+.

The synthetic route of 194853-86-6 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6393-40-4, name is 4-Amino-3-nitrobenzonitrile, A new synthetic method of this compound is introduced below., Safety of 4-Amino-3-nitrobenzonitrile

General procedure: 2-Nitroaniline derivative (1 mmol) was added to a mixture of indium powder (574 mg, 5.0 mmol for 2-nitroaniline, 918 mg 8.0 mmol for 1,2-dinitroarene), and acetic acid (0.572 mL, 10 mmol) in ethyl acetate (2 mL), followed by the addition of trimethyl orthoester (2.0 mmol) in ethyl acetate (3 mL for 2-nitroaniline; 8 mL for 1,2-dinitroarene). The reaction mixture was stirred at reflux under a nitrogen atmosphere. After the reaction was completed, the reaction mixture was diluted with ethyl acetate (30 mL), filtered through Celite, poured into 10% NaHCO3 (30 mL), and then extracted with ethyl acetate (30 mL×3). The combined organic extracts were dried over MgSO4, filtered, and concentrated. The residue was eluted with ethyl acetate/hexane (v/v=10/90) for 2-phenylbenzimidazole derivatives or methanol/dichloromethane (v/v=1/99) for 2-methylbenzimidazole derivatives through a silica gel column to give the corresponding benzimidazoles. The structures of the benzimidazoles were characterized by 1H NMR, 13C NMR, FTIR, and GC-MS, and were mostly known compounds. HRMS data were reported in addition for unknown compounds.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.