Tag: M.W=100-200

Related Products of 859855-53-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 859855-53-1, name is 3-Amino-4-fluorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.

To a stirring of imidazo[1,2-a]pyridine-3-carboxylic acid (1) (3.0 g, 18.5 mmol) in anhydrous dichloromethane (50 mL) at 0 C. was added dropwise oxalyl chloride (4.84 mL, 55.5 mmol). Then, three drops of anhydrous DMF was added and the reaction mixture was stirred at room temperature for 15 minutes. The solvent was concentrated and the crude solid was added to a stirring solution of 3-amino-4-fluorobenzonitrile (48) (2.5 g, 18.5 mmol) in anhydrous pyridine (50 mL) at room temperature. The reaction was stirred for 20 minutes and quenched with water (200 mL) with stirring for another 10 minutes. Then the precipitate was filtered and dried in air to yield N-(5-cyano-2-fluorophenyl)imidazo[1,2-a]pyridine-3-carboxamide (49). 1H NMR (400 MHz, d6-DMSO) delta 10.40 (s, 1H), 9.43 (td, J=1.2, 6.8 Hz, 1H), 8.63 (s, 1H), 8.21 (dd, J=2.0, 7.2 Hz, 1H), 7.78-7.84 (m, 2H), 7.54-7.63 (m, 2H), 7.22 (dt, J=1.2, 6.8, 1H). MS m/z 281.1 (M+1)+.

The chemical industry reduces the impact on the environment during synthesis 3-Amino-4-fluorobenzonitrile. I believe this compound will play a more active role in future production and life.

Synthetic Route of 5332-06-9,Some common heterocyclic compound, 5332-06-9, name is 4-Bromobutanenitrile, molecular formula is C4H6BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 2-methoxy-phenylpiperazine (8 g), K2CO3 (2.5 eq) and 4-bromobutyronitrile (1.05 eq) in CH3CN (150 mL) was refluxed for 10 h. After filtration and concentration in vacuo, the residue is taken up in AcOEt (1000 ml), washed with H2O, the organic layer is washed with aqueous HCl (50 mL, 1 M). Then the acid layer is washed with AcOEt (2 x 20 ml) and neutralized with aqueous NH3 (28% in H2O) untill pH 11. Extraction is carried out with AcOEt, the organic layer is dried with Na2SO4 and concentrated in vacuo. The residual solid is cristallized in hexane to give the title compound (6.8 g, 75%, mp 74C). 1H NMR (200 MHz, CDCl3) delta 1.80-1.94 (m, 2H), 2.43-2.57 (m, 4 H), 2.62-2.67 (m, 4 H), 3.09 (m, 4 H), 3.87 (s, 3 H), 6.85-7.04. 13C NMR (50 MHz, CDCl3) delta 14.9, 22.7, 50.5, 53.2, 55.3, 56.3, 111.1, 118.1, 119.8, 120.9, 122.9, 141.1, 152.2.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Bromobutanenitrile, its application will become more common.

Electric Literature of 874-89-5, A common heterocyclic compound, 874-89-5, name is 4-(Hydroxymethyl)benzonitrile, molecular formula is C8H7NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of 25.0 g (150 mmol) of 4- (hydroxymethyl) benzonitrile, 20.8 g (300 mmol) of hydroxyamine hydrochloride and 50.4 g (600 mmol) of sodium bicarbonate in 250 [ML] of methanol was heated to reflux and stirred for 20 h. The reaction mixture was cooled to rt and filtered. The solid was washed with 100 mL of methanol. The combined methanol solution was concentrated to dryness to afford [31.] 0 g (99 %) of the title compound: 1H NMR (400 Mhz, CD30D) [8] 4.63 (s, 2H), 7.39 (d, J= 8.0, 2H), 7.62 (d, J= 8.0, 2H).

The synthetic route of 874-89-5 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 29509-06-6, name is 4-Methyl-3-oxopentanenitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 29509-06-6, COA of Formula: C6H9NO

General procedure: To the hydrazine either as free base or as a hydrochloride or a trifluoroacetic acid mono or di-salt (1 equiv) and the cyanoketone (from 1.0 to 1.5 equiv) in ethanol or toluene at RT is added DIPEA (from 0 to 2.0 equiv). Then the reaction mixture is heated at reflux until the reaction is finished. The reaction mixture is concentrated in vacuo to afford a crude mixture which is used as such or purified by flash chromatography on silica gel to afford the aminopyrazole as its free base.

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These common heterocyclic compound, 17626-40-3, name is 3,4-Diaminobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 3,4-Diaminobenzonitrile

A 0.03 mol% Lewis acid-base bifunctional catalyst I (where Rf = CF3; R1, R2, R3, R4, R5, R6 = F) was added to a 100 mL single-mouth flask.0.2 mol of 4-fluoro-benzaldehyde (R7=4-F-C6H4), 0.1 mol of p-cyano o-phenylenediamine (R9=CN; R8, R10, R11=H), 15 mL of toluene, reacting at 25C Stir for 5 hours,TLC followed the reaction until the reaction was complete. The reaction results showed that the yield of product II (R7=4-F-C6H4; R9=CN; R8, R10, R11=H) was 94%; after repeated use of the catalyst system for 10 times, the catalytic performance did not decrease.

The synthetic route of 3,4-Diaminobenzonitrile has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 3598-13-8, name is 2-(4-Chlorophenoxy)acetonitrile, molecular formula is C8H6ClNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C8H6ClNO

Step 1 (5-methoxy-2-nitrophenyl)-acetonitrile 24.0 g (214 mmol) potassium-tert-butoxide in 100 mL DMF were slowly added dropwise to a solution of 13.2 g (86.0 mmol) 4-nitroanisole and 18.0 g (107 mmol) 4-chlorophenoxyacetonitrile in 50 mL DMF. The reaction mixture was stirred for 30 min at -10 C. and then poured into 300 g of a 1:1 mixture of conc. hydrochloric acid and ice. After extraction with EtOAc the organic phase was washed with water, dried and evaporated to dryness by rotary evaporation in vacuo with gentle heating. The residue was treated with a 1:1 mixture of petroleum ether/EtOAc and the product that crystallised out was suction filtered. After washing with a 1:1 mixture petroleum ether/EtOAc the crystals were dried in the air. Yield: 6.5 g (39% of theoretical) ESI-MS: m/z=210 (M+NH4)+

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3598-13-8, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 67515-59-7, name is 4-Fluoro-3-(trifluoromethyl)benzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 67515-59-7, SDS of cas: 67515-59-7

K2CO3 (2.0 eq.) and 2.0 equiv. of the corresponding nucleophile (Nu in scheme 16) were added to a solution of 4-fluoro-3-(trifluoromethyl)benzonitrile (1.0 eq.) in DMSO. The mixture was heated at 90 0C overnight. The mixture was cooled to r.t. and the solids were removed by filtration. Water was added to the filtrate and the product was precipitated, collected by filtration, washed with water and dried under vacuum.The following substances were synthesized following general procedure D for the nucleophilic aromatic substitution of 4-fluoro-3-(trifluoromethyl)-benzonitrile. The solvent system used for the purification, the yield and analytical data is given for each compound. Yield: 80%1H NMR (CDCl3) delta 7.92 (d, IH), 7.79 (m, IH), 7.33 (d, IH), 3.86 (m, 4H), 3.95 (m, 4H)

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Application of 3759-28-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3759-28-2, name is 2-(Cyanomethyl)benzonitrile, This compound has unique chemical properties. The synthetic route is as follows.

Sodium hydride (60%, 12.0g, 0.3mol) was added to tetrahydrofuran (150mL), cooled to 0 degrees in an ice water bath, and a solution of compound 18 (14.2g, 0.1mol) in tetrahydrofuran (50mL) was added dropwise. Stir for 1 hour. The reaction solution was cooled again to 0 degrees, CH3I (57.0g, 0.4mol) was added dropwise, stirred at room temperature overnight, poured into ice water (200mL) to quench, extracted with ethyl acetate (50mL x 2), the organic phase was dried over sodium sulfate concentrate. Methyl tert-butyl ether (20 mL) and petroleum ether (50 mL) were added, filtered with stirring, and dried in vacuo to give compound 19 as a yellow solid (13.8 g, yield 18.1%).

The chemical industry reduces the impact on the environment during synthesis 2-(Cyanomethyl)benzonitrile. I believe this compound will play a more active role in future production and life.

Reference of 5332-06-9, The chemical industry reduces the impact on the environment during synthesis 5332-06-9, name is 4-Bromobutanenitrile, I believe this compound will play a more active role in future production and life.

Piperidine (3 equiv.) and toluene (5.5 volumes based on 4-bromobutanenitrile weight) were mixed and heated to 55-60 C. To this mixture, 4-bromobutanenitrile (1 equiv.) was added slowly while keeping temperature below 80 C. Note the addition is exothermic and the exotherm is addition-controlled. A white solid was observed to crystallize during the addition (piperidine hydrobromide). After complete addition, the reaction was stirred at 55-60 C. for an additional 1 hour. Progress of the reaction was monitored by 1H NMR in CDCl3 by sampling from the slurry, filtering, and evaporating solvent. After reaction is finished, the mixture was cooled to 10-20 C. and stirred for 1 hour. Solids were removed by filtration, and the cake washed with toluene (2×1.5 volumes based on 4-bromobutanenitrile weight). The combined filtrates were evaporated under vacuum (15-50 mmHg) at 40-50 C. until 120-200% of the theoretical weight was obtained. The solution was again filtered to remove remaining piperidine hydrobromide solids. The filtrate was then further evaporated under vacuum (15-50 mmHg) at 40-50 C. until no more solvent distilled. 1H NMR in CDCl3 was done to quantify residual amount of toluene for correction in next step and to verify that there was no residual piperidine present.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromobutanenitrile, other downstream synthetic routes, hurry up and to see.

455-18-5, name is 4-(Trifluoromethyl)benzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C8H4F3N

Step A (4-Trifluoromethylphenyl)thiocarboxamide To a stirred solution of 25.0 grams (0.146 mole) of 4-(trifluoromethyl)benzonitrile in 190 ml of pyridine was added 14.8 grams (0.146 mole) of triethylamine. During a two hour period, hydrogen sulfide gas was bubbled into the reaction mixture. The reaction mixture was stirred under a dry nitrogen atmosphere for 15 minutes and then was poured into ice-water. The aqueous mixture was extracted with three portions of diethyl ether. The organic extracts were combined and washed in succession with 10% hydrochloric acid, water, and an aqueous, saturated sodium chloride solution. The washed extract was dried over anhydrous sodium sulfate and was filtered. The filtrate was evaporated under reduced pressure to yield 28.3 grams of (4-trifluoromethylphenyl)thiocarboxamide as a solid.

The synthetic route of 455-18-5 has been constantly updated, and we look forward to future research findings.