Tag: M.W=100-200

Related Products of 3218-45-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3218-45-9, name is 2-(2,3-Dichlorophenyl)acetonitrile, This compound has unique chemical properties. The synthetic route is as follows.

(i) 2,,3-Dichlorophenylacetic acid Concentrated hydrochloric acid (100ml) was poured onto crushed ice (150ml), the solution added to 2,3-dichlorophenylacetonitrile (30.6gms), and the mixture refluxed for 3 hours. After cooling, the mixture was diluted with water (500ml), extracted with EtOAc (600ml) and the organic phase washed with brine before drying over MgSO4. Evaporation of the solvent left a white solid, 31.3gms.

The chemical industry reduces the impact on the environment during synthesis 2-(2,3-Dichlorophenyl)acetonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Patent; THE WELLCOME FOUNDATION LIMITED; EP459819; (1991); A2;,
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In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 63069-50-1 as follows. category: nitriles-buliding-blocks

To a solution of reagent 1 (13 g, 0.096 mol) in 200 mL of CH2CI2 was added ICI (20 g, 0.12 mol) at room temperature. The mixture was stirred at room temperature overnight. The mix- ture was evaporated to dryness. Flash chromatography (silica, petroleum ether: EtOAc 50:1 ) gave reagent 2 (13.6 g, 54%). 1H NMR (CDCI3) delta 7.72 (t, 1 H), 7.24-7.27 (m, 1 H), 4.70 (br s, 2 H).

According to the analysis of related databases, 63069-50-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; H. LUNDBECK A/S; ESKILDSEN, J¡ãrgen; WO2014/49133; (2014); A1;,
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Synthetic Route of 19472-74-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 19472-74-3, name is 2-Bromophenylacetonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A flask was equipped with a magnetic stir bar and charged with 1Hpyrrole-2-carbaldehyde (2a; 19.0 mg, 0.2 mmol, 1.0 equiv), 2-bromophenylacetonitrile(1a; 39.2 mg, 0.2 mmol, 1.0 equiv), and K3PO4(63.6 mg, 0.3 mmol, 1.5 equiv). The flask was evacuated and filledwith N2, and then anhydrous DMSO (2.0 mL) was introduced via a syringe.The flask was heated in a 130 C oil bath for 24 h, at which timeTLC analysis [petroleum ether (bp 60-90 C)-EtOAc, 10:1] indicatedcomplete consumption of 2a and 1a. The reaction mixture was cooledto r.t. and added to a sat. solution of NaCl (20 mL) and extracted withEtOAc (3 ¡Á 10 mL). The combined organic layers were dried (Na2SO4)and filtered. The filtrate was concentrated, and the residue was purified by column chromatography on SiO2 [petroleum ether (bp 60-90C)-EtOAc, 10:1 to 30:1] to give 3ab; Yield: 38.2 mg (93%); fluorescent yellow solid; mp 154.2-155.7 C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromophenylacetonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Jiang, Zeng-Qiang; Miao, Da-Zhuang; Tong, Yao; Pan, Qiang; Li, Xiao-Tong; Hu, Ren-He; Han, Shi-Qing; Synthesis; vol. 47; 13; (2015); p. 1913 – 1921;,
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Application of 654-70-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 654-70-6, name is 4-Cyano-3-trifluoromethylaniline belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a solution of the acetoxy derivative prepared in said example 2 (4.0 g, 0.0146 moles) in 20 mL of anhydrous toluene at room temperature is added 2.23 mL (0.016 moles) of triethylamine. After cooling to 0 C., 1.46 mL (0.0153 moles) of ethyl chloroformate is slowly added. After 1 hour the precipitated triethylamine hydrochloride formed is filtered off and 2.60 g (0.0140 moles) of 4-amino-2-trifluromethyl-benzonitrile dissolved in toluene is added to the filtrate and the resulting solution is heated at 75-80 C. until disappearance of the reagents is observed by HPLC.After cooling to room temperature the solution is washed with water, the phases are separated and dried with sodium sulphate and the solvent removed under reduced pressure. 5.85 g of crude intermediate is obtained which is used in the following reaction without further purification

The synthetic route of 4-Cyano-3-trifluoromethylaniline has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Pizzatti, Enrica; Vigano, Enrico; Lussana, Massimiliano; Landonio, Ernesto; US2006/41161; (2006); A1;,
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Adding a certain compound to certain chemical reactions, such as: 21524-39-0, name is 2,3-Difluorobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 21524-39-0, Recommanded Product: 21524-39-0

EXAMPLE 13 6-Fluoro[1]benzothieno[2,3-b]pyrazine-2,3(lH,4H)-dione 2,3-difluorobenzonitrile (5.0 g, 35.9 mmol) was reacted with 3-mercaptopropionitrile and bromonitromethane following the procedure outlined in example 7 (Method K). Yield 4.72 g (62%) of 3-amino-2-nitro-7-fluorobenzo[b]thiophene. M.p. 238-40 C. 1 H-NMR (DMSO-d6): delta7.48-7.65 (m, 2H), 8.21 (d, 1H), 8.65-10.3 (br. s, 2H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Novo Nordisk A/S; US5182279; (1993); A;,
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Related Products of 874-90-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 874-90-8, name is 4-Methoxybenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Aryl nitrile 4a-e (15.0mmol) was dissolved in ethanol (25mL) in a round-bottom two-necked balloon, under magnetic stirring, and hydroxylamine hydrochloride (2.085g, 30mmol) and aqueous NaOH (2 equiv, 10mL) were added to the mixture. The mixture was stirred at room temperature for 15-24h, monitoring the reaction by TLC. Then, the solvent was removed under rotary evaporation and water (20mL) was added to the crude mixture. The mixture was extracted with ethyl acetate (3¡Á20mL) and the organic layer was dried over anhydrous MgSO4 and filtered. The solvent was removed by rotary evaporation and the product was recrystallized from chloroform – hexane.

The chemical industry reduces the impact on the environment during synthesis 4-Methoxybenzonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Article; Mayer, Joao C.P.; Sauer, Andre C.; Iglesias, Bernardo A.; Acunha, Thiago V.; Back, Davi F.; Rodrigues, Oscar E.D.; Dornelles, Luciano; Journal of Organometallic Chemistry; vol. 841; (2017); p. 1 – 11;,
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Synthetic Route of 53312-81-5,Some common heterocyclic compound, 53312-81-5, name is 5-Amino-2-fluorobenzonitrile, molecular formula is C7H5FN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 64i 5-(DiallyIamino)-2-fluorobenzonitriIe Allyl bromide (4.66 mL, 55.10 mmol), 5-amino-2-fluorobenzonitrile (3.00 g, 22.04 mmol) and sodium carbonate (0.942 mL, 22.48 mmol) were dissolved in ethanol (70.00 mL) and water (20.00 mL) and refluxed over night. The reaction mixture was allowed to cool to room temperature and the ethanol was then evaporated in vacuo. The remaining water mixture was extracted with diethyl ether (twice). The combined organic layers were passed through a phase separator and concentrated in vacuo. The product was purified by silica chromatography using 0% to 50% ethyl acetate in heptane to give 5-(diallylamino)~ 2-fluorobenzonitrile (3.31 g, 70% yield): 1H NMR (500 MHz, DMSO-J6) delta ppm 7.22 – 7.32 (m, 1 H), 6.91 – 7.04 (m, 2 H), 5.76 – 5.88 (m, 2 H), 5.08 – 5.22 (m, 4 H), 3.95 (d, 4 H); MS (ES+) m/z 217 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Amino-2-fluorobenzonitrile, its application will become more common.

Reference:
Patent; ASTRAZENECA AB; BLID, Jan; GINMAN, Tobias; GRAVENFORS, Ylva; KARLSTROeM, Sofia; KIHLSTROeM, Jacob; KOLMODIN, Karin; LINDSTROeM, Johan; RAHM, Fredrik; SUNDSTROeM, Marie; SWAHN, Britt-Marie; VIKLUND, Jenny; VON BERG, Stefan; VON KIESERITZKY, Fredrik; WO2011/2408; (2011); A1;,
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Application of 57381-51-8,Some common heterocyclic compound, 57381-51-8, name is 4-Chloro-2-fluorobenzonitrile, molecular formula is C7H3ClFN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 13: 1-(4-chloro-2-(piperidin-1-yl)benzyl)-3-(2,3-dihydro-2-oxo-1H-benzo[d]imidazol-4-yl)urea Preparation of 4-chloro-2-(piperidin-1-yl)benzonitrile 16ah (scheme 8) To commercially available 2-fluoro-4-chlorobenzonitrile (2.2 g, 12.87 mmol) piperidine (4equiv., 5.6 ml) was added and the solution was heated at 80C overnight. The reaction was evaporated and to the residue water was added and the solid material was filtrated, washed with water and dried obtaining 3 g of a pale yellow solid. Yield = 97% 1HNMR (DMSO, 200 MHz) delta 1.54 (2H, m), 1.65 (4H, m), 3.14 (4H, m), 7.09 (1H, dd, J = 8.2 Hz, J’ = 2 Hz), 7.14 (1H, m), 7.69 (1H, d, J = 8.4 Hz)

The synthetic route of 57381-51-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Pharmeste S.r.l.; EP2377850; (2011); A1;,
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Synthetic Route of 31643-49-9, A common heterocyclic compound, 31643-49-9, name is 4-Nitrophthalonitrile, molecular formula is C8H3N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

9.2 g of 4-nitrophthalonitrile, 5.0 g of phenol, 7.3 g of potassium carbonate and 40 ml of DMSO were added under the protection of an inert gas such as nitrogen, and the mixture was stirred at room temperature for 48 hours,The mixture was then heated to 60 C for 2 hours and then heated. After cooling, the mixture was precipitated and filtered to give a yellow solid which was dried to give 11.6 g of compound 1.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; BEIJING BETA PHARMA, INC.; (43 pag.)TWI582078; (2017); B;,
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Synthetic Route of 193290-27-6, These common heterocyclic compound, 193290-27-6, name is 3-(2-Hydroxyethyl)benzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a cooled (0 C) solution of S154 (150 mg, 1.019 mmol) in CH2Cl2 (8 mL) were added MsCl (0.16 mL, 2.038 mmol) and Et3N (0.43 mL, 3.057 mmol). After stirring for 0.5 h at 0 C, brine was added. The layers were separated and the aqueous layer was extracted with CH2Cl2. The combined organic layers were dried over anhydrous Na2SO4 and concentrated in vacuo. To a cooled (0 C) solution of the crude mixture in THF/DMF (4/1, 15 mL) were added TrtSH (1.13 g, 4.076 mmol) and NaH (60% dispersion in mineral oil, 163 mg, 4.076 mmol). After stirring for 16 h at 25 C, the reaction mixture was quenched by the addition of saturated NH4Cl solution and diluted with EtOAc. The layers were separated and the aqueous layer was extracted with EtOAc. The combined organic layers were dried over anhydrous Na2SO4 and concentrated in vacuo. The residue was purified by column chromatography (silica gel, EtOAc/hexanes = 1/30) to afford S16 (1.8 g, 94% for two steps)

Statistics shows that 3-(2-Hydroxyethyl)benzonitrile is playing an increasingly important role. we look forward to future research findings about 193290-27-6.

Reference:
Article; Kim, Bumki; Park, Heekwang; Salvador, Lilibeth A.; Serrano, Patrick E.; Kwan, Jason C.; Zeller, Sabrina L.; Chen, Qi-Yin; Ryu, Soyoung; Liu, Yanxia; Byeon, Seongrim; Luesch, Hendrik; Hong, Jiyong; Bioorganic and Medicinal Chemistry Letters; vol. 24; 16; (2014); p. 3728 – 3731;,
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