Tag: M.W=100-200

Related Products of 2338-76-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2338-76-3, name is 3-(Trifluoromethyl)phenylacetonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

2-(3-(trifluoromethyl)phenyl)acetonitrile (3.000 g, 16.203 mmol) and sodium hydride (60.00percent, 1.426 g, 35.647 mmol) in N,N-dimethylformamide (100 mL) at 0 ¡ãC, After the addition of 1,3-dibromopropane (1.731 mL, 16.203 mmol) this mixture was stirred at room temperature for 17 hours, a saturated aqueous solution of sodium bicarbonate (10 mL) was added to the reaction mixture at room temperature and the reaction was stirred for 10 minutes. The solvent was removed from the reaction mixture under reduced pressure, the obtained concentrate was poured into water and extracted with ethyl acetate. The organic layer was washed with a saturated aqueous sodium chloride solution, and water was removed with anhydrous magnesium sulfate, followed by filtration and concentration under reduced pressure. The concentrate was purified by column chromatography (SiO2, 40 g cartridge; ethyl acetate / hexane = 0percent to 5percent) and concentrated to give the title compound (0.945 g, 25.9percent) as a colorless oil.

The synthetic route of 3-(Trifluoromethyl)phenylacetonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Chong Kun Dang Co., Ltd.; Kim, Yoon Tae; Lee, Chang Sik; Oh, Jung Taek; Song, Hey Sung; Choe, Jin; Lee, Jae Young; (210 pag.)KR2017/43091; (2017); A;,
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In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1009-35-4 as follows. Quality Control of 4-Fluoro-3-nitrobenzonitrile

10623] To a stirred solution of 4-fluoro-3-nitrobenzonitrile (1 g, 6.02 mmol) in CH2C12 (5 mE) was added potassium carbonate (1.66 g, 12.05 mmol) followed by cyclopropanamine (3.33 mE, 48.19 mmol) dropwise at 0¡ã C. under an inert atmosphere. The reaction mixture was gradually warmed to room temperature and stirred for 4 h. After consumption of starting material (by TEC), the reaction mixture was poured into water (30 mE) and extracted with EtOAc (2×50 mE). The combined organic extracts were dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford 4-(cyclopropylamino)-3-ni- trobenzonitrile (1.1 g) as a yellow solid. The crude material was taken to the next step without further purification.10624] ?H NMR (400 MHz, CDC13): oe 8.49 (d, J=1.9 Hz,1H), 8.41 (brs, 1H), 7.66-7.63 (m, 1H), 7.40 (d, J=9.0 Hz,1H), 2.68-2.61 (m, 1H), 1.04-0.98 (m, 2H), 0.75-0.70 (m,2H)10625] EC-MS: m/z 202.0 [M?H] at 2.88 RT (99.48percent purity)

According to the analysis of related databases, 1009-35-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Viamet Pharmaceuticals (NC), Inc.; Sparks, Steven; Yates, Christopher M.; Shaver, Sammy R.; Hoekstra, William J.; (156 pag.)US2018/185362; (2018); A1;,
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Application of 34403-48-0, A common heterocyclic compound, 34403-48-0, name is 4-((Methylamino)methyl)benzonitrile, molecular formula is C9H10N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 4-(methylaminomethyl)benzonitrile (5.0 g, 1 eq.) and triethylamine (8.65g, 2.5 eq.) in dichloromethane (100 ml.) was added 2,2,2-trifluoroethanesulfonyl chloride (0520) (7.49 g, 1 .2 eq.). The mixture was stirred at room temperature for two hours. Then ethyl acetate was added, the organic layer was washed with water, dried over sodium sulfate and (0521) concentrated in vacuo to yield the title compound (10.4g) as yellow solid witch was used without further purification

The synthetic route of 34403-48-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BASF SE; TERTERYAN-SEISER, Violeta; GRAMMENOS, Wassilios; QUINTERO PALOMAR, Maria Angelica; CRAIG, Ian Robert; WIEBE, Christine; MENTZEL, Tobias; FEHR, Marcus; ESCRIBANO CUESTA, Ana; WINTER, Christian Harald; LOHMANN, Jan Klaas; MUELLER, Bernd; GROTE, Thomas; CAMBEIS, Erica; (62 pag.)WO2018/114393; (2018); A1;,
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Application of 34916-10-4,Some common heterocyclic compound, 34916-10-4, name is 4-Oxo-cyclohexanecarbonitrile, molecular formula is C7H9NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Into a 250-mL 4-necked round-bottom flask purged and maintained with an inert atmosphere of nitrogen, was placed 119.1 (10 g, 81.20 mmol, 1.00 equiv), methanol (100 mL). This was followed by the addition of NaBH4 (1.52 g, 40.18 mmol, 0.50 equiv) at 0 C. in a water/ice bath. The resulting solution was stirred for 1 h at room temperature. The reaction was then quenched by the addition of 20 mL of NH4Cl (aq). The resulting solution was extracted with 2¡Á100 mL of ethyl acetate and the organic layers combined and dried over anhydrous sodium sulfate and concentrated under vacuum. This resulted in 10.02 g (99%) of 119.2 as colorless oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Oxo-cyclohexanecarbonitrile, its application will become more common.

Reference:
Patent; Gilead Apollo, LLC; Ghosh, Shomir; Greenwood, Jeremy Robert; Harriman, Geraldine C.; Leit De Moradei, Silvana Marcel; (290 pag.)US2017/166584; (2017); A1;,
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In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 613-46-7 as follows. category: nitriles-buliding-blocks

General procedure: A mixture of arylnitrile (2.0 mmol) and WR (1.07 g, 2.0 mmol) in 20 mL of dry toluene was refluxed for 8 h. Upon cooling to 90C 1.0 mL of water was added, the mixture was refluxed for another 1 h. After cooling to room temperature the reaction mixture was concentrated to ca. 5.0 mL and extracted with dichloromethane (20 mL x 3), the combined dichloromethane extracts were dried over MgSO4. The final residue was purified by silica gel chromatography (9 : 1 ethyl acetate /dichloromethane as eluent) to give the compounds 1a-1i.

According to the analysis of related databases, 613-46-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Hua, Guoxiong; Du, Junyi; Slawin, Alexandra M. Z.; Woollins, J. Derek; Synlett; vol. 25; 15; (2014); p. 2189 – 2195;,
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Application of 712-74-3, These common heterocyclic compound, 712-74-3, name is Benzene-1,2,4,5-tetracarbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Cocrystal IV. Equimolar(0.1 mmol) ANPO and TCNB were stirredand dissolved in 16 mL acetonitrile/dichloromethane (1:1) mixed solventswithin a ventilated glass flask. Evaporating for one week at ambient temperature, the mother liquid separated out orange rod-like crystals (Scheme 2).

Statistics shows that Benzene-1,2,4,5-tetracarbonitrile is playing an increasingly important role. we look forward to future research findings about 712-74-3.

Reference:
Article; Sun, Hao; Khan, Arshad; Usman, Rabia; Wang, Mingliang; Journal of Photochemistry and Photobiology A: Chemistry; vol. 371; (2019); p. 315 – 326;,
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67832-11-5, name is 4-Bromo-2-methylbenzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 4-Bromo-2-methylbenzonitrile

Example 1: Synthesis of 4-{4-{1-hydroxyethyl)pyridin-3-yl)-2-methylbenzonitrileStep 1: 2-methyl-4-(4,4,5l5-tetramethyl-1 ,3 2-dioxaborolan-2-yl)benzonitrile (1a)A mixture of 4-bromo-2-methylbenzonitrile (1 g, 5.10 mmol), bis(pinacolato)diboron (1.554 g, 6.12 mmol), potassium acetate (1.001 g, 10.20 mmol) and PdCI2(dppf).CH2CI2 adduct (0.208 g, 0.255 mmol) in 1 ,4-Dioxane (12.75 ml) was heated to 80 C for 5 hr. The mixture was concentrated, and the residue was purified via Biotage (0-10% EtOAc/heptane; SNAP50 column) giving compound 1 as white solid (860 mg, 69%). 1H NMR (400 MHz, CDCI3) delta ppm 1.28 (s, 12 H) 2.38 – 2.52 (m, 3 H) 7.51 (d, J=7.64 Hz, 1 H) 7.55 – 7.64 (m, 1 H) 7.67 (s, 1 H).

The synthetic route of 67832-11-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NOVARTIS AG; ALLAN, Martin; CHAMOIN, Sylvie; HU, Qi-Ying; IMASE, Hidetomo; PAPILLON, Julien; WO2011/61168; (2011); A1;,
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Adding a certain compound to certain chemical reactions, such as: 78473-00-4, name is 4-Amino-3,5-dichlorobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 78473-00-4, Product Details of 78473-00-4

EXAMPLE 17 2-Ethyl-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid (2,6-dichloro-4-cyanophenyl)amide Starting from 2-ethyl-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid 4-nitrophenyl ester (0.10 g) and 4-amino-3,5-dichlorobenzonitrile (0.12 g). Purification by column chromatography on silica with 20% then 30% then 50% ethyl acetate in hexane to give the title compound (0.051 g) as a cream solid. TLC Rf 0.125 (20% ethyl acetate in hexane)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Darwin Discovery, Ltd.; US6169090; (2001); A;,
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Synthetic Route of 612-24-8, A common heterocyclic compound, 612-24-8, name is 2-Nitrobenzonitrile, molecular formula is C7H4N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Nitrobenzene (0.6mmol), 5wt% Pd/C (0.5mmol %, 0.003mmol), H2O (10 equiv, 6.0mmol), B2(OH)4 (3.3 equiv, 2.0mmol), and CH3CN (1.0mL) were added in a 10mL tube. The reaction mixture was stirred at 50C for 24h. When the reaction was complete monitored by TLC, the mixture was cooled to room temperature. Water (5mL) was added, and extracted with EtOAc (3¡Á5mL). The combined organic phase was dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give aniline 2a (55mg, 99%).

The synthetic route of 612-24-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhou, Yanmei; Zhou, Haifeng; Liu, Sensheng; Pi, Danwei; Shen, Guanshuo; Tetrahedron; vol. 73; 27-28; (2017); p. 3898 – 3904;,
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Application of 621-03-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 621-03-4, name is 2-Cyano-N-phenylacetamide, This compound has unique chemical properties. The synthetic route is as follows.

Cyanoacetic acid (0.96 g, 11.1 mmol, 1 eq) was added to a mixture of PC15 (2.35 g, 11.1 mmol, 1 eq) in 200 mL of CH2C12, and the mixture refluxed for 30 minutes. After cooling, aniline (1.01 mL, 1.03 g, 11.1 mmol) was added and the solution was refluxed for 2hrs. The reaction mixture was allowed to cool to room temperature, and then concentrated to dryness at the rotary evaporator. A 50 mL portion of water was added and the suspension was filtered. The resulting solid was then washed with 25 mL of 1.0 N NaHC03 solution, 25 mL of water and then dried to afford the desired cyanoamide as a white amorphous solid (1.64 g, 92%). This solid was of sufficient purity to be used without further purification in the subsequent reaction. 1H NMR (400 MHz, acetone-d6) delta 9.58 (s, 1H), 7.62 (d, / = 8.4 Hz, 2H), 7.33 (t, / = 8.0 Hz, 2H), 7.11 (t, / = 7.2 Hz, 1H), 3.82 (s, 2H).A 0.9 g portion (12.8 mmol, 1.25 eq) of NH2OH HCl was added to Na2C03 (1.36 g, 12.8 mmol, 1.25 eq) dissolved in 5 mL of water, and the solution was diluted with 50 mL of methanol. The cyanoamide from the previous step (1.64 g, 10.2 mmol) was added and the mixture was refluxed for 2 hours. After cooling, the reaction mixture was concentrated in vacuo, and the resulting solid was mixed with a hot 3:1 mixture of ethyl acetate:hexane. The insoluble material was immediately removed by filtration, and the filtrate was concentrated to dryness at the rotary evaporator. The solid residue was purified by column chromatography (silica gel, ethyl acetate: methanol 20:1) and recrystallized to afford Example 1 as a white crystalline solid (0.67 g, 34%). 1H NMR (400 MHz, acetone-d6) delta 9.53 (s, 1H), 8.70 (s, 1H), 7.65-7.63 (m, 2H), 7.31-7.27 (m, 2H), 7.07-7.04 (m, 1H), 5.39 (s, 2H), 3.17 (s, 2H).

The chemical industry reduces the impact on the environment during synthesis 2-Cyano-N-phenylacetamide. I believe this compound will play a more active role in future production and life.

Reference:
Patent; THE JOHNS HOPKINS UNIVERSITY; CASERO, Robert, A.; BYTHEWAY, Ian; WOSTER, Patrick, M.; WO2012/34116; (2012); A2;,
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