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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Zhu, Guixian; Cheng, Lin; Liu, Gannan; Zhu, Lianqing researched the compound: Pyridine-4-thiol( cas:4556-23-4 ).Quality Control of Pyridine-4-thiol.They published the article 《Synthesis of gold nanoparticle stabilized on silicon nanocrystal containing polymer microspheres as effective surface-enhanced Raman scattering (SERS) substrates》 about this compound( cas:4556-23-4 ) in Nanomaterials. Keywords: gold nanoparticle silicon nanocrystal polymer microsphere SERS substrate; 4-mercaptopyridine; SERS; gold nanoparticle; pH value; silicon nanocrystal containing polymer microspheres. We’ll tell you more about this compound (cas:4556-23-4).

Developing ideal surface-enhanced Raman scattering (SERS) substrates is significant in biol. detection. Compared with free non-aggregated noble metal nanoparticles, loading metal nanoparticles on a large matrix can achieve a higher SERS effect due to the existence of many “”hot spots””. A novel SERS substrate with intense “”hot spots”” was prepared through reducing gold ions with silicon nanocrystal containing polymer microspheres. The substrate exhibits high SERS sensitivity with an enhancement factor of 5.4×107. By applying 4-mercaptopyridine as a Raman reporter, the developed SERS substrate can realize measurement of pH values. The intensity ratio of 1574 to 1607 cm-1 of 4-mercaptopyridine showed excellent pH sensitivity, which increased as the surrounding pH increased. With good stability and reliability, the pH sensor is promising in the design of biol. detection devices.

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Dai, Xin; Song, Zhi-Ling; Song, Wenjuan; Zhang, Jiling; Fan, Gao-Chao; Wang, Wei; Luo, Xiliang published the article 《Shell-Switchable SERS Blocking Strategy for Reliable Signal-On SERS Sensing in Living Cells: Detecting an External Target without Affecting the Internal Raman Molecule》. Keywords: SERS Raman spectroscopy.They researched the compound: Pyridine-4-thiol( cas:4556-23-4 ).Formula: C5H5NS. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:4556-23-4) here.

For SERS anal. in living cells, the inevitable desorption of Raman mol. on the substrate surface is a key challenge. To ensure high stability, SERS systems with Raman mols. protected inside the core-Raman mol.-shell (C-M-S) structures have been designed, but at the expense of sacrificed sensing performances. Here a shell-switchable SERS blocking strategy is developed for the reliable SERS anal. in living cells, relying on the shell blockers to regulate the SERS sensing signal without affecting the internal Raman mols. After several C-M-S structures were studied, the SERS blocking mechanism confirmed that thick shells (Au, Ag, ZnO, and MnO2) can cause a significant reduction in the internal SERS signal by obstructing the penetration of the laser or signal. The CAu-Mpy-SAu-SMnO2 nanoprobe is designed for the ratiometric SERS sensing in living cells, which retains sensing performances even though the Raman mol. is protected inside the nanostructure. This SERS strategy makes the turn-on sensing achievable in living cells with the MnO2 shell as a signal switch and a Raman reference Addnl., it allows for accurate monitoring of the degradation of MnO2 carriers in living cells, even without fluorescent labels.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Pyridine-4-thiol, is researched, Molecular C5H5NS, CAS is 4556-23-4, about Study of chemical enhancement mechanism in non-plasmonic surface enhanced Raman spectroscopy (SERS).Category: nitriles-buliding-blocks.

Surface enhanced Raman spectroscopy (SERS) has been intensively investigated during the past decades for its enormous electromagnetic field enhancement near the nanoscale metallic surfaces. Chem. enhancement of SERS, however, remains rather elusive despite intensive research efforts, mainly due to the relatively complex enhancing factors and inconsistent exptl. results. To study details of chem. enhancement mechanism, we prepared various low dimensional semiconductor substrates such as ZnO and GaN that were fabricated via metal organic chem. vapor deposition process. We used three kinds of mols. (4-MPY, 4-MBA, 4-ATP) as analytes to measure SERS spectra under non-plasmonic conditions to understand charge transfer mechanisms between a substrate and analyte mols. leading to chem. enhancement. We observed that there is a preferential route for charge transfer responsible for chem. enhancement, i.e., there exists a dominant enhancement process in non-plasmonic SERS. To further confirm our idea of charge transfer mechanism, we used a combination of 2-dimensional transition metal dichalcogenide substrates and analyte mols. We also observed significant enhancement of Raman signal from mols. adsorbed on 2-dimensional transition metal dichalcogenide surface that is completely consistent with our previous results. We also discuss crucial factors for increasing enhancement factors for chem. enhancement without involving plasmonic resonance.

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Quality Control of Pyridine-4-thiol. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Pyridine-4-thiol, is researched, Molecular C5H5NS, CAS is 4556-23-4, about Plasmon-coupled charge transfer in WO3-x semiconductor nanoarrays: toward highly uniform silver-comparable SERS platforms. Author is Hou, Xiangyu; Luo, Xiaoguang; Fan, Xingce; Peng, Zhaohui; Qiu, Teng.

Transition metal oxide semiconductors have been explored in surface-enhanced Raman scattering (SERS) active substrates, yet their detection sensitivity and enhancement effects are inferior. What’s more, the reported fabrication technique ignored the effects of the electromagnetic mechanisms and was far from satisfactory for practical applications. Herein, we report on a convenient nanotechnique to fabricate large-area hexagon plum-blossom-like WO3-x nanoarrays based on aluminum nanobowl array substrates. Localized surface plasmon resonance can be increased via adjusting the time of tungsten magnetron sputtering with H2 annealing treatment. The introduction of a double-switch experiment demonstrates that localized surface plasmon-coupled photoinduced charge transfer can not only increase SERS enhancement comparable to similar silver nanostructures but also implement a low limit of detection below 10-9 M. A triple-switch experiment offers specific rules in the mol. detection of WO3-x semiconductors and important guidance for the fabrication of SERS-active semiconducting platforms.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called HPLC determination of the related substances in Azathioprine Tablets, published in 2013-02-28, which mentions a compound: 4897-25-0, Name is 5-Chloro-1-methyl-4-nitroimidazole, Molecular C4H4ClN3O2, COA of Formula: C4H4ClN3O2.

A HPLC method for determination of related substances in Azathioprine Tablets was established. The C18 column (200 mm×4.6 mm, 5 μm) was used. The mobile phase consisted of methanol and 0.05% of sodium acetate solution (18:82) at the flow rate of 1.2 mL·min-1, and the detection wavelength was set at 300 nm. The linear ranges of the two typical related substances mercaptopurine and 5-chloro-1-methyl-4-nitroimidazole in Azathioprine Tablets were all 0.125-1.80μg·mL-1 (r=0.9997 and 0.9999) with the detection limits of 0.787 ng and 0.933 ng, and the average recoveries were 100.3% and 100.0% with the RSD of 0.64% and 0.14%. The method proposed for determining the related substances of Azathioprine Tablets is simple, quick and the result is accurate and specific.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Identification of mutaprodenafil in a dietary supplement and its subsequent synthesis.Synthetic Route of C4H4ClN3O2.

We isolated a new illegal sildenafil analog named mutaprodenafil (I) from a dietary supplement for erectile dysfunction (ED) and proposed that it is an aildenafil derivative containing an imidazole moiety. We subsequently synthesized mutaprodenafil from a thioaildenafil and authenticated its structure.

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Related Products of 4556-23-4. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Pyridine-4-thiol, is researched, Molecular C5H5NS, CAS is 4556-23-4, about Synthesis of different copper iodide/sulfide clusters via regulating the amount of ligand added. Author is Hu, Dandan; Zhang, Junqi; Song, Jinyu; Ren, Hongjun.

Here, the authors successfully reported two copper iodide/sulfide clusters, Cu6S2I4(C5NS)4 (CIS-1, 1) and Cu6(C5NS)4(CN)2 (CS-2, 2), via changing the amount of ligand (C5H5NS) to regulate its decomposing degree. In CIS-1, 4-pyridinethiol only acted as sulfur source, not as linker between clusters. Oppositely, in another open framework CS-2 containing 4-pyridinethiol, the coordinating capability of N/S from ligand was taken full advantage to connect surrounding clusters via Cu-N and Cu-S bond. UV-visible diffuse reflectance spectroscopy and photocurrent response were performed to research the photoelec. properties about these compounds, whose results demonstrate these hybrid materials belong to semiconductor. That makes them expected as potential semiconducting materials to apply in photoelec. devices.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Chloro-1-methyl-4-nitroimidazole( cas:4897-25-0 ) is researched.COA of Formula: C4H4ClN3O2.Pan, Fuyou; Liang, Huading published the article 《Reversed-phase high-performance liquid chromatographic determination of azathioprine and its intermediates》 about this compound( cas:4897-25-0 ) in Fenxi Huaxue. Keywords: azathioprine determination reversed phase HPLC; liquid chromatog determination azathioprine. Let’s learn more about this compound (cas:4897-25-0).

The RP-HPLC determination of Azathioprine and its intermediates (mercaptoprine, 1-methyl-4-nitro-5-chloro imidazole) capsules by using shim-pack CLC_ODS(5μm, 4.6 mm I.D. × 150 mm) column, acetonitrile-water(30:70 V/V) as mobile phase flow rater, 0.8 mL/min and UV 210 nm detector. Good linearity was obtained in the concentration range of 0.05 – 15 mg/L with standard calibration curve of Azathioprine y = 109821x – 2450,r = 0.9999, Mercaptoprine y = 68173x + 2034,r = 0.9998, 1-methyl-4-nitro-5-chlorine-imidazole y = 64438x – 1353,r = 0.9995. The method has been used to determine drug samples with satisfactory results.

The article 《Reversed-phase high-performance liquid chromatographic determination of azathioprine and its intermediates》 also mentions many details about this compound(4897-25-0)COA of Formula: C4H4ClN3O2, you can pay attention to it, because details determine success or failure

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Category: nitriles-buliding-blocks. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Chloronitroimidazoles as radiosensitizers of hypoxic cells in vitro. Author is Widel, M.; Watras, J.; Suwinski, J.; Salwinska, E..

In vitro studies in V79-379A cells on the radiosensitizing efficiency, cytotoxicity, and reactivity with blood thiols of a series of chloronitroimidazoles (I where R1 = Me or H, R2 = Cl, H, or Me, R4 = NO2, H, Cl, NO2H, or NO2Cl, and R5 = H, Cl, NO2, NO2H, NO2Cl) are presented. The derivatives of 4-nitroimidazole substituted in the 5 position with Cl show higher radiosensitizing efficiency to γ-rays than one might expect from their reduction potential. At the same time they are extremely toxic, especially for aerobic cells. It is thought that the high biol. activity of ortho-substituted 4-nitroimidazoles is connected with their considerable chem. reactivity towards thiols and suppression of those natural protective compounds in the cells. The corresponding 5-nitro isomers are ∼10-fold weaker sensitizers, and simultaneously much less cytotoxic, either in aerobic or in hypoxic conditions. The chloro-4(5)-nitroimidazoles are unsubstituted at N-1 and ionizable in aqueous solution are relatively weaker but at the same time less toxic radiosensitizers. The potential application in radiotherapy is indicated for those chloronitroimidazoles which show low aerobic cytotoxicity, moderate radiosensitizing ability, and no reactivity towards thiols. On the basis of the in vitro study, 1-methyl-2-chloro-4-nitroimidazole (P13) has been selected for screening in vivo.

Although many compounds look similar to this compound(4897-25-0)Category: nitriles-buliding-blocks, numerous studies have shown that this compound(SMILES:C1=NC(=C(Cl)[N]1C)[N+]([O-])=O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Stability-indicating assay for azathioprine and 6-mercaptopurine by reversed-phase high-performance liquid chromatography, published in 1979-12-30, which mentions a compound: 4897-25-0, Name is 5-Chloro-1-methyl-4-nitroimidazole, Molecular C4H4ClN3O2, Recommanded Product: 4897-25-0.

A rapid method based on reversed-phase high-performance liquid chromatog. is described for the separation and quantitation of azathioprine (I) [446-86-6], 6-mercaptopurine (II) [50-44-2] and their potential contaminants and degradants present in dosage forms. Procedures based on simple dissolution or extraction in 0.02 M NaOH give quant. precision of 1% relative standard deviation at the macro-level and 2% relative standard deviation for the microassay of analytes. The method is stability-indicating and was used for preliminary studies of the degradation of I in 0.9% NaCl injection, subjected to thermal or UV irradiation treatment. The content uniformity of dosage forms of I and II was measured. Only I injection as the freeze-dried Na salt [55774-33-9] contained detectable amounts of contaminants 1-methyl-4-nitro-5-chloroimidazole [4897-25-0] and hypoxanthine [68-94-0].

Although many compounds look similar to this compound(4897-25-0)Recommanded Product: 4897-25-0, numerous studies have shown that this compound(SMILES:C1=NC(=C(Cl)[N]1C)[N+]([O-])=O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Nitrile – Wikipedia,
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