Tag: M.W=100-200

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, MedChemComm called Design, synthesis, and structure-activity relationships of indole-3-carboxamides as novel water soluble cannabinoid CB1 receptor agonists, Author is Adam, Julia M.; Cairns, Jim; Caulfield, Wilson; Cowley, Phillip; Cumming, Iain; Easson, Morag; Edwards, Darren; Ferguson, Morag; Goodwin, Richard; Jeremiah, Fiona; Kiyoi, Takao; Mistry, Ashvin; Moir, Elizabeth; Morphy, Richard; Tierney, Jason; York, Mark; Baker, James; Cottney, Jean E.; Houghton, Andrea K.; Westwood, Paul J.; Walker, Glenn, which mentions a compound: 128717-77-1, SMILESS is O=C(C1=CNC2=C1C=CC=C2OC)O, Molecular C10H9NO3, Synthetic Route of C10H9NO3.

A novel CB1 receptor agonist lead series was identified using a high-throughput screening approach. The initial screen afforded a single confirmed hit with poor water solubility Structural variations were explored with the aim of introducing water solubility and improving potency. This led to the discovery of Org 28611, a potent, water soluble CB1 receptor agonist, which was selected for clin. evaluation as a potential i.v. analgesic agent.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Enhanced charge-transfer induced by conduction band electrons in aluminum-doped zinc oxide/molecule/Ag sandwich structures observed by surface-enhanced Raman spectroscopy, published in 2022-03-15, which mentions a compound: 4556-23-4, mainly applied to aluminum doped zinc oxide silver sandwich structure charge transfer; Al-doped ZnO; Charge-transfer; Conduction band; SERS, Recommanded Product: 4556-23-4.

In the semiconductor/mol./metal system, enhancing the efficiency of the charge-transfer (CT) plays a pivotal role in improving the sensitivity of semiconductor-based surface-enhanced Raman scattering (SERS). In this work, use of SERS for detection of an enhanced CT in a chem.-etched Al-doped ZnO (AZO), 4-mercaptopyridine (MPy) mol., and Ag nanoparticles (NPs) (AZO/MPy/Ag) sandwich structure is reported. A series of CT routes are proposed in the energy level diagram of AZO/MPy/Ag assemblies under the excitation line at 633 nm. Very interestingly, for the first of its kind, a significant CT route from the conduction band (CB) of AZO to the LUMO (LUMO) of MPy mol. is detected. This route can remarkably improve the degree of CT in the AZO/MPy/Ag system by about 48% compared with that of the ZnO/MPy/Ag system. Furthermore, the uniquely enhanced CT route is also further confirmed by alternative probe mols. like p-aminothiophenol (PATP) and 4-mercaptobenzoic acid (MBA). The discovery of this extra CT route will inevitably play an irreplaceable role in SERS enhancement through its participating in the CT enhancement mechanism.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 4897-25-0, is researched, SMILESS is C1=NC(=C(Cl)[N]1C)[N+]([O-])=O, Molecular C4H4ClN3O2Journal, Huaxue Yanjiu Yu Yingyong called A new synthetic technique of 5-chloro-1-methyl-4-nitroimidazole, Author is Liu, Cong; Yan, Xiaofei; Ren, Yingge; Shen, Ning; Liu, Qianfeng, the main research direction is chloro methyl nitroimidazole preparation Azathioprine intermediate.Safety of 5-Chloro-1-methyl-4-nitroimidazole.

A method for the preparation of 5-chloro-1-methyl-4-nitroimidazole was developed with di-Et oxalate, aqueous methylamine formate, phosphorus pentachloride, mixed acid etc as starting materials. The synthesis of the target compound was achieved (64% yield) by a sequence involving an aminolysis reaction, condensation and nitration reaction. The process provided an energy-saving high yield synthetic method (green chem.) and the product thus obtained was confirmed by MS, NMR, FT-IR. The title compound is an intermediate for 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-9H-purine [Azathioprine, Imuran, immunosuppressant].

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Quality Control of Pyridine-4-thiol. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Pyridine-4-thiol, is researched, Molecular C5H5NS, CAS is 4556-23-4, about Hydrogel microdomain encapsulation of stable functionalized silver nanoparticles for SERS pH and urea sensing.

Conceptual and com. examples of implantable sensors have been limited to a relatively small number of target analytes, with a strong focus on glucose monitoring. Recently, surface-enhanced Raman spectroscopy (SERS) pH sensors were demonstrated to track acid-producing enzymic reactions targeting specific analytes. We show here that SERS pH tracking in the basic regime is also possible, and can be used to monitor urea concentration To accomplish this, we developed a hydrogel consisting of polyelectrolyte multilayer microcapsules containing a SERS-sensitive pH reporter (4-mercapopyridine capped silver nanoparticles modified with bovine serum albumin). This pH sensing material exhibited a sensitive Raman scattering response to a wide range of pH from 6.5-9.7. By incorporating urease into the hydrogel matrix, the new sensor was capable of distinguishing urea concentrations of 0, 0.1, 1, and 10 mM. We also found that bovine serum albumin (BSA) prevented severe aggregation of the nanoparticle-based pH sensor, which improved sensing range and sensitivity. Furthermore, BSA safeguarded the pH sensor during the encapsulation procedure. Together, the combination of materials represents a novel approach to enabling optical sensing of reactions that generate pH changes in the basic range.

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Recommanded Product: Pyridine-4-thiol. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Pyridine-4-thiol, is researched, Molecular C5H5NS, CAS is 4556-23-4, about Gold nanoflowers grown in a porous Si/SiO2 matrix: The fabrication process and plasmonic properties. Author is Osminkina, Liubov A.; Zukovskaja, Olga; Agafilushkina, Svetlana N.; Kaniukov, Egor; Stranik, Ondrej; Gonchar, Kirill A.; Yakimchuk, Dmitry; Bundyukova, Victoria; Chermoshentsev, Dmitry A.; Dyakov, Sergey A.; Gippius, Nikolay A.; Weber, Karina; Popp, Jurgen; Cialla-May, Dana; Sivakov, Vladimir.

Highly branched metal nanostructures are of great interest for creating highly sensitive sensors of various mols. through the use of surface-enhanced Raman scattering. However, the method of manufacturing such nanostructures is often complex and difficult to reproduce. Herein, we report a simple, one-pot synthesis of flower-like gold nanostructures (AuNFs) in a porous Si/SiO2 matrix for potential surface enhanced Raman spectroscopy (SERS) applications. Templates covered with 500-nm diameter AuNFs with rough coral-like petals were obtained through a simple electroless reduction of gold(III) chloride salt in diluted hydrofluoric acid inside pores in the Si/SiO2 layer, which were obtained by swift heavy ion track technol. Detailed SERS anal. showed that single nanoflowers are capable of enhancing Raman signals and can be used as independent nanosensors. Having a few AuNFs in close proximity to each other enables more “”hot spots”” to be formed with an even greater increase in signal intensity. Using such substrates, reliable detection of 4-mercaptopyridine could be achieved down to 0.01μM concentration Finally, we theor. demonstrate that the AuNFs are characterized by a wide-band plasmonic mode as well as by hot spots in the electromagnetic near-field distribution, which can result in a high enhancement factor for Raman scattering.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Cobalt-Catalyzed Ligand-Controlled Divergent Regioselective Reactions of 1,6-Enynes with Thiols, published in 2020-06-08, which mentions a compound: 4556-23-4, mainly applied to cobalt catalyzed divergent regioselective cyclization reaction enyne thiol; carbocyclic organosulfur pyrrole pyrrolizine compound preparation reactivity, Application of 4556-23-4.

An efficient Co-catalyzed method for the synthesis of carbocyclic organosulfur compounds from 1,6-enynes and thiols was developed. The significance of this methodol. is the ability to give three different cyclization products depending on the ligands used. The products were obtained in moderate to good yields with broad substrate scope.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Chloro-1-methyl-4-nitroimidazole( cas:4897-25-0 ) is researched.Product Details of 4897-25-0.Yonehara, Ryo; Nada, Shigeyuki; Nakai, Tomokazu; Nakai, Masahiro; Kitamura, Ayaka; Ogawa, Akira; Nakatsumi, Hirokazu; Nakayama, Keiichi I.; Li, Songling; Standley, Daron M.; Yamashita, Eiki; Nakagawa, Atsushi; Okada, Masato published the article 《Structural basis for the assembly of the Ragulator-Rag GTPase complex》 about this compound( cas:4897-25-0 ) in Nature Communications. Keywords: Rag GTPase mTORC HBXIP protein structure lysosome. Let’s learn more about this compound (cas:4897-25-0).

The mechanistic target of rapamycin complex 1 (mTORC1) plays a central role in regulating cell growth and metabolism by responding to cellular nutrient conditions. The activity of mTORC1 is controlled by Rag GTPases, which are anchored to lysosomes via Ragulator, a pentameric protein complex consisting of membrane-anchored p18/LAMTOR1 and two roadblock heterodimers. Here we report the crystal structure of Ragulator in complex with the roadblock domains of RagA-C, which helps to elucidate the mol. basis for the regulation of Rag GTPases. In the structure, p18 wraps around the three pairs of roadblock heterodimers to tandemly assemble them onto lysosomes. Cellular and in vitro analyses further demonstrate that p18 is required for Ragulator-Rag GTPase assembly and amino acid-dependent activation of mTORC1. These results establish p18 as a critical organizing scaffold for the Ragulator-Rag GTPase complex, which may provide a platform for nutrient sensing on lysosomes.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 4556-23-4, is researched, SMILESS is SC1=CC=NC=C1, Molecular C5H5NSJournal, New Journal of Chemistry called Synthesis of mono/dinuclear rhenium(I) tricarbonyl substituted with 4-mercaptopyridine related ligands: spectral and theoretical evidence of thiolate/thione interconversion, Author is Gomez, Alejandra; Jara, Geraldine; Flores, Erick; Maldonado, Tamara; Godoy, Fernando; Munoz-Osses, Michelle; Vega, Andres; Mera, Raul; Silva, Carlos; Pavez, Jorge, the main research direction is mono dinuclear rhenium tricarbonyl mercaptopyridine preparation crystal mol structure; thiolate thione interconversion rhenium tricarbonyl mercaptopyridine complex.Safety of Pyridine-4-thiol.

The synthesis, characterization, and spectroscopic and theor. studies of new κ1-S monometallic Re-spy (1)/Re-thiopy (2) and κ1-N-bimetallic Re2-dps (3)/Re2-dpds (4) complexes substituted with 4-mercaptopyridine derivatives are reported. The obtainment of either monosulfide bridge-complex (3) or disulfide bridge-complex (4) depends on the reaction media. The structure of complex 3 was confirmed by monocrystal x-ray diffraction. Addnl. it was possible to determine the presence of an intramol. interconversion between 1 and 2 mediated by solvent mols. through the intermediate species 1-H+ using UV-Vis and NMR spectroscopy. Electronic spectra calculated by TD-DFT feature distinct MLCT transitions for 2 and show that the π-stacking interaction present in 1 is broken in the methanol/water mixture, leading to a structural distribution similar to 2. Cyclic voltammograms of all complexes display the characteristic reduction process for the rhenium center and the bipyridine ligand. Addnl., an irreversible process associated with the bridging ligand for 3 and 4 is observed

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Pyridine-4-thiol(SMILESS: SC1=CC=NC=C1,cas:4556-23-4) is researched.Safety of Pyridine-4-thiol. The article 《Monitoring the Changes of pH in Lysosomes during Autophagy and Apoptosis by Plasmon Enhanced Raman Imaging》 in relation to this compound, is published in Analytical Chemistry (Washington, DC, United States). Let’s take a look at the latest research on this compound (cas:4556-23-4).

Lysosomes are acidic organelles that not only participate in intracellular degradation but also relate to various cellular functions. Abnormal pH in lysosomes would lead to lysosomal dysfunction, which may further result in many diseases. In this work, the authors statistically analyze the pH change in the lysosomes of HeLa cells model by using surface enhanced Raman scattering (SERS) imaging technique. The authors prepared a plasmon Raman pH probe and localized the pH probe to lysosomes via an incubation-depletion method. The pH profiles within lysosomes during the process of cellular autophagy and apoptosis were monitored in situ by SERS imaging. The pH in lysosomes decreased slightly during the process of autophagy, while the pH in lysosomes increased during apoptosis. The phenomenon, in general, is consistent with the current biol. knowledge. However, the authors did not observe significant variation of pH between different individual cells. This information might provide an in depth understanding about the relationship of lysosomal pH with fundamental cellular functions and mechanism of diseases.

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Quality Control of Pyridine-4-thiol. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Pyridine-4-thiol, is researched, Molecular C5H5NS, CAS is 4556-23-4, about SERS-active carboxymethyl cellulose-based gold nanoparticles: high-stability in hypersaline solution and selective response in the Hofmeister series. Author is de Melo, Fernando Menegatti; Fante, Allef Soares; Zamarion, Vitor de M.; Toma, Henrique Eisi.

Gold nanoparticles (AuNP) were directly synthesized with sodium CM-cellulose (CMC) by a simple one-pot procedure, exhibiting surprising protection against salt-induced aggregation. The AuNP@CMC nanoparticles are reactive towards thiol ligands such as 4-mercaptopyridine (4MPy) and 2,4,6-trimercapto-1,3,5-triazine (TMT) indicating a labile character for the CMC coating. Aggregation can be promoted by those ligands combined with salt induced effects along the Hofmeister series, allowing one to explore the local enhanced elec. fields (hot spots) as surface enhanced Raman (SERS) sensors. Such behavior is selective for several salts within the Hofmeister series, exposing the role of the ligand exchange dynamics in the system.

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