Tag: M.W=100-200

Synthetic Route of C4H4ClN3O2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Mechanism of formation of 5-mercapto-1-methyl-4-nitroimidazole, a metabolite of the immunosuppressive drug azathioprine. Author is Chalmers, A. H..

Studies of the urine of mice and dogs after administration of azathioprine (I) [446-86-6] or 3 derivatives indicated that 5- mercapto-1-methyl-4-nitroimidazole (II) [6339-54-4] is formed from the glutathione-imidazole adduct,5-glutathionyl-1-methyl-4- nitroimidazole [36892-55-4]. Oral and i.v. administration of I to patients and dogs suggested that I is probably absorbed per se from the gut.

As far as I know, this compound(4897-25-0)Synthetic Route of C4H4ClN3O2 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Identification and determination of azathioprine in the presence of 6-mercaptopurine and 5-chloro-1-methyl-4-nitroimidazole, the main research direction is azathioprine spectrometry determination; mercaptopurine azathioprine determination; chloromethylnitroimidazole azathioprine determination; clomizole azathioprine determination.Formula: C4H4ClN3O2.

Azathioprine (I) [446-86-6] was separated from the other title compounds (substrates in I synthesis) by paper chromatog. with 4:1:1, BuOH-EtOH-H2O, 3:1 PrOH-N AcOH or 3:1 PrOH-0.2N aqueous NH3, the 1st 2 systems also being effective in thin-layer chromatog. on silica gel. Reduction of I with Zn in 5% aqueous NH3 saturated with NH4Cl gave a purple-red product. This color reaction was used for determining I in the title mixtures and in pharmaceutical preparations by photometry at 525 nm.

As far as I know, this compound(4897-25-0)Formula: C4H4ClN3O2 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Computed Properties of C5H5NS. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Pyridine-4-thiol, is researched, Molecular C5H5NS, CAS is 4556-23-4, about Iridium-Catalyzed Propenylation Reactions for the Synthesis of 4-Pyridone Derivatives. Author is Bai, Xue-dan; Wang, Jie; He, Ying.

Herein we report an iridium-catalyzed propenylation reaction of allylic carbonates with 4-hydroxypyridine derivatives The process efficiently provides 4-pyridone derivatives with high stereoselectivities under mild conditions. The products could constitute valuable building blocks for the synthesis of natural products and other bioactive mols. Preliminary mechanistic studies indicated that a tandem allylic substitution/isomerization reaction occurs to afford the propenylation products.

As far as I know, this compound(4556-23-4)Computed Properties of C5H5NS can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 4556-23-4, is researched, Molecular C5H5NS, about Detection of Metal-Molecule-Metal Junction Formation by Surface Enhanced Raman Spectroscopy, the main research direction is metal junction SERS Raman spectroscopy.Recommanded Product: 4556-23-4.

Vibrational modes play a key role in characterizing metal-mol.-metal junctions, but their detection currently either requires single-mol. sensitivity or the generation of defect-free large-scale junctions. Surface-enhanced Raman scattering (SERS) on nonideal surfaces can provide a significant amount of information despite many defects in the layer. The authors determine the vibrational signature of the mol. electronic junction for palladium ions complexed and reduced on 4-mercaptopyridine adsorbed on rough gold and gold nanoparticles using SERS and d. functional theory. These nonideal surfaces can be used to probe kinetics of metal ion complexation and establish the success of electrochem. metalization. SERS on nonideal surfaces is thus revealed as a useful tool to rapidly establish the key process parameters in making mol. electronic junctions before embarking on more detailed studies on single mols. or single crystal surfaces.

As far as I know, this compound(4556-23-4)Recommanded Product: 4556-23-4 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about 2-Chloro-4-nitroimidazole radiosensitizers of hypoxic tumor cells in vivo.Application In Synthesis of 5-Chloro-1-methyl-4-nitroimidazole.

The transplantable rhabdomyosarcoma in WAG/Rij rats was used to test the in vivo effectiveness of 1-methyl-2-chloro-4-nitroimidazole (P13) and its analog 1-(2-hydroxy-3-methoxypropyl)-2-chloro-4-nitroimidazole (P40) as tumor-cell radiosensitizers after their i.p. administration at low doses. Both compounds administered repeatedly at nontoxic concentrations (70-150 mg/kg body weight) in combination with moderate fractional doses of γ-irradiation (3.7 Gy) enhance the radiation effect on tumors. The local control of tumors on the 210th day in all exptl. groups was higher than in the control ones. In the case of P40 administered at the maximal dose, the increment in local control is significant. The regrowth delay has also been longer after treatment with radiosensitizers. In the course of treatment, no symptoms of neurotoxicity of the compounds were observed The mean body weight of rats during the administration of compounds remained at the level of control rats whose tumors were irradiated only.

In addition to the literature in the link below, there is a lot of literature about this compound(5-Chloro-1-methyl-4-nitroimidazole)Application In Synthesis of 5-Chloro-1-methyl-4-nitroimidazole, illustrating the importance and wide applicability of this compound(4897-25-0).

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Formula: C4H4ClN3O2. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Synthesis and trypanocidal evaluation of news 5-[N-(3-(5-substituted)-1,3,4-thiadiazolyl)]amino-1-methyl-4-nitroimidazoles. Author is Carvalho, A. S.; Gibaldi, D.; Pinto, A. C.; Bozza, M.; Boechat, N..

A series of 5-[N-(3-(5-substituted)-1,3,4-thiadiazolyl)]amino-1-methyl-4- nitroimidazoles, e.g., I (R = H, Me, CF3, Pr, Ph, 4-NO2C6H4, 4-FC6H4, 4-ClC6H4), has been synthesized and examined for their activity against Trypanosoma cruzi. The compounds were prepared by nucleophilic aromatic substitution.

In addition to the literature in the link below, there is a lot of literature about this compound(5-Chloro-1-methyl-4-nitroimidazole)Formula: C4H4ClN3O2, illustrating the importance and wide applicability of this compound(4897-25-0).

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Crystal Field Effects on Atomic and Functional-Group Distributed Polarizabilities of Molecular Materials, published in 2020-12-03, which mentions a compound: 4556-23-4, Name is Pyridine-4-thiol, Molecular C5H5NS, Electric Literature of C5H5NS.

To rationally design new mol. materials with desirable linear optical properties, such as refractive index or birefringence, we investigated how at. and functional-group polarizability tensors of prototypical mols. respond to crystal field effects. By building finite aggregates of urea, succinic acid, p-nitroaniline, 4-mercaptopyridine, or methylbenzoate, and by partitioning the cluster electronic d. using quantum theory of atoms in mols., we could extract atoms and functional groups from the aggregates and estimate their polarizability enhancements with respect to values calculated for mols. in isolation. The isotropic polarizability and its anisotropy for the mol. building blocks are used to understand the functional-group sources of optical properties in these model systems, which could help the synthetic chemist to fabricate efficient materials. This anal. is complemented by benchmarking d. functionals for at. distributed polarizabilities in gas phase, by comparing the results with refractive-index calculations under periodic boundary conditions, and by estimating functional-group optical properties from a classical electrostatic atom-dipole interaction model.

In addition to the literature in the link below, there is a lot of literature about this compound(Pyridine-4-thiol)Electric Literature of C5H5NS, illustrating the importance and wide applicability of this compound(4556-23-4).

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Chloro-1-methyl-4-nitroimidazole( cas:4897-25-0 ) is researched.Recommanded Product: 5-Chloro-1-methyl-4-nitroimidazole.Zhuang, Jian-fen; Zeng, Huan-qun published the article 《Determination of related substance in azathioprine by HPLC》 about this compound( cas:4897-25-0 ) in Zhongguo Xiandai Yingyong Yaoxue. Keywords: HPLC azathioprine mercaptopurine chloro methyl nitroimidazole. Let’s learn more about this compound (cas:4897-25-0).

The objective of this paper is to establish an HPLC method for the determination of related substance in azathioprine. Phenomenex C18 (4.6 mm × 200 mm, 5 μm) column was used, the mobile phase consisted of methanol-0.05% sodium acetate (18:82), at flow rate of 1.2 mL/min-1, detection wavelength was set at 240 nm. The results show that on the selection chromatog. condition, related substances of azathioprine, starting material, intermediate and etc were separated completely. The linear ranges were 0.45-1.125 μg/mL-1 (r = 0.9999) for mercaptopurine and 0.3-0.75 μg/mL-1 (r = 0.9999) for 5-chloro-1-methyl-4-nitroimidazole. The average recoveries (n = 9) of mercaptopurine and 5-chloro-1-methyl-4-nitroimidazole were 100.1% and 99.7% resp. The limit of quantitations were 3 ng/mL-1 and 2 ng/mL-1. It was concluded that the method proposed for the determination of the related substances of azathioprine is simple, accurate, and specific.

In addition to the literature in the link below, there is a lot of literature about this compound(5-Chloro-1-methyl-4-nitroimidazole)Recommanded Product: 5-Chloro-1-methyl-4-nitroimidazole, illustrating the importance and wide applicability of this compound(4897-25-0).

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5-Chloro-1-methyl-4-nitroimidazole(SMILESS: C1=NC(=C(Cl)[N]1C)[N+]([O-])=O,cas:4897-25-0) is researched.Recommanded Product: 2,9-Dimethyl-1,10-phenanthroline hemihydrate. The article 《Novel nitroimidazoles with trypanocidal and cell growth inhibition activities》 in relation to this compound, is published in Cytobios. Let’s take a look at the latest research on this compound (cas:4897-25-0).

Chagas’ disease, caused by the protozoan parasite Trypanosoma cruzi, affects 18 million people in Latin America and is an important cause of heart disease. Although transmission has been reduced, an effective therapy for the infected population is lacking. New nitroimidazoles were designed and synthesized aimed at the development of a trypanocidal drug. The coupling of nitroimidazoles with heterocyclic N-trifluoromethyltriazolyl and pyrazolyl groups, 5-[N-(3-(5-trifluoromethyl)-1H-1,2,4-triazolyl)]amino-1-methyl-4-nitroimidazole (compound 4) and 5-N-(1-pyrazolyl)-1-methyl-4-nitroimidazole (compound 5). The in vitro trypanocidal effects of compounds 4 and 5 were evaluated. The results demonstrated that compound 5 was the most active compound, killing about 100% and 64% of the parasites in 0.3 mg/mL and 0.003 mg/mL concentrations, resp. Interestingly, compound 4 also inhibited myeloma cell growth in a dose-dependent manner.

In addition to the literature in the link below, there is a lot of literature about this compound(5-Chloro-1-methyl-4-nitroimidazole)Formula: C4H4ClN3O2, illustrating the importance and wide applicability of this compound(4897-25-0).

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, U.S. Gov’t, Non-P.H.S., Analytical Chemistry (Washington, DC, United States) called Surface-Enhanced Raman Spectroscopy-Scanning Electrochemical Microscopy: Observation of Real-Time Surface pH Perturbations, Author is Hatfield, Kendrich O.; Gole, Matthew T.; Schorr, Noah B.; Murphy, Catherine J.; Rodriguez-Lopez, Joaquin, which mentions a compound: 4556-23-4, SMILESS is SC1=CC=NC=C1, Molecular C5H5NS, Formula: C5H5NS.

Understanding and controlling chem. dynamics at electrode interfaces is key to electrochem. applications in sensing, electrocatalysis, and energy storage. Here, we introduce colocalized surface-enhanced Raman scattering-scanning electrochem. microscopy (SERS-SECM) as a multimodal tool able to simultaneously probe and affect electrochem. interfaces in real time. As a model system to demonstrate SERS-SECM, we used a self-assembled monolayer of 4-mercaptopyridine (4MPy), a pH sensitive Raman indicator, anchored to silver nanoparticles as a substrate. We modulated the local pH at the surface with chronoamperometry, inducing the hydrogen evolution reaction (HER) at the SECM tip and observed subsequent Raman peak height changes in the 4MPy. We then performed cyclic voltammetry of HER at the SECM tip while measuring SERS spectra every 200 ms to highlight the technique’s real-time capabilities. Our results show the capability to sensitively interrogate and trigger chem./electrochem. dynamic surface phenomena. We hope SERS-SECM will provide insight on the link between heterogeneous and homogeneous reactivity at electrochem. interfaces.

In addition to the literature in the link below, there is a lot of literature about this compound(Pyridine-4-thiol)Formula: C5H5NS, illustrating the importance and wide applicability of this compound(4556-23-4).

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts