Tag: M.W=150-200

Rafiee, E. published the artcileCobalt polyoxometalate, [CoW₁₂O₄₀]^5-, as a new reusable catalyst for addition of trimethylsilyl cyanide to carbonyl compounds, Quality Control of 13312-84-0, the publication is Bulletin of the Korean Chemical Society (2005), 26(10), 1585-1587, database is CAplus.

A series of cyanohydrin trimethylsilyl ethers have been prepared via cyanosilylation of various carbonyl compounds with trimethylsilyl cyanide. The reaction was catalyzed with potassium dodecatungstocobaltate trihydrate which was found to be a convenient and reusable catalyst.

Bulletin of the Korean Chemical Society published new progress about 13312-84-0. 13312-84-0 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Alcohol,Benzene Compounds, name is 2-(2-Chlorophenyl)-2-hydroxyacetonitrile, and the molecular formula is C8H6ClNO, Quality Control of 13312-84-0.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Li, Wei published the artcileFacile synthesis of 1,2,4-trisubstituted imidazoles via aerobic copper catalyzed ligand-free [3+2] cycloaddition, Application of (E)-4-(2-Nitrovinyl)benzonitrile, the publication is Letters in Organic Chemistry (2014), 11(5), 386-392, database is CAplus.

A simple and facile approach to highly functionalized imidazoles in moderate to good yields was developed. This method involves Cu-catalyzed aerobic [3+2] cycloaddition of amidines with nitro olefins in absence of ligand. Based on observation of the intermediates, possible reaction mechanism different from the same reported approach was proposed.

Letters in Organic Chemistry published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C9H6N2O2, Application of (E)-4-(2-Nitrovinyl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Shyshkina, Olena O. published the artcileA novel synthesis and transformations of isothiochroman 2,2-dioxide, Recommanded Product: 2-(Chloromethyl)benzonitrile, the publication is Tetrahedron Letters (2012), 53(33), 4296-4299, database is CAplus.

A convenient synthesis of isothiochromen-4-one 2,2-dioxide was carried out via cyclization of o-cyanobenzyl thioacetate by a Thorpe reaction. The reactions of isothiochromen-4-one 2,2-dioxide with nitrogen-containing nucleophilic reagents have been investigated. X-rays single crystal structures of five compounds are shown.

Tetrahedron Letters published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C7H5I2NO3, Recommanded Product: 2-(Chloromethyl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Surzur, Jean M. published the artcileRadical addition to unsaturated alcohols. IV. Synthesis of 4-cyano-4-carbethoxytetrahydropyrans by intramolecular radical addition, SDS of cas: 30431-99-3, the publication is Bulletin de la Societe Chimique de France (1970), 3070-5, database is CAplus.

Esters (I) (Y = CN) were cyclized with Bz2O2 in refluxing cyclohexane. After decomposition of the excess peroxide, the products were distilled to sep. cyclohexane and the telomers. The distillate was analyzed by vapor-phase chromatog. I (m = 2, n = 0, R = H,Me) gave 71-88% tetrahydropyran derivative (II). I (m = 2; n = 1; R and R1 = H (or Me) gave 96-98% tetrahydropyran derivatives and no 7-membered heterocyclic O-containing compounds could be detected. I (m = n = 1, R = H and Me, and X = CO2Et, Y = CO2Et and CN) gave only polymerized products. This type of reaction gave substituted tetrahydropyran or tetrahydrofuran derivatives which are often not readily accessible by other methods. However, the presence of the O atom makes it necessary to operate at very high dilutions and to use longer reaction times if polymerization, is to be avoided.

Bulletin de la Societe Chimique de France published new progress about 30431-99-3. 30431-99-3 belongs to nitriles-buliding-blocks, auxiliary class Tetrahydropyran,Nitrile,Ester, name is Ethyl 4-cyanotetrahydro-2H-pyran-4-carboxylate, and the molecular formula is C8H7NO4, SDS of cas: 30431-99-3.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Alagoz, Dilek published the artcilePurification, immobilization and characterization of (R)-hydroxynitrile lyase from Prunus amygdalus turcomanica seeds and their applicability for synthesis of enantiopure cyanohydrins, SDS of cas: 13312-84-0, the publication is Journal of Molecular Catalysis B: Enzymatic (2014), 40-46, database is CAplus.

A hydroxynitrile lyase (HNL) was purified from wild almond seeds (Prunus amygdalus turcomanica Lincz.) for the first time. Native and subunit mol. masses of the HNL were determined as 100 and 25 kDa, resp. indicating that the enzyme is a homotetramer. The purified enzyme was immobilized onto Eupergit CM and Eupergit C 250 L supports and their lyase and carboligation (synthetic) activities were characterized in terms of optimal pH, temperature and kinetic parameters. While the optimal pH of the free HNL for the lyase activity was 6.0, it was 5.5 for both of the immobilized HNLs. Optimal temperature was determined as 25 °C for all HNL preparations For mandelonitrile cleavage, the apparent K_m – V_max values were 0.38 mM – 197.0 U mg protein^-1 for the free HNL, 1.30 mM – 26.0 U mg protein^-1 for HNL immobilized onto Eupergit CM (HNL-Eup CM) and 0.95 mM – 17.5 U mg protein^-1 for HNL immobilized onto Eupergit C 250 L (HNL-Eup C 250 L), resp. For the carboligation activity, the optimal pH was measured as 4.0 and optimal temperature was determined as 5 °C for all of the HNL preparations For mandelonitrile synthesis, the apparent K_m – V_max values were 14.0 mM – 2.70 U mg protein^-1 for the free HNL, 41.0 mM – 0.49 U mg protein^-1 for HNL-Eup CM and 38.0 mM – 0.54 U mg protein^-1 for HNL-Eup C 250 L, resp. All of the HNL preparations were employed for the synthesis of mandelonitrile, 2-chloromandelonitrile, 3,4-dihydroxymandelonitrile and 2-hydroxy-4-Ph butyronitrile in a biphasic tert-Bu Me ether-citrate buffer (pH 4.0) medium. The results showed that the immobilized HNL preparations were better than the free HNL in the synthesis of abovementioned cyanohydrins except 2-chloromandelonitrile with higher yields and enantiopurities.

Journal of Molecular Catalysis B: Enzymatic published new progress about 13312-84-0. 13312-84-0 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Alcohol,Benzene Compounds, name is 2-(2-Chlorophenyl)-2-hydroxyacetonitrile, and the molecular formula is C8H6ClNO, SDS of cas: 13312-84-0.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Gaspa, Silvia published the artcileMetal-Free Preparation of α-H-Chlorinated Alkylaromatic Hydrocarbons by Sunlight, Related Products of nitriles-buliding-blocks, the publication is ChemistrySelect (2018), 3(27), 7991-7995, database is CAplus.

A metal and additive free process for the synthesis of benzyl chloride and α-chloro alkyl arenes is reported. The proposed methodol. can be carried out by the use of sunlight. The yield and conversion of the obtained benzyl chlorides are very high.

ChemistrySelect published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Related Products of nitriles-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Huang, R. published the artcileSynthesis and performances of extended conjugated stilbene fluorescent dye, Application In Synthesis of 612-13-5, the publication is Pigment & Resin Technology (2017), 46(4), 1-14, database is CAplus.

The purpose of this research is to explore the optical performance of extended stilbene derivative Five steps were adopted to synthesize novel 4, 4′-bis(2-cyanostyryl) stilbene, which contained three vinyl units in the skeleton (S3E). The structure of S3E was characterized by ¹H NMR and EI-MS. Its absorption and emission spectra were given as well. Compared to C.I. Fluorescent Brightener 199, which contains two vinyl units in the skeleton, S3E showed obvious bathochromic shifts in both UV-VIS and FL spectra. The maximum absorption wavelength and fluorescent wavelength were at 390 nm and 464 nm, resp., with Stoke’s shift of 74 nm. The absolute fluorescence quantum yield was 0.42. Thermogravimetric anal. revealed that the weight loss of S3E was less than 5% at 300°C. Moreover, the light resistance test showed that S3E in PVC plate can keep the good fluorescent intensity for more than 7 days exposed to xenon light. Therefore, it is believed that S3E could satisfy the requirements of coloring PVC as a fluorescent dye. S3E can be used as a candidate of fluorescent dye in the development of thermoplastics. The present work designed and synthesized a new derivative of stilbene, which could become a preferred colorant for thermoplastics.

Pigment & Resin Technology published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Application In Synthesis of 612-13-5.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Zhang, Hong-Jian published the artcileSynthesis and pharmacological evaluation of new 3,4-dihydroisoquinolin derivatives containing heterocycle as potential anticonvulsant agents, Formula: C8H6ClN, the publication is Molecules (2016), 21(12), 1635-1650, database is CAplus and MEDLINE.

Novel, fused 3,4-dihydroisoquinolines I (R¹ = H, Me, n-C₅H₁₁, etc.) and II [R² = n-C₆H₁₃ (III), n-C₇H₁₅, n-C₈H₁₇, PhCH₂, 4-ClC₆H₄CH₂] were synthesized and evaluated for their anticonvulsant activity using maximal electroshock (MES) test and pentylenetetrazole (PTZ)-induced seizure test. Among them, compound III showed significant anticonvulsant activity in MES tests with an ED₅₀ value of 63.31 mg/kg and it showed wide margins of safety with protective index (PI > 7.9). Compound III showed much higher anticonvulsant activity than that of valproate. Compound III also demonstrated potent activity against PTZ-induced seizures. A docking study of compound III in the benzodiazepine (BZD)-binding site of γ-aminobutyric acid_A (GABA_A) receptor confirmed possible binding of compound with the BZD receptors.

Molecules published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C5H7NO, Formula: C8H6ClN.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Kalugin, V. E. published the artcileSynthesis of derivatives of pyrido[3′,2′:4,5]furo[3,2-c]isoquinoline heterocyclic system, Computed Properties of 612-13-5, the publication is Russian Chemical Bulletin (2014), 63(2), 426-430, database is CAplus.

An approach to the synthesis of derivatives of new heterocyclic system, pyrido[3′,2′:4,5]-furo[3,2-c]isoquinoline I [R = R¹= Me; R = Ph, R¹ = 4-MeC₆H₄, 2-thienyl; R = CF₃, R¹ = Ph], was suggested. A condensation reaction of substituted 3-cyanopyridin-2(1H)-ones with Me 2-(chloromethyl)benzoate and subsequent treatment of the condensation product with potassium tert-butoxide leads to substituted pyrido[3′,2′:4,5]furo[3,2-c]-isoquinolin-5(6H)-ones. Similarly, a condensation reaction of substituted 3-cyanopyridin-2(1H)-ones with 2-(chloromethyl)benzonitrile and subsequent treatment of the condensation product with potassium tert-butoxide gives substituted 5-aminopyrido[3′,2′:4,5]furo[3,2-c]-isoquinolines II.

Russian Chemical Bulletin published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Computed Properties of 612-13-5.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Kalugin, V. E. published the artcileSynthesis of substituted 5-aminobenzothieno[3,2-c]isoquinolines and their sulfinyl and sulfonyl derivatives, Category: nitriles-buliding-blocks, the publication is Russian Chemical Bulletin (2015), 64(4), 878-882, database is CAplus.

A method for the preparation of substituted 5-aminobenzothieno[3,2-c]isoquinolines I, (R = H, Me, Cl), in good yields by the condensation of substituted 2-mercaptobenzonitriles with 2-(chloromethyl)benzonitrile and a subsequent treatment of the condensation products with potassium tert-butoxide was suggested. The oxidation of the condensation products to sulfoxides or sulfones and a subsequent treatment of these compounds with potassium tert-butoxide led to the preparation of substituted 5-aminobenzothieno[3,2-c]isoquinoline 11-oxides or 5-aminobenzothieno[3,2-c]isoquinoline 11,11-dioxides in good yields.

Russian Chemical Bulletin published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Category: nitriles-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts