Tag: M.W=150-200

Wang, Jian-Shu published the artcileAcOH-catalyzed aza-Michael addition/N-nitrosation: An efficient approach to CF₂HCH₂-containing N-nitrosoamines, Name: (E)-4-(2-Nitrovinyl)benzonitrile, the publication is Tetrahedron (2018), 74(28), 3904-3911, database is CAplus.

A simple and highly efficient protocol for the AcOH-catalyzed three-component reaction of nitroalkenes, difluoroethylamine and tert-Bu nitrite through cascade aza-Michael addition/N-nitrosation has been developed. A range of CF₂HCH₂-containing N-nitrosoamines were obtained in good to excellent yields. This approach features easily available cheap materials, without using addnl. organic solvents, simple operation under room temperature, gram scalable preparation and functionally diverse products.

Tetrahedron published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C8H7N3, Name: (E)-4-(2-Nitrovinyl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Kovtunenko, V. A. published the artcileCondensed isoquinolines. 38*. azolo[b]isoquinolines from 2-(halomethyl)benzoic acid derivatives, COA of Formula: C8H6ClN, the publication is Chemistry of Heterocyclic Compounds (New York, NY, United States) (2011), 47(8), 996-1005, database is CAplus.

On interacting 2-(chloromethyl)-, 2-(bromomethyl)benzonitrile or Me 2-(bromomethyl)benzoate with 1-R-1H-imidazoles and 1-R-1H-benzimidazoles quaternary diazolium salts are formed, the heating of which with bases (K₂CO₃, Et₃N) led to the intramol. acylation products, 1-alkyl-10-amino-1H-imidazo[1,2-b]isoquinolin-4-ium halides, 5-alkyl-6-amino-5H-benzimidazo[1,2-b]isoquinolin-12-ium halides, or 1-alkyl-1H-imidazo[1,2-b]isoquinolin-4-ium-10-olate halides.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, COA of Formula: C8H6ClN.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Rokade, Balaji V. published the artcileSynthesis of substituted nitroolefins: a copper catalyzed nitrodecarboxylation of unsaturated carboxylic acids, COA of Formula: C9H6N2O2, the publication is Organic & Biomolecular Chemistry (2013), 11(39), 6713-6716, database is CAplus and MEDLINE.

A novel, mild and convenient method for the nitrodecarboxylation of substituted cinnamic acid derivatives to their nitroolefins is achieved using a catalytic amount of CuCl (10 mol%) and tert-Bu nitrite (2 equivalent) as a nitrating agent in the presence of air. This reaction provides a useful method for the synthesis of β,β-disubstituted nitroolefin derivatives, which are generally difficult to access from other conventional methods. Addnl., this reaction is selective as the E-isomer of the acid derivatives furnishes the corresponding E-nitroolefins. One more salient feature of the method is, unlike other methods, no metal nitrates or HNO₃ are employed for the transformation.

Organic & Biomolecular Chemistry published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C9H6N2O2, COA of Formula: C9H6N2O2.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Mehta, K. J. published the artcilePreparation and antimicrobial activity of p-chloro-p’-(α-carbamoylbenzylamino)diphenyl sulfones and 3-amino-2-aryl-5-p-chlorophenylsulfonylindoles, Quality Control of 13312-84-0, the publication is Acta Ciencia Indica, Chemistry (1985), 11(3), 187-90, database is CAplus.

4-ClC₆H₄SO₂C₆H₄NHCHRR¹ (I, R = Ph, 2-HOC₆H₄, 3-HOC₆H₄, 4-HOC₆H₄, MeOC₆H₄, 2-ClC₆H₄, 4-ClC₆H₄, 3,4-MeO(HO)C₆H₃, PhCH:CH, 4-O₂NC₆H₄, 2-furyl; R¹ = cyano) were prepared by treating RCH(OH)CN with 4-ClC₆H₄SO₂C₆H₄NH₂-4. Treatment of I (R¹ = cyano) with H₂SO₄ for 2 days gave I (R¹ = CONH₂) whereas after 7 days the indoles II were obtained. I (R¹ = CONH₂) have bactericidal activity against Staphylococcus aureus and Escherichia coli (no data).

Acta Ciencia Indica, Chemistry published new progress about 13312-84-0. 13312-84-0 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Alcohol,Benzene Compounds, name is 2-(2-Chlorophenyl)-2-hydroxyacetonitrile, and the molecular formula is C8H6ClNO, Quality Control of 13312-84-0.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Zhu, Yadong published the artcileOrganocatalytic enantioselective Michael addition of cyclic hemiacetals to nitroolefins: a facile access to chiral substituted 5- and 6-membered cyclic ethers, Application of (E)-4-(2-Nitrovinyl)benzonitrile, the publication is Organic & Biomolecular Chemistry (2015), 13(16), 4769-4775, database is CAplus and MEDLINE.

An efficient aminocatalytic enantioselective Michael addition of readily available cyclic hemiacetals to nitroolefins has been developed. The strategy serves as a powerful approach to synthetically valuable chiral 3-substituted tetrahydrofurans (THFs) I [R = Et, Ph, 3-NO₂-C₆H₄, etc.] and tetrahydropyrans (THPs) II. The synthetic utilities of the versatile Michael adducts also have been demonstrated in the synthesis of 2,3-disubstituted cyclic ethers, α-substituted lactones and venlafaxine analogs.

Organic & Biomolecular Chemistry published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C11H15NO2, Application of (E)-4-(2-Nitrovinyl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Maripally, Narsimulu published the artcileDMAP catalyzed addition-cyclization reaction of 2-hydroxyphenyl-para-quinone methide with nitroalkenes: facile entry into highly substituted chromane derivatives, SDS of cas: 5153-73-1, the publication is Tetrahedron Letters (2020), 61(9), 151554, database is CAplus.

The base catalyzed reaction of 2-hydroxyphenyl-para-quinone methide (p-QM) with nitroalkenes was reported. The DMAP-catalyzed reaction afforded substituted chromane derivatives I [R = H, 7-Me, 6-MeO, 6-F, 6-Cl, 6-Br; R¹ = i-Bu, Ph, 2-thienyl, etc.; stereo = R or S] in excellent yields with moderate diastereoselectivity. The conversion of the initial products to other useful structures was also achieved.

Tetrahedron Letters published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C9H6N2O2, SDS of cas: 5153-73-1.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Benmohammed, Abdelmadjid published the artcileSynthesis and antimicrobial activities of new thiosemicarbazones and thiazolidinones in indole series, Quality Control of 612-13-5, the publication is Monatshefte fuer Chemie (2021), 152(8), 977-986, database is CAplus.

New thiosemicarbazones I [R¹ = H, 3-Cl, 4-F, etc.; R² = H, OMe] were synthesized via condensation of N-benzylindole-3-carboxaldehydes with N⁴-substituted thiosemicarbazides in excellent yield. These thiosemicarbazones I were reacted with Et bromoacetate to produce original heterocyclic-substituted indole derivatives possessing a 4-oxo-thiazolidine group II. Anal. IR and NMR spectra and elemental anal. were performed to reveal their structures. The antimicrobial activity of all synthesized compounds was evaluated for antibacterial activity in vitro against Gram-pos. and Gram-neg. bacteria. Antibacterial screening data showed that two compounds I and II demonstrated activity against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. These preliminary results indicated that newly synthesized compounds such as I [R¹ = 3-Cl, R² = OMe] and II [R¹ = H, R² = H] showed a promising antibacterial potency.

Monatshefte fuer Chemie published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Quality Control of 612-13-5.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Quan, Xue-Jing published the artcilep-Toluenesulfonic Acid Mediated 1,3-Dipolar Cycloaddition of Nitroolefins with NaN₃ for Synthesis of 4-Aryl-NH-1,2,3-triazoles, Safety of (E)-4-(2-Nitrovinyl)benzonitrile, the publication is Organic Letters (2014), 16(21), 5728-5731, database is CAplus and MEDLINE.

A p-TsOH-mediated 1,3-dipolar cycloaddition of nitroolefins and sodium azide for the synthesis of 4-aryl-NH-1,2,3-triazoles has been developed. p-TsOH was discovered as a vital additive in this type of 1,3-dipolar cycloaddition This novel cycloaddition reaction is a good method for the rapid synthesis of valuable 4-aryl-NH-1,2,3-triazoles in high yields.

Organic Letters published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C9H6N2O2, Safety of (E)-4-(2-Nitrovinyl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Quan, Xue-Jing published the artcilep-Toluenesulfonic Acid Mediated 1,3-Dipolar Cycloaddition of Nitroolefins with NaN₃ for Synthesis of 4-Aryl-NH-1,2,3-triazoles [Erratum to document cited in CA161:682131], Name: (E)-4-(2-Nitrovinyl)benzonitrile, the publication is Organic Letters (2015), 17(2), 393, database is CAplus and MEDLINE.

On page 5730, structure 4a in Scheme 2 was published incorrectly, and subsequent text corresponding to this Structure is also incorrect; the correct structure, name, and text are given.

Organic Letters published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C9H6N2O2, Name: (E)-4-(2-Nitrovinyl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Plaza, Manuel published the artcileHeterocyclization and Spirocyclization Processes Based on Domino Reactions of N-Tosylhydrazones and Boronic Acids Involving Intramolecular Allylborylations of Nitriles, Quality Control of 238088-16-9, the publication is Chemistry – A European Journal (2018), 24(55), 14836-14843, database is CAplus and MEDLINE.

Polycyclic mols. featuring all-carbon quaternary bridgehead centers were synthesized through domino cyclizations between N-tosylhydrazones and boronic acids. Variations of the general cascade have been applied for the preparation of 3-quinuclidinones and related alkaloid-like scaffolds through transannular heterocyclizations. Moreover, the employment of 3-cyanopropyl and 4-cyanobutylboronic acids and α,β-unsaturated N-tosylhydrazones led to spirocycles through unprecedented formal [n+1] cyclizations, including the stereoselective spirocyclization of the Hajos-Parrish ketone. The common feature of all the new reactions described is the creation of an all-carbon quaternary center by formation of two Csp³-C bonds on the hydrazonic carbon atom. DFT-based calculations suggested the occurrence of cascade processes, which involve a diazo compound carboborylation followed by a 1,3-borotropic rearrangement on an intermediate allylboronic acid and a novel bora-aza-ene cyclization.

Chemistry – A European Journal published new progress about 238088-16-9. 238088-16-9 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Boronic acid and ester,Aliphatic cyclic hydrocarbon,Boronic Acids,Boronate Esters, name is 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)butanenitrile, and the molecular formula is C10H18BNO2, Quality Control of 238088-16-9.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts