Tag: M.W=150-200

Li, Yuanxiang published the artcileSynthesis and herbicidal activities of 2-[3-(2-substituted phenyl)-1H-pyrazol-1-yl]-4,6-dimethoxypyrimidine derivatives, COA of Formula: C8H6ClN, the publication is Youji Huaxue (2011), 31(3), 306-311, database is CAplus.

Twenty two novel 2-[3-(2-substitutedphenyl)-1H-pyrazol-1-yl]-4,6-dimethoxypyrimidine derivatives have been designed and synthesized using 1-(2-hydroxyphenyl)ethanone as starting material. All synthesized compounds were confirmed by ¹H NMR, MS techniques and elemental anal. The preliminary bioassay showed that some of them exhibited certain herbicidal activities.

Youji Huaxue published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, COA of Formula: C8H6ClN.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Luo, Wenqiang published the artcileChiral phosphoric acid catalyzed 1,3-dipolar cycloadditions of aldehydes, diethyl α-aminomalonate, and nitroalkenes, Recommanded Product: (E)-4-(2-Nitrovinyl)benzonitrile, the publication is Tetrahedron: Asymmetry (2014), 25(10-11), 787-791, database is CAplus.

A one-pot three component 1,3-dipolar cycloaddition reaction of an aldehyde, α-aminomalonate, and nitroalkene has been developed through a BINOL-derived chiral phosphoric acids. This reaction represents one of the most enantioselective catalytic approaches to access structurally diverse pyrrolidine derivatives Under optimized conditions the synthesis of the target compounds was achieved using (11bR)-2,6-bis(9-anthracenyl)-4-(hydroxy)dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin (binaphthalenediol-derived cyclic phosphate) as catalyst.

Tetrahedron: Asymmetry published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C9H6N2O2, Recommanded Product: (E)-4-(2-Nitrovinyl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Zhou, Enshan published the artcileBINOL-quinine-squaramides as efficient organocatalysts for the asymmetric Michael addition of 2-hydroxy-1,4-naphthoquinone to nitroalkenes, Recommanded Product: (E)-4-(2-Nitrovinyl)benzonitrile, the publication is Tetrahedron: Asymmetry (2014), 25(2), 181-186, database is CAplus.

A set of BINOL-quinine-squaramides were synthesized, and then used as organocatalysts to promote the catalytic enantioselective Michael addition reaction of 2-hydroxy-1,4-naphthoquinone to nitroalkenes with excellent yields and ees (up to 99% yield and 93% ee) at low catalyst loading (0.5 mol %).

Tetrahedron: Asymmetry published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C15H24S, Recommanded Product: (E)-4-(2-Nitrovinyl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Li, Zhi-Long published the artcileOrganocatalytic, asymmetric [2+2+2] annulation to construct six-membered spirocyclic oxindoles with six continuous stereogenic centers, Formula: C9H6N2O2, the publication is Catalysts (2016), 6(5), 65/1-65/14, database is CAplus.

Lactols and cyclic hemiaminals were directly used in a one-pot organo/organo dual catalytic system induced [2+2+2] tandem reaction for the asym. construction of six-membered carbocycles. The enamine-based stereoselective Michael addition of lactols or cyclic hemiaminals to electron-deficient olefinic oxindole motifs provided chiral C4 components, which were further combined with triethylamine catalyzed Michael/H sequential reactions affording spirocyclic oxindole derivatives containing six continuous stereogenic centers with excellent enantioselectivities as a single diastereoisomer. All these desired products have versatile mol. complexity, which might have potential applications in synthetic organic chem. and the pharmaceutical industry.

Catalysts published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C9H6N2O2, Formula: C9H6N2O2.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Pan, Nianjuan published the artcileNovel pyrimidine derivatives bearing a 1,3,4-thiadiazole skeleton: design, synthesis, and antifungal activity, Application of 2-(Chloromethyl)benzonitrile, the publication is Frontiers in Chemistry (Lausanne, Switzerland) (2022), 922813, database is CAplus and MEDLINE.

In this study, twenty novel pyrimidine derivatives bearing a 1,3,4-thiadiazole skeleton were designed and synthesized. Then their antifungal activity against Botrytis cinereal (B. cinereal), Botryosphaeria dothidea (B. dothidea), and Phomopsis sp. were determined using the poison plate technique. Biol. test results showed that I revealed lower EC₅₀ values (25.9 and 50.8μg/mL) on Phompsis sp. than those of pyrimethanil (32.1 and 62.8μg/mL).

Frontiers in Chemistry (Lausanne, Switzerland) published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Application of 2-(Chloromethyl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Gu, Zhun published the artcileSynthesis and characterization of o-cyano-DL-phenylalanine hydrochloride, SDS of cas: 612-13-5, the publication is Huaxue Yanjiu Yu Yingyong (2008), 20(7), 866-868, database is CAplus.

A method for the synthesis of the title compound [i.e., 2-cyano-DL-phenylalanine hydrochloride] is reported here. A non-natural amino acid, o-cyano-D,L-phenylalanine hydrochloride, and its four intermediates were synthesized using di-Et malonate as starting material. Factors influencing the reaction were studied, the processing methods were improved and the yield of each reaction was increased. The structures of the compounds mentioned above were determined by IR, NMR, elementary anal. and m.p.

Huaxue Yanjiu Yu Yingyong published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, SDS of cas: 612-13-5.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Lin, Yongqiang published the artcileSynthesis and anti-HIV evaluation of novel 1,3-disubstituted thieno[3,2-c][1,2,6]thiadiazin-4(3H)-one 2,2-dioxides(TTDDs), Name: 2-(Chloromethyl)benzonitrile, the publication is Bioorganic & Medicinal Chemistry (2008), 16(1), 157-163, database is CAplus and MEDLINE.

A series of novel 1,3-disubstituted thieno[3,2-c] [1,2,6]thiadiazin-4(3H)-one 2,2-dioxides (TTDDs), designed as nonnucleoside reverse transcriptase inhibitors (NNRTIs), was synthesized, structurally confirmed by spectral anal. and evaluated for their anti-HIV-1 activities by inhibition of HIV-1(IIIB)-induced cytopathogenicity in MT-4 cell culture. The structure-activity relationship studies showed marked potency of TTDD analogs as anti-HIV-1 agents. The most active and selective compound (I) had EC₅₀ of 4.0 μM and a selectivity index (SI) of >76. The structure-activity relationship (SAR) is discussed.

Bioorganic & Medicinal Chemistry published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Name: 2-(Chloromethyl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Ng, Wing-Hin published the artcileZwitterion-Catalyzed Amino-Dibromination of Nitroalkenes: Scope, Mechanism and Application to The Synthesis of Glycinamides, HPLC of Formula: 5153-73-1, the publication is Asian Journal of Organic Chemistry (2021), 10(5), 1131-1140, database is CAplus.

Herein, a zwitterion-catalyzed aminobromination of nitroalkenes using N-bromosuccinimide as the Br source and the amide donor was reported. The resulting aminobromide products were converted into glycinamides.

Asian Journal of Organic Chemistry published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C9H6N2O2, HPLC of Formula: 5153-73-1.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Fan, Pei published the artcileNickel/Photo-Cocatalyzed Asymmetric Acyl-Carbamoylation of Alkenes, Quality Control of 119396-88-2, the publication is Journal of the American Chemical Society (2020), 142(5), 2180-2186, database is CAplus and MEDLINE.

An unprecedented asym. acyl-carbamoylation of pendant alkenes tethered on aryl carbamic chlorides with both aliphatic and aromatic aldehydes has been developed via the cooperative catalysis of a chiral nickel-PHOX complex and tetrabutylammonium decatungstate. This reaction represents the first example of merging hydrogen-atom-transfer photochem. and asym. transition metal catalysis in difunctionalization of alkenes. Using this protocol, a variety of oxindoles bearing a challenging quaternary stereogenic center are furnished under mild conditions in highly enantioselective manner.

Journal of the American Chemical Society published new progress about 119396-88-2. 119396-88-2 belongs to nitriles-buliding-blocks, auxiliary class Fluoride,Nitrile,Benzene,Ether, name is 2-Fluoro-4,5-dimethoxybenzonitrile, and the molecular formula is C9H8FNO2, Quality Control of 119396-88-2.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Bakke, J. E. published the artcileMetabolism of 2,6-dichlorobenzonitrile, 2,6-dichlorothiobenzamide in rodents and goats, Application In Synthesis of 3336-34-3, the publication is Xenobiotica (1988), 18(9), 1063-75, database is CAplus and MEDLINE.

Twelve ¹⁴C-labeled metabolites were isolated from either urine or bile from either rats (11 metabolites) or goats (7 metabolites) given single oral doses of 2,6-dichlorobenzo[¹⁴C]nitrile (DCBN). Five of these metabolites were also excreted in urine from rats dosed orally with 2,6-dichlorothiobenz[¹⁴C]-amide (DCTBA). All metabolites from either DCBN or DCTBA were benzonitriles with the following ring substituents: Cl₂, OH (three isomers); Cl₂, (OH)₂; Cl, (OH)₂; Cl, OH, SH; Cl, OH, SCH₃; SCH₃, SOCH₃, OH; Cl₂, S-(N-acetyl)cysteine; Cl, S-(N-acetyl)cysteine; Cl, OH, S-(N-acetyl)cysteine. The thiobenzamide moiety of DCTBA was converted to the nitrile in all the excreted urinary metabolites. No hydrolysis of the nitrile in DCBN to either an amide or an acid was detected. Urine was the major route for excretion; however, enterohepatic circulation occurred. Whole-body autoradiog. of ¹⁴C-DCBN and ¹⁴C-DCTBA in mice showed the presence of bound residues in the mucosa of the nasal cavity, trachea, tongue, esophagus, the kidney, liver, and the intestinal contents.

Xenobiotica published new progress about 3336-34-3. 3336-34-3 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Phenol, name is 2,6-Dichloro-3-hydroxybenzonitrile, and the molecular formula is C7H3Cl2NO, Application In Synthesis of 3336-34-3.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts