Tag: M.W=150-200

Qian, Wenyuan published the artcileAccelerating Effect of Triazolyl and Related Heteroaryl Substituents on SNAr Reactions: Evidence of Hydrogen-Bond Stabilized Transition States, Category: nitriles-buliding-blocks, the main research area is accelerating triazolyl heteroaryl SNAr hydrogen bond transition.

The remarkable accelerating effect of 1,2,3-triazolyl substituents on SNAr reactions was studied through systematic experiments and d. functional theory calculations The lone pair electrons of an ortho-triazolo substituent play a key role in lowering the activation energy for nucleophilic addition via formation of a preferential hydrogen bond with the amine nucleophile at the transition state for addition In an extension of this finding, related heteroaryl groups with similar electron pair donor properties also facilitate SNAr reactions. The exptl. determined solvent effect provides further support for this rationale, which was used to achieve an ortho-selective substitution on a difluoroarene substrate.

Journal of the American Chemical Society published new progress about Activation energy. 204078-32-0 belongs to class nitriles-buliding-blocks, name is 2-Morpholinobenzonitrile, and the molecular formula is C11H12N2O, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Saito, Tetsuji published the artcile6,7-Dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidines and their derivatives as novel corticotropin-releasing factor 1 receptor antagonists, HPLC of Formula: 170737-93-6, the main research area is cyclopentapyrazolopyrimidine derivative preparation corticotropin releasing factor antagonist SAR pharmacokinetic.

To identify an orally active corticotropin-releasing factor 1 receptor antagonist, a series of 6,7-dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidines and their derivatives were designed, synthesized and evaluated. An in vitro study followed by in vivo and pharmacokinetic studies of these heterotricyclic compounds led to the discovery of an orally active CRF1 receptor antagonist, I. The results of a structure-activity relationship study are presented.

Bioorganic & Medicinal Chemistry published new progress about Anxiety disorders. 170737-93-6 belongs to class nitriles-buliding-blocks, name is 2-(2-Chloro-4-methoxyphenyl)acetonitrile, and the molecular formula is C9H8ClNO, HPLC of Formula: 170737-93-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kajiwara, Rikuo published the artcileBipyridine-Type Bidentate Auxiliary-Enabled Copper-Mediated C-H/C-H Biaryl Coupling of Phenols and 1,3-Azoles, Quality Control of 87150-13-8, the main research area is heterobiaryl preparation; phenol azole coupling bipyridine type bidentate auxiliary copper.

A copper-mediated dehydrogenative C-H/C-H biaryl coupling of phenols and 1,3-azoles has been developed. The key to its success is the introduction of a bipyridine-type bidentate auxiliary, 4,4′-di(tert-butyl)-2,2′-bipyridine, on the phenol oxygen, which is readily prepared and easily attachable, detachable, and recyclable. The reaction proceeds smoothly in the presence of copper salt alone to form the corresponding phenol-azole heterobiaryls, which are prevalent motifs in functional mols. such as excited-state intramol. proton transfer materials.

Organic Letters published new progress about Coupling reaction. 87150-13-8 belongs to class nitriles-buliding-blocks, name is 4-(5-Oxazolyl)benzonitrile, and the molecular formula is C10H6N2O, Quality Control of 87150-13-8.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Tu, Hua published the artcileDistinctive molecular inhibition mechanisms for selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1, Quality Control of 97009-67-1, the main research area is sulfonamide triazole hydroxysteroid dehydrogenase inhibitor preparation; non insulin dependent diabetes antidiabetic hydroxysteroid dehydrogenase inhibitor.

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) catalyzes the NADPH dependent interconversion of inactive cortisone to active cortisol. Excess 11β-HSD1 or cortisol leads to insulin resistance and metabolic syndrome in animal models and in humans. Inhibiting 11β-HSD1 activity signifies a promising therapeutic strategy in the treatment of Type 2 diabetes and related diseases. Herein, the authors report two highly potent and selective small mol. inhibitors of human 11β-HSD1. While compound (I), a sulfonamide, functions as a simple substrate competitive inhibitor, compound (II), a triazole, shows the kinetic profile of a mixed inhibitor. Co-crystal structures reveal that both compounds occupy the 11β-HSD1 catalytic site, but present distinct mol. interactions with the protein. Strikingly, compound (II) interacts much closer to the cofactor NADP+ and likely modifies its binding. Together, the structural and kinetic analyses demonstrate two distinctive mol. inhibition mechanisms, providing valuable information for future inhibitor design.

Bioorganic & Medicinal Chemistry published new progress about Antidiabetic agents. 97009-67-1 belongs to class nitriles-buliding-blocks, name is 1-(4-Fluorophenyl)cyclopropanecarbonitrile, and the molecular formula is C10H8FN, Quality Control of 97009-67-1.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yu, Tian-Yang published the artcileDirect C2-Heteroarylation of Indoles by Rhodium-Catalyzed C-C Bond Cleavage of Secondary Alcohols, COA of Formula: C10H6N2O, the main research area is biheteroaryl preparation; indole secondary alc heteroarylation carbon bond cleavage rhodium catalyst.

A rhodium-catalyzed direct heteroarylation of indoles by cleavage of an inert C-C bond of alcs. is reported. This catalytic system exhibits high reactivity and tolerates various functional groups. This reaction provides a tool for the rapid construction of biheteroaryls without pre-activation of the starting materials. Control experiments were conducted to determine a possible mechanism. This reaction makes a significant contribution to the field of C-C bond activation of alcs.

Asian Journal of Organic Chemistry published new progress about C-C bond activation. 87150-13-8 belongs to class nitriles-buliding-blocks, name is 4-(5-Oxazolyl)benzonitrile, and the molecular formula is C10H6N2O, COA of Formula: C10H6N2O.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Tu, Hua published the artcileDistinctive molecular inhibition mechanisms for selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1, Quality Control of 97009-67-1, the main research area is sulfonamide triazole hydroxysteroid dehydrogenase inhibitor preparation; non insulin dependent diabetes antidiabetic hydroxysteroid dehydrogenase inhibitor.

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) catalyzes the NADPH dependent interconversion of inactive cortisone to active cortisol. Excess 11β-HSD1 or cortisol leads to insulin resistance and metabolic syndrome in animal models and in humans. Inhibiting 11β-HSD1 activity signifies a promising therapeutic strategy in the treatment of Type 2 diabetes and related diseases. Herein, the authors report two highly potent and selective small mol. inhibitors of human 11β-HSD1. While compound (I), a sulfonamide, functions as a simple substrate competitive inhibitor, compound (II), a triazole, shows the kinetic profile of a mixed inhibitor. Co-crystal structures reveal that both compounds occupy the 11β-HSD1 catalytic site, but present distinct mol. interactions with the protein. Strikingly, compound (II) interacts much closer to the cofactor NADP+ and likely modifies its binding. Together, the structural and kinetic analyses demonstrate two distinctive mol. inhibition mechanisms, providing valuable information for future inhibitor design.

Bioorganic & Medicinal Chemistry published new progress about Antidiabetic agents. 97009-67-1 belongs to class nitriles-buliding-blocks, name is 1-(4-Fluorophenyl)cyclopropanecarbonitrile, and the molecular formula is C10H8FN, Quality Control of 97009-67-1.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yu, Tian-Yang published the artcileDirect C2-Heteroarylation of Indoles by Rhodium-Catalyzed C-C Bond Cleavage of Secondary Alcohols, COA of Formula: C10H6N2O, the main research area is biheteroaryl preparation; indole secondary alc heteroarylation carbon bond cleavage rhodium catalyst.

A rhodium-catalyzed direct heteroarylation of indoles by cleavage of an inert C-C bond of alcs. is reported. This catalytic system exhibits high reactivity and tolerates various functional groups. This reaction provides a tool for the rapid construction of biheteroaryls without pre-activation of the starting materials. Control experiments were conducted to determine a possible mechanism. This reaction makes a significant contribution to the field of C-C bond activation of alcs.

Asian Journal of Organic Chemistry published new progress about C-C bond activation. 87150-13-8 belongs to class nitriles-buliding-blocks, name is 4-(5-Oxazolyl)benzonitrile, and the molecular formula is C10H6N2O, COA of Formula: C10H6N2O.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Perciner, Hulya published the artcileA study on antiviral 2-(α-hydroxybenzyl)benzimidazole derivatives, Application of 2-(2-Chlorophenyl)-2-hydroxyacetonitrile, the publication is Journal of Faculty of Pharmacy of Gazi University (1990), 7(2), 125-40, database is CAplus.

Title compounds I (R = H, Cl, NO₂; R¹ = H, 4-Cl, 2-Cl, 4-F, 2-F, 4-Me) were prepared by cyclocondensation of o-phenylenediamines 1,2-(NH₂)₂C₆H₃R-4 with either DL-mandelic acid or R¹C₆H₄CH(OH)CN. I were tested as virucides against Herpes Simplex-1 (HSV-1) and Coxsackie B virus (CBV-3). All were significantly active against CBV-3 and I (R = R¹ = H) was the most active against HSV-1 compared to amantadine as a reference

Journal of Faculty of Pharmacy of Gazi University published new progress about 13312-84-0. 13312-84-0 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Alcohol,Benzene Compounds, name is 2-(2-Chlorophenyl)-2-hydroxyacetonitrile, and the molecular formula is C8H6ClNO, Application of 2-(2-Chlorophenyl)-2-hydroxyacetonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Hemmaragala, Nanjundaswamy Marishetty published the artcileFunctionalized Silver Nanoparticle Catalyzed [3+2] Cycloaddition Reaction: Greener Route to Substituted-1,2,3-triazolines, Application of (E)-4-(2-Nitrovinyl)benzonitrile, the publication is Catalysis Letters (2016), 146(2), 464-473, database is CAplus.

The [3+2] cycloaddition reaction between nitroolefins and alkyl/aryl azides was studied using functionalized silver nanoparticles (FnAgNPs) of average diameter 23 ± 1 nm as catalyst produced by the plant extract Protorhus longifolia. FnAgNPs was found to catalyze the reactions efficiently yielding a series of 1,5-disubstituted-1,2,3-triazolines, e.g. I, under mild reaction conditions with no side products. The catalytic activity of FnAgNPs was compared with naked AgNPs and FnAgNPs found to be very effective. Except solvents, the whole experiments do not require any chem./reagent which makes the process green.

Catalysis Letters published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C9H6N2O2, Application of (E)-4-(2-Nitrovinyl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Autade, Snehalata B. published the artcileSulfated tungstate a heterogeneous acid catalyst for synthesis of 4-aryl-NH-1,2,3-triazoles by 1,3-dipolar cycloaddition of nitroolefins with NaN₃, Quality Control of 5153-73-1, the publication is Synthetic Communications (2019), 49(15), 1947-1956, database is CAplus.

A facile and new method for the synthesis of 4-aryl-NH-1,2,3-triazoles from nitroolefins and NaN₃ by 1,3-dipolar cycloaddition reaction, employing a mild solid inorganic acid sulfated tungstate as a heterogeneous catalyst was developed. The protocol emphasized broad substrate scope with many functionalities, less reaction time, stability to open air, easy work-up, and with good to excellent yields.

Synthetic Communications published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C9H6N2O2, Quality Control of 5153-73-1.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts