Tag: M.W=150-200

Bakherad, Mohammad published the artcileMetal-free green synthesis of aryl amines in magnetized distilled water: experimental aspects and molecular dynamics simulation, Formula: C11H12N2O, the main research area is aryl halide secondary amine arylation magnetized water green chem; arylamine preparation.

A simple, green, and transition metal-free approach to the N-arylation of secondary amines with aryl halides in magnetized distilled water (MDW), as a solvent was introduced. This method offered the advantages of short reaction times, low costs, and an additive-free process, and it also enabled new planning strategies for the construction of aryl amine-containing pharmacophores. Also, the reaction rates were followed spectrophotometrically by monitoring the changes in the absorption spectrum of the reaction mixture in ordinary and magnetized distilled water. Furthermore, the reliable mol. dynamics (MD) simulations were used as predictive tools to interpret and describe the interactions between reactants in the ordinary and magnetized distilled water. The RDFs anal. of interactions revealed that morpholine and iodobenzene reactants were surrounded by more solvents in MDW than ordinary distilled water (ODW) 90°C. Consequently, the high reactivity observed for two reactants in MDW at 90°C can be explained by MD simulation, and there comes an established synergy between the theor. calculation and experiment

Green Chemistry published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 204078-32-0 belongs to class nitriles-buliding-blocks, name is 2-Morpholinobenzonitrile, and the molecular formula is C11H12N2O, Formula: C11H12N2O.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Coskun, Necdet published the artcileDirect conversion of aldehydes to nitriles via O-phenylcarbamoylated aldoximes, Synthetic Route of 5653-62-3, the main research area is aldehyde conversion nitrile; phenylcarbamoylated aldoxime preparation conversion nitrile; nitrile preparation.

O-arylcarbamoylated hydroxylamine tosylate reacts with aldehydes at room temperature to give the corresponding O-carbamoylated oximes. The reaction of carbamoylated hydroxylamine with aromatic aldehydes in THF or in toluene at reflux affords the corresponding nitriles and anilinium tosylate in high yield. Attempts to cyclize the O-carbamoylated oximes in the presence of AcCl lead again to the formation of nitriles.

Tetrahedron published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 5653-62-3 belongs to class nitriles-buliding-blocks, name is 2,3-Dimethoxybenzonitrile, and the molecular formula is C9H9NO2, Synthetic Route of 5653-62-3.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Abele, E. published the artcileNovel synthesis of aromatic and heteroaromatic nitriles from aldehydes under liquid-liquid phase transfer catalysis conditions, Safety of 2,3-Dimethoxybenzonitrile, the main research area is aldehyde conversion nitrile phase transfer catalysis; nitrile preparation.

A PTC method of synthesis of aromatic nitrile from the corresponding aldehydes was developed based on dichlorocarbene-mediated dehydration of intermediate aldoximes and products were isolated in 37-67% yields. The method was less successful in the case of heteroaromatic nitriles, especially for pyridine derivatives because of side reactions.

Latvijas Kimijas Zurnals published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 5653-62-3 belongs to class nitriles-buliding-blocks, name is 2,3-Dimethoxybenzonitrile, and the molecular formula is C9H9NO2, Safety of 2,3-Dimethoxybenzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Tamilselvan, Pitchiah published the artcileCobalt(II)-catalyzed dehydration of aldoximes. A highly efficient practical procedure for the synthesis of nitriles, COA of Formula: C9H9NO2, the main research area is aryl aldoxime dehydration cobalt catalyst; aromatic nitrile preparation.

Cobalt(II) chloride catalyzes the conversion of a variety of aldoximes, including salicylaldoxime and substituted salicylaldoximes, into corresponding nitriles in the presence of an inorganic base in acetonitrile. The reaction proceeds under mild conditions and the yields are generally very good to excellent.

Catalysis Communications published new progress about Aldoximes Role: RCT (Reactant), RACT (Reactant or Reagent). 5653-62-3 belongs to class nitriles-buliding-blocks, name is 2,3-Dimethoxybenzonitrile, and the molecular formula is C9H9NO2, COA of Formula: C9H9NO2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Moussa, Ziad published the artcileNMR Studies and electrophilic properties of triphenylphosphine-trifluoromethanesulfonic anhydride; a remarkable dehydrating reagent system for the conversion of aldoximes into nitriles, Application of 2,3-Dimethoxybenzonitrile, the main research area is oxime dehydration triphenylphosphine triflic anhydride; nitrile preparation.

NMR studies on the reaction of triphenylphosphine with various amounts of triflic anhydride at 0 °C are described. The reagent formed on mixing 1.3 equiv of Ph3P with Tf2O (1.0 mmol) was shown to be an equilibrium mixture consisting mainly of triphenyl(trifluoromethylsulfonyloxy)phosphonium trifluoromethanesulfinate and the corresponding bis(triphenyl)oxodiphosphonium trifluoromethanesulfinate dimer. The electrophilic properties of the system have been exploited in the development of a mild method for converting aldoximes into nitriles. The dehydration occurs at 0 °C under very mild conditions by initial activation of the oxime oxygen, followed by treatment with a base and subsequent elimination of triphenylphosphine oxide. The substrate scope and functional group tolerance of this useful method are explored.

Tetrahedron Letters published new progress about Aldoximes Role: RCT (Reactant), RACT (Reactant or Reagent). 5653-62-3 belongs to class nitriles-buliding-blocks, name is 2,3-Dimethoxybenzonitrile, and the molecular formula is C9H9NO2, Application of 2,3-Dimethoxybenzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chand, Pooran published the artcileDesign and Synthesis of Benzoic Acid Derivatives as Influenza Neuraminidase Inhibitors Using Structure-Based Drug Design, Safety of Methyl 3-amino-5-cyanobenzoate, the main research area is benzoic acid derivative preparation neuraminidase inhibitor; structure activity benzoic acid neuraminidase inhibitor; crystal structure benzoic acid neuraminidase complex; influenza neuraminidase inhibitor benzoic acid preparation.

A series of 94 benzoic acid derivatives were synthesized and tested for their ability to inhibit influenza neuraminidase. The enzyme-inhibitor complex structure was determined by x-ray crystallog. anal. for compounds which inhibited the enzyme. The most potent compound tested in vitro, (4-(acetylamino)-3-guanidinobenzoic acid) (I), had an IC50 = 2.5 × 10-6 M against N9 neuraminidase. Compound I was oriented in the active site of the neuraminidase in a manner that was not predicted from the reported active site binding of GANA (II) with neuraminidase. In a mouse model of influenza, I did not protect the mice from weight loss due to the influenza virus when dosed intranasally.

Journal of Medicinal Chemistry published new progress about Structure-activity relationship (neuraminidase-inhibiting). 199536-01-1 belongs to class nitriles-buliding-blocks, name is Methyl 3-amino-5-cyanobenzoate, and the molecular formula is C9H8N2O2, Safety of Methyl 3-amino-5-cyanobenzoate.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhou, Mingwei published the artcileEfficient cyclopropanation of aryl/heteroaryl acetates and acetonitriles with vinyl diphenyl sulfonium triflate, Product Details of C10H8FN, the main research area is cyclopropanation aryl heteroaryl acetate acetonitrile; vinyl diphenyl sulfonium triflate cyclopropanation acetate acetonitrile.

A convenient method was developed for the cyclopropanation of aryl acetates and aryl acetonitrile using vinyl di-Ph sulfonium triflate salt. The newly developed conditions are simple, mild, and compatible with a wide range of functional groups, without the need to apply an inert atm., or alkali bases.

Tetrahedron Letters published new progress about Acetates Role: RCT (Reactant), RACT (Reactant or Reagent). 97009-67-1 belongs to class nitriles-buliding-blocks, name is 1-(4-Fluorophenyl)cyclopropanecarbonitrile, and the molecular formula is C10H8FN, Product Details of C10H8FN.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ban, Yong-Liang published the artcileThiocyanate radical mediated dehydration of aldoximes with visible light and air, COA of Formula: C9H9NO2, the main research area is nitrile preparation; aldoxime thiocyanate radical dehydration visible light air aizenuranine catalyst.

Herein, a new means of activating aldoximes by an in situ generated thiocyanate radical from ammonium thiocyanate and mol. oxygen at room temp has been discussed. With a catalytic amount of organic dye aizenuranine as the photocatalyst, the dehydration of aldoximes proceeds smoothly under visible light irradiation, providing a simple to handle, excellent functional group tolerance, and metal-free protocol for a wide range of nitriles.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 5653-62-3 belongs to class nitriles-buliding-blocks, name is 2,3-Dimethoxybenzonitrile, and the molecular formula is C9H9NO2, COA of Formula: C9H9NO2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lehmann, Johannes published the artcileThe Kondrat’eva Reaction in Flow: Direct Access to Annulated Pyridines, COA of Formula: C10H6N2O, the main research area is annulated pyridine preparation; continuous flow inverse electron demand Kondrateva cycloaddition reaction; cycloaddition reaction continuous flow oxazole cycloalkene.

A continuous flow inverse-electron-demand Kondrat’eva reaction has been developed that provides direct access to cycloalka[c]pyridines from unactivated oxazoles and cycloalkenes. The cycloadditions of both unactivated alkenes and deactivated oxazoles are promoted in continuous flow at elevated temperatures and pressures (230 °C, 750psi). E.g., reaction of 5-phenyloxazole and cyclopentene in presence of TFA gave 55% 4-phenyl-6,7-dihydro-5H-cyclopenta[c]pyridine (I). Annulated pyridines obtained by this one-step process are valuable scaffolds for medicinal chem.

Organic Letters published new progress about Cycloalkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 87150-13-8 belongs to class nitriles-buliding-blocks, name is 4-(5-Oxazolyl)benzonitrile, and the molecular formula is C10H6N2O, COA of Formula: C10H6N2O.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Hao, Xiaowei published the artcileAir-stable and highly efficient indenyl-derived phosphine ligand: Application to Buchwald-Hartwig amination reactions, Product Details of C11H12N2O, the main research area is palladium complex mesitylindenyldicyclohexylphosphine preparation catalyst Buchwald Hartwig amination; aryl halide Buchwald Hartwig amination palladium catalyst.

2-Mesitylindenyl phosphine ligand (I) and [(2-mesitylindenyl)dicyclohexylphosphine]PdCl2 (II) have been synthesized and fully characterized by NMR and elemental anal., as well as by X-ray crystallog. for II. A Highly active catalyst system derived from a palladium precatalyst and bulky 2-mesitylindenyl phosphine ligand (I) for the Buchwald-Hartwig amination reaction of aryl halides with primary and secondary amines has been developed. This method allows for the preparation of a wide variety of amines in moderate to excellent yields and displays a high level of activity for the coupling of aryl chlorides as well as hindered aryl bromides.

Journal of Organometallic Chemistry published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 204078-32-0 belongs to class nitriles-buliding-blocks, name is 2-Morpholinobenzonitrile, and the molecular formula is C11H12N2O, Product Details of C11H12N2O.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts