Tag: M.W=150-200

Shelke, Nilesh B. published the artcileSNAr reaction in aqueous medium in the presence of mixed organic and inorganic bases, Computed Properties of 204078-32-0, the main research area is diaminoquinazoline preparation; amine fluorobenzonitrile guanidine arylation chemoselective regioselective.

Synthesis of 2,4-diaminoquinazolines I [R = H, 5-F, 7-F, etc.] and arylamines II [R1R2 = (CH2)5, CH2CH2OCH2CH2, CH2CH(CH3)NHCH(CH3)CH2; R1 = H; R2 = CH2C6H5] via arylation of amines with fluorobenzonitriles is described. A mixture of N,N-diisopropylethyl amine and Na2CO3 (1 : 1) is found to achieve maximum conversion by refluxing for 3 h in water. The product can be easily isolated by solvent extraction

RSC Advances published new progress about Aromatic nitriles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 204078-32-0 belongs to class nitriles-buliding-blocks, name is 2-Morpholinobenzonitrile, and the molecular formula is C11H12N2O, Computed Properties of 204078-32-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reddy, P. Linga published the artcileCu(0)@Al2O3/SiO2 NPs: an efficient reusable catalyst for the cross coupling reactions of aryl chlorides with amines and anilines, Synthetic Route of 204078-32-0, the main research area is amine preparation green chem; aryl chloride amine copper nanocatalyst cross coupling reaction; alumina silica support copper nanoparticle catalyst preparation.

The C-N cross coupling reaction of aryl chlorides with various alkyl/aryl amines catalyzed by copper nanoparticles impregnated on alumina/silica support (Cu(0)@Al2O3/SiO2) was investigated. The prepared catalyst was characterized for its intrinsic physico-chem. and textural properties using XRD, XPS, HR-TEM, BET surface area, SEM-EDAX, H2-TPR and ICP-AES techniques. The catalyst exhibited excellent reactivity and efficacy in the cross-coupling of a wide range of alkyl/aryl amines including challenging anilines with aryl chlorides. The catalyst offers significant advantages such as brevity, milder reaction conditions, excellent yields and high functional group tolerance for C-N cross coupling when compared with the other reported methods. This atom-economical methodol. does not require an addnl. ligand or co-catalyst/activator. The Cu(0)@Al2O3/SiO2 catalyst was efficiently applied to a gram scale synthesis of 7-chloro-4-(4-(2-nitrophenyl)piperazin-1-yl)quinolone. The robustness of the catalyst was examined by reusing it for five consecutive runs.

RSC Advances published new progress about Aryl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 204078-32-0 belongs to class nitriles-buliding-blocks, name is 2-Morpholinobenzonitrile, and the molecular formula is C11H12N2O, Synthetic Route of 204078-32-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Moore, Jared T. published the artcileCatalytic alkene cyclization reactions for the stereoselective synthesis of complex “”terpenoid-like”” heterocycles, Formula: C9H9NO2, the main research area is terpenoid like heterocyclic compound preparation stereoselective synthesis.

A new catalytic synthesis of densely substituted tetrahydroquinoline derivatives is described. This reaction forms up to two rings, three bonds and three stereogenic centers with excellent stereocontrol and regiocontrol in a single step. Although control experiments demonstrate that the active catalyst is protic acid, Sc(OTf)3 serves as an effective and practical pre-catalyst. The scope of this reaction is demonstrated with cyclization reactions and bicyclization reactions. The synthesis of the target compounds (terpenoid derivatives) was achieved using geraniol derivatives as intermediates. The title compounds thus formed included a quinoline thioether derivative (I) and an isoquinoline derivative (II) and related substances, such as selenium ether derivatives

Chemical Science published new progress about Bicyclic compounds Role: SPN (Synthetic Preparation), PREP (Preparation). 5653-62-3 belongs to class nitriles-buliding-blocks, name is 2,3-Dimethoxybenzonitrile, and the molecular formula is C9H9NO2, Formula: C9H9NO2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Liu, Yuxiao published the artcileRuthenium Trichloride Catalyzed Highly Efficient Deoximation of Oximes to the Carbonyl Compounds and Nitriles without Acceptors, Application In Synthesis of 5653-62-3, the main research area is ketone preparation green chem; ketoxime deoximation ruthenium trichloride catalyst; nitrile preparation green chem; aldoxime deoximation ruthenium trichloride catalyst.

The acceptor-free catalysis protocol for the deoximation of ketoximes e.g., I and aldoximes RCH:NOH (R = C6H5, 2,3-(H3CO)2C6H3, 4-H3CC6H4, 2-HOC6H4) using RuCl3 as the catalyst has been developed. Under the optimized conditions, various oximes were converted to ketones e.g., II and nitriles RCN with excellent isolated yields.

Chinese Journal of Chemistry published new progress about Aromatic nitriles Role: SPN (Synthetic Preparation), PREP (Preparation). 5653-62-3 belongs to class nitriles-buliding-blocks, name is 2,3-Dimethoxybenzonitrile, and the molecular formula is C9H9NO2, Application In Synthesis of 5653-62-3.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kramm, Frederik published the artcileIron-Catalyzed Cycloisomerization and C-C Bond Activation to Access Non-canonical Tricyclic Cyclobutanes, COA of Formula: C10H8FN, the main research area is cyclopropyl enyne iron catalyst diastereoselective cycloisomerization; octahydrocyclobutacyclopenta pyrrole preparation; Cyclobutanes; Cycloisomerization; Cyclopropanes; Iron Catalysis; Rearrangement.

Cycloisomerizations are powerful skeletal rearrangements that allow the construction of complex mol. architectures in an atom-economic way. Here an unusual type of cyclopropyl enyne cycloisomerization that couples the process of a cycloisomerization with the activation of a C-C bond in cyclopropanes was presented . A set of substituted non-canonical tricyclic cyclobutanes were synthesized under mild conditions using [(Ph3P)2Fe(CO)(NO)]BF4 as catalyst in good to excellent yields with high levels of stereocontrol.

Angewandte Chemie, International Edition published new progress about Cyclobutanes Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 97009-67-1 belongs to class nitriles-buliding-blocks, name is 1-(4-Fluorophenyl)cyclopropanecarbonitrile, and the molecular formula is C10H8FN, COA of Formula: C10H8FN.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhou, Jingwei published the artcileCatalyst-free photoinduced selective oxidative C(sp3)-C(sp3) bond cleavage in arylamines, HPLC of Formula: 204078-32-0, the main research area is arylamine selective oxidative bond cleavage photochem catalyst free.

Due to the directional nature of sp3-hybridized orbitals and the absence of π-orbitals, the oxidative cleavage of the kinetically and thermodynamically stable C(sp3)-C(sp3) bond is extremely difficult and remains scarcely explored. In this work, under the double argument of quantum mechanics (QM) computations and meticulous experiments on authors’ well-designed C-C single bond cleavage mechanism, authors discovered a means of photoinduced selective oxidative C(sp3)-C(sp3) bond cleavage in arylamines, easily achieved by simple visible light irradiation using O2 as a benign oxidant under very mild conditions. The utility of methodol. was demonstrated by the C(sp3)-C(sp3) bond cleavage in morpholine/piperazine arylamines with excellent functional group tolerance. Importantly, this methodol. is noteworthy, not only it does not require any catalysts, but also it provides valuable possibilities for the scalable functionalization of clin. drugs and natural products.

Green Chemistry published new progress about C-C bond cleavage (photochem.). 204078-32-0 belongs to class nitriles-buliding-blocks, name is 2-Morpholinobenzonitrile, and the molecular formula is C11H12N2O, HPLC of Formula: 204078-32-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lee, Taegyo published the artcileRhodium-Catalyzed Enantioselective Silylation of Cyclopropyl C-H Bonds, Safety of 1-(4-Fluorophenyl)cyclopropanecarbonitrile, the main research area is rhodium catalyzed enantioselective silylation cyclopropylmethanol ethylsilane; chiral hydroxycyclopropanol preparation crystal structure; mol structure chiral hydroxycyclopropanol; carbon hydrogen bond activation silylation cyclopropylmethanol rhodium catalyst; kinetic isotope effect silylation cyclopropylmethanol rhodium catalyst; C−H activation; asymmetric catalysis; cyclopropanes; rhodium; silylation.

Hydrosilyl ethers, generated in situ by the dehydrogenative silylation of cyclopropylmethanols with diethylsilane, undergo asym., intramol. silylation of cyclopropyl C-H bonds in high yields and with high enantiomeric excesses in the presence of a Rh catalyst derived from a Rh precursor and the bisphosphine (S)-DTBM-SEGPHOS. The resulting enantioenriched oxasilolanes are suitable substrates for the Tamao-Fleming oxidation to form cyclopropanols with conservation of the ee value from the C-H silylation. Preliminary mechanistic data suggest that C-H cleavage probably is the turnover-limiting and enantioselectivity-determining step.

Angewandte Chemie, International Edition published new progress about C-H bond activation. 97009-67-1 belongs to class nitriles-buliding-blocks, name is 1-(4-Fluorophenyl)cyclopropanecarbonitrile, and the molecular formula is C10H8FN, Safety of 1-(4-Fluorophenyl)cyclopropanecarbonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Goeker, Hakan published the artcileSynthesis and potent antifungal activity against Candida species of some novel 1H-benzimidazoles, COA of Formula: C7H5N3O2, the main research area is benzimidazole preparation nucleophilic substitution reduction aryl diamine benzaldehyde heterocyclization; fungal infection antifungal structure activity Candida.

A series of 47 novel N1-alkylated-2-aryl-5(6)-substituted-1H-benzimidazoles and their three novel indole analogs were synthesized and evaluated for in vitro antifungal activities against Candida species by the tube dilution method. The results showed that I and II, having pyridine at the position C-2, of benzimidazoles exhibited the greatest activity with MIC values of 6.25-3.12 μg/mL. Indole analogs III (R1 = H, R2 = Br; R1 = Pr, R2 = Br, CN) have no inhibitory activity.

Journal of Heterocyclic Chemistry published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 87331-46-2 belongs to class nitriles-buliding-blocks, name is 2-Amino-3-nitrobenzonitrile, and the molecular formula is C7H5N3O2, COA of Formula: C7H5N3O2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nishino, Mayuko published the artcileCopper-Mediated C-H/C-H Biaryl Coupling of Benzoic Acid Derivatives and 1,3-Azoles, Application of 4-(5-Oxazolyl)benzonitrile, the main research area is biaryl preparation; amide aromatic heteroaromatic coupling azole copper mediated.

A precious metal-free copper-mediated intermol. diaryl coupling of aromatic and heteroaromatic amides XC(O)NHQ (Q = 8-quinolinyl; X = Ph, 3-MeC6H4, 4-t-BuC6H4, 1-naphthyl, 2-furyl, 2-thienyl, 1-methyl-2-indolyl, 4-pyridyl, etc.) with 1,3-azoles R-H (R = 2-benzoxazolyl, 5-phenyl-2-oxazolyl, 2-thiazolyl, 1-methyl-2-imidazolyl, etc.) to provide the corresponding biaryls o-RXC(O)NHQ has been developed. The key to success is the installation of an amide-based bidentate coordinating group, which can be easily transformed into an ester group after the coupling reaction. Kinetic studies indicated that the rate-limiting step is the aromatic C-H bond cleavage of the N-(8-quinolinyl) amides.

Angewandte Chemie, International Edition published new progress about Arylation. 87150-13-8 belongs to class nitriles-buliding-blocks, name is 4-(5-Oxazolyl)benzonitrile, and the molecular formula is C10H6N2O, Application of 4-(5-Oxazolyl)benzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lesieur, Mathieu published the artcileDevelopment of a flow photochemical aerobic oxidation of benzylic C-H Bonds, Synthetic Route of 103589-67-9, the main research area is aryl ketone alc preparation; benzylic compound oxidation photocatalyst.

A continuous mesofluidic process has been developed for benzylic C-H oxidation with moderate to good yields using a photocatalyst (riboflavin tetraacetate, RFT) activated by a UV lamp and an iron additive [Fe(ClO4)2] via incorporation of singlet oxygen (1O2) for the direct formation of oxidized C=O or CH-OH compounds, e. g., I.

Organic Letters published new progress about Aryl ketones Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 103589-67-9 belongs to class nitriles-buliding-blocks, name is 3-Chloro-6,7-dihydro-5H-cyclopenta[c]pyridine-4-carbonitrile, and the molecular formula is C9H7ClN2, Synthetic Route of 103589-67-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts