Tag: M.W=150-200

Beynon, Kenneth I. published the artcileBreakdown of the herbicide chlorthiamid-14C. II. Glasshouse studies of breakdown in soils and in crops grown in the soils, Synthetic Route of 3336-34-3, the publication is Journal of the Science of Food and Agriculture (1968), 19(12), 727-32, database is CAplus.

Plants were grown to harvest in a glasshouse in soils treated once with chlorthiamid-14C(2,6-dichlorothiobenzamide) at dosage levels (1-3 lb./acre active mols.) near those recommended for com. field use. Rice plants (stems and leaves) grown in soil treated at 1 lb./acre contained dichlobenil (2,6-dichlorobenzonitrile, 0.03 ppm.) and 2,6-dichlorobenzamide (0.06 ppm.) and the grain itself showed a total residue of 14C-labeled components of only 0.06 ppm. (expressed as equivalent weight of chlorthiamid) at harvest. Winter wheat plants (stalks and leaves) grown in medium loam treated at 1.2 lb./acre contained residues of 2,6-dichlorobenzamide and free and conjugated 3-hydroxy-2,6-dichlorobenzamide, together with traces of sugar conjugates of 3-hydroxy- and 4-hydroxy-2,6-di-chlorobenzonitrile. The fruit of apple grown in a glasshouse in soil treated once at 1.5 lb./acre, showed no detectable residue (<0.004 ppm.) in spite of total residues of up to 2.4 ppm. in the leaves. The latter probably resulted from sublimation of dichlobenil from the soil. Such a mode of uptake would be unlikely to lead to as much residue in the leaves under field conditions. Traces of dichlobenil (0.005 ppm.), 2,6-dichlorobenzamide (0.02 ppm.) with larger amounts of glycosides of 3-hydroxy-2,6-dichlorobenzamide (1.3 ppm.) and 3-hydroxy- and 4-hydroxy-2,6-dichlorobenzonitriles (0.6 ppm. and 0.5 ppm., resp.) were identified in the leaves at harvest. All of the breakdown products of chlorthiamid that have been identified are of low acute oral mammalian toxicity.

Journal of the Science of Food and Agriculture published new progress about 3336-34-3. 3336-34-3 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Phenol, name is 2,6-Dichloro-3-hydroxybenzonitrile, and the molecular formula is C7H3Cl2NO, Synthetic Route of 3336-34-3.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Pang, Maofu published the artcileAddition of a B-H Bond across an Amido-Cobalt Bond: Co^II-H-Catalyzed Hydroboration of Olefins, Product Details of C10H18BNO2, the publication is Organometallics (2018), 37(9), 1462-1467, database is CAplus.

This paper describes a well-defined cobalt(II) half-sandwich complex bearing a phosphinoaminato ligand, Cp*Co(1,2-Ph₂PC₆H₄NH) (1), that can activate pinacolborane (HBpin) for catalytic terminal hydroboration of olefins. The cooperative cobalt(II)-amido reactivity in 1 enables the B-H bond cleavage, affording the 17-electron cobalt(II) hydride Cp*Co(1,2-Ph₂PC₆H₄N^H(Bpin)), abbreviated H1(Bpin), in which the borenium ion is captured by the uncoordinated nitrogen atom of the phosphinoaminato ligand. Hydroboration of the C:C bond can be promoted by a heteroatom such as N or O at the β-position of terminal alkenes. The mechanism of such hydroboration was established by various stoichiometric reactions based on the cobalt(II) hydride. With cooperative Co^II-N reactivity for the B-H bond cleavage, our catalysis depends on the Co^II-H hydride generated by the system itself.

Organometallics published new progress about 238088-16-9. 238088-16-9 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Boronic acid and ester,Aliphatic cyclic hydrocarbon,Boronic Acids,Boronate Esters, name is 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)butanenitrile, and the molecular formula is C10H18BNO2, Product Details of C10H18BNO2.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Saha, Arijit published the artcileFacile Synthesis of 1,3,5-Triarylbenzenes and 4-Aryl-NH-1,2,3-Triazoles Using Mesoporous Pd-MCM-41 as Reusable Catalyst, Related Products of nitriles-buliding-blocks, the publication is European Journal of Organic Chemistry (2019), 2019(1), 104-111, database is CAplus.

We report mesoporous nano-Pd-MCM-41 catalyzed rapid and efficient synthesis of 1,3,5-triarylbenzenes via de-nitrative cyclotrimerization of β-nitrostyrenes. All the reactions were very fast and high yielding. The Pd-MCM-41 was also very effective in catalyzing de-nitrative [3+2] cycloaddition of β-nitrostyrenes with TMSN₃ to synthesize 4-aryl-NH-1,2,3-triazoles. The catalyst was reused at least up to eight times with min. loss of catalytic activity.

European Journal of Organic Chemistry published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C9H6N2O2, Related Products of nitriles-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Bai, Hong Ye published the artcile1,8,16,23-Tetrakis(2-cyanobenzyl)bis-p-xylylbis-m-xylyldiamine, Application In Synthesis of 612-13-5, the publication is Acta Crystallographica, Section E: Structure Reports Online (2008), 64(11), o2142, o2142/1-o2142/11, database is CAplus and MEDLINE.

The title compound {systematic name: 2,2′,2”,2”’-[3,7,11,15-tetraaza-1(1,4),5(1,3),9(1,4),13(1,3)-tetrabenzenacyclohexadecaphane-3,7,11,15-tetrayltetramethylene]tetrabenzonitrile}, C₆₄H₅₆N₈, is a centrosym. macrocycle that is consolidated into the crystal structure by C-H···π interactions. Crystallog. data are given.

Acta Crystallographica, Section E: Structure Reports Online published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Application In Synthesis of 612-13-5.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Wang, Hui published the artcileSelective Coupling of 1,2-Bis-Boronic Esters at the more Substituted Site through Visible-Light Activation of Electron Donor-Acceptor Complexes, COA of Formula: C10H18BNO2, the publication is Angewandte Chemie, International Edition (2022), 61(18), e202202061, database is CAplus and MEDLINE.

1,2-Bis-boronic esters are useful synthetic intermediates particularly as the two boronic esters can be selectively functionalized. Usually, the less hindered primary boronic ester reacts, but herein, we report a coupling reaction that enables the reversal of this selectivity. This is achieved through the formation of a boronate complex with an electron-rich aryllithium which, in the presence of an electron-deficient aryl nitrile, leads to the formation of an electron donor-acceptor complex. Following visible-light photoinduced electron transfer, a primary radical is generated which isomerizes to the more stable secondary radical before radical-radical coupling with the arene radical-anion, giving β-aryl primary boronic ester products. The reactions proceed under catalyst-free conditions. This method also allows stereodivergent coupling of cyclic cis-1,2-bis-boronic esters to provide trans-substituted products, complementing the selectivity observed in the Suzuki-Miyaura reaction.

Angewandte Chemie, International Edition published new progress about 238088-16-9. 238088-16-9 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Boronic acid and ester,Aliphatic cyclic hydrocarbon,Boronic Acids,Boronate Esters, name is 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)butanenitrile, and the molecular formula is C14H31NO2, COA of Formula: C10H18BNO2.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Li, Ying published the artcileSynthesis and cytotoxicity of dihydroartemisinin ethers containing cyanoarylmethyl group, COA of Formula: C8H6ClNO, the publication is Bioorganic & Medicinal Chemistry (2003), 11(6), 977-984, database is CAplus and MEDLINE.

A new type of ether of dihydroartemisinin containing cyano and aryl groups was prepared and tested for cytotoxicity to A549, P388, L1210 and HT29 cells using the MTT assay. Compounds 12k and 12l were the most cytotoxic compounds Compound 13, lacking the peroxy group, showed a 1000-fold less potency than 12l. Similarly, the inactive compound 14 indicated that the position of cyano groups was also important. Flow cytometry data showed that the compounds caused an accumulation of P388 cells in the G₁-phase of the cell cycle.

Bioorganic & Medicinal Chemistry published new progress about 13312-84-0. 13312-84-0 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Alcohol,Benzene Compounds, name is 2-(2-Chlorophenyl)-2-hydroxyacetonitrile, and the molecular formula is C8H6ClNO, COA of Formula: C8H6ClNO.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Li, Zhi published the artcileSeparation of chiral cyanohydrin enantiomers by gas chromatography, Application In Synthesis of 13312-84-0, the publication is Fenxi Huaxue (1997), 25(6), 708-713, database is CAplus.

The enantiomers of 14 cyanohydrins were separated on permethylated β-cyclodextrin column (fused silica, 25 m × 0.22 mm) by derivatization. The acetyl chloride and trifluoroacetic anhydride were used as derivatization reagents. All racemates were separated to baseline with separation factors (α) = 1.02-1.13. The enantiomer excess values of some enantiomers from asym. synthesis samples were determined, and they were identical with those by optical purity and HPLC methods. The separation effect of the two derivatization methods and the separation mechanism of enantiomers are discussed.

Fenxi Huaxue published new progress about 13312-84-0. 13312-84-0 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Alcohol,Benzene Compounds, name is 2-(2-Chlorophenyl)-2-hydroxyacetonitrile, and the molecular formula is C8H6ClNO, Application In Synthesis of 13312-84-0.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Li, Xiangmin published the artcileOne-Pot Synthesis of Deuterated Aldehydes from Arylmethyl Halides, Application of 2-(Chloromethyl)benzonitrile, the publication is Organic Letters (2018), 20(7), 1712-1715, database is CAplus and MEDLINE.

A facile, one-pot approach for synthesizing deuterated aldehydes from arylmethyl halides was developed using D₂O as the deuterium source. The efficient process is realized by a sequence of formation, H/D exchange and oxidation of pyridinium salt intermediates. The mild and air-compatible reaction conditions enable efficient synthesis of diverse deuterated aldehydes with high deuterium incorporation.

Organic Letters published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Application of 2-(Chloromethyl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Wu, Lulu published the artcileSynthesis of Optically Active 2H-Thiopyrano[2,3-b]quinolines with Three Contiguous Stereocenters via an Organocatalytic Asymmetric Tandem Michael-Henry Reaction [Erratum to document cited in CA160:033796], COA of Formula: C9H6N2O2, the publication is Advanced Synthesis & Catalysis (2014), 356(6), 1134, database is CAplus.

The authors were made of aware of an error regarding the x-ray anal. data for the absolute configuration of compound 5ad; the corrected structure is given and the NMR data and spectra can be found in the Supporting Information.

Advanced Synthesis & Catalysis published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C8H11NO, COA of Formula: C9H6N2O2.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Zhao, Guangkuan published the artcileCucurbit[7]uril promoting PdCl₂-catalyzed cross-coupling reaction of benzyl halides and arylboronic acids in aqueous media, Recommanded Product: 2-(Chloromethyl)benzonitrile, the publication is Tetrahedron Letters (2014), 55(38), 5319-5322, database is CAplus.

The research provides a novel approach for producing diarylmethane derivatives using CB[7]-NaCl-PdCl₂ catalyzed Suzuki cross-coupling reaction of benzyl chloride derivatives and arylboronic acids in ethanol aqueous solution

Tetrahedron Letters published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C5H10O2S, Recommanded Product: 2-(Chloromethyl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts