Tag: M.W=200-250

Nitrile is any organic compound with a −C≡N functional group. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. Recommanded Product: 4-(2-Bromoacetyl)benzonitrile.

Yadav, Sanjay;Suresh, Surisetti research published 《 N-Heterocyclic Carbene (NHC)-Catalyzed Intramolecular Stetter Reaction to Access Dibenzo-fused Seven-membered Heterocycles》, the research content is summarized as follows. Herein, an NHC-catalyzed transformation to access dibenzo-fused seven-membered heterocyclic compounds via intramol. Stetter reaction under ambient conditions was delineated. A range of dibenzo[b,f]oxepine and dibenzo[b,f]thiepine derivatives was generated in very good to excellent yields. The 1,4-dicarbonyl functionality of a representative derivative was undergone further heterocyclization via Paal-Knorr reaction.

Recommanded Product: 4-(2-Bromoacetyl)benzonitrile, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 1835-49-0, formula is C8F4N2, Name is Tetrafluoroterephthalonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Application of C8F4N2.

Yan, Zhi-Ping;Liu, Ting-Ting;Wu, Ruixia;Liang, Xiao;Li, Zhi-Qiang;Zhou, Liang;Zheng, You-Xuan;Zuo, Jing-Lin research published 《 Chiral Thermally Activated Delayed Fluorescence Materials Based on R/S-N²,N²′-Diphenyl-[1,1′-binaphthalene]-2,2′-diamine Donor with Narrow Emission Spectra for Highly Efficient Circularly Polarized Electroluminescence》, the research content is summarized as follows. In this study, two pairs of chiral thermally activated delayed fluorescence (TADF) materials enabling circularly polarized luminescence (CPL) named R/S-p-BAMCN (rod-shape) and R/S-o-BAMCN (helix-shape) are prepared based on a new pair of chiral donor (D*), R/S-N2,N2′-diphenyl-[1,1′-binaphthalene]-2,2′-diamine (R/S-BAM), and two cyano (CN) acceptors. Due to the rigid mol. structure and special intramol. arrangement, the chiral TADF materials show high photoluminescence quantum efficiency (up to 0.86) with narrow full-width at half-maximum (38 nm in cyclohexane, 51 nm in toluene) and photoluminescence dissymmetry factor (|gPL|) up to 5.3 x 10^-3. Particularly, the circularly polarized OLEDs (CP-OLEDs) with rod-shaped R/S-p-BAMCN as the emitter show high device performances with the maximum external quantum efficiency nearing 28%. Meanwhile, the semi-transparent CP-OLEDs based on helix-shaped R/S-o-BAMCN exhibit obvious circularly polarized electroluminescence (CPEL) properties with the electroluminescence |gEL| factors around 4.6 x 10-3. The strategy of rigid D*-A-D* structure with special arrangement of chiral donor provides a direct way to obtain efficient CP-TADF materials with narrow emission spectra and promising CPL properties for better CPEL performance.

1835-49-0, Tetrafluoroterephthalonitrile can react with alkyl grignard reagents to form 4-alkyltetraflurorobenzonitriles. It acts as a four electron donor ligand. Tetrafluoroterephthalonitrile can be used to synthesize polymers of intrinsic microporosity. It has been used to study UV rearranged polymers of teh PIM-1 type membrane for the efficient separation of H2 and CO2.
Tetrafluoroterephthalonitrile reacts with alkyl Grignard reagents to form corresponding 4-alkyltetrafluorobenzonitriles. Tetrafluoroterephthalonitrile acts as a four-electron donor ligand and forms tungsten(II)η 2-nitrile complexes.
Tetrafluoroterephthalonitrile is a hydroxyl group-containing organic chemical compound . It has been used in analytical chemistry as a reagent for the determination of peptide binding constants and disulfide bonds. Tetrafluoroterephthalonitrile binds to nucleophilic sites on proteins, such as the pim-1 protein, and can be used to transport other molecules across cell membranes. In addition, it has been used to produce polymers for use in analytical chemistry. This chemical is also able to bind with magnetic particles under constant pressure conditions, which makes it useful for optical sensor applications. , Application of C8F4N2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 1835-49-0, formula is C8F4N2, Name is Tetrafluoroterephthalonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Formula: C8F4N2.

Yang, Chongqing;Jiang, Kaiyue;Zheng, Qi;Li, Xinle;Mao, Haiyan;Zhong, Wenkai;Chen, Cheng;Sun, Bing;Zheng, Haimei;Zhuang, Xiaodong;Reimer, Jeffrey A.;Liu, Yi;Zhang, Jian research published 《 Chemically stable polyarylether-based metallophthalocyanine frameworks with high carrier mobilities for capacitive energy storage》, the research content is summarized as follows. Covalent organic frameworks (COFs) with efficient charge transport and exceptional chem. stability are emerging as an import class of semiconducting materials for opto-/electronic devices and energy-related applications. However, the limited synthetic chem. to access such materials and the lack of mechanistic understanding of carrier mobility greatly hinder their practical applications. Herein, we report the synthesis of three chem. stable polyarylether-based metallophthalocyanine COFs (PAE-PcM, M = Cu, Ni, and Co) and facile in situ growth of their thin films on various substrates (i.e., SiO₂/Si, ITO, quartz) under solvothermal conditions. We show that PAE-PcM COFs thin films with van der Waals layered structures exhibit p-type semiconducting properties with the intrinsic mobility up to ~19.4 cm² V^-1 s^-1 and 4 orders of magnitude of increase in conductivity for PAE-PcCu film (0.2 S m^-1) after iodine doping. D. functional theory calculations reveal that the carrier transport in the framework is anisotropic, with the out-of-plane hole transport along columnar stacked phthalocyanine more favorable. Furthermore, PAE-PcCo shows the redox behavior maximumly contributes ~88.5% of its capacitance performance, giving rise to a high surface area normalized capacitance of ~19 μF cm^-2. Overall, this work not only offers fundamental understandings of electronic properties of polyarylether-based 2D COFs but also paves the way for their energy-related applications.

1835-49-0, Tetrafluoroterephthalonitrile can react with alkyl grignard reagents to form 4-alkyltetraflurorobenzonitriles. It acts as a four electron donor ligand. Tetrafluoroterephthalonitrile can be used to synthesize polymers of intrinsic microporosity. It has been used to study UV rearranged polymers of teh PIM-1 type membrane for the efficient separation of H2 and CO2.
Tetrafluoroterephthalonitrile reacts with alkyl Grignard reagents to form corresponding 4-alkyltetrafluorobenzonitriles. Tetrafluoroterephthalonitrile acts as a four-electron donor ligand and forms tungsten(II)η 2-nitrile complexes.
Tetrafluoroterephthalonitrile is a hydroxyl group-containing organic chemical compound . It has been used in analytical chemistry as a reagent for the determination of peptide binding constants and disulfide bonds. Tetrafluoroterephthalonitrile binds to nucleophilic sites on proteins, such as the pim-1 protein, and can be used to transport other molecules across cell membranes. In addition, it has been used to produce polymers for use in analytical chemistry. This chemical is also able to bind with magnetic particles under constant pressure conditions, which makes it useful for optical sensor applications. , Formula: C8F4N2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Safety of 4-(2-Bromoacetyl)benzonitrile.

Yang, Dongfeng;Wang, Chengyi;Wang, Yu;Liu, Guohua;Cheng, Tanyu;Liu, Rui research published 《 One-pot enantioselective construction of 3,4-dihydro-2H-1,4-oxazines over Ru/Au relay catalysis and its mechanistic serendipity》, the research content is summarized as follows. The preparation of enantiomerically pure 1,4-oxazines remains a continuous challenge in synthetic chem. because of their potential application in the total synthesis of morpholines. Herein, a one-pot asym. transfer hydrogenation/cyclization enantio-relay process catalyzed by Ru and Au bimetallic catalysts was developed. This enantio-relay process firstly allows the asym. transfer hydrogenation of alkynones to form chiral alkynols in the presence of (S,S)-mesityleneRuClTsDPEN (TsDPEN = N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine) and then the chiral alkynols could be converted into 3,4-dihydro-2H-1,4-oxazines in moderate to good yields with excellent enantioselectivity retention accompanied by AuCl(PPhz₃)/AgNTf₂ and HCOOH. A series of sulfonamide-tethered alkynones were well tolerated in this process. Mechanistic studies indicated that the alkynols formed in the first step were initially transformed into a methylenemorpholine intermediate when AuCl(PPh₃)/AgNTf₂ and HCOOH were added, which can be further isomerized into chiral 3,4-dihydro-2H-1,4-oxazines with the addition of a second HCOOH. This protocol offers not only a practical method to access 3,4-dihydro-2H-1,4-oxazines from alkynones in an enantioselective version, but also enriches the arsenal of gold chem. from a mechanistic point of view.

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Safety of 4-(2-Bromoacetyl)benzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. Name: 4-(2-Bromoacetyl)benzonitrile.

Yang, Wen-Fei;Shu, Tao;Chen, Hong-Ru;Qin, Hua-Li;Tang, Haolin research published 《 A cascade reaction for regioselective construction of pyrazole-containing aliphatic sulfonyl fluorides》, the research content is summarized as follows. A copper-catalyzed cascade reaction of α-diazocarbonyl compounds with ethenesulfonyl fluoride (ESF) is developed, affording a variety of highly functionalized pyrazolyl aliphatic sulfonyl fluorides in good to excellent yields (66-98%). This transformation features broad substrates, exclusive regioselectivity, high atom economy and operational simplicity, thus providing a straightforward method for the direct construction of pyrazole-containing aliphatic sulfonyl fluorides, which will provide great applicable value in medicinal chem. and other related disciplines.

Name: 4-(2-Bromoacetyl)benzonitrile, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Application In Synthesis of 20099-89-2.

Yang, Zhonglie;Cao, Kun;Peng, Xiaoyan;Lin, Li;Fan, Danchen;Li, Jun-Long;Wang, Jingxia;Zhang, Xiaobin;Jiang, Hezhong;Li, Jiahong research published 《 Micellar Catalysis: Visible-Light Mediated Imidazo[1,2-a]pyridine C-H Amination with N-Aminopyridinium Salt Accelerated by Surfactant in Water》, the research content is summarized as follows. A light-promoted metal-free protocol for the amination of imidazo[1,2-a]pyridines with N-aminopyridinium salt by the assistance of surfactants in water was reported, charactering mild and environmentally benign conditions, as well as great functional group tolerance. Micelles with neg. charged polar surface and hydrophobic core formed from sodium dodecyl sulfate serve as an ideal medium for visible-light mediated radical reaction of cationic pyridine salt and imidazo[1,2-a]pyridine in aqueous phase. The electrostatic interaction between pos. charged N-aminopyridinium and neg. charged surface of micelles was of great significance in this method.

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Application In Synthesis of 20099-89-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 1835-49-0, formula is C8F4N2, Name is Tetrafluoroterephthalonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Product Details of C8F4N2.

Ye, Chunchun;Wang, Anqi;Breakwell, Charlotte;Tan, Rui;Grazia Bezzu, C.;Hunter-Sellars, Elwin;Williams, Daryl R.;Brandon, Nigel P.;Klusener, Peter A. A.;Kucernak, Anthony R.;Jelfs, Kim E.;McKeown, Neil B.;Song, Qilei research published 《 Development of efficient aqueous organic redox flow batteries using ion-sieving sulfonated polymer membranes》, the research content is summarized as follows. Redox flow batteries using aqueous organic-based electrolytes are promising candidates for developing cost-effective grid-scale energy storage devices. However, a significant drawback of these batteries is the cross-mixing of active species through the membrane, which causes battery performance degradation To overcome this issue, here we report size-selective ion-exchange membranes prepared by sulfonation of a spirobifluorene-based microporous polymer and demonstrate their efficient ion sieving functions in flow batteries. The spirobifluorene unit allows control over the degree of sulfonation to optimize the transport of cations, while the microporous structure inhibits the crossover of organic mols. via mol. sieving. Furthermore, the enhanced membrane selectivity mitigates the crossover-induced capacity decay while maintaining good ionic conductivity for aqueous electrolyte solution at pH 9, where the redox-active organic mols. show long-term stability. We also prove the boosting effect of the membranes on the energy efficiency and peak power d. of the aqueous redox flow battery, which shows stable operation for about 120 h (i.e., 2100 charge-discharge cycles at 100 mA cm^-2) in a laboratory-scale cell.

Product Details of C8F4N2, Tetrafluoroterephthalonitrile can react with alkyl grignard reagents to form 4-alkyltetraflurorobenzonitriles. It acts as a four electron donor ligand. Tetrafluoroterephthalonitrile can be used to synthesize polymers of intrinsic microporosity. It has been used to study UV rearranged polymers of teh PIM-1 type membrane for the efficient separation of H2 and CO2.
Tetrafluoroterephthalonitrile reacts with alkyl Grignard reagents to form corresponding 4-alkyltetrafluorobenzonitriles. Tetrafluoroterephthalonitrile acts as a four-electron donor ligand and forms tungsten(II)η 2-nitrile complexes.
Tetrafluoroterephthalonitrile is a hydroxyl group-containing organic chemical compound . It has been used in analytical chemistry as a reagent for the determination of peptide binding constants and disulfide bonds. Tetrafluoroterephthalonitrile binds to nucleophilic sites on proteins, such as the pim-1 protein, and can be used to transport other molecules across cell membranes. In addition, it has been used to produce polymers for use in analytical chemistry. This chemical is also able to bind with magnetic particles under constant pressure conditions, which makes it useful for optical sensor applications. , 1835-49-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 1835-49-0, formula is C8F4N2, Name is Tetrafluoroterephthalonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Electric Literature of 1835-49-0.

Ye, Hanchen;Chen, Dongyun;Li, Najun;Xu, Qingfeng;Li, Hua;He, Jinghui;Lu, Jianmei research published 《 Polymer of intrinsic microporosity coated on a metal-organic framework composite membrane for highly efficient dye separation》, the research content is summarized as follows. The dyes contained in some industrial wastewater are very harmful pollutants. The application of nanofiltration membrane separation technol. for dye separation has been intensively studied. In this paper, a carbon nanotube film is applied as the substrate on which to grow a dense layer of UiO-66, and a kind of polymer of intrinsic microporosity is used to coat its surface. The resulting composite membrane material exhibits an excellent separation property for various dyes, and the separation efficiency can exceed 90%. In addition, the separation mechanism of this membrane is briefly discussed, which mainly relies on a sieving effect and an electrostatic effect to achieve efficient dye separation

Electric Literature of 1835-49-0, Tetrafluoroterephthalonitrile can react with alkyl grignard reagents to form 4-alkyltetraflurorobenzonitriles. It acts as a four electron donor ligand. Tetrafluoroterephthalonitrile can be used to synthesize polymers of intrinsic microporosity. It has been used to study UV rearranged polymers of teh PIM-1 type membrane for the efficient separation of H2 and CO2.
Tetrafluoroterephthalonitrile reacts with alkyl Grignard reagents to form corresponding 4-alkyltetrafluorobenzonitriles. Tetrafluoroterephthalonitrile acts as a four-electron donor ligand and forms tungsten(II)η 2-nitrile complexes.
Tetrafluoroterephthalonitrile is a hydroxyl group-containing organic chemical compound . It has been used in analytical chemistry as a reagent for the determination of peptide binding constants and disulfide bonds. Tetrafluoroterephthalonitrile binds to nucleophilic sites on proteins, such as the pim-1 protein, and can be used to transport other molecules across cell membranes. In addition, it has been used to produce polymers for use in analytical chemistry. This chemical is also able to bind with magnetic particles under constant pressure conditions, which makes it useful for optical sensor applications. , 1835-49-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Safety of 4-(2-Bromoacetyl)benzonitrile.

Yoon, Seok Hyun;Kim, Sung June;Kim, Ikyon research published 《 One-Pot Four-Component Coupling Approach to Polyheterocycles: 6H-Furo[3,2-f]pyrrolo[1,2-d][1,4]diazepine》, the research content is summarized as follows. A novel polyheterocyclic chem. space, 6H-furo[3,2-f]pyrrolo[1,2-d][1,4]diazepine, was generated by a one-pot four-component coupling reaction where multiple bonds (three C-C, one C-O, and one C-N) were formed through a domino sequence. Two heterocyclic rings (furan and diazepine) were sequentially constructed from the monocyclic pyrrole derivative under environment-friendly reaction conditions to furnish the tricyclic fused scaffold.

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Safety of 4-(2-Bromoacetyl)benzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile is any organic compound with a −C≡N functional group. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. Computed Properties of 20099-89-2.

Williams, Matthew B.;Boyer, Alistair research published 《 Modular Synthesis of Highly Substituted 3-Azapyrroles by Rh(II) Catalyzed N-H Bond Insertion and Cyclodehydration》, the research content is summarized as follows. A modular synthesis of highly substituted 3-azapyrroles, e.g., I has been developed using a three-step sequence comprising: copper catalyzed alkyne-azide cycloaddition (CuAAC), N-H bond insertion and cyclodehydration. The compound 1-sulfonyl-1,2,3-triazoles (1-STs), e.g., 4-tolyl-1-tosyl-triazole can be accessed from common alkynes, e.g., 4-ethynyltoluene and sulfonyl azides, e.g., 4-toluenesulfonyl azide building blocks by CuAAC using copper(I) thiophene-2-carboxylate. Rhodium(II) acetate promoted 1-ST denitrogenation results in highly electrophilic rhodium azavinyl carbenes that, here, underwent insertion into the N-H bond of secondary α-aminoketones, e.g., 1-(4-tolyl)-2-(4-tolylamino)ethan-1-one to form 1,2-aminoalkenes, e.g., 1-[(2-oxo-2-(4-tolyl)ethyl)(4-tolyl)amino]-1-(4-tolyl)-2-(tosylamino)ethene. These products were cyclized and dehydrated using BF₃OEt₂ into highly substituted 3-azapyrroles, e.g., I. The three steps: CuAAC, N-H bond insertion and cyclodehydration could be telescoped into a one-pot process. The method proved to be highly efficient and tolerated a wide range of substituents.

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Computed Properties of 20099-89-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts