Tag: M.W=200-250

Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. SDS of cas: 20099-89-2.

Sever, Belgin;Altintop, Mehlika Dilek;Ciftci, Gulsen Akalin;Ozdemir, Ahmet research published 《 A New Series of Triazolothiadiazines as Potential Anticancer Agents for Targeted Therapy of Non-Small Cell Lung and Colorectal Cancers: Design, Synthesis, In silico and In vitro Studies Providing Mechanistic Insight into Their Anticancer Potencies》, the research content is summarized as follows. Targeted therapies acting on specific mol. targets in cancer cells with better curative efficacy and lower toxicity have come into prominence for the management of nonsmall cell lung cancer (NSCLC) and colorectal cancer (CRC). COX-2 stands out as a plausible target for anticancer agents due to its pivotal role in tumor initiation, progression and invasion. Due to the importance of triazolothiadiazine scaffold in targeted anticancer drug discovery, the aim of this work is the design of new triazolothiadiazines as potential anticancer agents for the targeted therapy of NSCLC and CRC. New triazolo[3,4-b]-1,3,4-thiadiazines (2a-g) were synthesized via the ring closure reactions of 2-bromo-1-arylethanones with 4-amino-5-((5-methoxy-2-methyl-1H-indol-3-yl)methyl)-2,4- dihydro-3H-1,2,4-triazole-3-thione (1), which was obtained via the solvent-free reaction of 5- methoxy-2-methyl-3-indoleacetic acid with thiocarbohydrazide. MTT assay was performed to determine their cytotoxic effects on A549 human lung adenocarcinoma, Caco-2 human colorectal adenocarcinoma and CCD-19Lu human lung fibroblast cells. The most potent compounds were evaluated for their effects on apoptosis, caspase-3, mitochondrial membrane potential, cell cycle, ultrastructural morphol. changes and COX-2 in A549 and Caco-2 cells. In silico docking and Absorption, Distribution, Metabolism and Excretion (ADME) studies were also performed using Schrodinger′s Maestro mol. modeling package. 6-(4-Chlorophenyl)-3-[(5-methoxy-2-methyl-1H-indol-3-yl)methyl]-7H-[1,2,4]triazolo[3,4- b][1,3,4]thiadiazine (2e) was the most potent and selective anticancer agent in this series against A549 and Caco-2 cell lines. Compound 2e induced early apoptosis, caused mitochondrial membrane depolarization and arrested cell cycle at G₀/G₁ phase in A549 cells. On the other hand, compound 2e triggered intrinsic apoptotic pathway involving caspase-3 activation in Caco-2 cells. Compound 2e caused apoptotic morphol. changes in both cancer cell lines. The cytotoxic and apoptotic effects of this compound on CRC were found to be related to its selective COX-2 inhibitory activity. According to mol. docking studies, compound 2e showed good affinity to the active site of COX-2 (PDB code: 4COX). Based on in silico ADME studies, the compound is predicted to possess a favorable ADME profile. According to in vitro and in silico studies, compound 2e was identified as a potential orally bioavailable anticancer agent for COX-2-targeted therapy of CRC.

SDS of cas: 20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Reference of 20099-89-2.

Shang, Xiao;Liu, Xuan;Sun, Yujie research published 《 Flexible on-site halogenation paired with hydrogenation using halide electrolysis》, the research content is summarized as follows. Direct electrochem. halogenation has appeared as an appealing approach in synthesizing organic halides in which inexpensive inorganic halide sources are employed and elec. power is the sole driving force. However, the intrinsic characteristics of direct electrochem. halogenation limit its reaction scope. Herein, we report an on-site halogenation strategy utilizing halogen gas produced from halide electrolysis while the halogenation reaction takes place in a reactor spatially isolated from the electrochem. cell. Such a flexible approach is able to successfully halogenate substrates bearing oxidatively labile functionalities, which are challenging for direct electrochem. halogenation. In addition, low-polar organic solvents, redox-active metal catalysts, and variable temperature conditions, inconvenient for direct electrochem. reactions, could be readily employed for our on-site halogenation. Hence, a wide range of substrates including arenes, heteroarenes, alkenes, alkynes, and ketones all exhibit excellent halogenation yields. Moreover, the simultaneously generated H₂ at the cathode during halide electrolysis can also be utilized for on-site hydrogenation. Such a strategy of paired halogenation/hydrogenation maximizes the atom economy and energy efficiency of halide electrolysis. Taking advantage of the on-site production of halogen and H₂ gases using portable halide electrolysis but not being suffered from electrolyte separation and restricted reaction conditions, our approach of flexible halogenation coupled with hydrogenation enables green and scalable synthesis of organic halides and value-added products.

Reference of 20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Synthetic Route of 20099-89-2.

Shelke, Sushil V.;Dhumal, Sambhaji T.;Karale, Akshay Y.;Deshmukh, Tejshri R.;Patil, Meghshyam K. research published 《 A facile synthesis of quinoxalines by using SO₄^2-/ZrO₂-TiO₂ as an efficient and recyclable heterogeneous catalyst》, the research content is summarized as follows. Quinoxaline derivatives have been synthesized in good to excellent yields by the cyclocondensation reaction of o-pheneylenediamine with substituted phenacyl bromides/benzil in the presence of SO₄^2-/ZrO₂-TiO₂ as an efficient and heterogeneous catalyst. The catalyst can be recovered up to five catalytic cycles without significant loss in catalytic activity. The reported SO₄^2-/ZrO₂-TiO₂ catalyst has been thoroughly characterized by using IR spectroscopy, differential scanning calorimetry (DSC), thermogravimetric anal. (TGA), and powder X-ray diffraction (XRD). Here, we have used ethanol as a green solvent in this cyclocondensation. This new method has several advantages, such as excellent yields, short reaction time, nontoxic, and easily recoverable cyclocondensation catalyst.

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Synthetic Route of 20099-89-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 1835-49-0, formula is C8F4N2, Name is Tetrafluoroterephthalonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Computed Properties of 1835-49-0.

Shin, Dong Jin;Hwang, Soon Jae;Lim, Junseop;Jeon, Chae Yeon;Lee, Jun Yeob;Kwon, Jang Hyuk research published 《 Reverse intersystem crossing accelerating assistant dopant for high efficiency and long lifetime in red hyperfluorescence organic light-emitting diodes》, the research content is summarized as follows. A highly efficient deep-red hyper fluorescence device achieving long device lifetime was fabricated by adopting a newly designed 2,5-bis(12H-benzo[4,5]thieno[2,3-a]carbazole-12-yl)-3,6-di(9H-carbazol-9-yl)terephthalonitrile (12BTCzTPN) thermally activated delayed fluorescence (TADF) assistant dopant. The 12BTCzTPN was designed via donor modification of 2,3,5,6-tetra(9H-carbazol-9-yl)terephthalonitrile (4CzTPN) to increase reverse intersystem crossing (RISC) rate for fast up-conversion. The carbazole donor moiety was replaced with 12H-benzo[4,5]thieno[2,3-a]carbazole (12BTCz) donor, which induced a small singlet-triplet energy gap and large spin-orbit coupling via the heavy atom effect of sulfur, resulting in 4.5-times faster RISC rate than the 4CzTPN TADF mol. The addition of 12BTCzTPN as an assistant dopant to a deep-red hyper fluorescence device resulted in a device with a high external quantum efficiency of 19.9% and a long device lifetime of 1312 h at 3000 cd/m2, which is up to 90% of the initial luminance.

Computed Properties of 1835-49-0, Tetrafluoroterephthalonitrile can react with alkyl grignard reagents to form 4-alkyltetraflurorobenzonitriles. It acts as a four electron donor ligand. Tetrafluoroterephthalonitrile can be used to synthesize polymers of intrinsic microporosity. It has been used to study UV rearranged polymers of teh PIM-1 type membrane for the efficient separation of H2 and CO2.
Tetrafluoroterephthalonitrile reacts with alkyl Grignard reagents to form corresponding 4-alkyltetrafluorobenzonitriles. Tetrafluoroterephthalonitrile acts as a four-electron donor ligand and forms tungsten(II)η 2-nitrile complexes.
Tetrafluoroterephthalonitrile is a hydroxyl group-containing organic chemical compound . It has been used in analytical chemistry as a reagent for the determination of peptide binding constants and disulfide bonds. Tetrafluoroterephthalonitrile binds to nucleophilic sites on proteins, such as the pim-1 protein, and can be used to transport other molecules across cell membranes. In addition, it has been used to produce polymers for use in analytical chemistry. This chemical is also able to bind with magnetic particles under constant pressure conditions, which makes it useful for optical sensor applications. , 1835-49-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile is any organic compound with a −C≡N functional group. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. Name: 4-(2-Bromoacetyl)benzonitrile.

Shin, Young Sup;Lee, Jun Young;Noh, Soojin;Kwak, Yoonna;Jeon, Sangeun;Kwon, Sunoh;Jin, Young-hee;Jang, Min Seong;Kim, Seungtaek;Song, Jong Hwan;Kim, Hyoung Rae;Park, Chul Min research published 《 Discovery of cyclic sulfonamide derivatives as potent inhibitors of SARS-CoV-2》, the research content is summarized as follows. Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) continues to spread worldwide, with 25 million confirmed cases and 800 thousand deaths. Effective treatments to target SARS-CoV-2 are urgently needed. In the present study, we have identified a class of cyclic sulfonamide derivatives as novel SARS-CoV-2 inhibitors. Compound 13c of the synthesized compounds exhibited robust inhibitory activity (IC₅₀ = 0.88μM) against SARS-CoV-2 without cytotoxicity (CC₅₀ > 25μM), with a selectivity index (SI) of 30.7. In addition, compound 13c exhibited high oral bioavailability (77%) and metabolic stability with good safety profiles in hERG and cytotoxicity studies. The present study identified that cyclic sulfonamide derivatives are a promising new template for the development of anti-SARS-CoV-2 agents.

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Name: 4-(2-Bromoacetyl)benzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile is any organic compound with a −C≡N functional group. 1835-49-0, formula is C8F4N2, Name is Tetrafluoroterephthalonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. Recommanded Product: Tetrafluoroterephthalonitrile.

Sizov, Victor E.;Zefirov, Vadim V.;Volkova, Yulia A.;Gusak, Danil I.;Kharitonova, Elena P.;Ponomarev, Igor I.;Gallyamov, Marat O. research published 《 Celgard/ PIM -1 proton conducting composite membrane with reduced vanadium permeability》, the research content is summarized as follows. Renewable energy systems need efficient and cheap storage devices and vanadium redox flow batteries (VRB) may become one of them. However, better performance of VRB membranes yet should be achieved. Novel composite Celgard-based films coated with PIM-1 for aqueous electrolyte VRB applications are presented. Two types of the composites with different PIM-1 loadings are obtained. Their properties are studied and compared with the original Celgard films. The deposited PIM-1 forms a smooth layer on the outer Celgard surface and penetrates inside the porous matrix, thus significantly reducing the pores diameter and affecting the transport properties of the composite film. The nanoporous structure of PIM-1 permits size-screening of H₃O⁺/hydrated vanadium ions when used in aqueous vanadium redox flow batteries applications, which allows to tailor the membrane permeability for the two types of ions and, therefore, to increase its selectivity from 4.3 x 10⁶ to 1.3 x 10⁷ mS min cm^-3, while maintaining high proton conductivity

Recommanded Product: Tetrafluoroterephthalonitrile, Tetrafluoroterephthalonitrile can react with alkyl grignard reagents to form 4-alkyltetraflurorobenzonitriles. It acts as a four electron donor ligand. Tetrafluoroterephthalonitrile can be used to synthesize polymers of intrinsic microporosity. It has been used to study UV rearranged polymers of teh PIM-1 type membrane for the efficient separation of H2 and CO2.
Tetrafluoroterephthalonitrile reacts with alkyl Grignard reagents to form corresponding 4-alkyltetrafluorobenzonitriles. Tetrafluoroterephthalonitrile acts as a four-electron donor ligand and forms tungsten(II)η 2-nitrile complexes.
Tetrafluoroterephthalonitrile is a hydroxyl group-containing organic chemical compound . It has been used in analytical chemistry as a reagent for the determination of peptide binding constants and disulfide bonds. Tetrafluoroterephthalonitrile binds to nucleophilic sites on proteins, such as the pim-1 protein, and can be used to transport other molecules across cell membranes. In addition, it has been used to produce polymers for use in analytical chemistry. This chemical is also able to bind with magnetic particles under constant pressure conditions, which makes it useful for optical sensor applications. , 1835-49-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 1835-49-0, formula is C8F4N2, Name is Tetrafluoroterephthalonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Recommanded Product: Tetrafluoroterephthalonitrile.

Ricci, Eleonora;Benedetti, Francesco M.;Noto, Antonella;Merkel, Timothy C.;Jin, Jianyong;De Angelis, Maria Grazia research published 《 Enabling experimental characterization and prediction of ternary mixed-gas sorption in polymers: C₂H₆/CO₂/CH₄ in PIM-1》, the research content is summarized as follows. In this work, a new exptl. protocol was designed to measure sorption of ternary gas mixtures in polymer membranes for the first time. We measured the sorption isotherms of binary and ternary mixtures of C₂H₆, CO₂, and CH₄ in PIM-1, using a pressure decay apparatus, working at constant composition and variable pressure of the gas phase. The results show competitive sorption effects in all gas mixtures analyzed, affecting each species in proportion to the total sorbed concentration of the other components. It was found that the presence of C₂H₆ in the mixture reduces the sorption of both CH₄ and CO₂ to a similar extent, so that the CO₂/CH₄ solubility-selectivity is not markedly affected. The exptl. data were used to validate predictions of the Non-Equilibrium Lattice Fluid (NELF) model of binary and ternary sorption isotherms. The NELF model is generally in close agreement, both in the prediction of pressure and mixture composition effects, proving to be a reliable tool to assess mixed-gas sorption, even in complex scenarios.

1835-49-0, Tetrafluoroterephthalonitrile can react with alkyl grignard reagents to form 4-alkyltetraflurorobenzonitriles. It acts as a four electron donor ligand. Tetrafluoroterephthalonitrile can be used to synthesize polymers of intrinsic microporosity. It has been used to study UV rearranged polymers of teh PIM-1 type membrane for the efficient separation of H2 and CO2.
Tetrafluoroterephthalonitrile reacts with alkyl Grignard reagents to form corresponding 4-alkyltetrafluorobenzonitriles. Tetrafluoroterephthalonitrile acts as a four-electron donor ligand and forms tungsten(II)η 2-nitrile complexes.
Tetrafluoroterephthalonitrile is a hydroxyl group-containing organic chemical compound . It has been used in analytical chemistry as a reagent for the determination of peptide binding constants and disulfide bonds. Tetrafluoroterephthalonitrile binds to nucleophilic sites on proteins, such as the pim-1 protein, and can be used to transport other molecules across cell membranes. In addition, it has been used to produce polymers for use in analytical chemistry. This chemical is also able to bind with magnetic particles under constant pressure conditions, which makes it useful for optical sensor applications. , Recommanded Product: Tetrafluoroterephthalonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.1835-49-0, formula is C8F4N2, Name is Tetrafluoroterephthalonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Related Products of 1835-49-0.

Rochat, Sebastien;Tian, Mi;Atri, Ria;Mays, Timothy J.;Burrows, Andrew D. research published 《 Enhancement of gas storage and separation properties of microporous polymers by simple chemical modifications》, the research content is summarized as follows. Owing to their large surface area and good solvent processability, polymers of intrinsic microporosity (PIMs) have been widely investigated for gas storage and separation processes. In this article, we show how chem. modifying the polymers can fine-tune their properties for specific, targeted applications. We find that converting the archetypal microporous polymer PIM-1 into a polycarboxylate salt enhances its separation capabilities for H₂/CO₂ mixtures (relevant to hydrogen production), whereas appending multiple amine groups significantly improves gas separation properties for N₂/CO₂ mixtures (relevant to flue gas treatment). Adsorption-based separation processes have received less attention than size-sieving processes in porous polymeric materials, however they could provide a suitable alternative technol. to energy-intensive separation processes such as cryogenic distillation We also report the hydrogen storage properties of the modified polymers, which we find to depend on the chem. modification carried out. By coupling the simplicity of the proposed chem. modifications with the scalability and porous properties of PIMs, we provide a blueprint to create new multifunctional materials with adapted properties for targeted applications.

1835-49-0, Tetrafluoroterephthalonitrile can react with alkyl grignard reagents to form 4-alkyltetraflurorobenzonitriles. It acts as a four electron donor ligand. Tetrafluoroterephthalonitrile can be used to synthesize polymers of intrinsic microporosity. It has been used to study UV rearranged polymers of teh PIM-1 type membrane for the efficient separation of H2 and CO2.
Tetrafluoroterephthalonitrile reacts with alkyl Grignard reagents to form corresponding 4-alkyltetrafluorobenzonitriles. Tetrafluoroterephthalonitrile acts as a four-electron donor ligand and forms tungsten(II)η 2-nitrile complexes.
Tetrafluoroterephthalonitrile is a hydroxyl group-containing organic chemical compound . It has been used in analytical chemistry as a reagent for the determination of peptide binding constants and disulfide bonds. Tetrafluoroterephthalonitrile binds to nucleophilic sites on proteins, such as the pim-1 protein, and can be used to transport other molecules across cell membranes. In addition, it has been used to produce polymers for use in analytical chemistry. This chemical is also able to bind with magnetic particles under constant pressure conditions, which makes it useful for optical sensor applications. , Related Products of 1835-49-0

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 1835-49-0, formula is C8F4N2, Name is Tetrafluoroterephthalonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Recommanded Product: Tetrafluoroterephthalonitrile.

Rong, Siyi;Su, Pengcheng;Chen, Shizheng;Jia, Miaomiao;Li, Wanbin research published 《 Sub-5 nm porous polymer decoration toward superhydrophobic MOFs with enhanced stability and processability》, the research content is summarized as follows. Metal-organic frameworks (MOFs) show great potential for various applications, but many of them suffer from the drawbacks of hydrolysis propensity and poor processability. Herein, we employ polymers of intrinsic microporosity (PIMs) with hydrophobic pores to decorate MOFs toward substantially improved water stability and shapeability. Through simple PIM-1 decoration, the sub-5 nm polymer layers can be uniformly deposited on MOF surfaces with almost no deterioration in porosity. Owing to the existence of superhydrophobic coating and the obstruction of water entrance into MOFs, the PIM-1 coated CuBTC exhibits impressive water resistance and excellent pore preservation ability after exposure in water, even in acidic and alk. solutions Moreover, polymer decoration improves the processability of MOFs, while various MOF/PIM-1 bulk wafers and oil-water separators can be obtained straightforwardly.

1835-49-0, Tetrafluoroterephthalonitrile can react with alkyl grignard reagents to form 4-alkyltetraflurorobenzonitriles. It acts as a four electron donor ligand. Tetrafluoroterephthalonitrile can be used to synthesize polymers of intrinsic microporosity. It has been used to study UV rearranged polymers of teh PIM-1 type membrane for the efficient separation of H2 and CO2.
Tetrafluoroterephthalonitrile reacts with alkyl Grignard reagents to form corresponding 4-alkyltetrafluorobenzonitriles. Tetrafluoroterephthalonitrile acts as a four-electron donor ligand and forms tungsten(II)η 2-nitrile complexes.
Tetrafluoroterephthalonitrile is a hydroxyl group-containing organic chemical compound . It has been used in analytical chemistry as a reagent for the determination of peptide binding constants and disulfide bonds. Tetrafluoroterephthalonitrile binds to nucleophilic sites on proteins, such as the pim-1 protein, and can be used to transport other molecules across cell membranes. In addition, it has been used to produce polymers for use in analytical chemistry. This chemical is also able to bind with magnetic particles under constant pressure conditions, which makes it useful for optical sensor applications. , Recommanded Product: Tetrafluoroterephthalonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.1835-49-0, formula is C8F4N2, Name is Tetrafluoroterephthalonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Related Products of 1835-49-0.

Saadatkish, Niloufar;Karimi-Sabet, Javad;Sharif, Alireza research published 《 A molecular dynamics simulation study on the solubilities of monomers of a PIM-1 polymer in supercritical carbon dioxide》, the research content is summarized as follows. The absolute solubilities of tetrahydroxy-3,3,3′,3′-tetramethyl-1,1′-spirobisindane (TTSBI) and tetrafluoroterephthalonitrile (TFTPN), the monomers of a polymer of intrinsic microporosity-1 (PIM-1), in supercritical carbon dioxide (SCCO₂), are studied by mol. dynamics (MD) simulation method. Solvation free energies of the monomers in SCCO₂ are simulated at different temperatures and pressures by the thermodn. integration method. Furthermore, a new procedure is proposed to calculate the external pressure dependency of the monomers vapor pressures by MD simulation. These two quantities are used to estimate the absolute solubility of each monomer in SCCO₂ medium. TFTPN showed higher solubility (than TTSBI) which was ascribed to its CO₂-philic structure and low vapor pressure. Exptl. measured solubilities are in good agreement with the simulated ones confirming the accuracy of the proposed method for the calculation of vapor pressures. Finally, SCCO₂ medium is suggested as a suitable medium for synthesis of PIM-1 polymer provided that small amounts of a cosolvent are used or high external pressures (greater than 30 MPa) are applied.

Related Products of 1835-49-0, Tetrafluoroterephthalonitrile can react with alkyl grignard reagents to form 4-alkyltetraflurorobenzonitriles. It acts as a four electron donor ligand. Tetrafluoroterephthalonitrile can be used to synthesize polymers of intrinsic microporosity. It has been used to study UV rearranged polymers of teh PIM-1 type membrane for the efficient separation of H2 and CO2.
Tetrafluoroterephthalonitrile reacts with alkyl Grignard reagents to form corresponding 4-alkyltetrafluorobenzonitriles. Tetrafluoroterephthalonitrile acts as a four-electron donor ligand and forms tungsten(II)η 2-nitrile complexes.
Tetrafluoroterephthalonitrile is a hydroxyl group-containing organic chemical compound . It has been used in analytical chemistry as a reagent for the determination of peptide binding constants and disulfide bonds. Tetrafluoroterephthalonitrile binds to nucleophilic sites on proteins, such as the pim-1 protein, and can be used to transport other molecules across cell membranes. In addition, it has been used to produce polymers for use in analytical chemistry. This chemical is also able to bind with magnetic particles under constant pressure conditions, which makes it useful for optical sensor applications. , 1835-49-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts