Tag: M.W=200-250

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Product Details of C9H6BrNO.

Reddy Singam, Maneesh Kumar;Suri Babu, Undamatla;Suresh, Vavilapalli;Nanubolu, Jagadeesh Babu;Sridhar Reddy, Maddi research published 《 Rhodium-Catalyzed Annulation of Phenacyl Ammonium Salts with Propargylic Alcohols via a Sequential Dual C-H and a C-C Bond Activation: Modular Entry to Diverse Isochromenones》, the research content is summarized as follows. Given their omnipresence in natural products and pharmaceuticals, isochromenone congeners are one of the most privileged scaffolds to synthetic chemists. Disclosed herein is a dual (ortho/meta) C-H and C-C activation of phenacyl ammonium salts (acylammonium as traceless directing group) for annulation with propargylic alcs. to accomplish rapid access to novel isochromenones by means of rhodium catalysis from readily available starting materials. This operationally simple protocol features broad substrate scope and wide functional group tolerance. Importantly, the protocol circumvents the need for any stoichiometric metal oxidants and proceeds under aerobic conditions.

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Product Details of C9H6BrNO

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile is any organic compound with a −C≡N functional group. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. Recommanded Product: 4-(2-Bromoacetyl)benzonitrile.

Nemeth, Andras Gy.;Marlok, Bence;Domjan, Attila;Gao, Qinghe;Han, Xinya;Keseru, Gyorgy M.;Abranyi-Balogh, Peter research published 《 Convenient Multicomponent One-Pot Synthesis of 2-Iminothiazolines and 2-Aminothiazoles Using Elemental Sulfur Under Aqueous Conditions》, the research content is summarized as follows. Herein, we present a novel one-pot aqueous reaction for the synthesis of 2-iminothiazolines and 2-aminothiazoles using isocyanides, amines, sulfur, and 2′-bromoacetophenones. The three-component preparation of thioureas is followed by the one-pot cyclization leading to the heterocyclic product. This efficient and mild procedure features excellent step- and atom-economy and enables the chromatog.-free preparation of diversely substituted 2-iminothiazoline and 2-aminothiazole derivatives

Recommanded Product: 4-(2-Bromoacetyl)benzonitrile, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. Electric Literature of 20099-89-2.

Oliveira, Nereu Junio Candido;Teixeira, Iasmin Natalia Santos;Fernandes, Philipe Oliveira;Verissimo, Gabriel Correa;Valerio, Aline Dias;Moreira, Carolina Paula de Souza;Freitas, Tulio Resende;Fonseca, Anna Clara Ventura;Sabino, Adriano de Paula;Johann, Susana;Maltarollo, Vinicius Goncalves;de Oliveira, Renata Barbosa research published 《 Computer-aided molecular design, synthesis and evaluation of antifungal activity of heterocyclic compounds》, the research content is summarized as follows. In this perspective, heterocyclic compounds namely thiazolylhydrazones I [R¹ = H, Me, F, Cl, CN; R² = CHt-Bu, CMe(CH₂)₂OH, etc.], furans II [R¹ = Cl, NO₂], tetrazoles III [R¹ = Me, NO₂; R² = CH₂CH₂OH, cyclohexyl, (CH₂)₃CH₂OH, (CH₂)₅CH₂OH], triazole IV [R¹ = (CH₂)₃CH₂OH, (CH₂)₅CH₂OH] and thiadiazoline derivatives were synthesized and tested in vitro against seven clin. importance Cryptococcus and Candida species. In this study, virtual screening techniques were applied using a scaffold-hopping database, FDA approved drugs and a ZINC subset. Some of the compounds evaluated showed promising antifungal activity against C. albicans, C. glabrata, C. krusei, C. parapsilosis, C. tropicalis, C. neoformans and C. gatti, displaying minimal inhibitory concentration (MIC) values in the range of 0.12-250μM.

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Electric Literature of 20099-89-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Recommanded Product: 4-(2-Bromoacetyl)benzonitrile.

Osmaniye, Derya;Gorgulu, Sennur;Saglik, Begum Nurpelin;Levent, Serkan;Ozkay, Yusuf;Kaplancikli, Zafer Asim research published 《 Design, synthesis, in vitro and in silico studies of some novel thiazole-dihydrofuran derivatives as aromatase inhibitors》, the research content is summarized as follows. Aromatase inhibitors used against hormone-dependent breast cancer, especially in post-menopausal women, are very susceptible to the development of resistance due to their limited number and long-term use. In this study, it is aimed to obtain new aromatase inhibitors including thiazole and dihydrofuran ring systems. Synthesis of compounds (2a-2l) were performed according to literature methods. Their structures were elucidated by 1H NMR, 13C NMR and APCI-MS spectroscopic methods. MTT test was carried out to assess the cell proliferation effects of the different compounds on two different pulmonary cell lines (A549, CCD-19Lu) and mammary cell line (MCF7). According to MTT assay, it was observed that the calculated IC50 values of some compounds for the CCD-19Lu cell line were found higher than for the A549 and MCF7 cell lines. Considering the viability results, it was found that the selected compounds (2a, 2c, 2e, 2g, 2h, 2l) showed favorable safety profile and have anticancer activities. Apoptotic activities of the selected compounds were investigated by flow cytometry anal. And were found that have apoptotic effects on cancerous cell lines. In the light of this information, the aromatase inhibition potentials of 2g and 2l compounds, which are the most active derivatives, were examined in vitro and it was determined that they showed a similar inhibition profile with letrazole. Interaction modes between aromatase enzyme and compounds 2g and 2l were investigated by docking studies. In conclusion, findings of these study indicate that compounds 2g and 2l possess significant anticancer activity.

Recommanded Product: 4-(2-Bromoacetyl)benzonitrile, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. Quality Control of 20099-89-2.

Osmaniye, Derya;Karaca, Sevval;Kurban, Berkant;Baysal, Merve;Ahmad, Iqrar;Patel, Harun;Ozkay, Yusuf;Asim Kaplancikli, Zafer research published 《 Design, synthesis, molecular docking and molecular dynamics studies of novel triazolothiadiazine derivatives containing furan or thiophene rings as anticancer agents》, the research content is summarized as follows. In this study, new triazolothiadiazine derivatives I [X = O, S; R = H, Me, MeO, Cl; R¹ = H, Cl; R² = H, Me, MeO, etc.] were synthesized and their anticancer activities were investigated. Compounds I [X = O, R = R² = Cl, R¹ = H; X = S, R = H, Cl, R¹ = H, R² = Cl] showed inhibitor activity against MCF-7 cell line with IC₅₀ = 4.63 ± 0.10; 2.23 ± 0.16; 3.13 ± 0.08μM value, resp. As a result of in-vitro aromatase enzyme inhibition test, compound I [X = S, R = R¹ = H, R² = Cl] was the most active derivative with IC₅₀ = 0.058 ± 0.023μM. In addition, DNA synthesis inhibition percentages of the compounds I were measured by the BrdU method. The intermol. interactions of the promising compounds I with aromatase enzyme were investigated through the SP docking approach, which revealed significant binding interaction energies associated with these compounds Following that, the interaction’s stability was assessed using a typical atomistic 100 ns dynamic simulation study. A number of parameters derived from MD simulation trajectories were computed and validated for the protein-ligand complex’s stability under the dynamic conditions.

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Quality Control of 20099-89-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile is any organic compound with a −C≡N functional group. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. Category: nitriles-buliding-blocks.

Osmaniye, Derya;Gorguelue, Sennur;Saglik, Beguem Nurpelin;Levent, Serkan;Ozkay, Yusuf;Kaplancikli, Zafer Asim research published 《 Synthesis and biological evaluation of novel 1,3,4-oxadiazole derivatives as anticancer agents and potential EGFR inhibitors》, the research content is summarized as follows. Herein, novel quinoxalin-oxadiazole derivatives I (R¹ = H, F, Cl; R² = H, CH₃, CN, etc.) were synthesized as EGFR inhibitors in this study. Synthesis of compounds I was performed according to the literature methods. Structure elucidation was performed for compound I (R¹ = H; R² = NO₂) using 2D NMR technique. MTT test was performed to assess the cell proliferation effects of the different compounds on lung and mammary cell lines (A549, MCF7). In addition, obtained compounds I were screened against healthy CCD19-Lu cell line (human lung fibroblast normal cells) to determine selectivity of the cytotoxic activities. Among the tested compounds, I (R¹ = H; R² = NO₂) and I (R¹ = Cl; R² = Cl) showed significant cytotoxic activity against A549 cancer cell. Moreover, compound I (R¹ = H; R² = Cl) and I (R¹ = H; R² = Br) displayed good activity. And the compounds I (R¹ = H; R² = NO₂) and I (R¹ = Cl; R² = Cl) performed significant EGFR inhibition. Interaction modes of the compounds I (R¹ = H; R² = NO₂), I (R¹ = Cl; R² = Cl) were investigated against EGFR tyrosine kinase by means of docking studies. As a result of the studies, the importance of the quinoxaline ring and the NO₂ substituent has been understood. The activity can be contributed by using other heterocyclic rings instead of the oxadizaole ring.

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. Safety of 4-(2-Bromoacetyl)benzonitrile.

Osmaniye, Derya;Alasan, Ramazan;Saglik, Begum Nurpelin;Levent, Serkan;Ozkay, Yusuf;Kaplancikli, Zafer Asim research published 《 Novel thiazolyl-hydrazone derivatives including piperazine ring: synthesis, in vitro evaluation, and molecular docking as selective MAO-A inhibitor》, the research content is summarized as follows. MAO-A inhibitors are used in the treatment of depression. There are many studies showing that the thiazolyl-hydrazone structure is a pharmacophore structure for the MAO enzyme. In previous studies by our team, activity studies were carried out with thiazolyl-hydrazone derivatives containing pyrrolidine, morpholine, and piperazine. All of them were displayed MAO-A selective inhibition profile. Addnl., derivatives containing piperazine ring were most active. For this purpose, thiazolyl-hydrazone derivatives containing piperazine were synthesized, but this time an active group, formyl group, was added to the piperazine ring as a substituent. Based on this view, new thiazolyl-hydrazone compounds were synthesized, characterized, and screened for their hMAO-A and hMAO-B inhibitory activity by an in vitro fluorometric method. The structure of the compound was tried to be fully elucidated using 2D NMR technique. The compound including 2,4-di-Me substituent (3i) were found to be the most effective agents in the series against MAO-A enzyme with the IC50 value of 0.080 ± 0.003 μM. The docking study of compound 3i revealed that there is a strong interaction between the active sites of hMAO-A and analyzed compound

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Safety of 4-(2-Bromoacetyl)benzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Synthetic Route of 20099-89-2.

Palabindela, Rambabu;Guda, Ramu;Ramesh, Gondru;Myadaraveni, Prabhakar;Banothu, Devendar;Ravi, Gangalla;Korra, Rajashekar;Mekala, Himabindu;Kasula, Mamatha research published 《 Novel tryptanthrin hybrids bearing aminothiazoles as potential EGFR inhibitors: design, synthesis, biological screening, molecular docking studies, and ADME/T predictions》, the research content is summarized as follows. A variety of novel tryptanthrin aminothiazole analogs I (R = Ph, 4-NCC₆H₄, 4-HOC₆H₄, etc.) and II possessing a biol. active thiazole moiety were synthesized by the reaction of tryptanthrin thiosemicarbazones with different α-bromo-4-substituted-acetophenones compounds All the novel synthesized compounds were investigated for their in vitro anticancer activity against three human cancer cell lines (MCF-7, A549, and HeLa) by taking cisplatin as a reference drug. The compounds I (R = 4-NCC₆H₄, 4-MeOC₆H₄) displayed excellent anticancer activities against the growth of three human cancer cell lines. EGFR targeting mol. docking investigation revealed that tryptanthrin aminothiazole analogs had better binding energies compared with EGFR inhibitors (Gefitinib, Erlotinib, and Lapatinib). The mol. docking findings back up the exptl. anticancer activity results very well. The compounds were also tested for their antibacterial and antioxidant activities. In silico ADME/T predictions had been performed that these tryptanthrin aminothiazole analogs have a good pharmacokinetic profile.

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Synthetic Route of 20099-89-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Name: 4-(2-Bromoacetyl)benzonitrile.

Pandey, Rajat;Singh, Gurdeep;Gour, Vinod;Anand, Ramasamy Vijaya research published 《 Base-mediated sequential one-pot approach for the synthesis of 2,3-disubstituted indoles from 2-(tosylamino)aryl-substituted para-quinone methides》, the research content is summarized as follows. A one-pot approach had been developed for the synthesis of 2,3-disubstituted indoles I [R¹ = H, 4-SMe, Ph, etc.; R = H, 6-Cl, 7-Me] through a base-mediated N-alkylation of 2-(tosylamino)aryl-substitued para-quinone methides with halomethylaryl ketones followed by intramol. cyclization and tosyl group elimination sequence. This one-pot protocol provided direct access to a wide range of 2,3-disubstituted indoles I in moderate to good yields under mild conditions.

Name: 4-(2-Bromoacetyl)benzonitrile, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Category: nitriles-buliding-blocks.

Melnichenko, V. E.;Kudryavtseva, T. N.;Grekhneva, E. V.;Lamanov, A. Y.;Kudryavcev, T. A. research published 《 Synthesis of New 2-(6H-Indolo[2,3-b]quinoxalin-6-yl)-1-phenylethan-1-ones》, the research content is summarized as follows. A series of new 2-(6H-indolo[2,3-b]quinoxalin-6-yl)-1-phenylethan-1-ones I (R¹ = H, F, OMe, Cl, Br; R² = H, OMe, CN, NO₂) was synthesized by the reaction of various 6H-indolo[2,3-b]quinoxalines II (R¹ = H, F, OMe, Cl, Br) with 4-substituted 2-bromophenylethan-1-ones in a DMSO-K₂CO₃ system.

Category: nitriles-buliding-blocks, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts