Tag: M.W=200-250

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 1835-49-0, formula is C8F4N2, Name is Tetrafluoroterephthalonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Computed Properties of 1835-49-0.

Meng, Qi;Feng, Qingxia;Cui, Liwen;Li, Fei;Cheng, Yixiang;Li, Yunzhi;Wang, Yuxiang research published 《 Chiral binaphthylamine based emitters with donor-acceptor structures: Facile synthesis and circularly polarized luminescence》, the research content is summarized as follows. Materials capable of circularly polarized luminescence (CPL) have generated intensive interest for their potential applications. However, constructing chiral mols. with tunable CPL signals remains a challenge. In this paper, two pairs of binaphthylamine based chiral donors R/S-2 and R/S-3 were synthesized by Pd-catalyzed C-N coupling and intramol. oxidative coupling with good yields. Then three pairs of chiral D-A type mols. R/S-4∼6 can be synthesized by introducing two kinds of achiral acceptors. The extention of the chiral binaphthy skeleton endows these chiral compounds with CPL signals ranged from 417 nm to 544 nm in solutions and film states. The g_lum can be up to -2.9 × 10^-3 for R-2 in solution The introduction of terephthalonitrile as acceptor endow R/S-4 thermally activated delayed fluorescence (TADF). Furthermore, when benzophenone is chosen as achiral acceptor, the obtained chiral D-A mols. R/S-5 and R/S-6 can exhibit reversed CPL signals compared with their corresponding chiral donors. This work demonstrates the introduction of chiral D-A structure not only alters the wavelength of the CPL signals but also can reverse the CPL sign.

1835-49-0, Tetrafluoroterephthalonitrile can react with alkyl grignard reagents to form 4-alkyltetraflurorobenzonitriles. It acts as a four electron donor ligand. Tetrafluoroterephthalonitrile can be used to synthesize polymers of intrinsic microporosity. It has been used to study UV rearranged polymers of teh PIM-1 type membrane for the efficient separation of H2 and CO2.
Tetrafluoroterephthalonitrile reacts with alkyl Grignard reagents to form corresponding 4-alkyltetrafluorobenzonitriles. Tetrafluoroterephthalonitrile acts as a four-electron donor ligand and forms tungsten(II)η 2-nitrile complexes.
Tetrafluoroterephthalonitrile is a hydroxyl group-containing organic chemical compound . It has been used in analytical chemistry as a reagent for the determination of peptide binding constants and disulfide bonds. Tetrafluoroterephthalonitrile binds to nucleophilic sites on proteins, such as the pim-1 protein, and can be used to transport other molecules across cell membranes. In addition, it has been used to produce polymers for use in analytical chemistry. This chemical is also able to bind with magnetic particles under constant pressure conditions, which makes it useful for optical sensor applications. , Computed Properties of 1835-49-0

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 1835-49-0, formula is C8F4N2, Name is Tetrafluoroterephthalonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. COA of Formula: C8F4N2.

Mohsenpour, Sajjad;Ameen, Ahmed W.;Leaper, Sebastian;Skuse, Clara;Almansour, Faiz;Budd, Peter M.;Gorgojo, Patricia research published 《 PIM-1 membranes containing POSS – graphene oxide for CO₂ separation》, the research content is summarized as follows. PIM-1 mixed matrix membranes (MMMs) were fabricated with polyhedral oligomeric silsesquioxane (POSS) and graphene oxide (GO) functionalized with POSS (GO-POSS), and tested for CO₂/N₂ (single gas) and CO₂/CH₄ (1:1, v:v gas mixture). The CO₂ permeability of the best performing fresh MMM (containing 0.05 wt% GO-POSS) was ∼ 12000 Barrer, which is 69% higher than that of the neat PIM-1 membrane, with about the same selectivity (CO₂/CH₄ selectivity ∼ 12 and CO₂/N₂ selectivity ∼ 20). In both cases, the gas separation data surpass the 2008 Robeson upper bound. In addition to the initial CO₂ permeability enhancement, the use of GO-POSS is an efficient strategy to slow down phys. aging. The MMM at a filler loading of 0.75 wt% showed less than half of the reduction in CO₂ permeability than the neat PIM-1 membrane 160 days after preparation (26% for the MMM vs 58% for the purely polymeric one).

1835-49-0, Tetrafluoroterephthalonitrile can react with alkyl grignard reagents to form 4-alkyltetraflurorobenzonitriles. It acts as a four electron donor ligand. Tetrafluoroterephthalonitrile can be used to synthesize polymers of intrinsic microporosity. It has been used to study UV rearranged polymers of teh PIM-1 type membrane for the efficient separation of H2 and CO2.
Tetrafluoroterephthalonitrile reacts with alkyl Grignard reagents to form corresponding 4-alkyltetrafluorobenzonitriles. Tetrafluoroterephthalonitrile acts as a four-electron donor ligand and forms tungsten(II)η 2-nitrile complexes.
Tetrafluoroterephthalonitrile is a hydroxyl group-containing organic chemical compound . It has been used in analytical chemistry as a reagent for the determination of peptide binding constants and disulfide bonds. Tetrafluoroterephthalonitrile binds to nucleophilic sites on proteins, such as the pim-1 protein, and can be used to transport other molecules across cell membranes. In addition, it has been used to produce polymers for use in analytical chemistry. This chemical is also able to bind with magnetic particles under constant pressure conditions, which makes it useful for optical sensor applications. , COA of Formula: C8F4N2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. Formula: C9H6BrNO.

Moolman, Chantalle;van der Sluis, Rencia;Beteck, Richard M.;Legoabe, Lesetja J. research published 《 Exploration of benzofuran-based compounds as potent and selective Plasmodium falciparum glycogen synthase kinase-3 (PfGSK-3) inhibitors》, the research content is summarized as follows. A series of benzofuran-based compounds I [R¹ = H, HO, MeO, Cl; R² = H, HO, MeO, (₅H₂C)N; R³ = H, HO, MeO, Br; R⁴ = H, MeO, Cl; R⁵ = H, F, NC, MeO, Cl, Br] was synthesized and evaluated as inhibitors of recombinantly expressed and purified PfGSK-3 and human glycogen synthase kinase-3 beta (HsGSK-3β). Of this series, five compounds I [R¹ = H; R² = H, MeO; R³ = H, MeO; R⁴ =H, MeO, Cl; R⁵ = H, F, NC, Cl] preferentially inhibited PfGSK-3, with four of these compounds exhibiting IC₅₀ values in the sub-micromolar range (0.00048-0.440μM). Evaluation of the structure-activity relationships required for PfGSK-3 selective inhibition indicated that a C6-OCH₃ substitution on ring A was preferred, while the effect of the ring B substituent on activity, in decreasing order was: C4′-CN > C4′-F > C3′-OCH₃ > C3′,4′-di-Cl. To date, development of PfGSK-3 inhibitors was limited to the 4-phenylthieno[2,3-b]pyridine class. Chalcone-based scaffolds, such as the benzofurans I described herein, are promising new hits which can be explored for future design of PfGSK-3 selective inhibitors.

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Formula: C9H6BrNO

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Electric Literature of 20099-89-2.

Musci, Pantaleo;Colella, Marco;Andresini, Michael;Aramini, Andrea;Degennaro, Leonardo;Luisi, Renzo research published 《 Flow technology enabled preparation of C3-heterosubstituted 1-azabicyclo[1.1.0]butanes and azetidines: accessing unexplored chemical space in strained heterocyclic chemistry》, the research content is summarized as follows. The use of flow technol. as an enabling tool for accessing 1-azabicyclo[1.1.0]butanes bearing strained 3-, 4-, and 5-membered O-heterocycles with C3(N-het)-C2(O-het) connectivity I [R = H, Me, CH₂CH₂Br, etc.; R¹ = Ph, 2-ClC₆H₄, CH:CHC₆H₅, etc.], II [X = 1, 2; R2 = Ph, 2-thienyl, 2-naphthyl, etc.] and III [n = 2, 3; R³ = Ph, 4-BrC₆H₄, 1-naphthyl, etc.] was reported. Reactivity and chemoselectivity (N-ring vs. O-ring) were also evaluated. New chem. space was explored and new structural motifs such as ABB-aziridines IV [n = 1, 2, 3; R⁴ = Boc, Ts; R⁵ = Cl, Br, SPh, etc.; Ar = Ph, 4-FC₆H₄, 4-MeC₆H₄, 4-OMeC₆H₄] or spiro azetidine-oxazetidine V were also reported.

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Electric Literature of 20099-89-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 1835-49-0, formula is C8F4N2, Name is Tetrafluoroterephthalonitrile. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. HPLC of Formula: 1835-49-0.

Ma, Yao;Bruno, Nicholas C.;Zhang, Fengyi;Finn, M. G.;Lively, Ryan P. research published 《 Zeolite-like performance for xylene isomer purification using polymer-derived carbon membranes》, the research content is summarized as follows. Polymers of intrinsic microporosity (PIMs) have been used as precursors for the fabrication of porous carbon mol. sieve (CMS) membranes. PIM-1, a prototypical PIM material, uses a fused-ring structure to increase chain rigidity between spirobisindane repeat units. These two factors inhibit effective chain packing, thus resulting in high free volume within the membrane. However, a decrease of pore size and porosity was observed after pyrolytic conversion of PIM-1 to CMS membranes, attributed to the destruction of the spirocenter, which results in the ‘flattening’ of the polymer backbone and graphite-like stacking of carbonaceous strands. Here, a spirobifluorene-based polymer of intrinsic microporosity (PIM-SBF) was synthesized and used to fabricate CMS membranes that showed significant increases in p-xylene permeability (approx. four times), with little loss in p-xylene/o-xylene selectivity (13.4 vs. 14.7) for equimolar xylene vapor separations when compared to PIM-1-derived CMS membranes. This work suggests that it is feasible to fabricate such highly microporous CMS membranes with performances that exceed current state-of-the-art zeolites at high xylene loadings.

HPLC of Formula: 1835-49-0, Tetrafluoroterephthalonitrile can react with alkyl grignard reagents to form 4-alkyltetraflurorobenzonitriles. It acts as a four electron donor ligand. Tetrafluoroterephthalonitrile can be used to synthesize polymers of intrinsic microporosity. It has been used to study UV rearranged polymers of teh PIM-1 type membrane for the efficient separation of H2 and CO2.
Tetrafluoroterephthalonitrile reacts with alkyl Grignard reagents to form corresponding 4-alkyltetrafluorobenzonitriles. Tetrafluoroterephthalonitrile acts as a four-electron donor ligand and forms tungsten(II)η 2-nitrile complexes.
Tetrafluoroterephthalonitrile is a hydroxyl group-containing organic chemical compound . It has been used in analytical chemistry as a reagent for the determination of peptide binding constants and disulfide bonds. Tetrafluoroterephthalonitrile binds to nucleophilic sites on proteins, such as the pim-1 protein, and can be used to transport other molecules across cell membranes. In addition, it has been used to produce polymers for use in analytical chemistry. This chemical is also able to bind with magnetic particles under constant pressure conditions, which makes it useful for optical sensor applications. , 1835-49-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Reference of 20099-89-2.

Mane, Kishor D.;Rupanawar, Bapurao D.;Suryavanshi, Gurunath research published 《 Visible Light-Promoted, Photocatalyst-Free C(sp²)-H Bond Functionalization of Indolizines via EDA Complexes》, the research content is summarized as follows. The catalyst and additive-free, photo-driven cross dehydrogenative coupling (CDC) reaction initiated by electron donor-acceptor (EDA) complexes between electron rich indolizines and electron poor quinones had been demonstrated to obtain indolizine coupled quinones I [R = H, Cl; R¹ = H, 1-Me, 7-Me, 8-Me; R² = Ph, 4-MeC₆H₄, 3-BrC₆H₄, etc.; R³ = H, Br, NO₂]. This green transformation revealed the advantages of operational simplicity, mild reaction conditions and good functional group tolerances.

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Reference of 20099-89-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Quality Control of 20099-89-2.

Mathew, Bini;Ruiz, Pedro;Dutta, Shilpa;Entrekin, Jordan T.;Zhang, Sixue;Patel, Kaval D.;Simmons, Micah S.;Augelli-Szafran, Corinne E.;Cowell, Rita M.;Suto, Mark J. research published 《 Structure-activity relationship (SAR) studies of N-(3-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (SRI-22819) as NF-κB activators for the treatment of ALS》, the research content is summarized as follows. ALS is a rare type of progressive neurol. disease with unknown etiol. It results in the gradual degeneration and death of motor neurons responsible for controlling the voluntary muscles. Identification of mutations in the superoxide dismutase (SOD) 1 gene has been the most significant finding in ALS research. SOD1 abnormalities have been associated with both familial as well as sporadic ALS cases. SOD2 is a highly inducible SOD that performs in concurrence with SOD1 to detoxify ROS. Induction of SOD2 can be obtained through activation of NF-κBs. We previously reported that SRI-22819 increases NF-κB expression and activation in vitro, but it has poor ADME properties in general and has no oral bioavailability. Our initial studies were focused on direct modifications of SRI-22819. There were active compounds identified but no improvement in microsomal stability was observed In this context, we focused on making more significant structural changes in the core of the mol. Ataluren, an oxadiazole compound that promotes read-through and expression of dystrophin in patients with Duchenne muscular dystrophy, bears some structural similarity to SRI-22819. Thus, we synthesized a series of SRI-22819 and Ataluren (PTC124) hybrid compounds Several compounds from this series exhibited improved activity, microsomal stability and lower calculated polar surface area (PSA). This manuscript describes the synthesis and biol. evaluation of SRI-22819 analogs and its hybrid combination with Ataluren.

Quality Control of 20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile is any organic compound with a −C≡N functional group. 1835-49-0, formula is C8F4N2, Name is Tetrafluoroterephthalonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. Application In Synthesis of 1835-49-0.

Li, Meng;Wu, Mingwei;Pan, Biwei;Xu, Dandan;Lvsong, Zhuopu;Li, Dongqing;Zhang, Fangrong;Huang, Jun research published 《 Aerobic Oxidation of 2,3,6-Trimethylphenol with Reusable Homogenized Copper Catalysts》, the research content is summarized as follows. The oxidation of 2,3,6-trimethylphenol(TMP) can produce both 2,3,5-trimethyl-1,4-benzoquinone(TMQ) and 2,3,5-trimethyl-1,4-hydroquinone(TMHQ) as important intermediates of vitamin E. With a soluble and porous polymer of intrinsic microporosity(PIM-1), we developed a highly active and reusable CuO@PIM-1 catalyst for the aerobic oxidation of TMP to TMQ and TMHQ. The CuO@PIM-1 catalyst is high active and selective for the aerobic oxidation of TMP, and TMQ and TMHQ can be obtained in yields of 81% and 19%, resp. The CuO@PIM-1 catalyst has both advantages of homogeneous and heterogeneous and the CuO@PIM-1 catalyst showed a higher activity than homogeneous(CuCl₂) and heterogeneous(supported CuO) catalysts. Moreover, CuO@PIM-1 catalyst can be recovered easily and reused at least 5 times without deactivation.

1835-49-0, Tetrafluoroterephthalonitrile can react with alkyl grignard reagents to form 4-alkyltetraflurorobenzonitriles. It acts as a four electron donor ligand. Tetrafluoroterephthalonitrile can be used to synthesize polymers of intrinsic microporosity. It has been used to study UV rearranged polymers of teh PIM-1 type membrane for the efficient separation of H2 and CO2.
Tetrafluoroterephthalonitrile reacts with alkyl Grignard reagents to form corresponding 4-alkyltetrafluorobenzonitriles. Tetrafluoroterephthalonitrile acts as a four-electron donor ligand and forms tungsten(II)η 2-nitrile complexes.
Tetrafluoroterephthalonitrile is a hydroxyl group-containing organic chemical compound . It has been used in analytical chemistry as a reagent for the determination of peptide binding constants and disulfide bonds. Tetrafluoroterephthalonitrile binds to nucleophilic sites on proteins, such as the pim-1 protein, and can be used to transport other molecules across cell membranes. In addition, it has been used to produce polymers for use in analytical chemistry. This chemical is also able to bind with magnetic particles under constant pressure conditions, which makes it useful for optical sensor applications. , Application In Synthesis of 1835-49-0

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Application of C9H6BrNO.

Li, Wangbing;Lu, Zhichao;Hammond, Gerald B.;Xu, Bo research published 《 Unbalanced-Ion-Pair-Catalyzed Nucleophilic Fluorination Using Potassium Fluoride》, the research content is summarized as follows. An unbalanced ion pair promoter (e.g., tetrabutylammonium sulfate), consisting of a bulky and charge-delocalized cation and a small and charge-localized anion, greatly accelerated nucleophilic fluorinations using easy handling KF. An inexpensive and com. available ion-exchange resin was successfully converted to the polymer-supported ion pair promoter (A26-SO₄^2-), which could be reused after filtration. Moreover, A26-SO₄^2- could be used in continuous flow conditions. Water was well-tolerated.

Application of C9H6BrNO, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 1835-49-0, formula is C8F4N2, Name is Tetrafluoroterephthalonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Name: Tetrafluoroterephthalonitrile.

Ling, Honglei;Jin, Jianyong research published 《 Improved synthesis route and performance of azide modified polymers of intrinsic microporosity after thermal self-crosslinking》, the research content is summarized as follows. A new azide modified biscatechol monomer was first obtained and characterized by single-crystal XRD, but its polymerization only afforded a low mol. weight azide-containing polymer of intrinsic microporosity (PIM-N3). The high-mol. PIM-N3 was then obtained via post-modification on PIM-Me, prepared by the fluoride-mediated PIM synthesis method developed by our group in 2015. The crosslinking temperature was set at 220°C based on the thermogravimetric anal. (TGA) data. The thermal self-crosslinking of PIM-N3 significantly enhanced gas permeability. The 6-h crosslinked PIM-N3 (PIM-N3-6 h) exhibited the best combination of CO₂ permeability, and selectivity for CO₂ over N₂ and CH₄, traversing the 2008 Robeson upper bound.

Name: Tetrafluoroterephthalonitrile, Tetrafluoroterephthalonitrile can react with alkyl grignard reagents to form 4-alkyltetraflurorobenzonitriles. It acts as a four electron donor ligand. Tetrafluoroterephthalonitrile can be used to synthesize polymers of intrinsic microporosity. It has been used to study UV rearranged polymers of teh PIM-1 type membrane for the efficient separation of H2 and CO2.
Tetrafluoroterephthalonitrile reacts with alkyl Grignard reagents to form corresponding 4-alkyltetrafluorobenzonitriles. Tetrafluoroterephthalonitrile acts as a four-electron donor ligand and forms tungsten(II)η 2-nitrile complexes.
Tetrafluoroterephthalonitrile is a hydroxyl group-containing organic chemical compound . It has been used in analytical chemistry as a reagent for the determination of peptide binding constants and disulfide bonds. Tetrafluoroterephthalonitrile binds to nucleophilic sites on proteins, such as the pim-1 protein, and can be used to transport other molecules across cell membranes. In addition, it has been used to produce polymers for use in analytical chemistry. This chemical is also able to bind with magnetic particles under constant pressure conditions, which makes it useful for optical sensor applications. , 1835-49-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts