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Application of 117918-23-7. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (R)-3-(tert-Butoxycarbonyl)-5,5-dimethylthiazolidine-4-carboxylic acid, is researched, Molecular C11H19NO4S, CAS is 117918-23-7, about Search for substrate-based inhibitors fitting the S2′ space of malarial aspartic protease plasmepsin II. Author is Kiso, Aiko; Hidaka, Koushi; Kimura, Tooru; Hayashi, Yoshio; Nezami, Azin; Freire, Ernesto; Kiso, Yoshiaki.

Plasmepsin (Plm) has been identified as an important target for the development of new antimalarial drugs, since its inhibition leads to the starvation of Plasmodium falciparum. A series of substrate-based dipeptide-type Plm II inhibitors containing the hydroxymethylcarbonyl isostere as a transition-state mimic were synthesized. The general design principle was provision of a conformationally restrained hydroxyl group (corresponding to the set residue at the P2′ position in native substrates) and a bulky unit to fit the S2′ pocket.

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Quality Control of 2,4,5-Triphenylimidazole. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2,4,5-Triphenylimidazole, is researched, Molecular C21H16N2, CAS is 484-47-9, about Evidence for the Formation of 1,2-Dioxetane as a High-Energy Intermediate and Possible Chemiexcitation Pathways in the Chemiluminescence of Lophine Peroxides. Author is Boaro, Andreia; Reis, Roberta Albino; Silva, Carolina Santana; Melo, Diego Ulysses; Pinto, Alexander Garreta Goncalves Costa; Bartoloni, Fernando Heering.

A kinetic study of the chemiluminescent (CL) reaction mechanism of lophine-derived hydroperoxides and silyl peroxides induced by a base and fluoride, resp., provided evidence for the formation of a 1,2-dioxetane as a high-energy intermediate (HEI) of this CL transformation. This was postulated using a linear Hammett relationship, consistent with the formation of neg. charge on the transition state of HEI generation (ρ > 1). The decomposition of this HEI leads to chemiexcitation with overall low singlet excited state formation quantum yield (ΦS from 1.1 to 14.5 x 10-5 E mol-1); nonetheless, ΦS = 1.20 x 10-3 E mol-1 was observed with both peroxides substituted with bromine. The use of electron-donating substituents increases chemiexcitation efficiency, while it also reduces the rate for both formation and decomposition of the HEI. Different possible pathways for HEI decomposition and chemiexcitation are discussed in light of literature data from the perspective of the substituent effect. This system could be explored in the future for anal. and labeling purposes or for biol. oxidation through chemiexcitation.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (R)-3-(tert-Butoxycarbonyl)-5,5-dimethylthiazolidine-4-carboxylic acid, is researched, Molecular C11H19NO4S, CAS is 117918-23-7, about Structure-activity relationships of novel HIV-1 protease inhibitors containing the 3-amino-2-chlorobenzoyl-allophenylnorstatine structure, the main research direction is HIV1 protease inhibitor allophenylnorstatine derivative preparation structure activity.Computed Properties of C11H19NO4S.

A series of peptidomimetic human immunodeficiency virus (HIV) protease inhibitors containing substituted allophenylnorstatine (Apns: (2S,3S)-3-amino-2-hydroxy-4-phenylbutyric acid) were designed and synthesized. From the structure-activity relation of this series of compounds, SM-309515 was found to have potent antiviral activity against wild-type and resistant HIV-1s and to possess a desirable pharmacokinetic profile in dogs.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2,4,5-Triphenylimidazole(SMILESS: C1(C2=CC=CC=C2)=NC(C3=CC=CC=C3)=C(C4=CC=CC=C4)N1,cas:484-47-9) is researched.Recommanded Product: 1116-98-9. The article 《Synthesis and characterization of a new polymeric catalyst and used for the synthesis of imidazole derivatives》 in relation to this compound, is published in Research on Chemical Intermediates. Let’s take a look at the latest research on this compound (cas:484-47-9).

Cross-linked poly(4-vinylpyridine) supported TiCl4 abbreviated as [P4-VP]-Ti(IV) as a new polymeric catalyst was easily prepared and characterized by using the X-ray spectroscopy, EDS, mapping, TGA/DTG and FTIR techniques. This catalyst was used for synthesis of imidazole derivatives via one-pot three-component condensation reaction of benzil, ammonium acetate and aldehydes. This protocol offers advantages such as short reaction time, simple reaction work-up with reusability of catalyst.

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Product Details of 166329-43-7. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: tert-Butyl (2-(bromomethyl)phenyl)carbamate, is researched, Molecular C12H16BrNO2, CAS is 166329-43-7, about Synthesis of amino substituted benzyltriphenylphosphonium bromides. Author is Hong, Wei; Wang, Hao.

The amino substituted benzyltriphenylphosphonium bromides could be used as Wittig reagents in Wittig reaction and were synthesized efficiently from 2 or 3 or 4-hydroxymethyl anilines by a three-step reaction, protection, bromination and nucleophilic substitution, in total yield of 70%.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 484-47-9, is researched, Molecular C21H16N2, about synthesis of some novel derivative of 2,4,5-triphenyl imidazole through the novel method, the main research direction is triphenyl imidazole derivative preparation antifungal.Recommanded Product: 2,4,5-Triphenylimidazole.

Herein, synthesis of some novel derivatives of 2,4,5-tri-Ph imidazole is described. The importance aspects of this protocol are high yielding, mild reaction conditions, availability of the precursor and purity of the obtained product with no further crystallization In conclusion mol. iodine was found to be a mild and effective catalyst for the formation of 2,4,5-tri-Ph substituted imidazoles in excellent yields. The use of this in expensive easily available catalyst under solvent free conditions make this protocol practical and economically attractive.

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Synthetic Route of 68385-95-5, These common heterocyclic compound, 68385-95-5, name is 2-Amino-3,5-dibromobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Bromine (110 mmol, 5.6 mL) was added dropwise to an acetic acid solution (150 mL) of 2-aminobenzonitrile (50 mmol, 5.9 g) in an argon atmosphere, and the mixture was stirred at room temperature for 5 hours. The reaction solution was poured into ice water (200 mL), and the resulting solid was collected by filtration and washed with water.The residue was recrystallized from ethyl acetate to obtain 2-amino-3,5-dibromobenzonitrile (6.9 g, yield 50%).The obtained 2-amino-3,5-dibromobenzonitrile (10.0 mmol, 2.75 g), tetrabutylammonium fluoride trihydrate (5.0 mmol, 1.58 g), trimethylsilyl azide (TMSN3) (15 0.0 mmol, 2.0 mL) was stirred at 85 C. for 2 hours under an argon atmosphere. Ethyl acetate was added to the reaction solution, and the mixture was extracted 3 times with 1M hydrochloric acid (5 mL), and then the organic layer was dried over magnesium sulfate and dried under reduced pressure.Ethyl acetate was distilled off. The residue was subjected to silica gel column chromatography (ethyl acetate: ethanol = 10: 1), and 2,4-dibromo-6- (1H-tetrazol-5-yl) aniline (1.40 g, yield 44%) was white. Obtained as a solid.

The synthetic route of 68385-95-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Tohoku University; Uozumi, Nobuyuki; Arisawa, Mieko; Suzuki, Futoshi; Endo, Akira; Hamamoto, Susumu; Ikenokami, Yoshiaki; (20 pag.)JP2019/137678; (2019); A;,
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Adding a certain compound to certain chemical reactions, such as: 499983-13-0, name is 4-Bromo-3-fluorophenylacetonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 499983-13-0, Formula: C8H5BrFN

A solution of 4-bromo-3-fluorophenylacetonitrile (Ig, 4.6 mmoles) in toluene (4 ml) is added with 0.6 ml (7 mmoles) of 1,2-dibromoethane, a 50% NaOH aqueous solution (4 ml) and tetrabutylammonium bromide (0.32 g, 1 mmoles). The mixture is kept under stirring at room temperature for 4 hours, then diluted with water and extracted with ethyl acetate. The organic phase is recovered and solvent is eliminated under vacuum to give a brown solid, which is subjected to silica gel chromatography purification, to afford an orange to yellow product in the solid form (I g, yield 90%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-3-fluorophenylacetonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CHIESI FARMACEUTICI S.P.A.; PIVETTI, Fausto; FORNARETTO, Maria Gioia; RE, Marco; WO2011/15287; (2011); A2;,
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Electric Literature of 5866-98-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5866-98-8, name is 2,6-Dichloro-3-nitrobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.

To a stirred solution of 2,6-dichloro-3-nitrobenzonitrile (750.0 g, 3.45 mol, 1.0 equiv.) in ethanol (7.5 L, 10.0 V) at 15-20 C. was slowly added hydrazine hydrate (519.0 g, 10.36 mol, 3.0 equiv.) while maintaining the reaction mass below 25 C (Observation: Addition is slightly exothermic and solid formation will begin upon addition). The reaction mixture temperature was slowly raised to room temperature and then the mixture was stirred for 3 h (Observation: the quantity of solids will increase during this time). After completion of the reaction (monitored by TLC), the mixture was diluted with water (7.5 L, 10.0 V) and further stirred for 1 h at room temperature. The solids were isolated via filtration and then were washed with water (2.25 L, 3.0 V). The wet solid was washed with a 1 : 1 ratio mixture of acetone (1.875 L, 2.5 V) and hexanes (1.875 L, 2.5 V). Bulk residual water was removed from the solids by maintaining vacuum filtration for 60-90 min. The wet solid was finally dried in a hot air oven for 7-8 h at 50 C (until moisture content reaches below 1.5%) to get the dried product, 4-chloro-7-nitro-li/-indazol-3 -amine (549.0 g, 75% yield) as a brick red- colored solid. NMR (400 MHz, CDCL): d 10.36 (bs, 1H), 8.20 (d, J= 8.4 Hz, 1H), 7.07 (d, J= 8.40 Hz, 1H), 4.73 (bs, 2H).

The chemical industry reduces the impact on the environment during synthesis 2,6-Dichloro-3-nitrobenzonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; IWUAGWU, Christiana; PEESE, Kevin M.; (0 pag.)WO2020/58844; (2020); A1;,
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These common heterocyclic compound, 1114546-30-3, name is 4-Bromo-2-fluoro-3-methylbenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 4-Bromo-2-fluoro-3-methylbenzonitrile

General procedure: A mixture of 4-bromo-2-fluoro-3-methylbenzonitrile (7.00 g, 32.7mmol), potassium vinyltrifluoroborate (5.3 g, 39 mmol) and Pd(dppf)Cl2 (0.5 g, 0.7 mmol) in 70 mL of EtOH and 30mL of TEA was refluxed under Ar for 4 hours. Concentrated, the residue was purified by column chromatography(petrol ether: EtOAc = 10 :1) to afford 4-ethenyl-2-fluoro-3-methylbenzonitrile.

The synthetic route of 4-Bromo-2-fluoro-3-methylbenzonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Merck Sharp & Dohme Corp.; PASTERNAK, Alexander; BLIZZARD, Timothy; CHOBANIAN, Harry; DE JESUS, Reynalda; DING, Fa-Xiang; DONG, Shuzhi; GUDE, Candido; KIM, Dooseop; TANG, Haifeng; WALSH, Shawn; PIO, Barbara; JIANG, Jinlong; (128 pag.)EP2744499; (2016); B1;,
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