Tag: M.W=200-300

Electric Literature of 1953-99-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1953-99-7, name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a 100 mL flask was added the solid (4- (biphenyl-2-ylamino) -3,5,6-trichlorophthalonitrile) (1.0 g), 3,4,5,6-Tetrachlorophthalonitrile (0.67 g), 1,8-Diazabicycloundec-7-ene (1.5 g) and 1-pentanol (15 mL). Thereafter, zinc acetate (0.23 g) is added and refluxed with heating. After completion of the reaction, the solvent was removed,Purify by chromatography. Dichloromethane was appropriately added to the obtained solid to dissolve the solid, and hexane was added to obtain crystals. At this time, the obtained solid was filtered and dried under vacuum to obtain a compound represented by the following general formula (8).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, other downstream synthetic routes, hurry up and to see.

These common heterocyclic compound, 302912-31-8, name is Ethyl 2-(4-cyanophenyl)-2-oxoacetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 302912-31-8

To a solution of ethyl (4-cyanophenyl)(oxo)acetate (5.0 g, 24.6 mmol) in water (100 mL) was added concentrated hydrochloric acid (100 mL). The solution was heated to reflux for 16 hours. The solution was cooled to ambient temperature and the solids were filtered and dried to give 4- (carboxycarbonyl)benzoic acid as a white solid. ESIMS calcd 195.0 (M+ + H), found 195.0 (M+ + H).

The synthetic route of Ethyl 2-(4-cyanophenyl)-2-oxoacetate has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5866-98-8 as follows. name: 2,6-Dichloro-3-nitrobenzonitrile

To a 1 L two-neck round bottom flask was added 2,6-dichloro-3-nitrobenzonitrile (11. I g, 51.1 mmol) followed by ethyl acetate (102 mL). The flask was equipped with an internal thermometer and magnetic stir bar and cooled to 5 0C by immersion into an ice bath. Methylamine was added dropwise to the cooled reaction mixture as a 40% aqueous solution (8.9 mL, 115 mmol) with vigorous stirring. The reaction mixture was stirred for an additional 3 hours with cooling, after which more methylamine (1.8 ?iL, 23 r?mol) was added. The reaction vessel was removed from the ice bath and stirred for an additional 1.5 hours. To the reaction mixture was added water (30 mL) followed immediately by hexane (45 mL) and the resulting slurry was stirred for 15 minutes. The solid was recovered by filtration and washed with water followed by methanol to provide 6-chloro-2-methylamino-3-nitro- benzonitrile (10.49 g, 96%) as a bright yellow solid, which was used directly without further purification. 1H NMR (400 MHz, OMSO-de) delta 8.55 – 8.53 (m, IH), 8.28 (d, IH, J= 9.0 Hz), 6.95 (d, IH), J = 9.0 Hz), 3.30 (d, IH, 7= 5.5 Hz).

According to the analysis of related databases, 5866-98-8, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 68385-95-5, name is 2-Amino-3,5-dibromobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 2-Amino-3,5-dibromobenzonitrile

General procedure: 4.3.1. General procedure for tacrine analogs. To a mixture of 2-amino-3,5-dibromobenzonitrile (1.0 mmol) and ketone (1.10 mmol) in toluene (12 mL) placed in a round bottom flask connected to a reflux condenser was added Lewis acid (1.20 mmol). The mixture was heated at 120 C for 24 h under stirring. After cooling to room temperature, the remaining solids were treated with NaOH solution (2 mol L-1, 12 mL) and this mixture was heated at reflux for 24 h. On cooling to room temperature, the reaction mixture was extracted with CHCl3 (3*25 mL), and the organic layers were combined and dried over Na2SO4. The solvent was evaporated under reduced pressure to give the desired product. The procedures were performed under an argon atmosphere in the presence of ZnCl2, InCl3, FeCl3, and BiCl3. The isolated products appeared to be sufficiently clean and no further purification was conducted.

According to the analysis of related databases, 68385-95-5, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 57381-49-4, name is 2-Bromo-4-chlorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., name: 2-Bromo-4-chlorobenzonitrile

Example 6A2-Bromo-4-chlorobenzylamine; 13.9 ml (13.9 mmol) of borane-THF complex (1 M) are provided with ice cooling. Slowly a solution of 604 mg (2.8 mmol) of 2-bromo-4-chlorobenzonitrile (Example 1A) in 60 ml of THF is added. Thereafter the reaction mixture is heated under reflux for 1 h, cooled, and 20 ml of 1N hydrochloric acid are added dropwise with ice cooling. For the work up, the solution is rendered alkaline with a 1N sodium hydroxide solution and extracted with dichloromethane. The organic phase is dried over sodium sulfate and concentrated on a rotary evaporator. The crude product (450 mg, about 73% pure) is reacted further without purification.1H NMR (300 MHz, CDCl3): delta=3.89 (s, 2H), 7.35-7.45 (m [ABM], 2H), 7.55 (d, 1H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 57381-49-4.

Electric Literature of 1953-99-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1953-99-7, name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Tetrachlorophthalonitrile (26.6 parts by weight),m-mercaptobenzoic acid (15.4 parts by weight),To a solution of dimethylformamide (200 parts by weight),Add potassium carbonate (15 parts by weight)The reaction was allowed to proceed for 1 hour at room temperature.Subsequently, thionyl chloride (50 parts by weight) was added and reacted at 70 C. for 1 hour. After cooling to room temperature, 1-methoxy-2-propanol (10 parts by weight) was added, and the mixture was further heated to reflux for 4 hours. .After completion of the reaction, liquid separation with ethyl acetate and 1N aqueous hydrochloric acid was performed.The organic layer was concentrated and purified by silica gel column chromatography. Subsequently, sodium tungstate for the purified sample(5 parts by weight), hydrogen peroxide (30%, 6.8 parts by weight) acetic acid(5 parts by weight) and ethanol (50 parts by weight) were added and stirred at 50 C. for 5 hours. After completion of the reaction, separation and purification by silica gel column chromatography gave Intermediate A-103 (10 parts by weight).

The synthetic route of 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 22972-63-0 as follows. category: nitriles-buliding-blocks

A solution of DIBAL ([1 M] in toluene) (1 60.9 ml_, 160.9 mmol, 2.5 eq) was added dropwise to a stirred solution of 2-(3,5-Dimethoxy-phenyl)-2-methyl-propionitrile (13.2 g, 64.36 mmol, 1 eq) in dry CH2CI2 (320 ml_) under nitrogen at -78 SC. The reaction mixture was stirred at -78 SC for 1 h. An aqueous solution of potassium sodium tartrate (10% solution in water) was added dropwise and the reaction mixture was warmed to room temperature and stirred vigorously overnight. The solid was filtered through celite and rinsed with CH2CI2, the product was extracted with CH2CI2. The combined organic layers were washed with brine and water, dried over anhydrous MgSC , filtered and the solvent was removed under reduced pressure. The product was purified by chromatography on silica gel (heptane/EtOAc, from 100:0 to 80:20). The desired fractions were collected and concentrated to afford the title product as a colorless oil. (1 1 .6 g, 86.5 %). 1 H NMR (300 MHz, CDC ) d 9.46 (s, 1 H), 6.40 (s, 3H), 3.79 (s, 6H), 1 .43 (s, 6H). LC-MS (ESI+): 209.1 (M+H+); R.T. : 1 .388 min. (HPLC Method E).

According to the analysis of related databases, 22972-63-0, the application of this compound in the production field has become more and more popular.

185836-35-5, name is 4-(Benzyloxy)-2-fluorobenzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C14H10FNO

Preparation 26 tert-butyl (3R,4S)-4-(5-(benzyloxy)-2-cvanophenoxy)-3-fluoropiperidine-1-carboxylate To a solution of 4-(benzyloxy)-2-fluorobenzonitrile (WO2006016548, 1 g, 4.4 mmol) in DMF (20 ml_) was added tert-butyl-(3R,4S)-3-fluoro-4-hydroxypiperidine (JOC (2013), 78 (17), 8892-8897, 1 g, 4.84 mmol) and cesium carbonate (2.86 g, 8.802 mmol). The reaction was heated to 100C for 16 hours before cooling and diluting with EtOAc. The solution was washed with water, brine, dried over sodium sulphate and concentrated in vacuo. The residue was purified using silica gel column chromatography eluting with 10% EtOAc in hexanes to afford the title compound as a yellow gum (1.7 g, 90%). 1 H NMR (400 MHz, DMSO-d6):5 ppm 1.40 (s, 9H), 1 .70-1.90 (m, 2H), 2.95-3.40 (m, 2H), 3.80-3.90 (m, 1 H), 4.00-4.15 (m, 1 H), 4.86-5.00 (m, 2H), 5.19 (s, 2H), 6.77-6.79 (m, 1 H), 6.99 (s, 1 H), 7.34-7.47 (m, 5H), 7.65-7.67 (m, 1 H). MS m/z 427 [M+H]+

The synthetic route of 185836-35-5 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 85068-32-2, name is 2-(3,5-Bis(trifluoromethyl)phenyl)acetonitrile, A new synthetic method of this compound is introduced below., Quality Control of 2-(3,5-Bis(trifluoromethyl)phenyl)acetonitrile

[0156] 0.46 g (1.33 mmol) of the Nile-red compound derivative, 0.50 g (1.99 mmol) of 3,5-bis(trifluoromethyl)phenylacetonitrile, and 50 ml of acetic anhydride were placed in a 100 ml pear-shaped flask. The solution in the pear-shaped flask was heated in a silicone oil bath to 135 C. and allowed to react for 2 hours. Acetic anhydride was distilled off with an evaporator and the residue was dissolved in chloroform. This chloroform solution was washed with a 5% aqueous solution of sodium hydroxide and then with water. After the addition of sodium sulfate, the solution was allowed to stand for 30 minutes to be dried. The dried solution was concentrated with an evaporator. The obtained solid was purified by a column chromatography that used silica gel and benzene. 14 mg of violaceous solid was obtained. The melting point of the violaceous solid was 183-185 C. An NMR chart of this product is shown in FIG. 11. The results of elemental analysis of this violaceous product are as follows. Based on these results, the obtained product was identified as the Nile Red luminescent compound represented by formula (22). [0157] The results of elemental analysis [0158] Found values: C: 67.02, H: 4.77, N: 5.13 [0159] Calculated values: C: 66.90, H: 4.71, N: 5.03

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

1835-49-0, name is Tetrafluoroterephthalonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C8F4N2

About 1.25 g (about 6.25 mmol) of the 1,4-dicyano-2,3,5,6-tetrafluorobenzene synthesized according to the procedure described in Example 1 was transferred into about 57.5 mL of N2 bubbled toluene, which was at about 0 C. About 17.5 ml (about 17.5 mmol) of 1 M DIBAL-H (diisopropylaluminumhydride) toluene solution was added. After the reaction mixture was stirred for about 2.5 hours at room temperature, the mixture was cooled to about 0 C.About 30 mL of about 2 N HCl was added until the pH of the mixture was less than about 2 units.The aqueous layer was then extracted several times with CH2Cl2.The organic layer was combined and dried by evaporation.The crude product was chromatographed with toluene as a carrier through silica gel and produced about 0.79 g of product (about 62%).The 1H NMR resonance of this product in CDCl3 was delta 10.36 and the 19F NMR resonance was delta -144.1 (singlet).The reaction scheme (5) is illustrated below.

The synthetic route of 1835-49-0 has been constantly updated, and we look forward to future research findings.