Tag: M.W=200-300

Synthetic Route of 1953-99-7, The chemical industry reduces the impact on the environment during synthesis 1953-99-7, name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, I believe this compound will play a more active role in future production and life.

To a 100 mL flask was added the solid (4- (biphenyl-2-ylamino) -3,5,6-trichlorophthalonitrile) (1.0 g), 3,4,5,6-tetrachlorophthalonitrile (2.0 g), 1,8-Diazabicycloundec- -ene (3.0 g), and 1-pentanol (30 mL), and dissolve by heating. Then, zinc acetate (0.46 g) is added and refluxed with heating. After completion of the reaction, the solvent was removed, and the residue was purified by column chromatography. Dichloromethane was appropriately added to the obtained solid to dissolve the solid, and hexane was added to crystallize. At this time, the obtained solid was filtered and dried under vacuum to obtain a compound represented by the following general formula (7).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Cheil Industries Co., Ltd.; Choe, Say Young; Kwon, JaeYoung; Park, Uhn B; Lee, Jong Son; Lee, Chang Ryul; Jong, Ju Ho; Choe, Mi Jin; Choe, Sung Gip; Hyung, Gyung Hee; (28 pag.)KR2015/130131; (2015); A;,
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Related Products of 58633-04-8, These common heterocyclic compound, 58633-04-8, name is 4-Amino-3,5-dibromobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 26 PREPARATION OF 3,5-DIBROMOBENZONITRILE STR38 To a stirred solution of t-butylnitrite (53.5 muL, 0.449 mmoles) in 1 ml sieve dried dimethylformamide at 50 C. under an atmosphere of nitrogen was added a solution of 4-amino-3,5-dibromobenzonitrile (50 mg, 0.179 mmoles) in 1 mL of DMF. The mixture was stirred at 50 C. for 0.5 hour and partitioned between diethyl ether, ice-water, and ammonium chloride. The organic phase was separated, washed with water and brine, dried over anhydrous sodium, filtered, and evaporated. Purification by plate layer chromatography using hexane-ethyl acetate (9:1) as the eluant provided 28 mg (59%) of white, crystalline product. NMR (CDCl3) delta:7.7 (d, J=1.8Hz, 2H), 7.9 (t, J=1.8Hz, 1H).

Statistics shows that 4-Amino-3,5-dibromobenzonitrile is playing an increasingly important role. we look forward to future research findings about 58633-04-8.

Reference:
Patent; Merck & Co. Inc.; US5455239; (1995); A;,
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Adding a certain compound to certain chemical reactions, such as: 179897-89-3, name is 5-Bromo-2-fluorobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 179897-89-3, Safety of 5-Bromo-2-fluorobenzonitrile

To 5-Bromo-2-fluoro-benzonitrile (10.05 g, 50.25 mmol) in DMSO (30 mL) is added sodiummethanethiolate (3.87 g, 55.27 mmol) portionwise at 0 C. The reaction mixture is stirred for 2 h at r.t. Sodiummethanethiolate (1.06 g, 15.07 mmol) is added and stirred for further 2 h at r.t. The reaction mixture is diluted with water (100 mL) and the precipitate is filtered off and dried in vacuo at 50 C. [0325] Yield 88% m/z 228/230 [M+H]+, rt 1.26 min, LC-MS Method V018_S01

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ANDERSKEWITZ, Ralf; GRAUERT, Matthias; GRUNDL, Marc; OOST, Thorsten; PAUTSCH, Alexander; PETERS, Stefan; US2014/275159; (2014); A1;,
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Application of 75344-77-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 75344-77-3, name is 4-Bromo-3,5-dimethylbenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.

4-Bromo-3,5-dimethyl benzonitrile (5.0 g) is dissolved in HCl in dioxane (4 M, 17.3 mL) and EtOH (5 mL) added. After stirring for 16 h volatiles are evaporated in vacuo and the crude residue (6.5 g) used as such in the next step.

The chemical industry reduces the impact on the environment during synthesis 4-Bromo-3,5-dimethylbenzonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HAMPRECHT, Dieter; FRATTINI, Sara; LINGARD, Iain; PETERS, Stefan; US2013/324514; (2013); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 20099-89-2, name is 4-(2-Bromoacetyl)benzonitrile, A new synthetic method of this compound is introduced below., COA of Formula: C9H6BrNO

2-Aminopyridine (1.88 g) and 2-bromo-4′-cyanoacetophenone (4.48 g) were dissolved in ethanol (40 mL), and sodium hydrogencarbonate (1.85 g) was added to the solution, followed by refluxing for 10 hours. Water was added to the reaction mixture, and the mixture was extracted with chloroform, followed by drying over magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was subjected to flash column chromatography. Fractions eluted by dichloromethane-methanol (100 : 1) were concentrated under reduced pressure, and the solid was recovered through filtration by use of diethyl ether, to thereby yield 4-imidazo[1,2-a]pyridin-2-ylbenzonitrile (3.82 g). 1H-NMR(400MHz,DMSO-d6)delta:6.94(1H,tt,J=1.0,6.8Hz), 7.30(1H,ddt,J=1.0,6.8,9.0Hz),7.62(1H,d,J=9.0Hz), 7.90(2H,d,J=8.5Hz),8.16(2H,d,J=8.5Hz), 8.56(1H,ddd,J=1.0,2.0,6.8Hz),8.60(1H,s).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Fujifilm RI Pharma Co., Ltd.; Daiichi Sankyo Company, Limited; EP1956013; (2008); A1;,
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In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 92616-49-4 as follows. Recommanded Product: 4-Bromo-1-naphthonitrile

To a solution of 4-bromo-1-naphthonitrile 10 (5g, 21.7mmol) in 1,4-dioxane and water (V:V=5:1, 100ml), was added bis(pinacolato)diboron (11g, 43.4mmol), PdCl2(dppf) (1.588g, 2.17mmol), KOAc (3.189g ,32.5mmol). The mixture was heated to 90 C and stirred for 16 h under N2. The solution was allowed to cool to room temperature and the water (200ml) was added to the solution. Then the solution was extracted with ethyl acetate (80ml¡Á3). The organic phase was combined and dried over Na2SO4, filtered, and concentrated to give crude 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-naphthonitrile 11 (4.3g, yield = 71%), which was used without further purification.

According to the analysis of related databases, 92616-49-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Yang, Xintuo; Pang, Xuehai; Fan, Lei; Li, Xinghai; Chen, Yuanwei; Bioorganic and Medicinal Chemistry Letters; vol. 27; 9; (2017); p. 1919 – 1922;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1953-99-7, name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, A new synthetic method of this compound is introduced below., Recommanded Product: 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile

To a 100 mL flask2,4-Bis (alpha,alpha-dimethylbenzyl) -2-yloxy) -3,5,6-trichloro-phthalonitrile (1 g), 3,4,6-Trichloro-5-pentoxy-phthalonitrile (0.7 g),1,8-Diazabicycloundec-7-ene (0.8 g), 1-pentanol (7 g) and zinc acetate (0.3 g) were added and stirred while heating to 140 ¡ã C. After completion of the reaction, the mixture is concentrated and purified by column chromatography. The liquid obtained after purification is concentrated to obtain a solid. The crystallized solid is vacuum-dried to obtain a compound represented by the following general formula (9).

The synthetic route of 1953-99-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Samsung SDI Co., Ltd; Jeong Ui-su; Seo Hye-won; Shin Myeong-yeop; Han Gyu-seok; (40 pag.)KR2019/13136; (2019); A;,
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Adding a certain compound to certain chemical reactions, such as: 1503-49-7, name is 4-Benzoylbenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1503-49-7, Quality Control of 4-Benzoylbenzonitrile

To a vial containing 4-benzoylbenzonitrile (0.181 g, 0.873 mmol; prepared according to the procedure described by L.J. omicronomicronbetaepsiloneta and K. Ghosh, Angew. Chem. Int. Ed. 2001, 40, 3458), NBS (0.171 g, 0.961 mmol), p-toluenesulfonic acid monohydrate (0.083 g, 0.437 mmol) and palladium (II) acetate (0.020 g, 0.087 mmol), was added DCE (10 mL). The vial was briefly purged with N2 and then it was sealed and the mixture was stirred at 80C (block temperature) overnight. The cooled mixture was evaporated and the residue was taken up in a minimum volume of DCM and then adsorbed on a silica gel pre-column. Flash chromatography (ISCO/ 0-50% EtOAc-hexane) gave 4-benzoyl-2- bromobenzonitrile (0.138 g, 55.2% yield) as a white crystalline solid. LC-MS (Method J): 1.272 min, [M + H]+ = no ion observed; H NMR (400 MHz, OMSO-d6) delta ppm 8.11 (d, J= 7.8 Hz, 1H), 8.09 (d, J= 1.2 Hz, 1H), 7.81 (dd, J= 1.6, 7.8 Hz, 1H), 7.76 (d, J= 7.4 Hz, 2H), 7.72 (t, /= 7.4 Hz, 1H), 7.58 (t, /= 7.6 Hz, 2H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; UNIVERSITE DE MONTREAL; BRISTOL-MYERS SQUIBB COMPANY; PRIESTLEY, Eldon, Scott; REZNIK, Samuel, Kaye; RUEDIGER, Edward, H.; GILLARD, James, R.; HALPERN, Oz, Scott; JIANG, Wen; RICHTER, Jeremy; RUEL, Rejean; TRIPATHY, Sasmita; YANG, Wu; ZHANG, Xiaojun; (642 pag.)WO2018/5591; (2018); A1;,
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Adding a certain compound to certain chemical reactions, such as: 905710-66-9, name is 4-Bromo-3-(hydroxymethyl)benzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 905710-66-9, Formula: C8H6BrNO

To a solution of 4-bromo-3-(l -hydroxy ethyl)benzonitrile (0.95 g, 0.0045 mol) in dichloromethane (CH2CI2; 10 mL) at 0 C were added NN-diisopropylethylamine (DIPEA; 2.0 g, 0.0157 mol) and methyl chloromethyl ether (MOMCl; 0.72 g, 0.009 mol) slowly. The resulting mixture was stirred at room temperature overnight. The reaction mass was quenched with H2O and extracted with CH2CI2. The organic layer was washed with H2O and brine, dried over Na2S04 and concentrated to provide the crude product. Purification by flash column chromatography (S1O2; gradient of 0-15 % EtOAc in hexane) gave the title compound as a colorless oil (1 g, 90%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-3-(hydroxymethyl)benzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; DOW AGROSCIENCES LLC; BRAVO-ALTAMIRANO, Karla; CASTELLO, Olena; GRUBER, Joseph M.; MARKLEY, Lowell; RIAR, Dilpreet S.; ROTH, Joshua; YAP, Maurice C.; (62 pag.)WO2018/156554; (2018); A1;,
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These common heterocyclic compound, 1835-65-0, name is 3,4,5,6-Tetrafluorophthalonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C8F4N2

Example 20 CoPcF8 (PhO) 8 (SO3 H) 6 Synthesis example (4) of starting material CoPcF8 (Pho) 8 20.0 g (100 mmol) of tetrafluorophthalonitrile, 18.8 g (100 mmol) of phenol, 10.8 g of KF and 100 ml of acetonitrile were fed into a 200 ml of a four-necked flask, and the reaction mixture was stirred at 5¡ã C. for 3 hours. Thereafter, the solid matter was filtrated and the filtrate was evaporated for dryness. There was thus obtained 27.4 g of 3,6-difluoro-4,5-bisphenoxyphthalonitrile.

The synthetic route of 3,4,5,6-Tetrafluorophthalonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nippon Shokubai Co., Ltd.; US5359056; (1994); A;,
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