In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 123-06-8 as follows. 123-06-8
To a solution of ethoxymethylenemalonodinitrile (S) (80 mmol) in benzene is added hydrazine (150 mmol). The reaction is stirred at reflux for 1 hr, diluted into ethyl acetate, washed with sodium bicarbonate solution and concentrated under vacuum, to provide T.
According to the analysis of related databases, 123-06-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; CONCERT PHARMACEUTICALS INC.; WO2008/5471; (2008); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts