Related Products of 50670-64-9, A common heterocyclic compound, 50670-64-9, name is 5-Amino-2-methylbenzonitrile, molecular formula is C8H8N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: The respective amine (1.1 equivalent) and methyl thioglycolate(1.0 equivalent) were added to an ice-cooled solution of 1,19-carbonyldiimidazole (1.1 equivalent) in 30 ml of absolute methylenechloride. The reaction mixture was stirred at room temperature for3 days and then washed three times with 3 M HCl. The solvent wasremoved, and the crude solid was purified by recrystallization fromtoluene or by flash column chromatography.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Oppermann, Sina; Schrader, Florian C.; Elsaesser, Katharina; Dolga, Amalia M.; Kraus, Anna Lena; Doti, Nunzianna; Wegscheid-Gerlach, Christof; Schlitzer, Martin; Culmsee, Carsten; Journal of Pharmacology and Experimental Therapeutics; vol. 350; 2; (2014); p. 273 – 289;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts