Chen, Ying published the artcileAssembly of α-(Hetero)aryl Nitriles via Copper-Catalyzed Coupling Reactions with (Hetero)aryl Chlorides and Bromides, Formula: C16H13NO, the main research area is aryl heteroaryl nitrile synthesis; copper catalyzed coupling decarboxylation aryl heteroaryl halide cyanoacetate; C−C cross-coupling; anti-inflammatory drugs; copper; oxalamide ligands; α-(hetero)aryl nitriles.
α-(Hetero)aryl nitriles are important structural motifs for pharmaceutical design. The known methods for direct synthesis of these compounds via coupling with (hetero)aryl halides suffer from narrow reaction scope. Herein, we report that the combination of copper salts and oxalic diamides enables the coupling of a variety of (hetero)aryl halides (Cl, Br) and Et cyanoacetate under mild conditions, affording α-(hetero)arylacetonitriles via one-pot decarboxylation. Addnl., the CuBr/oxalic diamide catalyzed coupling of (hetero)aryl bromides with α-alkyl-substituted Et cyanoacetates proceeds smoothly at 60°C, leading to the formation of α-alkyl (hetero)arylacetonitriles after decarboxylation. The method features a general substrate scope and is compatible with various functionalities and heteroaryls. Thus, e.g., 4-chloroanisole + Et cyanoacetate → 2-(4-methoxyphenyl)acetonitrile (up to 80%).
Angewandte Chemie, International Edition published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent) (and heteroaryl). 42872-30-0 belongs to class nitriles-buliding-blocks, name is 2-(3-Benzoylphenyl)propanenitrile, and the molecular formula is C16H13NO, Formula: C16H13NO.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts