Hachiya, Iwao published the artcileTitanium Tetraiodide/Trimethylsilyl Iodide Synergistically Induced Cyclization of N-(2-Cyanophenyl)benzamides into 2-Aryl-4-iodoquinazolines, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is iodoquinazoline aryl preparation iodination cyclization cyanophenyl benzamide.
Synthesis of 2-aryl-4-iodoquinazolines I (R1 = H, Cl, Me, R2 = 4-Cl, 4-F, 4-Br, H, Me, 2-Cl, 3-Cl, 3,5-Cl2) is developed using titanium tetraiodide/trimethylsilyl iodide synergistically induced cyclization of N-(2-cyanophenyl)benzamides II. The cyclization reactions proceeded to give the 2-aryl-4-iodoquinazolines in moderate to high yields. Remarkable synergetic effect of titanium tetraiodide and trimethylsilyl iodide was observed to promote the cyclization. The method was applied to the formal synthesis of a potent analgesic agent.
ACS Omega published new progress about Cyclization. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts