Month: November 2022

Liu, Yuxiao published the artcileRuthenium Trichloride Catalyzed Highly Efficient Deoximation of Oximes to the Carbonyl Compounds and Nitriles without Acceptors, Application In Synthesis of 5653-62-3, the main research area is ketone preparation green chem; ketoxime deoximation ruthenium trichloride catalyst; nitrile preparation green chem; aldoxime deoximation ruthenium trichloride catalyst.

The acceptor-free catalysis protocol for the deoximation of ketoximes e.g., I and aldoximes RCH:NOH (R = C6H5, 2,3-(H3CO)2C6H3, 4-H3CC6H4, 2-HOC6H4) using RuCl3 as the catalyst has been developed. Under the optimized conditions, various oximes were converted to ketones e.g., II and nitriles RCN with excellent isolated yields.

Chinese Journal of Chemistry published new progress about Aromatic nitriles Role: SPN (Synthetic Preparation), PREP (Preparation). 5653-62-3 belongs to class nitriles-buliding-blocks, name is 2,3-Dimethoxybenzonitrile, and the molecular formula is C9H9NO2, Application In Synthesis of 5653-62-3.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lang, Simon B. published the artcileActivation of Alcohols with Carbon Dioxide: Intermolecular Allylation of Weakly Acidic Pronucleophiles, COA of Formula: C16H13NO, the main research area is nitroalkane allyl alc carbon dioxide palladium allylation catalyst; nitrile allyl alc carbon dioxide palladium allylation catalyst; aldehyde allyl alc carbon dioxide palladium allylation catalyst; allylated product preparation.

The direct coupling of allyl alcs. with nitroalkanes, nitriles, and aldehydes using catalytic Pd(PPh3)4 has been accomplished via activation of C-OH bonds with CO2. The in situ formation of carbonates from alcs. and CO2 facilitates oxidative addition to Pd to form reactive π-allylpalladium intermediates. In addition, the formation of a strong base activates nucleophiles toward the reaction with the π-allylpalladium electrophile. Overall, this atom economical reaction provides a new C-C bond without the use of an external base and generates water as the only byproduct.

Organic Letters published new progress about Alkanes, nitro Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 42872-30-0 belongs to class nitriles-buliding-blocks, name is 2-(3-Benzoylphenyl)propanenitrile, and the molecular formula is C16H13NO, COA of Formula: C16H13NO.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Faroughi Niya, Homayoun published the artcileA One-pot Multicomponent Synthesis of Pyrroloacridine-1(2H)-one and 1,8-Dioxodecahydroacridine Derivatives Catalyzed by Salicylic Acid in Polyethylene Glycol, Quality Control of 1885-29-6, the main research area is pyrroloacridinone dioxodecahydroacridine preparation green chem; aniline aldehyde dimedone multicomponent reaction salicylic acid catalyst; isatine aniline dimedone multicomponent reaction.

Two efficient, straightforward and ecofriendly protocols are described for one-pot multicomponent synthesis of pyrrolo[2,3,4-kl]acridin and 1,8-dioxodecahydroacridine derivatives using salicylic acid as the catalyst and polyethylene glycol (PEG-200) as the promoter solvent. The reported approach shows significant advantages, such as operational simplicity, the use of an inexpensive and nontoxic catalyst, high yields, short reaction time, and the product isolation ease without chromatog. separation An important feature of this work is the route of the reaction that depends on the reaction solvent.

Polycyclic Aromatic Compounds published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Quality Control of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Hachiya, Iwao published the artcileTitanium Tetraiodide/Trimethylsilyl Iodide Synergistically Induced Cyclization of N-(2-Cyanophenyl)benzamides into 2-Aryl-4-iodoquinazolines, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is iodoquinazoline aryl preparation iodination cyclization cyanophenyl benzamide.

Synthesis of 2-aryl-4-iodoquinazolines I (R1 = H, Cl, Me, R2 = 4-Cl, 4-F, 4-Br, H, Me, 2-Cl, 3-Cl, 3,5-Cl2) is developed using titanium tetraiodide/trimethylsilyl iodide synergistically induced cyclization of N-(2-cyanophenyl)benzamides II. The cyclization reactions proceeded to give the 2-aryl-4-iodoquinazolines in moderate to high yields. Remarkable synergetic effect of titanium tetraiodide and trimethylsilyl iodide was observed to promote the cyclization. The method was applied to the formal synthesis of a potent analgesic agent.

ACS Omega published new progress about Cyclization. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhang, Guofu published the artcileA cascade process for directly converting nitriles (RCN) to cyanamides (RNHCN) via SO2F2-activated Tiemann rearrangement, Related Products of nitriles-buliding-blocks, the main research area is cyanamide preparation atom economy; amidoxime key intermediate preparation Tiemann rearrangement sulfonyl difluoride promoted; nitrile hydroxylamine oximation.

A simple, mild and practical process for the direct conversion of nitriles RCN (R = H, t-Bu, 2-thienyl, 4-ClC6H4, etc.) to cyanamides RNHCN was newly discovered and exhibited a wide substrate scope as well as great functional group-tolerability (36 examples). In this efficient strategy, in situ generated amidoximes R(NH2)C:NOH obtained from the reaction of nitriles with hydroxylamine subsequently underwent Tiemann rearrangement, producing corresponding cyanamides with great isolated yields under SO2F2. Addnl., the control experiments reportedly shed light on tentative mechanism involved in formation and elimination of key intermediate: a sulfonyl ester.

Organic & Biomolecular Chemistry published new progress about Atom economy. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Krasavin, Mikhail published the artcileContinued exploration of 1,2,4-oxadiazole periphery for carbonic anhydrase-targeting primary arene sulfonamides: discovery of subnanomolar inhibitors of membrane-bound hCA IX isoform that selectively kill cancer cells in hypoxic environment, COA of Formula: C6H4N2, the main research area is oxadiazole arenesulfonamide preparation antitumor carbonic anhydrase inhibitor hypoxia SAR; 1,2,4-Oxadiazole; Cancer cells; Carbonic anhydrase; Hypoxic environment; Isoform-selective inhibitors; Isosteric replacement; Periphery groups; Primary sulfonamides; Subnanomolar inhibition.

An expanded set of diversely substituted 1,2,4-oxadiazole-containing primary aromatic sulfonamides I (R1 = cyclopropyl, Ph, 2-MeOC6H4, 3-MeOC6H4, pyridin-2-yl) and II (X = m-phenylene, p-phenylene, thiophene-2,4-diyl, etc.; R2 = Me, cyclopropyl, Ph, thiophen-2-yl, etc.) was synthesized and tested for inhibition of human carbonic anhydrase I, II, IX and XII isoforms. The initial biochem. profiling revealed a significantly more potent inhibition of cancer-related, membrane-bound isoform hCA IX (reaching into submicromolar range), on top of potent inhibition of hCA XII that is another cancer target. The observed structure-activity relationships have been rationalized by mol. modeling. Comparative single-concentration profiling of the carbonic anhydrase inhibitors synthesized for antiproliferative effects against normal (ARPE-19) and cancer (PANC-1) cell lines under chem. induced hypoxia conditions revealed several candidate compounds selectively targeting cancer cells. More in-depth characterization of these leads revealed two structurally related compounds that showed promising selective cytotoxicity against pancreatic cancer (PANC-1) and melanoma (SK-MEL-2) cell lines.

European Journal of Medicinal Chemistry published new progress about Antitumor agents. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, COA of Formula: C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Gayyur published the artcileSynergetic copper/zinc catalysis: synthesis of aryl/heteroaryl-fused 1H-pyrrolo[3,2-c]pyridines, Application In Synthesis of 1885-29-6, the main research area is aryl pyrrolopyridine preparation; amino arylnitrile ynamide cyclization reaction copper zinc catalyst.

A synergetic copper/zinc-catalyzed one-step annulation reaction of 2-amino (hetero)arylnitriles e.g., 2-aminobenzonitrile with ynamide-derived buta-1,3-diynes R1N(S(O)2R)CCCCN(S(O)2R)R1 (R = Bn, Me; R1 = Me, Ph, 4-methylphenyl, etc.) to deliver 1H-pyrrolo[3,2-c]quinoline-2,4-diamine derivatives I (R2 = H, 8-Me, 7-Cl, 9-F, etc.) in moderate to good yields was reported. The annulation reaction follows a double cyclization pathway. The gram-scale synthesis of 1H-pyrrolo[3,2-c]quinoline-2,4-diamine proves the practicality of this protocol.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application In Synthesis of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Frost, Grant B. published the artcileChemoselectivity for Alkene Cleavage by Palladium-Catalyzed Intramolecular Diazo Group Transfer from Azide to Alkene, Product Details of C7H6N2, the main research area is benzyl alkenyl phenyl carbamoyl azide preparation palladium catalyst chemoselective; benzo dihydroquinazolinone preparation; alkene cleavage; azides; cycloreversion; diazo group transfer; palladium.

A palladium-catalyzed intramol. azide to alkene DGT, which granted chemoselectivity over competing aziridination. The data supported a catalytic cycloreversion mechanism distinct from other known metal-catalyzed azide/alkene reactions: nitrenoid/metalloradical and (3+2) cycloadditions Kinetics experiments revealed an unusual mechanistic profile in which the catalyst was not operative during the rate-controlling step, rather, it was active during the product-determining step. Catalytic DGT was used to synthesize N-heterocyclic quinazolinones, a medicinally relevant structural core. On the competing aziridination and subsequent ring expansion to another N-heterocyclic core structure of interest, benzodiazepinones was also reported.

Chemistry – A European Journal published new progress about Chemoselectivity. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Product Details of C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhu, Yiwen published the artcileCobalt-catalyzed carbonylative cyclization of N-(2-Vinylphenyl)picolinamides to access (NH)-quinolin-2(1H)-ones, Related Products of nitriles-buliding-blocks, the main research area is TFBen vinylphenyl picolinamide copper catalyst regioselective carbonylative cyclization; quinolinone preparation.

A cobalt-catalyzed carbonylative cyclization of N-(2-vinylphenyl)picolinamides for the construction of (NH)-quinolin-2(1H)-one scaffolds was developed. In this reaction, various free (NH)-quinolin-2(1H)-ones were produced in good yields (up to 92%) by employing benzene-1,3,5-triyl triformate (TFBen) as the CO source and picolinamide as the traceless directing group. Moreover, several synthetic transformations of the obtained (NH)-quinolin-2(1H)-ones were performed and a facile and rapid access to the core skeleton of Tipifarnib was realized to demonstrate the utility of this protocol.

Molecular Catalysis published new progress about Anilines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yang, Tao published the artcileThe Cascade Methylation/Cyclization of ortho-Cyanoarylacrylamides with Dicumyl Peroxide, Quality Control of 1885-29-6, the main research area is methylquinolinedione preparation; cyanoarylacrylamide dicumyl peroxide cascade methylation cyclization.

A radical cascade methylation/cyclization of ortho-cyanoarylacrylamides was developed by utilizing dicumyl peroxide as a methylation reagent. This transformation provides a simple and straight forward approach to methylated quinoline-2,4(1H,3H)-diones, and exhibits a wide substrate scope. Furthermore, this reaction could be readily scaled up. A possible mechanism is also proposed.

European Journal of Organic Chemistry published new progress about Cyclization. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Quality Control of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts