Adding a certain compound to certain chemical reactions, such as: 19472-74-3, name is 2-Bromophenylacetonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19472-74-3, Application In Synthesis of 2-Bromophenylacetonitrile
Step 1. Paraformaldehyde (2.17 ml, 14.8 mmol) and K2CO3 (1.37 g, 9.9 mmol) are added to a solution of commercially available 2-bromophenylacetonitrile (1.32 mL, 9.9 mmol) in DMF (60 mL). The reaction is stirred at 80C for 1 night. After cooling to r.t., water (100 mL) is added and the aqueous layer is extracted with EtOAc (150 mL, 50 mL). The combined organic extracts are washed with brine, dried over MgSC>4, filtered and evaporated. The crude compound is purified by prep. HPLC (Prep-HPLC-3 conditions) to give 2-(2- bromophenyl)acrylonitrile ( 561 mg, 27% yield) as an orange oil. 1H NMR (400 MHz, DMSO) <5: 7.77-7.74 (m, 1 H), 7.53-7.48 (m, 2 H), 7.42 (ddd, J1 = 2.9 Hz, J2 = 6.3 Hz, J3 = 8.0 Hz, 1 H), 6.61 (s, 1 H), 6.36 (s, 1 H).
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Reference:
Patent; IDORSIA PHARMACEUTICALS LTD; BOLLI, Martin; BROTSCHI, Christine; LESCOP, Cyrille; WILLIAMS, Jodi T.; (0 pag.)WO2019/234115; (2019); A1;,
Nitrile – Wikipedia,
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