In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 185836-35-5 as follows. Recommanded Product: 4-(Benzyloxy)-2-fluorobenzonitrile
Step 2: Production of 4-benzyloxy-2-fluoro-N-hydroxybenzamidine To a suspension of 4-benzyloxy-2-fluorobenzonitrile (15.0 g, 66 mmol) in water (150 ml) and ethanol (150 ml) were added hydroxylamine hydrochloride (6.42 g, 92.4 mmol) and sodium carbonate (10.5 g, 99.0 mmol), and the mixture was heated under reflux for 18 hr. The reaction mixture was appropriately evaporated under reduced pressure and the residue was extracted with chloroform. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate. After filtration, the solvent was evaporated under reduced pressure, and the obtained solid was washed with a mixed solvent of n-hexane:ethyl acetate=1:1 to give 4-benzyloxy-2-fluoro-N-hydroxybenzamidine (14.7 g, yield 86%). 1H-NMR(400MHz, deltappm, DMSO-d6): 9.51(1H, s), 7.31-7.45 (6H, m), 6.92(1H, dd, J=12.8, 2.0Hz), 6.85(1H, dd, J=8.8, 2.8Hz), 5.71(2H, s), 5.14(2H, s).
According to the analysis of related databases, 185836-35-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Japan Tobacco Inc.; EP1688420; (2006); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts