Related Products of 555-21-5, A common heterocyclic compound, 555-21-5, name is 4-Nitrophenylacetonitrile, molecular formula is C8H6N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Compound 1 (10 g, 61.67 mmol) was dissolved in methanol (50 mL).Add 10% Pd/C (1.0g),Replace the reaction system four times with H2,Stir at room temperature overnight in H2 environment (0.5 MPa).TLC analysis, the reaction was complete, and the reaction solution was filtered through celite.The filtrate was concentrated under reduced pressure to give 8.08g of Compound 2,The yield was 99.1%.
The synthetic route of 555-21-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Yancheng Normal College; Nanjing University Of Technology Dafeng Ocean Industrial Institute; Zhang Lijie; Sun Yaquan; Gu Huiwen; (12 pag.)CN108409647; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts