Synthetic Route of 85363-04-8,Some common heterocyclic compound, 85363-04-8, name is N-(tert-Butoxycarbonyl)-2-aminoacetonitrile, molecular formula is C7H12N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
N-BOC-Glycinonitrile [sic] (12.0 g, 76.8 mmol) and diethylamine (0.16 ml, 2.1 mmol) were dissolved in toluene (100 ml). The solution was cooled to -10 C., saturated with hydrogen sulfide and subsequently stirred overnight at room temperature. The precipitate formed was filtered off with suction and washed with toluene. The product was dried in vacuo at 45 C. Yield: 13.2 g (69.4 mmol, 90.3%, yellowish solid)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route N-(tert-Butoxycarbonyl)-2-aminoacetonitrile, its application will become more common.
Reference:
Patent; Abbott GmbH & Co., KG; US6740647; (2004); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts