Application of 33143-29-2, A common heterocyclic compound, 33143-29-2, name is 2,2-Dimethyl-2H-chromene-6-carbonitrile, molecular formula is C12H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: The enantioselective epoxidation of 6-CN-2,2-DMB was carried out following the procedure reported elsewhere [13,14]. Briefly,20 mol% of S,S or R,R catalyst with 6-CN-2,2-DMB (0.0625 mmol) as substrate and 0.1875 mmol of KHSO5(Oxonedissolved in 4 mLH2O) as oxygen source were used. The catalyst and 6-CN-2,2-DMB were dissolved in acetone (4 mL), and the reaction was initiated by the stepwise addition of an aqueous KHSO5 solution, where as,the pH value of the reaction mixture was monitored and adjusted to 8.0-8.5 by slow addition of aqueous 5 wt% NaHCO3 solution,under continuous stirring. After complete addition of the aqueous KHSO5 solution, magnetic stirring was stopped and the obtained solid (catalyst and inorganic salts) was recovered by simple filtration, and it was washed with enough water. The obtained dark brown residue (recovered catalyst) was dissolved in 4 mL of acetone and reused in a further reaction. The liquid phase separated from the reaction system was extracted with CH2Cl2, the aqueous phase was discarded, and the organic phase was washed and dried with anhydrous sodium sulfate. The obtained mixture was concentrated under vacuum and the product was analyzed by GC-MS. The effectof 4-phenylpyridine N-oxide (4-PPNO, 0.0125 mmol) as additive, and the reaction temperature were also evaluated.
The synthetic route of 33143-29-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Romanelli, Gustavo; Sathicq, Angel; Vazquez, Patricia; Villa, Aida; Alarcon, Edwin; Grajales, Edwing; Cubillos, Jairo; Journal of Molecular Catalysis A: Chemical; vol. 398; (2015); p. 11 – 16;,
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