Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4426-11-3, name is Cyclobutanecarbonitrile, A new synthetic method of this compound is introduced below., name: Cyclobutanecarbonitrile
l-[5-(trifluoromethyl)pyridin-2-yl]cyclobutanecarbonitrile[187] 2-Fluoro-5-(trifluoromethyl)pyridine (0.603 mL, 5 mmol) and cyclobutane- carbonitrile (0.514 mL, 5.50 mmol) were dissolved in toluene (20 mL). 1M NaHMDS (5.50 mL, 5.50 mmol) in THF was added, and the reaction stirred at ambient temperature for 3 days. The reaction mixture was quenched with water and extracted three times with diethyl ether. The combined organic layers were washed with brine, dried with MgS04, filtered, and concentrated. The residue was chromatographed on an AnaLogix SF25-60 g column and eluted with 5% EtOAc in hexanes to give Example 115A (0.36 g, 1.592 mmol, 31.8% yield). MS (DCI+): m/z 244.0 (M+NH4). XH NMR (300 MHz, DMSO-d6) ? 9.09 – 9.02 (m, 1H), 8.33 (dd, J= 8.3, 2.2 Hz, 1H), 7.85 (d, J= 8.3 Hz, 1H), 2.89 – 2.69 (m, 4H), 2.39 – 2.21 (m, 1H), 2.16 – 2.00 (m, 1H).
The synthetic route of 4426-11-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ABBVIE INC.; BAYBURT, Erol K.; CLAPHAM, Bruce; COX, Phil B.; DAANEN, Jerome F.; GOMTSYAN, Arthur; KORT, Michael E.; KYM, Philip R.; VOIGHT, Eric A.; SCHMIDT, Robert G.; DART, Michael J.; GFESSER, Gregory; WO2013/62966; (2013); A2;,
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