Adding a certain compound to certain chemical reactions, such as: 118431-88-2, name is 3-Cyclopropyl-3-oxopropanenitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 118431-88-2, Recommanded Product: 3-Cyclopropyl-3-oxopropanenitrile
3-Cyclopropyl-3-oxopropanenitrile (3.30 g, 30 mmol) and4-hydrazinylpyridine-HC1 (3g, 20 mmol) were dissolved in ethanol and the solution was heated at reflux for 12 h. The reaction mixture was concentrated and re-dissolvedethyl acetate. The solution was neutralized with NaOH solution and the aqueous layer was extracted with ethyl acetate, the combined organic layers were washed with brine, then dried over anhydrous Na2SO4. The volatile components were removed on a rotary evaporator and the residues were dissolved in methanol (10 mL) followed by addition of CF3CO2H (10 mL). The reaction mixture was stirred at room temperature for 12 h and the volatile components were removed on a rotary evaporator. The remaining residues were purified by flash column chromatography affording 3-cyclopropyl-1-(pyridin-4-yl)-1H-pyrazol-5-amine in 3.52 g. ?H NMR (300 MHz, MeOD-d4): 8.56 (dd, I = 4.75, 1.58 Hz, 2H), 7.68 (dd, I = 4.74, 1.59 Hz, 2H), 5.58 (s, 1H), 1.84-1.74 (m, 1H), 0.90-0.82 (m, 2H), 0.66-0.60 (m, 2H). ESI-MS calculated for C11H13N4 [M+H]= 201.11; Observed: 201.58.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Cyclopropyl-3-oxopropanenitrile, and friends who are interested can also refer to it.
Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF MICHIGAN; WANG, Shaomeng; ZHAO, Yujun; ZHOU, Bing; AGUILAR, Angelo; (114 pag.)WO2016/138332; (2016); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts