194853-86-6, name is 4-Fluoro-2-(trifluoromethyl)benzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 4-Fluoro-2-(trifluoromethyl)benzonitrile
To a solution of frans-1 ,2-diaminocycloheptane dihydrochloride [racemic (±)] (1.0 g, 4.97 mmol) in DMSO (25 ml_) under argon atmosphere was added triethylamine (1 .37 ml_, 9.94 mmol) followed by 4-fluoro-2-(trifluoromethyl)benzonitrile (0.845 g, 4.47 mmol) at RT and the resulting reaction mixture was heated to 45 C. After stirring for 16 h, the reaction mixture was cooled to RT, poured onto ice-water (50 ml_), basified with 1 N NaOH solution, and extracted with ethyl acetate (100 ml_ x 2). The combined organic layer was washed with water (50 ml_) followed by brine (50 ml_), dried over Na2SC>4, and concentrated under reduced pressure to give the title compound (1.1 g) as a brown residue. The crude residue was directly used for next step without further purification.
The synthetic route of 194853-86-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVARTIS AG; BOCK, Mark; CHIKKANNA, Dinesh; GERSPACHER, Marc; KHAIRNAR, Vinayak; LAGU, Bharat; PANDIT, Chetan; WO2013/84138; (2013); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts