Lee, Seok Beom published the artcileOne-Pot Synthesis of 4-Quinolone via Iron-Catalyzed Oxidative Coupling of Alcohol and Methyl Arene, Application of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is amino phenyl ketone alc methyl arene iron catalyst tandem; quinolone preparation; oxidative coupling condensation Mannich cyclization oxidation aldehyde.
Herein, we describe the iron(III)-catalyzed oxidative coupling of alc./methyl arene with 2-amino Ph ketone to synthesize 4-quinolone. Alcs. and Me arenes are oxidized to the aldehyde in the presence of an iron catalyst and di-tert-Bu peroxide, followed by a tandem process, condensation with amine/Mannich-type cyclization/oxidation, to complete the 4-quinolone ring. This method tolerates various kinds of functional groups and provides a direct approach to the synthesis of 4-quinolones from less functionalized substrates.
Organic Letters published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application of 2-Aminobenzonitrile(Flakes or Chunks).
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts