Month: November 2022

Sun, Huan published the artcileIron-Catalyzed Tandem Radical Addition/Cyclization: Highly Efficient Access to Methylated Quinoline-2,4-diones, Computed Properties of 1885-29-6, the main research area is methyl quinoline dione preparation; cyanoaryl acrylamide dimethyl sulfoxide photochem methylation iron catalyst.

A visible-light-induced and iron-catalyzed oxidative radical addition/cyclization cascade reaction of N-(o-cyanoaryl)acrylamides I [R1 = 4-Cl, 5-CF3, 3-Br, etc.; R2 = Me, Bn; R3 = Me, [(2,2-dimethylpropanoyl)oxy]methyl, Bn, Ph, (acetyloxy)methyl, (1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl] with DMSO has been developed. The method exhibits a wide substrate scope and an excellent functional-group tolerance, thus providing an efficient and convenient access to a variety of methylated quinoline-2,4-diones II (R4 = 6-Cl, 6-CF3, 5-Br, etc.).

Synlett published new progress about Cyclization. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Computed Properties of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhong, Jing published the artcileRhodium-Catalyzed Pyridine N-Oxide Assisted Suzuki-Miyaura Coupling Reaction via C(O)-C Bond Activation, Category: nitriles-buliding-blocks, the main research area is benzoylpyridine nitrogen oxide preparation rhodium catalyst; boronic acid benzoylpyridine nitrogenoxide Suzuki Miyaura carbon bond activation.

A rhodium-catalyzed Suzuki-Miyaura coupling reaction via C(O)-C bond activation to form 2-benzoylpyridine N-oxide derivatives is reported. Both the C(O)-C(sp2) and C(O)-C(sp3) bond could be activated during the reaction with yields up to 92%. The N-oxide moiety could be employed as a traceless directing group, leading to free pyridine ketones.

Organic Letters published new progress about Boronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Peng, Dao published the artcileHighly active and reusable copper phthalocyanine derivatives catalyzed the hydroxylation of (hetero)aryl halides, SDS of cas: 91-15-6, the main research area is metal phthalocyanine catalyst preparation; hetero aryl halide hydroxylation.

Authors have researched and developed a series of copper phthalocyanine derivatives as new highly active and reusable catalysts for the hydroxylation of (hetero)aryl halides. The perfluorinated copper phthalocyanine (CuPcF16) showed the highest activity for the hydroxylation of aryl iodide with an excellent yield (up to 98%) under low catalytic loading (0.5 mol% CuPcF16). Similarly, the hydroxylation of aryl bromides and aryl chlorides catalyzed by CuPcF16 also had high activity with 42-98% yield. Moreover, the recyclability of this catalyst can up to 6 times without significant loss in catalytic activity.

Molecular Catalysis published new progress about Homogeneous catalysis. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, SDS of cas: 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Cai, Yue-Ming published the artcileCatalyst-free oxidative N-N coupling for the synthesis of 1,2,3-triazole compounds with tBuONO, Application of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is benzotriazinone preparation; aminobenzamide coupling; benzothiadiazole preparation; aminothiol N S coupling; triazolopyridine preparation; pyridinyl methanamine coupling.

A catalyst-free method was developed to synthesize 1,2,3-benzotriazinones I [R = H, 6-Cl, 6-Br, etc.] and 1,2,3-benzothiadiazoles II [R1 = H, 6-Cl, 6-Br, etc.] from 2-amino-benzamides and 2-amino thiols. Of particular note was that the one-step synthesis route to access [1,2,3]triazolo[1,5-a]pyridines III [R2 = H, Ph, 4-ClC6H4; R3 = H, 7-Me, 7-Br] from pyridin-2-ylmethanamine was reported for the first time. This approach featured no use of catalyst, extremely mild conditions and excellent efficiency.

Organic Chemistry Frontiers published new progress about Aryl aldehydes, heteroaryl Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ding, Weijie published the artcileSynthesis of Unsymmetrical Aromatic Azoxy Compounds by Silver-Mediated Oxidative Coupling of Aromatic Amines with Nitrosoarenes, Category: nitriles-buliding-blocks, the main research area is aniline nitrosobenzene silver mediator oxidative coupling; phenyl phenyldiazene oxide preparation.

A silver(I) oxide-mediated synthesis of unsym. aromatic azoxy compounds was successfully achieved, wherein oxidative coupling reactions between aromatic amines and nitrosoarenes take place in ethanol under air. This reaction has very high economic value because silver(I) oxide is the only oxidant required and no other additive is needed. The resulted silver particles can be easily recovered, while the only other byproduct is water. This new procedure is compatible with various functional groups and proceeds under mild reaction conditions.

Advanced Synthesis & Catalysis published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sun, Kai published the artcileRadical annulation of a designed diene system: access to nitro-benzo[b]azepines, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is nitromethyl benzazepine preparation; allyl arylvinyl aniline chemoselective regioselective radical annulation.

Herein, a novel O2N·-triggered ordered addition/7-endo cyclization reaction of N-allylic o-(arylvinyl)anilines I (R1 = H, F, Cl, Br, Me, MeO, R2 = H; R1 = H, R2 = Cl, Me; R3 = Ts, PhCO, Cbz; R4 = H, Me; Ar = Ph, 2-ClC6H4, 4-MeC6H4, etc.) with excellent chemo- and regioselectivity is described. With such a strategy, 28 structurally diverse (nitromethyl)benzo[b]azepines II were prepared Large-scale operation and handy N-Ts and N-Cbz deprotection revealed the promising utility of this methodol. Mechanistic studies suggested that the reaction proceeds through a radical pathway.

Chemical Communications (Cambridge, United Kingdom) published new progress about Benzazepines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lee, Seok Beom published the artcileOne-Pot Synthesis of 4-Quinolone via Iron-Catalyzed Oxidative Coupling of Alcohol and Methyl Arene, Application of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is amino phenyl ketone alc methyl arene iron catalyst tandem; quinolone preparation; oxidative coupling condensation Mannich cyclization oxidation aldehyde.

Herein, we describe the iron(III)-catalyzed oxidative coupling of alc./methyl arene with 2-amino Ph ketone to synthesize 4-quinolone. Alcs. and Me arenes are oxidized to the aldehyde in the presence of an iron catalyst and di-tert-Bu peroxide, followed by a tandem process, condensation with amine/Mannich-type cyclization/oxidation, to complete the 4-quinolone ring. This method tolerates various kinds of functional groups and provides a direct approach to the synthesis of 4-quinolones from less functionalized substrates.

Organic Letters published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Dahiya, Amit published the artcileOrthogonal and Modular Arylation of Alkynylgermanes, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is alkyne preparation chemoselective; alkynylgermane alkynyl silane aryl halide arylation blue light gold.

While alkynyl silanes are ubiquitously employed in synthetic handles, especially in the build-up of more complex alkynes, such as alkyne-based polyaromatic materials, the identification of a similar robust functionality with ideally orthogonal reactivity space would greatly expand the modularity and scope in the construction of functional alkynes. Authors herein disclose the efficient, mild, and modular arylation of alkynylgermanes, which is enabled by blue light-assisted gold catalysis and allows for the chemoselective arylation of the alkynylgermane moiety at room temperature in 2 h over alkynyl silanes, aryl halides, aryl BPin, and various other functional groups. Conversely, the alkynylgermane proved to be uniquely stable toward typical alkynyl silane deprotection conditions as well as Sonogashira cross-coupling conditions, which underlines its orthogonal reactivity space and significant potential as a complementary robust alkyne handle.

ACS Catalysis published new progress about Aromatic hydrocarbons, aryl alkynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lee, Taegyo published the artcileRhodium-Catalyzed Enantioselective Silylation of Cyclopropyl C-H Bonds, Safety of 1-(4-Fluorophenyl)cyclopropanecarbonitrile, the main research area is rhodium catalyzed enantioselective silylation cyclopropylmethanol ethylsilane; chiral hydroxycyclopropanol preparation crystal structure; mol structure chiral hydroxycyclopropanol; carbon hydrogen bond activation silylation cyclopropylmethanol rhodium catalyst; kinetic isotope effect silylation cyclopropylmethanol rhodium catalyst; C−H activation; asymmetric catalysis; cyclopropanes; rhodium; silylation.

Hydrosilyl ethers, generated in situ by the dehydrogenative silylation of cyclopropylmethanols with diethylsilane, undergo asym., intramol. silylation of cyclopropyl C-H bonds in high yields and with high enantiomeric excesses in the presence of a Rh catalyst derived from a Rh precursor and the bisphosphine (S)-DTBM-SEGPHOS. The resulting enantioenriched oxasilolanes are suitable substrates for the Tamao-Fleming oxidation to form cyclopropanols with conservation of the ee value from the C-H silylation. Preliminary mechanistic data suggest that C-H cleavage probably is the turnover-limiting and enantioselectivity-determining step.

Angewandte Chemie, International Edition published new progress about C-H bond activation. 97009-67-1 belongs to class nitriles-buliding-blocks, name is 1-(4-Fluorophenyl)cyclopropanecarbonitrile, and the molecular formula is C10H8FN, Safety of 1-(4-Fluorophenyl)cyclopropanecarbonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yao, Hua published the artcileCyanomethylation of the Benzene Rings and Pyridine Rings via Direct Oxidative Cross-Dehydrogenative Coupling with Acetonitrile, SDS of cas: 1885-29-6, the main research area is arylacetonitrile preparation regioselective green chem; arylamine acetonitrile dehydrogenative coupling cyanomethylation.

A novel and efficient approach for the amine-directed dehydrogenative C(sp2)-C(sp3) coupling of arylamines RNH2 (R = Ph, 5-chloropyridin-2-yl, pyrazin-2-yl, etc.) with acetonitrile was reported by using FeCl2 as the catalyst. Arylamines react with inactive acetonitrile to form the corresponding arylacetonitriles R1CH2CN (R1 = 2-amino-5-chloropyridin-3-yl, 2-aminophenyl, 6-amino-1,3-benzothiazol-7-yl, etc.) in moderate to good yields. This protocol features nontoxic iron catalysis, efficient atom economy, nonprefunctionalized starting materials, good regioselectivity, and excellent compatibility of functional groups and aromatic rings, providing a novel, straightforward, and green approach toward arylacetonitriles.

Organic Letters published new progress about Aromatic amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, SDS of cas: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts