Category: 1885-29-6

Pramanik, Sourav published the artcileAccess to densely functionalized spirocyclopentenonyl oxindole frameworks via aza- and carbo-Piancatelli rearrangement, Quality Control of 1885-29-6, the main research area is spirocyclopentenonyl oxindole preparation phosphomolybdic acid catalyst; furanyl indolinone aniline Piancatelli rearrangement.

A new strategy for access to spirocyclopentenonyl oxindole frameworks is disclosed. Suitably anchored furfuryl alc. at C3 of an oxindole was used for the aza-Piancatelli rearrangement, which furnished spirocyclic aminocyclopentenone frameworks with catalytic phosphomolybdic acid. The scope of the transformation was extended to the carbo-Piancatelli rearrangement with various indole derivatives

Organic & Biomolecular Chemistry published new progress about Furans Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Quality Control of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Xiong, Biquan published the artcileSilver-catalyzed regioselective 1,6-hydroarylation of para-quinone methides with anilines and phenols, Related Products of nitriles-buliding-blocks, the main research area is alpha diarylmethyl aniline phenol preparation regioselective; para quinone methide aniline phenol hydroarylation silver catalyst.

A simple and efficient method for the silver-catalyzed regioselective 1,6-hydroarylation of para-quinone methides (p-QMs) with anilines and phenols has been established. Without the need for pre-protection, a broad range of anilines (primary amine, secondary amine and tertiary amine), phenols and para-quinone methides are well tolerated under mild conditions, giving the corresponding 1,6-hydroarylation products with moderate to good yields. Moreover, a series of modified natural products can be synthesized via this simple method. Control experiments were also performed to gain insights into the plausible reaction mechanism. This protocol has high atom economy, and may have significant implications for the formation of C(sp3)-C(sp2) bonds in organic synthesis.

Organic Chemistry Frontiers published new progress about Hydroarylation. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhang, Zhen published the artcileK2S2O8/I2-Promoted Electrophilic Selenylative Cyclization To Access Seleno-Benzo[b]azepines, Application of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is selenobenzoazepine preparation regioselective; allylphenylvinylaniline diselenide selenylative cyclization.

A novel and simple organoselenium-involved 7-membered cyclization to access diverse seleno-benzo[b]azepines has been developed. This protocol involves an electrophilic cyclization process and is accomplished under mild conditions. Discussion of the mechanism rationalizes the regioselectivity observed in transformation. The studies of further transformation of seleno-benzo[b]azepines and large-scale experiment reveal the promising utility of this methodol.

Organic Letters published new progress about Benzenesulfonamides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Tathe, Akash G. published the artcileGold-Catalyzed 1,2-Aminoarylation of Alkenes with External Amines, Synthetic Route of 1885-29-6, the main research area is aminochroman preparation gold catalyzed aminoarylation alkene external amine; amino tetrahydronaphthalene preparation gold catalyzed aminoarylation alkene external amine; aminoindane preparation gold catalyzed aminoarylation alkene external amine.

Reported herein is the gold-catalyzed 1,2-aminoarylation of alkenes that engages external amine as a coupling partner. Careful optimization studies revealed a significant role of the concentration of base to achieve highly chemoselective access to the aminoarylation products over potential C-N cross-coupled products. Overcoming all the limitations, the current strategy provided straightforward access to the medicinally relevant 3-aminochroman, 2-aminotetrahydronaphthalene, and 2-aminoindane derivatives

ACS Catalysis published new progress about Allylation. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Synthetic Route of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Dahiya, Amit published the artcileOrthogonal and Modular Arylation of Alkynylgermanes, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is alkyne preparation chemoselective; alkynylgermane alkynyl silane aryl halide arylation blue light gold.

While alkynyl silanes are ubiquitously employed in synthetic handles, especially in the build-up of more complex alkynes, such as alkyne-based polyaromatic materials, the identification of a similar robust functionality with ideally orthogonal reactivity space would greatly expand the modularity and scope in the construction of functional alkynes. Authors herein disclose the efficient, mild, and modular arylation of alkynylgermanes, which is enabled by blue light-assisted gold catalysis and allows for the chemoselective arylation of the alkynylgermane moiety at room temperature in 2 h over alkynyl silanes, aryl halides, aryl BPin, and various other functional groups. Conversely, the alkynylgermane proved to be uniquely stable toward typical alkynyl silane deprotection conditions as well as Sonogashira cross-coupling conditions, which underlines its orthogonal reactivity space and significant potential as a complementary robust alkyne handle.

ACS Catalysis published new progress about Aromatic hydrocarbons, aryl alkynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lee, Seok Beom published the artcileOne-Pot Synthesis of 4-Quinolone via Iron-Catalyzed Oxidative Coupling of Alcohol and Methyl Arene, Application of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is amino phenyl ketone alc methyl arene iron catalyst tandem; quinolone preparation; oxidative coupling condensation Mannich cyclization oxidation aldehyde.

Herein, we describe the iron(III)-catalyzed oxidative coupling of alc./methyl arene with 2-amino Ph ketone to synthesize 4-quinolone. Alcs. and Me arenes are oxidized to the aldehyde in the presence of an iron catalyst and di-tert-Bu peroxide, followed by a tandem process, condensation with amine/Mannich-type cyclization/oxidation, to complete the 4-quinolone ring. This method tolerates various kinds of functional groups and provides a direct approach to the synthesis of 4-quinolones from less functionalized substrates.

Organic Letters published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sun, Kai published the artcileRadical annulation of a designed diene system: access to nitro-benzo[b]azepines, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is nitromethyl benzazepine preparation; allyl arylvinyl aniline chemoselective regioselective radical annulation.

Herein, a novel O2N·-triggered ordered addition/7-endo cyclization reaction of N-allylic o-(arylvinyl)anilines I (R1 = H, F, Cl, Br, Me, MeO, R2 = H; R1 = H, R2 = Cl, Me; R3 = Ts, PhCO, Cbz; R4 = H, Me; Ar = Ph, 2-ClC6H4, 4-MeC6H4, etc.) with excellent chemo- and regioselectivity is described. With such a strategy, 28 structurally diverse (nitromethyl)benzo[b]azepines II were prepared Large-scale operation and handy N-Ts and N-Cbz deprotection revealed the promising utility of this methodol. Mechanistic studies suggested that the reaction proceeds through a radical pathway.

Chemical Communications (Cambridge, United Kingdom) published new progress about Benzazepines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ding, Weijie published the artcileSynthesis of Unsymmetrical Aromatic Azoxy Compounds by Silver-Mediated Oxidative Coupling of Aromatic Amines with Nitrosoarenes, Category: nitriles-buliding-blocks, the main research area is aniline nitrosobenzene silver mediator oxidative coupling; phenyl phenyldiazene oxide preparation.

A silver(I) oxide-mediated synthesis of unsym. aromatic azoxy compounds was successfully achieved, wherein oxidative coupling reactions between aromatic amines and nitrosoarenes take place in ethanol under air. This reaction has very high economic value because silver(I) oxide is the only oxidant required and no other additive is needed. The resulted silver particles can be easily recovered, while the only other byproduct is water. This new procedure is compatible with various functional groups and proceeds under mild reaction conditions.

Advanced Synthesis & Catalysis published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Cai, Yue-Ming published the artcileCatalyst-free oxidative N-N coupling for the synthesis of 1,2,3-triazole compounds with tBuONO, Application of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is benzotriazinone preparation; aminobenzamide coupling; benzothiadiazole preparation; aminothiol N S coupling; triazolopyridine preparation; pyridinyl methanamine coupling.

A catalyst-free method was developed to synthesize 1,2,3-benzotriazinones I [R = H, 6-Cl, 6-Br, etc.] and 1,2,3-benzothiadiazoles II [R1 = H, 6-Cl, 6-Br, etc.] from 2-amino-benzamides and 2-amino thiols. Of particular note was that the one-step synthesis route to access [1,2,3]triazolo[1,5-a]pyridines III [R2 = H, Ph, 4-ClC6H4; R3 = H, 7-Me, 7-Br] from pyridin-2-ylmethanamine was reported for the first time. This approach featured no use of catalyst, extremely mild conditions and excellent efficiency.

Organic Chemistry Frontiers published new progress about Aryl aldehydes, heteroaryl Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sun, Huan published the artcileIron-Catalyzed Tandem Radical Addition/Cyclization: Highly Efficient Access to Methylated Quinoline-2,4-diones, Computed Properties of 1885-29-6, the main research area is methyl quinoline dione preparation; cyanoaryl acrylamide dimethyl sulfoxide photochem methylation iron catalyst.

A visible-light-induced and iron-catalyzed oxidative radical addition/cyclization cascade reaction of N-(o-cyanoaryl)acrylamides I [R1 = 4-Cl, 5-CF3, 3-Br, etc.; R2 = Me, Bn; R3 = Me, [(2,2-dimethylpropanoyl)oxy]methyl, Bn, Ph, (acetyloxy)methyl, (1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl] with DMSO has been developed. The method exhibits a wide substrate scope and an excellent functional-group tolerance, thus providing an efficient and convenient access to a variety of methylated quinoline-2,4-diones II (R4 = 6-Cl, 6-CF3, 5-Br, etc.).

Synlett published new progress about Cyclization. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Computed Properties of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts