Tag: M.W=100-150

Garcia-Vazquez, Rocio published the artcileDirect Cu-mediated aromatic 18F-labeling of highly reactive tetrazines for pretargeted bioorthogonal PET imaging, COA of Formula: C8H8N2O, the main research area is fluoro isotope labeled aryl tetrazine preparation PET imaging.

In this work, a simple, scalable and reliable direct 18F-labeling procedure was developed. Initially the applicability of different leaving groups and labeling methods was studied to develop this procedure. The copper-mediated 18F-labeling exploiting stannane precursors showed the most promising results. This approach was then successfully applied to a set of tetrazines, including highly reactive H-tetrazines, suitable for pretargeted PET imaging. The labeling succeeded in radiochem. yields (RCYs) of up to approx. 25%. The new procedure was then applied to develop a pretargeting tetrazine-based imaging agent. The tracer was synthesized in a satisfactory RCY of ca. 10%, with a molar activity of 134 ± 22 GBq μmol-1 and a radiochem. purity of >99%. Further evaluation showed that the tracer displayed favorable characteristics (target-to-background ratios and clearance) that may qualify it for future clin. translation.

Chemical Science published new progress about Positron emission tomography. 269411-71-4 belongs to class nitriles-buliding-blocks, name is 3-Amino-5-methoxybenzonitrile, and the molecular formula is C8H8N2O, COA of Formula: C8H8N2O.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Tathe, Akash G. published the artcileGold-Catalyzed 1,2-Aminoarylation of Alkenes with External Amines, Synthetic Route of 1885-29-6, the main research area is aminochroman preparation gold catalyzed aminoarylation alkene external amine; amino tetrahydronaphthalene preparation gold catalyzed aminoarylation alkene external amine; aminoindane preparation gold catalyzed aminoarylation alkene external amine.

Reported herein is the gold-catalyzed 1,2-aminoarylation of alkenes that engages external amine as a coupling partner. Careful optimization studies revealed a significant role of the concentration of base to achieve highly chemoselective access to the aminoarylation products over potential C-N cross-coupled products. Overcoming all the limitations, the current strategy provided straightforward access to the medicinally relevant 3-aminochroman, 2-aminotetrahydronaphthalene, and 2-aminoindane derivatives

ACS Catalysis published new progress about Allylation. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Synthetic Route of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Qi, Jing published the artcileNew Radical Borylation Pathways for Organoboron Synthesis Enabled by Photoredox Catalysis, Name: Phthalonitrile, the main research area is organoboron preparation photoredox catalysis mechanism electron transfer calculation borylation; crystal structure mol cyanoaryl boronate preparation; radical borylation photoredox catalysis; N-heterocyclic carbenes; borylations; organoborons; photocatalysis; radicals.

Radical borylation using N-heterocyclic carbene (NHC)-BH3 complexes as boryl radical precursors has emerged as an important synthetic tool for organoboron assembly. However, the majority of reported methods are limited to reaction modes involving carbo- and/or hydroboration of specific alkenes and alkynes. Moreover, the generation of NHC-boryl radicals relies principally on hydrogen atom abstraction with the aid of radical initiators. A distinct radical generation method is reported, as well as the reaction pathways of NHC-boryl radicals enabled by photoredox catalysis. NHC-boryl radicals are generated via a single-electron oxidation and subsequently undergo cross-coupling with the in-situ-generated radical anions to yield gem-difluoroallylboronates. A photoredox-catalyzed radical arylboration reaction of alkenes was achieved using cyanoarenes as arylating components from which elaborated organoborons were accessed. Mechanistic studies verified the oxidative formation of NHC-boryl radicals through a single-electron-transfer pathway.

Angewandte Chemie, International Edition published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Name: Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Dahiya, Amit published the artcileOrthogonal and Modular Arylation of Alkynylgermanes, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is alkyne preparation chemoselective; alkynylgermane alkynyl silane aryl halide arylation blue light gold.

While alkynyl silanes are ubiquitously employed in synthetic handles, especially in the build-up of more complex alkynes, such as alkyne-based polyaromatic materials, the identification of a similar robust functionality with ideally orthogonal reactivity space would greatly expand the modularity and scope in the construction of functional alkynes. Authors herein disclose the efficient, mild, and modular arylation of alkynylgermanes, which is enabled by blue light-assisted gold catalysis and allows for the chemoselective arylation of the alkynylgermane moiety at room temperature in 2 h over alkynyl silanes, aryl halides, aryl BPin, and various other functional groups. Conversely, the alkynylgermane proved to be uniquely stable toward typical alkynyl silane deprotection conditions as well as Sonogashira cross-coupling conditions, which underlines its orthogonal reactivity space and significant potential as a complementary robust alkyne handle.

ACS Catalysis published new progress about Aromatic hydrocarbons, aryl alkynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lee, Seok Beom published the artcileOne-Pot Synthesis of 4-Quinolone via Iron-Catalyzed Oxidative Coupling of Alcohol and Methyl Arene, Application of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is amino phenyl ketone alc methyl arene iron catalyst tandem; quinolone preparation; oxidative coupling condensation Mannich cyclization oxidation aldehyde.

Herein, we describe the iron(III)-catalyzed oxidative coupling of alc./methyl arene with 2-amino Ph ketone to synthesize 4-quinolone. Alcs. and Me arenes are oxidized to the aldehyde in the presence of an iron catalyst and di-tert-Bu peroxide, followed by a tandem process, condensation with amine/Mannich-type cyclization/oxidation, to complete the 4-quinolone ring. This method tolerates various kinds of functional groups and provides a direct approach to the synthesis of 4-quinolones from less functionalized substrates.

Organic Letters published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sun, Kai published the artcileRadical annulation of a designed diene system: access to nitro-benzo[b]azepines, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is nitromethyl benzazepine preparation; allyl arylvinyl aniline chemoselective regioselective radical annulation.

Herein, a novel O2N·-triggered ordered addition/7-endo cyclization reaction of N-allylic o-(arylvinyl)anilines I (R1 = H, F, Cl, Br, Me, MeO, R2 = H; R1 = H, R2 = Cl, Me; R3 = Ts, PhCO, Cbz; R4 = H, Me; Ar = Ph, 2-ClC6H4, 4-MeC6H4, etc.) with excellent chemo- and regioselectivity is described. With such a strategy, 28 structurally diverse (nitromethyl)benzo[b]azepines II were prepared Large-scale operation and handy N-Ts and N-Cbz deprotection revealed the promising utility of this methodol. Mechanistic studies suggested that the reaction proceeds through a radical pathway.

Chemical Communications (Cambridge, United Kingdom) published new progress about Benzazepines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ding, Weijie published the artcileSynthesis of Unsymmetrical Aromatic Azoxy Compounds by Silver-Mediated Oxidative Coupling of Aromatic Amines with Nitrosoarenes, Category: nitriles-buliding-blocks, the main research area is aniline nitrosobenzene silver mediator oxidative coupling; phenyl phenyldiazene oxide preparation.

A silver(I) oxide-mediated synthesis of unsym. aromatic azoxy compounds was successfully achieved, wherein oxidative coupling reactions between aromatic amines and nitrosoarenes take place in ethanol under air. This reaction has very high economic value because silver(I) oxide is the only oxidant required and no other additive is needed. The resulted silver particles can be easily recovered, while the only other byproduct is water. This new procedure is compatible with various functional groups and proceeds under mild reaction conditions.

Advanced Synthesis & Catalysis published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Cai, Yue-Ming published the artcileCatalyst-free oxidative N-N coupling for the synthesis of 1,2,3-triazole compounds with tBuONO, Application of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is benzotriazinone preparation; aminobenzamide coupling; benzothiadiazole preparation; aminothiol N S coupling; triazolopyridine preparation; pyridinyl methanamine coupling.

A catalyst-free method was developed to synthesize 1,2,3-benzotriazinones I [R = H, 6-Cl, 6-Br, etc.] and 1,2,3-benzothiadiazoles II [R1 = H, 6-Cl, 6-Br, etc.] from 2-amino-benzamides and 2-amino thiols. Of particular note was that the one-step synthesis route to access [1,2,3]triazolo[1,5-a]pyridines III [R2 = H, Ph, 4-ClC6H4; R3 = H, 7-Me, 7-Br] from pyridin-2-ylmethanamine was reported for the first time. This approach featured no use of catalyst, extremely mild conditions and excellent efficiency.

Organic Chemistry Frontiers published new progress about Aryl aldehydes, heteroaryl Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Peng, Dao published the artcileHighly active and reusable copper phthalocyanine derivatives catalyzed the hydroxylation of (hetero)aryl halides, SDS of cas: 91-15-6, the main research area is metal phthalocyanine catalyst preparation; hetero aryl halide hydroxylation.

Authors have researched and developed a series of copper phthalocyanine derivatives as new highly active and reusable catalysts for the hydroxylation of (hetero)aryl halides. The perfluorinated copper phthalocyanine (CuPcF16) showed the highest activity for the hydroxylation of aryl iodide with an excellent yield (up to 98%) under low catalytic loading (0.5 mol% CuPcF16). Similarly, the hydroxylation of aryl bromides and aryl chlorides catalyzed by CuPcF16 also had high activity with 42-98% yield. Moreover, the recyclability of this catalyst can up to 6 times without significant loss in catalytic activity.

Molecular Catalysis published new progress about Homogeneous catalysis. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, SDS of cas: 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhong, Jing published the artcileRhodium-Catalyzed Pyridine N-Oxide Assisted Suzuki-Miyaura Coupling Reaction via C(O)-C Bond Activation, Category: nitriles-buliding-blocks, the main research area is benzoylpyridine nitrogen oxide preparation rhodium catalyst; boronic acid benzoylpyridine nitrogenoxide Suzuki Miyaura carbon bond activation.

A rhodium-catalyzed Suzuki-Miyaura coupling reaction via C(O)-C bond activation to form 2-benzoylpyridine N-oxide derivatives is reported. Both the C(O)-C(sp2) and C(O)-C(sp3) bond could be activated during the reaction with yields up to 92%. The N-oxide moiety could be employed as a traceless directing group, leading to free pyridine ketones.

Organic Letters published new progress about Boronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts